Clinical trials: Acquired Immune Deficiency Syndrome Virus
Human Immunodeficiency Virus (HIV), Tuberculosis (TB)
Diagnosis and Treatment of Co-infection With Human Immunodeficiency Virus /Latent Tuberculosis Infection (HIV/TBL)
The purpose of this study is to determine of once identified to the subjects infected with human immunodeficiency virus (positive VIH), to diagnose latent Tuberculosis, and to treat her with isoniazid for six months, measuring…
- Conditions
- Human Immunodeficiency Virus (HIV), Tuberculosis (TB), Latent Tuberculosis Infection (LTI)
- Trial name
- HIV/TB (NCT01875952)
- Testing
- Isoniazid
- Where
- 2 sites in Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
HIV Infections
C2P - Phase III: MPowerment and Community Promise
One of the objectives of the C2P coalition is the successful delivery of a CDC-endorsed community-level HIV prevention program aimed at changing the risk profiles of youth.
- Trial name
- NCT00381784
- Testing
- Printed materials, Peer advocates
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus, Depression
Our Family Our Future: A Resilience-oriented Family Intervention to Prevent Adolescent HIV/STI Infection and Depression in South Africa
The purpose of this study is to test the efficacy of Our Family Our Future, an integrated intervention for preventing HIV and depression onset among adolescents.
- Conditions
- Human Immunodeficiency Virus, Depression, Sexually Transmitted Diseases
- Trial name
- NCT03231358
- Testing
- Our Family Our Future
- Where
- South Africa
- Volunteers
- 1,758 people, healthy volunteers welcome
- Sponsor
- Brown University
Human Immunodeficiency Virus, Obesity
Adipose Tissue and Immune Activation in HIV
The prevalence of HIV-associated wasting declined dramatically with the introduction of effective antiretroviral therapy (ART), but as patients survive longer on treatment the proportion of overweight (body mass index [BMI] >25…
- Trial name
- AIAC (NCT04439448)
- Testing
- dual-energy X-ray absorptiometry (DEXA) scan, Carotid and branchial artery ultrasound, 2-hour oral glucose tolerace test
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
HIV/AIDS
A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans
Project Rise is a randomized controlled trial (RCT) of an innovative, culturally congruent treatment education (TE) intervention for African Americans with HIV that targets cultural and social issues contributing to health…
- Trial name
- NCT03331978
- Testing
- Rise - Treatment Education
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- RAND
Contraception, Hiv
Contraceptive/HIV Affecting Risk in Adolescents
This study will evaluate the impact of hormonal contraceptives on HIV risk associated with changes to the innate immunity in the female genital tract in a cross-sectional study.
- Trial name
- CHARA (NCT03301480)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pittsburgh
Contraception
Acceptability of Depo-subQ in Uniject
This is an observational study to assess the experience of current depot medroxyprogesterone acetate (DMPA) intramuscular (IM) clients and providers when they try Depo-subQ in Uniject and offer recommendations for the…
- Trial name
- NCT01667276
- Where
- 2 sites in Senegal, Uganda
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- FHI 360
Adherence, Patient, HIV/AIDS
Group Clinical Visit Adherence Intervention for HIV+ Women of Color
The investigators will conduct a pilot randomized controlled trial (RCT) of Sisters-GPS with HIV-positive women of color with suboptimal ARV adherence and detectable HIV viral loads (VL).
- Conditions
- Adherence, Patient, HIV/AIDS, Group Meetings
- Trial name
- NCT03109743
- Testing
- Sisters-GPS: Group Clinical Visits, Control: One-on-one Adherence Counseling
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
HIV, HIV/AIDS
Peg-Interferon Alpha 2b Combined With Two Intravenous Broadly HIV-1 Neutralizing Antibodies 3BNC117 and 10-1074 (BEAT-2)
This study will evaluate the safety, tolerability and innate immune mechanisms activation following administration of the combination of Pegylated Interferon alpha 2b (peg-IFN-α2b) with two broadly neutralizing antibodies…
- Conditions
- HIV, HIV/AIDS, HIV-1 Infection
- Trial name
- BEAT-2 (NCT03588715)
- Testing
- Pegylated Interferon alpha 2b (peg-IFN-α2b), 3BNC117 + 10-1074
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Luis Montaner
HIV Infections
FREE Study: Efficacy and Toxicity of Trizivir
Antiretroviral naïve patients with <350 xE6/l CD4 cells and a HIV-viral load of > 30.000 cop/ml are started on combivir ® and Kaletra ®.
- Trial name
- NCT00405925
- Testing
- Trizivir, zidovudine,lamivudine,abacavir
- Where
- Netherlands
- Volunteers
- 207 people
- Sponsor
- Rijnstate Hospital
Pneumococcus; Pneumonia, Hiv
Experimental Pneumococcal Carriage in People Living With HIV
The goal of this experimental pneumococcal carriage study is to to characterise rates and determinants of experimental pneumococcal carriage in PLHIV.
- Trial name
- NCT05698225
- Testing
- Streptococcus pneumoniae serotype 6B
- Where
- Malawi
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
HIV Infections
A Study of Azidothymidine Plus Methadone in Patients With AIDS and AIDS Related Complex (ARC)
To determine if methadone treatment will affect the blood levels of zidovudine (AZT) in patients with AIDS or AIDS-related complex (ARC) who are receiving oral AZT and methadone therapy.
- Trial name
- NCT00001008
- Testing
- Methadone hydrochloride, Zidovudine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, Drug Use
Technology-Enhanced Peer Navigation to Improve IDUs' Engagement in HIV Care
The purpose of the mPeer2Peer Study (mP2P) is to see if we can use a smartphone and a Peer Navigator (PN) to improve medical care for HIV-positive people who have been out of HIV care for over one year.
- Trial name
- mP2P (NCT01941108)
- Testing
- Peer Navigation Arm
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Human Immunodeficiency Virus, Hepatitis C
Computer-based Intervention for Alcohol-using HIV/HCV+ Women
The study harnessed the multidisciplinary expertise of our research team to develop a brief, computer-based, alcohol reduction intervention tailored for HIV/HCV co-infected women and evaluate its efficacy.
- Conditions
- Human Immunodeficiency Virus, Hepatitis C, Alcohol Abuse
- Trial name
- NCT03362476
- Testing
- Computer-based alcohol reduction intervention, Brief clinician-delivered MET, Standard of care
- Where
- 2 sites in United States, Russia
- Volunteers
- 200 people
- Sponsor
- New York University
HIV/AIDS
Universal Coverage of Antiretroviral Treatment in Senegal
Senegal plans a rapid scale up of HIV treatment for all people living with HIV, regardless of cluster of differentiation 4 (CD4) count or viral suppression.
- Trial name
- NCT03880006
- Testing
- Case management
- Where
- 4 sites in Senegal
- Volunteers
- 596 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV/AIDS
Community Health Worker And MHealth to ImProve Viral Suppression
The overall goal of this study is to evaluate the effects of the CHAMPS intervention for people living with HIV (PLWH) in a randomized controlled trial.
- Trial name
- CHAMPS (NCT04562649)
- Testing
- Wise App with medication adherence reminders, CHW Sessions
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Columbia University
Infection, Human Immunodeficiency Virus, HIV Infections
Pharmacokinetic Study of Cabotegravir Long-acting in Healthy Adult Volunteers
Cabotegravir (CAB) long-acting (LA) is a promising candidate for human immunodeficiency virus (HIV) pre exposure prophylaxis (PrEP) due to its potent antiretroviral activity and infrequent dosing requirements.
- Trial name
- NCT02478463
- Testing
- Cabotegravir tablet 30 mg once daily for 28 days., Cabotegravir injection 3 mL (200 mg/mL) IM given once on Day 1.
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Metabolic Syndromes, HIV Infection
Pilot Study of Metabolic Syndromes and HIV Infections in Indian Tibetans
Kaohsiung Medical University Chung-Ho Memorial Hospital will provide a long-term free medical service in Indian Tibetans since July 2010.
- Trial name
- NCT01261221
- Where
- Taiwan
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Pneumonia, Pneumocystis Carinii, HIV Infections
A Randomized, Comparative, Prospective Study of Daily Trimethoprim / Sulfamethoxazole (TMS) and Thrice-Weekly TMS for Prophylaxis Against PCP in HIV-Infected Patients
To compare the safety and efficacy of two dosage regimens (daily and thrice-weekly) of sulfamethoxazole/trimethoprim (SMX/TMP; TMS) in the prevention of Pneumocystis carinii pneumonia (PCP) in high-risk HIV-infected patients.
- Trial name
- NCT00000748
- Testing
- Sulfamethoxazole-Trimethoprim
- Where
- 24 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV-1 Infection
Study to Evaluate Effects of Vorinostat and HXTC on Persistent HIV-1 Infection in HIV-Infected Subjects Started on Antiretroviral Therapy (ART)
This is a phase I, single-site, study to evaluate the effects of VOR and HIV-1 Antigen Expanded Specific T Cell Therapy (HXTC) on persistent HIV-1 Infection in HIV-infected individuals suppressed on ART.
- Trial name
- XTRA (NCT03212989)
- Testing
- Vorinostat, HXTC
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
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