Clinical trials: Acquired Immune Deficiency Syndrome Virus
HIV - Human Immunodeficiency Virus, Hepatitis B Virus (HBV)
Combating Related Epidemics in HCV
This is a two-arm cluster randomized control trial to evaluate the effectiveness of a single-visit point-of-care (POC) test and treat bundle (intervention arm) compared to the current standard-of-care (SOC, control arm).
- Conditions
- HIV - Human Immunodeficiency Virus, Hepatitis B Virus (HBV), HEPATITIS C (HCV)
- Trial name
- CREST (NCT07560046)
- Testing
- Cepheid GeneXpert HCV Test, Abbott Determine HIV - 1/2 Ag/Ab, Abbott Determine HbsAg 2
- Volunteers
- 1,280 people
- Sponsor
- Duke University
Pneumonia, Pneumocystis Carinii, HIV Infections
A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT)
To determine if the drug combination sulfamethoxazole-trimethoprim (SMX-TMP), given by mouth, and the drug pentamidine (PEN), given by inhaled aerosol, are effective in preventing a relapse of Pneumocystis carinii pneumonia (PCP)…
- Trial name
- NCT00000727
- Testing
- Pentamidine isethionate, Pyrimethamine, Sulfamethoxazole/Trimethoprim
- Where
- 9 sites in United States
- Volunteers
- 322 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus (HIV) Positive
Positive Health Check Evaluation Trial
The purpose of the study is to evaluate the effect of Positive Health Check (PHC), an online intervention that delivers tailored, evidence-based prevention messages to HIV positive patients, on improving clinical outcomes and…
- Trial name
- (PHC) (NCT03292913)
- Testing
- Positive Health Check, Standard of Care
- Where
- 4 sites in United States
- Volunteers
- 799 people
- Sponsor
- RTI International
Immunosuppression
Influenza Vaccination in Immunocompromized Patients
Evaluation of the immunogenicity and reactogenicity of two different formulations of commercially avail-able influenza vaccines in 4 different groups of immunocompromized outpatients (HIV positive patients, patients suffering…
- Trial name
- NCT00783380
- Testing
- Virosomal influenza vaccine, Subunit influenza vaccine
- Where
- 3 sites in Switzerland
- Volunteers
- 304 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hiv
Joining Under-connected Networks to Optimize "Salud" (Health) ("JUNTOS")
The objective of this study is to evaluate the JUNTOS Referral Network as an implementation strategy to enhance the reach of HIV-prevention and treatment services to Latino gay, bisexual, and other men who have sex with men (MSM).
- Trial name
- NCT06432725
- Testing
- JUNTOS, Referral Sheet
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University of Miami
HIV Infections
The Safety and Effectiveness of Bis-POM PMEA in HIV-Infected Patients
To study the safety, tolerance, single and multiple dose pharmacokinetics, and anti-HIV activity of bis-POM PMEA ( adefovir dipivoxil ) versus placebo when administered orally on a daily basis for 2 weeks to HIV-infected patients.
- Trial name
- NCT00002346
- Testing
- Adefovir dipivoxil
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Gilead Sciences
HIV Infections
Safety Study of TXA127 to Elevate CD4+ T-Lymphocyte Counts in HIV-Infected Patients on Stable HAART Therapy
The purpose of this study is to test the safety of an investigational medication, TXA127, and its ability to increase T-lymphocyte counts, specifically CD4+ T-lymphocytes, in persons infected with human immunodeficiency virus who…
- Trial name
- NCT00757250
- Testing
- Angiotensin 1-7
- Where
- 3 sites in United States
- Volunteers
- 13 people
- Sponsor
- US Biotest, Inc.
HIV-1 Infection, Acquired Immunodeficiency Syndrome
Qiling Yiqi Tablets Plus Antiretroviral Therapy for HIV Immune Non-responders With Lung-Spleen Qi Deficiency
This pragmatic randomized controlled trial evaluates whether Qiling Yiqi Tablets combined with antiretroviral therapy (ART) improves immune reconstitution in people with HIV who meet criteria for immune reconstitution failure and…
- Conditions
- HIV-1 Infection, Acquired Immunodeficiency Syndrome, Immune Reconstitution Failure, Immunological Non-responder
- Trial name
- QLYQ-INR-pRCT (NCT07698574)
- Testing
- Qiling Yiqi Tablets plus ART, Antiretroviral Therapy (ART)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing University of Chinese Medicine
Infections, Human Immunodeficiency Virus and Hepatitis
Methadone-Dolutegravir (DTG - GSK1349572) Drug Interaction Study.
Dolutegravir (DTG, GSK1349572) is an integrase inhibitor that is currently in Phase 3 clinical development for the treatment of HIV infection.
- Trial name
- NCT01467518
- Testing
- Dolutegravir, Methadone
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Human Immunodeficiency Virus
Kaletra: Therapy With Double Protease Inhibitors
Therapy with lopinavir/ritonavir (Kaletra) and one other protease inhibitor in Human Immunodeficiency Virus participants
- Trial name
- NCT01075191
- Where
- 17 sites in Germany
- Volunteers
- 65 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Contraception
Assessing Preference for 3 Female Condoms: A Comparative Evaluation of the PATH Woman's Condom, FC2 and the Reddy 6
Evaluation of preference for three female condoms (FC).
- Trial name
- NCT01452503
- Testing
- Path Women's Condom, FC2 female condom, Reddy 6 female condom (V-Amour)
- Where
- South Africa
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- FHI 360
Acquired Immunodeficiency Syndrome
Longitudinal Study of HAART, Social Networks, & Adherence
Our study is a randomized controlled trial that aims to evaluate the effectiveness of modified directly observed therapy (mDOT) to (1) increase both short and long term adherence to HAART treatment, and (2) improve clinical…
- Trial name
- NCT00272220
- Testing
- modified directly observed therapy (mDOT)
- Where
- Mozambique
- Volunteers
- 350 people
- Sponsor
- University of Washington
HIV (Human Immunodeficiency Virus)
Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV
This observational research study is studying how substance use impacts scarring and inflammation of the heart. This study involves one study visit for a cardiac MRI.
- Trial name
- SPISE (NCT07461350)
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of California, San Francisco
HIV Infections
Monitoring Highly Active Antiretroviral Therapy in HIV-infected Parents in Thailand
The purpose of this study is to determine if a decision to switch to a subsequent antiretroviral regimen based upon the CD4 cell count rather than the standard switching strategy based on viral load could ensure the same…
- Trial name
- NCT00162682
- Testing
- Antiretroviral Drug Combination Switching Criteria
- Where
- 20 sites in Thailand
- Volunteers
- 716 people
- Sponsor
- Institut de Recherche pour le Developpement
Unhealthy Alcohol Use
Financial Incentives, Randomization With Stepped Treatment Trial
The investigators plan to determine the effectiveness of contingency management (CM) plus stepped care for unhealthy alcohol use in HIV-positive patients.
- Trial name
- FIRST (NCT03089320)
- Testing
- Contingency Management Counseling, Addiction Physician Management, Motivational Enhancement Therapy
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Yale University
HIV/AIDS
Demonstration Project of PrEP Among Female Sex Workers in Dakar, Senegal
Recent breakthroughs in antiretroviral (ARV)-based prevention provide new opportunities to rethink HIV prevention and treatment strategies, especially for key populations such as Female Sex Workers (FSWs).
- Trial name
- NCT02474303
- Testing
- Truvada
- Where
- 4 sites in Senegal
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Réseau Africain de Recherche sur le SIDA
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: If taking MK-8527 once a month works to prevent HIV-1 infection better than a…
- Trial name
- NCT07071623
- Testing
- MK-8527, Emtricitabine/tenofovir disoproxil (FTC/TDF)
- Where
- 30 sites in Kenya, South Africa and 1 more
- Volunteers
- 4,580 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Evaluation of the Performance of Chembio Diagnostics Systems, Inc. DPP® HIV 1/2 Rapid Test
This study has been designed to evaluate the performance of the Chembio Diagnostics Systems, Inc. DPP® HIV 1/2 rapid test. The device is intended to qualitatively detect the presence of antibodies against HIV-1/2 in oral fluid…
- Trial name
- NCT01032902
- Testing
- In Vitro Diagnostic Device
- Where
- 5 sites in United States
- Volunteers
- 2,808 people, healthy volunteers welcome
- Sponsor
- Chembio Diagnostic Systems, Inc.
HIV-1, AIDS
A Comparison Study of Kaletra Soft-Gel Capsules and Kaletra Tablets in an African American Cohort
The purpose of this study is to compare Kaletra tablets with Kaletra soft-gel capsules to see if there is any change in the side effects you may have and to see how people in the study feel about using the tablets.
- Trial name
- NCT00268827
- Testing
- Kaletra soft-gel capsules switched to Kaletra tablets, MOS-HIV Health and Medication Satisfaction Survey, Global Conditioning Improvement and Therapy Preference Questionnaire
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- AIDS Arms Inc.
HIV/AIDS
Risk of CV Events With EFV vs. EFV-free Regimens
The purpose of this study is to determine whether there is an increased risk of cardiovascular events (CV) with regimens containing efavirenz (EFV) versus other regimens in patients with HIV.
- Trial name
- NCT02426866
- Testing
- Efavirenz
- Volunteers
- 29,612 people
- Sponsor
- Bristol-Myers Squibb
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