Clinical trials: Acquired Immune Deficiency Syndrome Virus
HIV Infections
The Safety and Effectiveness of 524W91
To assess the safety and pharmacokinetics of single oral doses of 524W91 administered in HIV-infected patients. To determine the effects of food on bioavailability of 524W91.
- Trial name
- NCT00002335
- Testing
- Emtricitabine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Glaxo Wellcome
HIV Infections, AIDS
Vitamin D Dose Finding Study
Optimal vitamin D (vit D) concentration and metabolism are essential for normal immune function, growth, muscle, bone, and inflammatory status in children, adolescents and adults with HIV/AIDS.
- Trial name
- NCT01092338
- Testing
- Cholecalciferol (Vit D3)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Children's Hospital of Philadelphia
HIV (Human Immunodeficiency Virus), AIDS (Acquired Immunodeficiency Syndrome)
Video Information Provider for HIV-Associated Non-AIDS (VIP-HANA) Symptoms
The purpose of this study is to use technology to improve symptom status and ultimately improve patient centered outcomes in people living with HIV/AIDS (PLWHA).
- Trial name
- VIP-HANA (NCT03182738)
- Testing
- VIP app without HIV-related symptom strategies., VIP app that delivers HIV-related symptom strategies.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Columbia University
Hepatitis c
Feasibility of a Hepatitis C Virus (HCV) Decision-Making Intervention Among HIV-infected Adults
The purpose of the LEAP-C (learning, experiencing and preparing for hepatitis C treatment) study is to see if a brief (4-week) small group intervention will help people with HIV/HCV co-infection make an informed decision about…
- Trial name
- LEAP-C (NCT01472354)
- Testing
- Leap-c group intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
HIV Infections
A Phase I, Placebo-Controlled, Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Thalidomide in Subjects With HIV-1 Infection
PRIMARY: To evaluate the safety, tolerability, and pharmacokinetics of daily oral thalidomide. SECONDARY: To examine the effect of thalidomide on antiviral activity and tumor necrosis factor-alpha (TNF-alpha) production, and the…
- Trial name
- NCT00000812
- Testing
- Thalidomide
- Where
- 6 sites in United States
- Volunteers
- 36 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, Human Immunodeficiency Virus
Adequacy of the New Pediatric Isoniazid/Rifampin/Pyrazinamide (HRZ) Tablet
Lack of quality-assured pediatric formulations of the first-line antituberculosis (anti-TB) drugs is barrier to optimized tuberculosis (TB) treatment outcome in children.
- Conditions
- Tuberculosis, Human Immunodeficiency Virus, Coinfection
- Trial name
- NCT03800381
- Testing
- Observational PK study
- Where
- Ghana
- Volunteers
- 92 people
- Sponsor
- University of Florida
Compensated Cirrhosis
Safety and Efficacy of Grazoprevir and Elbasvir for GT1ang GT6 With and Without HIV
This study will evaluate the safety and efficacy of combination treatment with grazoprevir + elbasvir for compensated cirrhotic participants with chronic genotype 1 (GT1) and genotype 6 (GT6) hepatitis C virus (HCV) infection…
- Trial name
- NCT03037151
- Testing
- Grazaoprevir/Elbasavir, Grazaoprevir/Elbasavir/RBV
- Where
- 2 sites in Thailand
- Volunteers
- 100 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Sepsis, Septic Shock
Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa
Open-label phase 2a Randomized Controlled Trial (RCT) assessing the pharmacokinetics of two different doses of intravenous vitamin C given alongside vitamin B1 in adult medical patients with sepsis and hypotension.
- Conditions
- Sepsis, Septic Shock, HIV
- Trial name
- REVISTA-DOSE (NCT04999137)
- Testing
- Vitamin C, Vitamin B1
- Where
- 2 sites in Uganda
- Volunteers
- 60 people
- Sponsor
- Liverpool School of Tropical Medicine
Anal Cancer, High-grade Squamous Intraepithelial Lesion
Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions
The randomized phase of the trial compared topical or ablative treatment with active monitoring in preventing anal cancer in patients with human immunodeficiency virus (HIV) and high-grade squamous intraepithelial lesions (HSIL).
- Conditions
- Anal Cancer, High-grade Squamous Intraepithelial Lesion, HIV Infection, Human Papilloma Virus Infection
- Trial name
- ANCHOR (NCT02135419)
- Testing
- imiquimod, fluorouracil, infrared photocoagulation therapy
- Where
- 25 sites in United States, Puerto Rico
- Volunteers
- 4,446 people
- Sponsor
- AIDS Malignancy Consortium
Human Papillomavirus Infection, Human Immunodeficiency Virus Infection
HPV Infection, Sexually Transmitted Infections and Anal Dysplasia in the Transgender Population
The goal of this observational study is to estimate the prevalence of HPV infections anal and ENT level and according to HIV status in transgender (TG) population.
- Conditions
- Human Papillomavirus Infection, Human Immunodeficiency Virus Infection, Sexually Transmitted Diseases
- Trial name
- PrevHPV-TG (NCT05981807)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Sarcoma, Kaposi, HIV Infections
A Phase I Trial of Tecogalan Sodium ( DS-4152 ) Administered as an Infusion Weekly x 4
To evaluate the safety of different doses and dosing regimens of tecogalan sodium (DS-4152) and to establish the MTD at each of the different dosing schedules.
- Trial name
- NCT00002137
- Testing
- Tecogalan sodium
- Where
- United States
- Sponsor
- Daiichi Pharmaceuticals
Human Immunodeficiency Virus (HIV)
A Study of the Once Daily Combination of Etravirine and Darunavir/Ritonavir As Dual Therapy in Early Treatment-Experienced Patients
This study is a Phase II single arm, open-label, multicenter, study of 50 human immunodeficiency virus-1 (HIV) infected adult patients, all of whom will receive etravirine (ETR) 400mg and DRV/r 800/100mg each given orally once…
- Trial name
- INROADS (NCT01199939)
- Testing
- Etravirine, Ritonavir, Darunavir
- Where
- 23 sites in United States, Puerto Rico
- Volunteers
- 54 people
- Sponsor
- Tibotec, Inc
Hiv, Sexually Transmitted Diseases
Evaluation of Implementation of Pre-exposure Prophylaxis (PrEP) in Norway
Despite the significant preventive efforts to reduce HIV infections in the past decades, the incidence in MSM has plateaued at a higher level after the turn of the millennium.
- Conditions
- Hiv, Sexually Transmitted Diseases, Mental Health Wellness 1
- Trial name
- NCT03436407
- Where
- 9 sites in Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
HIV-1-infection
Kenya HIV Self-Testing in PrEP Delivery
In a three-arm, randomized trial, the investigators will test the use of HIV-1 self-testing to decrease the frequency and burden of clinic visits for PrEP while resulting in equivalent PrEP adherence and HIV testing.
- Trial name
- NCT03593629
- Testing
- 6-month PrEP + blood-based HIV self-test, 6-month PrEP + oral fluid HIV self-test
- Where
- Kenya
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University of Washington
Human Immunodeficiency Virus, Chronic Hepatitis b
Gut Microbiome in People Living With HIV and HBV
Building a Microbiome Data Platform and Conducting Clinical Evidence Research in Individuals Infected with the Human Immunodeficiency Virus (HIV) and Hepatitis B virus.
- Conditions
- Human Immunodeficiency Virus, Chronic Hepatitis b, Gut Microbiome
- Trial name
- NCT06130137
- Volunteers
- 200 people
- Sponsor
- Kangbuk Samsung Hospital
Human Immunodeficiency Virus (HIV)
ComBaCaL HIV Prevention TwiCs
This cluster-randomized intervention is embedded in the ComBaCaL (Community-Based Chronic disease care Lesotho) cohort study (EKNZ ID AO_2022-00058, clinicaltrials.gov ID NCT05596773, Lesotho NH-REC ID 210-2022), a platform for…
- Trial name
- CoPrev (NCT07581600)
- Testing
- CoPrev model, Referral to the nearest responsible health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Advanced HIV Disease, Poor Nutriyion Among HIV Patients
Factors Associated With Advanced HIV and Poor Nutrition Among People Living With HIV
Aim of the work: 1. To determine the frequency of advanced HIV among PLWH in Assiut University Hospital. 2. To assess the nutritional patterns and frequency of poor nutrition among PLWH. 3.
- Trial name
- NCT06852430
- Volunteers
- 100 people
- Sponsor
- Assiut University
HIV Infections
A Study of AZT in HIV-Infected Patients With AIDS-Related Kaposi's Sarcoma
To determine whether taking zidovudine (AZT) will change the natural course of HIV infection in patients with AIDS-associated Kaposi's sarcoma (KS) and whether administering AZT at a similar dose but at different intervals will…
- Trial name
- NCT00000994
- Testing
- Zidovudine
- Where
- 22 sites in United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
AIDS
Safety & Immunogenicity of HIV Vaccines in Healthy Kenyan Adults
The study is part of a long-term aim to develop an effective HIV-1 vaccine and will evaluate safety and immunogenicity of vaccines focusing T cell responses on the conserved region of the HIV-1 proteome.
- Trial name
- HIV-CORE 004 (NCT02099994)
- Testing
- Ad35-GRIN, MVA.HIVconsv, pSG2.HIVconsv DNA
- Where
- Kenya
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Oxford
AIDS-related Kaposi's Sarcoma
A Study of Selumetinib in Patients With Kaposi's Sarcoma
Cancer is a leading cause of death in individuals living with human immunodeficiency virus (HIV), and Kaposi's sarcoma (KS) remains the commonest HIV-associated cancer.
- Trial name
- SCART (NCT01752569)
- Testing
- Selumetinib
- Where
- 6 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
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