Clinical trials: Acquired Immune Deficiency Syndrome Virus
HIV Infections
A Study of Stavudine in HIV-Infected Patients Who Have Not Had Success With Other Anti-HIV Drugs
To make stavudine (d4T) available to patients with advanced HIV disease for whom no alternative antiretroviral is satisfactory. To study the safety and efficacy of two dose levels in a twice-daily regimen.
- Trial name
- NCT00002308
- Testing
- Stavudine
- Where
- United States
- Sponsor
- Bristol-Myers Squibb
AIDS, HIV Infections
Pediatric Nevirapine Resistance Study
This study is designed to test if a sequential protease-inhibitor (PI) - / nevirapine (NVP) -based regimen is effective for the treatment of HIV-infected children when previous NVP exposure has occurred as part of programs to…
- Trial name
- NCT00117728
- Testing
- nevirapine
- Where
- South Africa
- Volunteers
- 250 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV Infections, Cachexia
Evaluate Weight Gain Using 2 Different Formulations of Megestrol Acetate Oral Suspension for AIDS-related Weight Loss
Explore weight gain in HIV-positive patients who have weight loss associated with AIDS-related wasting (anorexia/cachexia). Patients are treated for 12 weeks with either megestrol acetate oral suspension nanocrystal dispersion…
- Conditions
- HIV Infections, Cachexia, Anorexia, AIDS Wasting Syndrome
- Trial name
- NCT00637572
- Testing
- Megestrol acetate oral suspension nanocrystal dispersion 115 mg/mL, Megestrol acetate oral suspension 40 mg/mL
- Where
- 12 sites in United States, India and 1 more
- Volunteers
- 63 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Hiv, HSV
Safety, PK, and PD Study of a Vaginal Insert Containing TAF and EVG
The purpose of this Phase I study is to assess the safety, pharmacokinetics, and pharmacodynamics of a combination vaginal insert containing tenofovir alafenamide (TAF) and elvitegravir (EVG).
- Trial name
- NCT03762772
- Testing
- TAF/EVG Vaginal Insert
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- CONRAD
Latent Tuberculosis Infection, HIV Infections
Impact of HIV Infection on Latent Tuberculosis (TB) Among Patients With HIV-TB Co-infection
HIV induced altered representation and function of regulatory T cell subsets (NKT and Treg cells) impair the protective T cell response against M.tuberculosis and disrupts LTBI, thus facilitates faster progression and development…
- Conditions
- Latent Tuberculosis Infection, HIV Infections, Tuberculosis
- Trial name
- HIV-TB (NCT00692809)
- Where
- India
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ministry of Science and Technology, India
Tobacco Use Cessation, Tobacco Cessation
Positively Smoke Free on the Web (PSFW) for Smokers Living With HIV
The purpose of this study is to evaluate the first web-based cessation program developed expressly for people living with HIV who smoke tobacco.
- Conditions
- Tobacco Use Cessation, Tobacco Cessation, Tobacco Use Disorder, Tobacco Dependence
- Trial name
- PSFW (NCT01570595)
- Testing
- Web-Based Tailored Smoking Cessation Intervention, Standard of Care
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Georgetown University
Infection, Human Immunodeficiency Virus
A Study of the Pharmacokinetics and Antiviral Activity of Dolutegravir in the Central Nervous System in HIV-1 Infected ART-naive Subjects
ING116070 is a Phase IIIb single-arm, open-label, multicenter study. The study will be conducted in approximately 14 HIV-1 infected antiretroviral therapy (ART)-naïve subjects.
- Trial name
- NCT01499199
- Testing
- Dolutegravir
- Where
- 3 sites in United States
- Volunteers
- 13 people
- Sponsor
- ViiV Healthcare
Hiv, HIV-1-infection
Retrospective Review of DTG/3TC Versus BIC/F/TAF Across a Multi Clinic Infectious Disease Organization in Southeast United States
This real-world retrospective study describes the clinical efficacy of 2DR (DOVATO® (DTG/3TC)) versus 3DR (BIKTARVY® (BIC/F/TAF)) in PWH, including those with at least 2 social determinants of health indicators, across a multi…
- Conditions
- Hiv, HIV-1-infection, HIV Infections
- Trial name
- NCT06393387
- Testing
- DTG/3TC versus BIC/F/TAF
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Midway Specialty Care Center
Human Immunodeficiency Virus, Stigma, Social
Mitigating Sexual Stigma Within Healthcare Interactions Improve Engagement of MSM in HIV Prevention
The purpose of this study is to explore drivers and mitigators of anal sex stigma in healthcare, and then to develop and pilot an intervention for health workers that mitigates the deterrent effects of this stigma on the…
- Conditions
- Human Immunodeficiency Virus, Stigma, Social, Patient Engagement
- Trial name
- NCT04779736
- Testing
- A set of implementation strategies to reduce sexual stigma
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
HIV Infection
Comparing Blood Vessel Endothelial Function in HIV-Infected People and Matched HIV-Uninfected People
The blood vessels that carry blood from the heart to the rest of the body are normally capable of relaxing and constricting when needed to provide more or less blood to the body.
- Trial name
- NCT00919724
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Indiana University
HIV Infections
A Study of Zidovudine Plus Acyclovir in HIV-Infected Patients
To compare the effect of zidovudine (AZT) given alone with the combination of AZT and acyclovir (ACV) on the human immunodeficiency virus (HIV) in persons infected with HIV, and to study the pharmacokinetics (how fast AZT reaches…
- Trial name
- NCT00001010
- Testing
- Zidovudine, Acyclovir
- Where
- 3 sites in United States
- Volunteers
- 72 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Tuberculosis
A Randomized Trial of Three Regimens to Prevent Tuberculosis in HIV-Infected Patients With Anergy
INTRODUCTION. To evaluate the efficacy of three regimens of prophylactic therapy for tuberculosis in HIV-infected patients with anergy. METHODS. Prospective, multi-center, randomized, comparative, and open clinical trial.
- Trial name
- NCT00402610
- Testing
- isoniazid, rifampin + isoniazid, rifampin + pyrazinamide or not treatment
- Where
- Spain
- Volunteers
- 332 people
- Sponsor
- Sociedad Andaluza de Enfermedades Infecciosas
Anxiety Disorders, HIV Infections
Treatment Effects of Escitalopram (Lexapro®) on Generalized Anxiety Disorder in Patients With HIV and AIDS
The purpose of this study is to evaluate whether escitalopram is safe, well tolerated, and effective in the treatment of HIV-infected patients with generalized anxiety disorder.
- Trial name
- NCT00887679
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Pneumonia, Pneumocystis Carinii, HIV Infections
A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate (Neutrexin) With Leucovorin Protection for European Adult Patients (>= 13 Years Old) With Pneumocystis Carinii Pneumonia
To evaluate the safety and efficacy of trimetrexate glucuronate with leucovorin protection in European patients with Pneumocystis carinii pneumonia (PCP) who are refractory to or have demonstrated severe or life-threatening…
- Trial name
- NCT00002103
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- United States
- Sponsor
- U.S. Bioscience
Hiv, Mental Health Issue
Striving Towards EmPowerment and Medication Adherence R01
This is a study for Black women living with HIV to test a counseling program for Black women living with HIV. This participant may be a good fit if the participant is a Black woman, living with HIV, has a history of trauma, and…
- Trial name
- NCT06463886
- Testing
- STEP-AD, Enhanced treatment as usual (E-TAU)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Miami
Human Immunodeficiency Virus
Jamii Bora: A Home-Based Couples Intervention
The purpose of the study is to develop and pilot-test a home-based intervention to facilitate sate HIV testing and disclosure within pregnant couples in order to increase use of prevention-of-mother-to-child-transmission (PMTCT)…
- Trial name
- NCT02403583
- Testing
- Intervention- Home Visits
- Where
- 5 sites in Kenya
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Infection, Human Immunodeficiency Virus
An Expanded Access Protocol for Subjects Who Have Completed Clinical Studies Involving Maraviroc
This is an open-label protocol designed to provide continued access to maraviroc to only those subjects who have completed previous studies of maraviroc and continue to receive clinical benefit.
- Trial name
- NCT01776996
- Testing
- Continued Access Arm
- Where
- 28 sites in Argentina, Belgium and 5 more
- Sponsor
- ViiV Healthcare
Cryptosporidiosis, HIV Infections
Open-Label "Compassionate" Use Study of Spiramycin for the Treatment of Diarrhea Due to Chronic Cryptosporidiosis in Immunocompromised Patients
This protocol provides for the availability of spiramycin under compassionate-use conditions for the treatment of chronic diarrhea due to cryptosporidium in patients with a compromised immune system, thus deriving additional…
- Trial name
- NCT00002062
- Testing
- Spiramycin
- Where
- United States
- Sponsor
- Rhone-Poulenc Rorer
HIV-1
Interventions to Decrease the Risk of Mother-to-Child Transmission of HIV in India
This study, conducted in Tamil Nadu, India, was initiated in response to the developing epidemic of HIV/AIDS in India. It is divided into two stages, as follows: Stage I All women registered in the pregnancy clinics at the…
- Trial name
- NCT00341796
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV/AIDS, Infant Morbidity
Assessing the Feasibility, Acceptability and Effects Of HIV Birth Testing In Maternity Settings In Zimbabwe
This study aims to assess the feasibility and, acceptability and effects of implementing HIV testing at birth testing using point-of-care (POC) HIV nucleic acid testing (NAT) in maternity settings.
- Conditions
- HIV/AIDS, Infant Morbidity, Perinatal HIV Infection, HIV Infections
- Trial name
- NCT04206241
- Testing
- Point of care early infant diagnosis (POC EID)
- Where
- 10 sites in Zimbabwe
- Volunteers
- 278,833 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
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