Clinical trials: Acquired Immune Deficiency Syndrome Virus
Hiv, Cardiovascular Diseases
Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV
Older people with HIV (OPWH) are disproportionately impacted by cardiovascular disease (CVD) attributable to behavioral risk factors, and chronic HIV immune dysregulation resulting inflammation.
- Trial name
- OM-OH (NCT06001814)
- Testing
- One-Mind One-Heart, Education
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mycobacterium Avium-intracellulare Infection, HIV Infections
A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS
To compare the efficacy and safety of clarithromycin combined with rifabutin, ethambutol, or both in the treatment of disseminated Mycobacterium avium Complex (MAC) disease in persons with AIDS, including individuals who have or…
- Trial name
- NCT00001058
- Testing
- Indinavir sulfate, Ritonavir, Ethambutol hydrochloride
- Where
- 34 sites in United States, Tanzania
- Volunteers
- 246 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV-infection, Pregnancy
The Effect of Phenytoin on the Pharmacokinetics of Nevirapine and the Development of Nevirapine Resistance
The primary objective of this two-phase trial is as follows: To determine the elimination half-life of NVP in HIV positive pregnant women receiving it as a single dose in labour in addition to the ZDV and 3TC with or without…
- Conditions
- HIV-infection, Pregnancy, Mother to Child Transmission
- Trial name
- VITA 2 (NCT01187719)
- Testing
- phenytoin
- Where
- 2 sites in Tanzania, Zambia
- Volunteers
- 66 people
- Sponsor
- Radboud University Medical Center
Herpes Simplex, HIV Infections
A Study to Compare the Efficacy and Safety of Valacyclovir Hydrochloride ( 256U87 ) Versus Acyclovir in the Treatment of Recurrent Anogenital Herpes Infections in HIV Infected Patients
To evaluate the safety and efficacy of oral valacyclovir hydrochloride (256U87) vs. acyclovir in the treatment of recurrent anogenital herpes in HIV-infected patients (CD4 greater than or equal to 100).
- Trial name
- NCT00002000
- Testing
- Valacyclovir hydrochloride, Acyclovir
- Where
- 22 sites in United States
- Sponsor
- Glaxo Wellcome
HIV
PrEP, Lube, and the Rectal Mucosa in MSM at Risk of HIV
The purpose of this study is to determine whether the use of rectal lubricants can affect how well the medication, Truvada, will work to prevent infection with HIV when someone is exposed to HIV in the rectum.
- Trial name
- NCT02401230
- Testing
- Truvada, Gel lubricant
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV Risk Behaviors, Heroin Injection
Efficacy of Drug and Risk Counseling Among Methadone Patients in Jakarta, Indonesia
According to UNAIDS, Indonesia is experiencing one of the most rapidly expanding HIV/AIDS epidemics in Asia. The epidemic in Indonesia has been fueled by injection drug use among heroin users and the national response includes…
- Conditions
- HIV Risk Behaviors, Heroin Injection, Retention in Methadone Treatment
- Trial name
- JAKPRO (NCT01360463)
- Testing
- Behavioral Drug and Risk Counseling (BDRC), methadone maintenance treatment
- Where
- Indonesia
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pneumonia, Pneumocystis Carinii, HIV Infections
Aerosols in the Treatment of Asymptomatic Pneumocystis Pneumonia: A Pilot Study Assessing the Effectiveness of Aerosolized Pentamidine as Treatment of Subclinical Pneumocystis Infection in Patients With No Clinical Symptoms
To confirm the ability of pulmonary (lung) function testing (PFT) to detect Pneumocystis carinii pneumonia (PCP) before the development of clinical symptoms and to determine if pentamidine (PEN), a drug used in treating PCP, can…
- Trial name
- NCT00000707
- Testing
- Pentamidine isethionate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Kidney Failure, Chronic
Retrovir Capsules in the Treatment of HIV-Infected Patients in Renal Failure
To evaluate the safety, tolerance, and pharmacokinetics of Retrovir (AZT) administration in HIV-infected patients in renal failure receiving maintenance hemodialysis.
- Trial name
- NCT00002047
- Testing
- Zidovudine
- Where
- United States
- Sponsor
- Glaxo Wellcome
HIV/AIDS
Project RAP: Family-based HIV Prevention in the Juvenile Drug Court
The purpose of this project is to compare the effect of a family-based HIV prevention program to the effect of an adolescent-only health promotion program on adolescent HIV risk and marijuana use among adolescents enrolled in the…
- Trial name
- Project RAP (NCT01403298)
- Testing
- Family-Based HIV prevention, Adolescent Only Health Promotion
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Human Immunodeficiency Virus
Supporting Adolescents to Adhere - an Intervention Using Airtime Rewards Allocated by a Prize Drawing
This study is an extension of Reminding Adolescents to Adhere (RATA) (Unique protocol ID: 1R01HD074925-01). Participants for SATA will be recruited during the RATA month 24 exit survey.
- Trial name
- SATA (NCT02918838)
- Testing
- Own Adherence Group, Fixed Adherence Group, Control Group
- Where
- Uganda
- Volunteers
- 216 people
- Sponsor
- RAND
Sarcoma, Kaposi, HIV Infections
A Study of Chemotherapy Plus Azidothymidine in the Treatment of Kaposi's Sarcoma in Patients With AIDS
To study the safety and maximum tolerated dose (MTD) of combined chemotherapy when it is administered to patients with advanced Kaposi's sarcoma together with one of two different doses of zidovudine (AZT).
- Trial name
- NCT00000987
- Testing
- Bleomycin sulfate, Vincristine sulfate, Doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Facial Lipoatrophy
Facial Lipoatrophy Correction Experience With SCULPTRA ("FACES" Study)
5 year, open-label study to evaluate safety of SCULPTRA on the signs of lipoatrophy of the face in at least 100 evaluable subjects with human immunodeficiency virus.
- Trial name
- FACES (NCT00360932)
- Testing
- SCULPTRA (poly-L-lactic acid injection)
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Bausch Health Americas, Inc.
Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD)
A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases
The purpose of this study is to assess the efficacy and safety of tabelecleucel in participants with EBV-associated diseases.
- Conditions
- Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD), EBV+ Lymphoproliferative Disease With Acquired (Non-congenital) Immunodeficiency (EBV+ AID LPD), EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)
- Trial name
- NCT04554914
- Testing
- Tabelecleucel
- Where
- 40 sites in United States, Austria and 5 more
- Volunteers
- 190 people
- Sponsor
- Pierre Fabre Medicament
Coronary Artery Disease, Human Immunodeficiency Virus (HIV)
Pericardial Fat and Inflammation in HIV Patients and Controls
The investigators propose to correlate 1) cardiac MRI pericardial adipose volume, 2) the presence of pericardial monocytes and 3) circulating immune biomarkers in persons with and without CHD and HIV infection compared to…
- Trial name
- NCT02399384
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
HIV Infections, HIV Seronegativity
Long-Term Effects of HIV Exposure and Infection in Children
As new drugs and vaccines are developed to prevent HIV disease progression and prolong survival of HIV infected patients, the short-term safety and effectiveness of these treatments are evaluated in research studies.
- Trial name
- NCT00006304
- Where
- 92 sites in United States, Puerto Rico
- Volunteers
- 4,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine
Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and eliminated through the kidneys in HIV infected patients. Part II studies the effect of probenecid and quinine on the same aspects.
- Trial name
- NCT00000706
- Testing
- Quinine sulfate, Probenecid, Zidovudine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Acquired Immunodeficiency Syndrome
Decision-Making of Hispanics and African-Americans With HIV/AIDS Participating in Clinical Trials
This study will use focus groups and in-depth individual interviews to explore factors that influence the decision of Hispanics and African-Americans with HIV/AIDS to participate in a research study.
- Trial name
- NCT00394004
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hiv
Defining the Potency of DTG/3TC for Suppressed HIV Patients in Real-life: the DUALING Study
This study aims to determine real-life clinical efficacy of virally suppressed patienst switching to DTG/3TC compared to DTG triple drug cART controls
- Trial name
- DUALING (NCT04707326)
- Testing
- Dolutegravir / Lamivudine Pill
- Where
- 9 sites in Netherlands
- Volunteers
- 2,040 people
- Sponsor
- Erasmus Medical Center
Infection, Human Immunodeficiency Virus
Study to Evaluate the Safety Tolerability and Acceptability of Long Acting Injections of the Human Immunodeficiency Virus (HIV) Integrase Inhibitor, GSK1265744, in HIV Uninfected Men (ECLAIR)
This study is a Phase IIa, randomized, multi-site, two-arm, double-blinded study to evaluate the safety, tolerability, and acceptability of GSK1265744 long acting injectable formulation (744 LA) in adult male subjects.
- Trial name
- NCT02076178
- Testing
- 744 Tablet, 744 LA Injection
- Where
- 10 sites in United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV (Human Immunodeficiency Virus)
mVIP (Use of mHealth Technology for Supporting Symptom Management in Underserved Persons Living With HIV)
The goal of this study is to facilitate the dissemination and implementation of patient centered outcomes research using mHealth technology to improve self-management of adverse symptoms in persons living with HIV/AIDS (PLWH).
- Trial name
- mVIP (NCT02897141)
- Testing
- Health Management App with symptom strategies, Control App
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Columbia University
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