Clinical trials: Acquired Immunodeficiency Syndrome
Heart Diseases, Acquired Immunodeficiency Syndrome
AIDS-Associated Heart Disease -- Incidence and Etiology
To detect by Doppler echocardiography the incidence of cardiac abnormalities in HIV-positive patients in a prospective, longitudinal study.
- Conditions
- Heart Diseases, Acquired Immunodeficiency Syndrome, Myocardial Diseases, HIV Infections
- Trial name
- NCT00005228
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
HIV Infections
RA Effect on Cell Surface Molecules in Vivo
This study will follow a group of healthy male participants for about 18 weeks to see the effect of taking Acitretin on their immune cells
- Trial name
- NCT03753867
- Testing
- Acitretin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Lymphoma, Sarcoma
Altretamine and Etoposide in Treating Patients With HIV-Related Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002936
- Testing
- altretamine, etoposide
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
HIV Infections
A Study of Retrovir and Epivir Alone or in Combination With 141W94 in HIV-Infected Patients
The purpose of this study is to see if it is safe and effective to add 141W94 to an anti-HIV regimen that includes retrovir plus epivir.
- Trial name
- NCT00002195
- Testing
- Amprenavir, Lamivudine, Zidovudine
- Where
- 9 sites in United States
- Volunteers
- 290 people
- Sponsor
- Glaxo Wellcome
Infection, Human Immunodeficiency Virus
A Study to Determine the Effect of Multiple Doses of BMS-955176 on the Electrocardiograph of Healthy Subjects
The purpose of the study is to determine the effect of multiple doses of BMS-955176 on the QT interval corrected with Fridericia's method (QTcF) in healthy subjects.
- Trial name
- NCT02576119
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Infections
Safety and Pharmacokinetic Study of Fixed Dose Combination of Zidovudine, Lamivudine, and Nevirapine in HIV-Infected Children in Thailand
In 2005, there were 50,620 HIV-infected children living in Thailand. Current anti-HIV regimens, comprised of individual pills for each drug, frequently lead to missed doses.
- Trial name
- NCT00672412
- Testing
- GPO-Vir Z30 tablet, Lamivudine, Nevirapine
- Where
- 4 sites in Thailand
- Volunteers
- 42 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Study on the Management of Combination Anti-HIV Drug Therapy in HIV-Positive Children With Prior Treatment
The purpose of this study is to determine the value of changing anti-HIV medications in children with progressive HIV disease who have received previous treatment.
- Trial name
- NCT00000902
- Testing
- Ritonavir, Nelfinavir mesylate, Nevirapine
- Where
- 62 sites in United States, Puerto Rico
- Volunteers
- 217 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Glaucoma, Cataract
Eye Drop Dispensers: Safety, Efficacy and Comfort.
One aspect to eye drop adherence is successful instillation of the drops; however, it is well known that many patients struggle with this task.
- Conditions
- Glaucoma, Cataract, Healthy Subjects
- Trial name
- NCT03417453
- Testing
- Eye Drop Dispenser TYPE Opticare, Eye Drop Dispenser Autodrop
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
HIV
HomeLink2: Reducing Posthospitalization Mortality Through Structured Home Care and Nutritional Support
People living with HIV (PLWH) are at high risk of poor health outcomes after being discharged from the hospital. This study is designed to test whether providing structured care at home-either with or without nutritional…
- Trial name
- NCT07102745
- Testing
- HomeLink, HomeLink Plus Nutritional Support
- Where
- South Africa
- Volunteers
- 780 people
- Sponsor
- Johns Hopkins University
HIV Infections
Non-virologic Methods to Diagnose Treatment Eligibility in HIV-exposed Infants
This study is designed to develop and evaluate a set of non-virologic diagnostic algorithms to monitor HIV-exposed children of unknown infection status for treatment eligibility during the first year of life.
- Trial name
- IDX (NCT01222130)
- Where
- 3 sites in Zambia
- Volunteers
- 1,126 people
- Sponsor
- University of North Carolina, Chapel Hill
Acquired Immunodeficiency Syndrome, HIV Infections
A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of HIV/AIDS Complicated With Infection
The goal of this observational study is to determine the incidence and spectrum of opportunistic infections among Chinese HIV/AIDS patients at this stage, to find intervention targets, to construct an early warning prediction…
- Trial name
- NCT06280001
- Volunteers
- 500 people
- Sponsor
- Zhejiang University
HIV Infections
A Study on Amprenavir in Combination With Other Anti-HIV Drugs in HIV-Positive Patients
The purpose of this study is to compare 4 different combinations of anti-HIV drugs and to determine the number of people whose HIV blood levels decrease to 200 copies/ml or less while on the treatment.
- Trial name
- NCT00000912
- Testing
- Indinavir sulfate, Abacavir sulfate, Amprenavir
- Where
- 45 sites in United States, Puerto Rico
- Volunteers
- 475 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, Acquired Immunodeficiency Syndrome
Safety, Immunogenicity, Efficacy of Ad26.Mos4.HIV, MVA-BN-HIV and PGT121, PGDM1400, and VRC07-523LS in HIV-1-Infected Adults
A multicenter, randomized, parallel-group, placebo-controlled, double-blind, Phase 1/2a clinical study to investigate the safety, tolerability, immunogenicity and exploratory efficacy of a vaccine regimen consisting of an…
- Conditions
- HIV, Acquired Immunodeficiency Syndrome, Immunologic Deficiency Syndrome, Acquired, Sexually Transmitted Diseases, Viral
- Trial name
- NCT04983030
- Testing
- Ad26.Mos4.HIV, MVA-BN-HIV, PGT121
- Where
- 6 sites in United States
- Volunteers
- 28 people
- Sponsor
- Boris Juelg, MD PhD
HIV
Combination Partner HIV Testing Strategies for HIV-positive and HIV-negative Pregnant Women
The overall objective of this study is to evaluate whether the addition of secondary distribution HIV self-test kits to existing partner notification guidelines increases the proportion of male partners who access facility-based…
- Trial name
- MP3 Pilot (NCT04124536)
- Testing
- HIV self-testing with partner notification.
- Where
- Zambia
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections
E-Health for Zero Infections - Facilitating Access to and Use of HIV Pre-Exposure Prophylaxis (PrEP) in the Netherlands
Offering PrEP care online and reducing the frequency of monitoring may increase access to HIV PrEP. The objective of this study is to assess the non-inferiority of an internet-based HIV PrEP-service and reduced frequency of…
- Trial name
- EZI-PREP (NCT05093036)
- Testing
- Variations in PrEP care delivery at public health services
- Where
- 4 sites in Netherlands
- Volunteers
- 469 people, healthy volunteers welcome
- Sponsor
- Public Health Service of Amsterdam
HIV Infections
An Ascending, Single Oral Dose Pharmacokinetic Study of 3'-Deoxy-3'-Fluorothymidine (FLT) in Asymptomatic Human Immunodeficiency Virus (HIV)-Infected Subjects
To characterize the pharmacokinetics of orally administered 3'-deoxy-3'-fluorothymidine (FLT), in a liquid formulation, after single doses in asymptomatic HIV-infected patients and to assess the safety and tolerance of the single…
- Trial name
- NCT00002271
- Testing
- Alovudine
- Where
- United States
- Sponsor
- Lederle Laboratories
HIV Infections
Using Mobile Technology to Prevent HIV and Related Youth Health Problems
Since the start of this study I have moved from NYSPI to City University of New York. The study is currently paused. The goal of the project is to find out how the investigators can use mobile phones to prevent HIV and address…
- Trial name
- YouthHealth (NCT05130151)
- Testing
- Youth Health SMS
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Stimulant Use, Human Immunodeficiency Virus (HIV)
Project neuroARTEMIS
The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave.
- Conditions
- Stimulant Use, Human Immunodeficiency Virus (HIV), Depression
- Trial name
- NCT06814275
- Testing
- ARTEMIS, Contingency management for Antiretroviral (ARV) adherence
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- Wake Forest University Health Sciences
HIV, Non Communicable Diseases
Effects of a Package of Evidence-based Interventions and Implementation Strategies Based on WHO PEN for People Living With HIV and Cardio-metabolic Conditions in Lusaka, Zambia
The purpose of this study is to evaluate the effects of a multi-level intervention known as "TASKPEN," adapted from the World Health Organization (WHO) Package of Essential Noncommunicable Disease Interventions (WHO-PEN) for the…
- Trial name
- TASKPEN UH3 (NCT05950919)
- Testing
- TASKPEN
- Where
- 12 sites in Zambia
- Volunteers
- 5,747 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections, Pregnancy
Combination Treatment With and Without Protease Inhibitors for Women Who Begin Therapy for HIV Infection During Pregnancy
The best anti-HIV treatment regimen for pregnant women is not known. Protease inhibitors (PIs) are often used, but they have side effects that may be harmful for pregnant women.
- Trial name
- NCT00017719
- Testing
- Lamivudine, Lamivudine/Zidovudine, Nelfinavir mesylate
- Where
- 49 sites in United States, Brazil and 2 more
- Volunteers
- 440 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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