Clinical trials: Acquired Immunodeficiency Syndrome
HIV Infections
A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4 Immunoglobulin (rCd4-IgG) Administered by Intravenous Bolus in Patients With AIDS and AIDS Related Complex
To study the safety and pharmacokinetics (blood levels) of recombinant human CD4 immunoglobulin (rCd4-IgG) in patients with AIDS or AIDS related complex (ARC) who have failed or declined therapy with zidovudine (AZT).
- Trial name
- NCT00000675
- Testing
- CD4-IgG
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anal Squamous Cell Carcinoma, HIV Infections
A Global Record of Patients With Anal Squamous Cell Carcinoma With and Without HIV Infection
Due to the scarcity of data on prognostic and predictive influence on CCA, epidemiological studies evaluating these factors need to be developed in patients with CCA.
- Trial name
- ACTION HIV (NCT05328765)
- Where
- 11 sites in Argentina, Brazil and 3 more
- Volunteers
- 369 people
- Sponsor
- Latin American Cooperative Oncology Group
People Living With HIV
A Hybrid Type II Trial of the Optimizing Resilience and Coping With HIV Through Internet Delivery in Ryan White Clinics in Chicago
Among people living with HIV (PLWH), positive affect is uniquely associated with lower levels of depression, slower disease progression, better adherence to medication, and higher likelihood of achieving suppressed viral load…
- Trial name
- ORCHID (NCT05123144)
- Testing
- BHS+ORCHID
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Northwestern University
HIV, Adolescent Behavior
Family Connection: Pilot of Family-based Self-management for HIV-infected Adolescents
The study design has two phases. The first phase is the refinement of intervention manual for an adolescent living with HIV (ALHIV)and their caregiver intervention, followed by a second phase feasibility pilot study.
- Conditions
- HIV, Adolescent Behavior, Caregivers, Africa
- Trial name
- NCT04442399
- Testing
- Family Connections
- Where
- Zambia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV Infections, Hyperlipidemia
Rosiglitazone in the Treatment of HIV-Associated Hyperlipidemia
The purpose of this research is to study the effects of rosiglitazone, a drug usually taken for Type II diabetes, on HIV-associated hyperlipidemia.
- Trial name
- NCT00006493
- Testing
- Rosiglitazone
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Contact Tracing
Enhancing Partner Services Among Men Who Have Sex With Men Living With HIV
Individuals will participate in a pilot randomized controlled trial (RCT) that implements and evaluates the feasibility, acceptability, and effectiveness of crowdsourced partner services (PS) or conventional PS among Chinese men…
- Trial name
- NCT04971967
- Testing
- Crowdsourced partner services intervention
- Where
- China
- Volunteers
- 121 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections
Effects of Changing HIV Therapy at Lower Versus Higher Viral Loads
This study will look at people who have been taking anti-HIV drugs but still have detectable levels of HIV. The purpose of the study is to find out what happens in those people who change anti-HIV drugs when their viral load…
- Trial name
- NCT00036465
- Testing
- Treatment regimen change
- Where
- 23 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Preexposure Prophylaxis
Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024)
The main purpose of the study is to evaluate the safety and tolerability of oral Islatravir (ISL) once monthly (QM) as Preexposure Prophylaxis (PrEP) in cisgender men who have sex with men (MSM) and transgender women (TGW) who…
- Trial name
- Impower-024 (NCT04652700)
- Testing
- ISL, FTC/TDF, FTC/TAF
- Where
- 25 sites in United States, Brazil and 5 more
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Project to Enhance Patient-Health Engagement in HIV Infection
The importance of patient involvement in their care is emerging as a crucial element in the active management of chronic conditions, including HIV infection.
- Trial name
- HIV-IN-ACTION (NCT07571044)
- Testing
- patient engagement
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease, Atherosclerosis, Coronary
HIV Infection And Evolvement of Atherosclerotic Plaque
In a prospective multi-center observational study, 200 HIV-infected patients treated with antiretroviral treatment (ART) and who suffered from coronary artery disease (CAD) will be enrolled.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Coronary, Hiv, HIV Infections
- Trial name
- HIVE (NCT04810364)
- Testing
- Quantitative coronary angiography, intravascular imaging with percutaneous intervention
- Where
- 2 sites in Russia
- Volunteers
- 1,000 people
- Sponsor
- Central Clinical Hospital of the Russian Academy of Sciences
Human Immunodeficiency Virus Infection
Study Comparing Lopinavir/Ritonavir (LPV/r) + Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) With a Nucleoside Sparing Regimen Consisting of Lopinavir/Ritonavir + Raltegravir (RAL)
The purpose of this study is to compare the safety, tolerability, and antiviral activity of the lopinavir/ritonavir tablet when administered in combination with reverse transcriptase inhibitors to lopinavir/ritonavir tablets when…
- Trial name
- PROGRESS (NCT00711009)
- Testing
- lopinavir/ritonavir (LPV/r), emtricitabine/tenofovir disoproxil fumarate (FTC/TDF), raltegravir (RAL)
- Where
- 37 sites in United States, Canada and 5 more
- Volunteers
- 206 people
- Sponsor
- Abbott
HIV Infections, Lipoatrophy
Study Comparing Reducing the Dose of Stavudine Versus Switching to Tenofovir in HIV-Infected Patients Receiving Antiretroviral Therapy
Background: Stavudine-containing regimens are associated with a potential for lipoatrophy and dyslipidemia. We assessed the safety and efficacy of reducing the dose of stavudine compared to switching to tenofovir or maintaining…
- Trial name
- NCT00312832
- Testing
- switching; dose reduction
- Volunteers
- 60 people
- Sponsor
- Hospital Clinic of Barcelona
HIV/AIDS, Myocardial Infarction
Inflammation and Cardiovascular Health in Women
Systemic immune activation and inflammation are believed to play a significant role in the development and clinical course of myocardial infarction (MI).
- Trial name
- NCT04224181
- Testing
- Cardiac PET, 99mTc-tilmanocept SPECT/CT, Contrast Enhanced Coronary and Aortic Computed Tomography Angiography
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Opioid-Related Disorders
Trial of Methadone Maintenance Versus Methadone Detox in Jail
Methadone maintenance treatment (MMT) has been shown to be effective in reducing drug use, criminal activity and recidivism. Given this effectiveness, maintaining individuals who are enrolled in community MMT when committed to…
- Trial name
- NCT01874964
- Testing
- Methadone Maintenance, Linkage to methadone maintenance
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- The Miriam Hospital
HIV, Drug Resistance
B-free Multistage Trial
The primary objective of the study is to evaluate the efficacy of a booster-free regimen including DOR/DTG/3TC among HIV-suppressed PLWH with previous virological failure.
- Conditions
- HIV, Drug Resistance, Drug Drug Interaction
- Trial name
- B-free (NCT06037564)
- Testing
- DOR/DTG/3TC
- Where
- 8 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
HIV-1-infection
10E8.4/iMab Bispecific Antibody and VRC07-523LS Monoclonal Antibody in HIV-infected Adults
This is an open-label phase 1b clinical trial enrolling people living with HIV (PLWH) who are antiretroviral therapy (ART)-naïve or have not been on ART for > 24 weeks.
- Trial name
- NCT05890963
- Testing
- ART, 10E8.4/iMab, VRC07-523LS
- Where
- Tanzania
- Volunteers
- 20 people
- Sponsor
- David Ho
HIV Infections, HIV Wasting Syndrome
A Comparison of Two Caloric Supplements in the Prevention of Weight Loss in Patients With AIDS Who Take Daily Multivitamin and Mineral Supplements
To compare a caloric supplement containing peptides and medium-chain triglycerides, a caloric supplement containing whole protein and long-chain triglycerides, and no caloric supplement for the prevention of weight loss in…
- Trial name
- NCT00001077
- Testing
- Multivitamin and mineral supplements, Peptamen, NuBasics
- Where
- 17 sites in United States
- Volunteers
- 536 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphoma
Peripheral Stem Cell Transplantation Followed By Infusion of White Blood Cells in Treating Patients With AIDS-Related Lymphoma
RATIONALE: Donor peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy. Sometimes the transplanted cells are rejected by the body's normal tissues.
- Trial name
- NCT00024128
- Testing
- anti-thymocyte globulin, therapeutic allogeneic lymphocytes, cyclophosphamide
- Sponsor
- AIDS Malignancy Consortium
HIV Infections
Partners PrEP Program
Through close collaboration with the Ugandan Ministry of Health, the investigators plan to provide PrEP for HIV-negative members of HIV serodiscordant couples by launching PrEP delivery within 12 public ART clinics in Kampala…
- Trial name
- PPP (NCT03586128)
- Testing
- PrEP, ART
- Where
- Uganda
- Volunteers
- 1,381 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections
Early Access of MK0518 in Combination With an Optimized Background Antiretroviral Therapy (0518-023)
This is a treatment use study to provide early access to MK0518 for the treatment of HIV-1 infection in patients who have limited or no treatment options due to virological failure, resistance, or intolerance to multiple…
- Trial name
- NCT00377065
- Testing
- raltegravir
- Sponsor
- Merck Sharp & Dohme LLC
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