Clinical trials: Acquired Immunodeficiency Syndrome
HIV Infections
Pharmacokinetics Safety and Acceptability of DRV/r for Children Living With HIV
The UNIVERSAL2 study is a research project designed to evaluate a newly developed formulation of an approved drug for children living with HIV aged over 3 years and weighing between 10 and 25 kg.
- Trial name
- UNIVERSAL2 (NCT06139796)
- Testing
- DRV/r FDC (120/20mg)
- Where
- 5 sites in Cameroon, Senegal and 2 more
- Sponsor
- PENTA Foundation
HIV Infections
Determining Characteristics and Behaviors of Adolescent Women Regarding HIV Risk and Microbicide Trial Participation
This study will examine characteristics and behaviors of young women in India and Tanzania to determine which challenges and opportunities exist for conducting future trials of HIV prevention treatments.
- Trial name
- NCT00872261
- Where
- Tanzania
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infection, Osteopenia
Bone Mineral Density Changes in HIV-positive Females With Osteopenia Switching to Raltegravir
Given the high prevalence of bone alteration in the course of HIV infection or antiretroviral treatment and the favourable properties of raltegravir the investigators designed this pilot randomized and controlled study.
- Trial name
- RALBAT (NCT01902186)
- Testing
- raltegravir and atazanavir and ritonavir, tenofovir/emtricitabine and atazanavir and ritonavir
- Where
- 2 sites in Italy
- Volunteers
- 4 people
- Sponsor
- Giovanni Di Perri
Disseminated Tuberculosis, HIV
Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis
The New Strat-TB trial is a superiority Phase III randomised control clinical trial with a 2X2 factorial design. The main aim of the study is to assess the efficacy and safety of high dose rifampicin and levofloxacin for 14 days…
- Trial name
- NEW-STRAT TB (NCT04951986)
- Testing
- Rifampin, Levofloxacin, Rifampicin, Pyrazinamide, Ethambutol and Isoniazid
- Where
- 2 sites in South Africa
- Volunteers
- 732 people
- Sponsor
- University of Cape Town
HIV Prevention, Substance Use
Host Led Harm Reduction Approach Among Men Who Have Sex With Men Who Engaged in Chemsex in Bangkok, Thailand: A Pre-Implementation Study
This study evaluates the pre-implementation phase of a host-led harm reduction model for men who have sex with men (MSM) engaging in chemsex in Bangkok, Thailand, focusing on understanding harms, contexts, and needs to develop a…
- Conditions
- HIV Prevention, Substance Use, Mental Health, Sexually Transmitted Infections (STIs)
- Trial name
- HAMMOCK (NCT07512869)
- Testing
- Self-administered questionnaire assessment, Semi-structured in-depth interviews (IDIs), Development and refinement of harm reduction model
- Where
- Thailand
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
HIV Infections
Harnessing Male Peer Networks to Enhance Engagement With HIV Prevention
Novel strategies are needed to engage men in Sub Saharan Africa (SSA) with HIV testing, treatment and prevention services to drive the epidemic towards elimination.
- Trial name
- IMPERATIVE (NCT06370923)
- Testing
- Peer Distribution, Community Health Worker Distribution
- Where
- Zimbabwe
- Volunteers
- 3,591 people, healthy volunteers welcome
- Sponsor
- University of Stellenbosch
HIV Infections
The Safety and Effectiveness of Interleukin-2 Plus Zidovudine in Patients With AIDS or AIDS Related Complex
To test the safety and tolerance of three different doses of recombinant human interleukin 2 (aldesleukin; IL-2), when it is given for five consecutive days to patients with AIDS or AIDS related complex (ARC), who have also…
- Trial name
- NCT00000986
- Testing
- Zidovudine, Aldesleukin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Opioid Dependence, Addiction
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
The purpose of this study is to conduct empiric studies of tuberculosis (TB) among people in prison with and without a history of opioid dependence.
- Conditions
- Opioid Dependence, Addiction, HIV/AIDS, Tuberculosis
- Trial name
- HARAPAN II (NCT03089983)
- Testing
- Isoniazid, Rifapentine
- Where
- Malaysia
- Volunteers
- 316 people
- Sponsor
- Yale University
Emotional Adjustment, Aids/Hiv Problem
Resilience-based Psychosocial Intervention Among Children Affected by HIV/AIDS
Parental illness and death from HIV/AIDS has a profound and lasting impact on a child's psychosocial well-being, potentially challenging the basic needs for survival and compromising the child's future.
- Trial name
- NCT04653441
- Testing
- Child-Caregiver-Advocacy-Resilience [ChildCARE] intervention
- Where
- United States
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Point-of-Care Testing, HIV
Ayaangwaamiziwin Initiative: Carefulness and Preparedness
The goal of this clinical trial is to implement a test, treat, and connect intervention approach using HIV and syphilis rapid point-of-care (POC) testing in 3 Canadian Prairie provinces (Alberta, Manitoba, and Saskatchewan)…
- Conditions
- Point-of-Care Testing, HIV, Syphilis
- Trial name
- AI (NCT06893159)
- Testing
- INSTI HIV-1/2 Antibody Test, INSTI Multiplex HIV-1/2 Syphilis Antibody Test, Multiplo Complete Syphilis (TP/nTP) Antibody Test
- Where
- 8 sites in Canada
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HIV Prevention
An Acceptance Based PrEP Intervention to Engage Young Black MSM in the South
Investigators will use a generalized framework for the adaptation of EBIs to inform the development of a brief Acceptance and Commitment Therapy (ACT)-based culturally appropriate pre-exposure prophylaxis (PrEP) intervention…
- Trial name
- NCT05087680
- Testing
- ACTPrEP, Enhanced Standard of Care
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Human Immunodeficiency Virus
Switch to DOVATO in Patients Suppressed on Biktarvy (SOUND)
An open-label, pilot study of switching patients to Dovato who are currently taking Bitarvy who are virological suppressed (HIV-1 < 50 copies/mL
- Trial name
- Sound (NCT04826562)
- Testing
- Dolutegravir/Lamivudine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Saint Michael's Medical Center
Human Immunodeficiency Virus
Clinical Trial of HIV Vaccine Combinations in Healthy Men and Women
A Phase I Single-Blind randomised trial investigating immunisation strategies using Ad4-EnvCN54, MVA-CN54 and CN54gp140/MPLA combinations in order to maximise antibody responses to Human Immunodeficiency Virus
- Trial name
- Ad4HIV (NCT03408262)
- Testing
- Ad4-EnvCN54, MVA-CN54, CN54gp140/MPLA
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Imperial College London
HIV Infection
Safety and Immunogenicity Study of tgAAC09, a Gag-PR-RT AAV HIV Vaccine
The purpose of this study is to determine safety and immunogenicity (ability to induce an immune response) of a novel HIV vaccine based on adeno-associated virus (AAV)
- Trial name
- A001 (NCT00482027)
- Testing
- tgAAC09
- Where
- 5 sites in Belgium, Germany and 1 more
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
AIDS
Effect on HIV Medications on EPC Cells
This is a 3 arm, non-Interventional pilot single time point cross sectional study for the duration of 1 year. Total of 30 candidates (10 in each Group) will be enrolled into three different groups taking three different…
- Trial name
- NCT03782142
- Testing
- Tenofovir, Rilpivirine, Prezcobix
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Sabyasachi Sen
PrEP Adherence, Methamphetamine Use Disorder
CHAMPION: Combining HIV And Meth Prevention and Treatment Interventions Optimized for HIV-Negative MSM
The goal of this randomized controlled trial is to pilot test new mobile health (mHealth) interventions to improve PrEP adherence among HIV-negative men who have sex with men (MSM) with mild to moderate methamphetamine use…
- Conditions
- PrEP Adherence, Methamphetamine Use Disorder, HIV
- Trial name
- CHAMPION (NCT07213258)
- Testing
- CHAMPION Intervention, Delayed CHAMPION Package
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Viral Control, Quality of Life
The Quality of Life and Viral Control Effect of AIDS Patients After Long-acting Injection of Cabotegravir and Rilpivirine
"AIDS" was once regarded as the Black Death of the 20th century. However, with the advent of cocktail therapy, the survival rate of infected people has been greatly improved and the average life expectancy has been increased.
- Conditions
- Viral Control, Quality of Life, Cabotegravir, Rilpivirine
- Trial name
- NCT07131826
- Testing
- Observational study, non-interventional
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Clinical Trial Center
Hiv, Stigma, Social
Buddhist Understanding and Reduction of Myanmar Experiences of HIV Stigma and Exclusion
This project aims to explore a multi-leveled conceptualization of the effects of HIV stigma on HIV care engagement in Myanmar by conducting a mixed-method study.
- Conditions
- Hiv, Stigma, Social, Mindfulness
- Trial name
- BURMESE (NCT05126225)
- Testing
- Stigma reduction
- Where
- 2 sites in Burma, Thailand
- Volunteers
- 19 people
- Sponsor
- University of California, Los Angeles
HIV Infections, Acquired Immunodeficiency Syndrome
Medications for Chronic HIV: Education and Collaboration
This study will examine whether a computerized, self-administered assessment of patient medication adherence and health behaviors, plus support for adherence, improves the ability of clinicians to identify adherence problems and…
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Medication Adherence
- Trial name
- MedCHEC (NCT01038076)
- Testing
- MedCHEC Tablet Computer & Adherence Care
- Where
- 3 sites in United States
- Volunteers
- 371 people
- Sponsor
- Boston University
HAART Non-Adherence, HIV
Cell Phone Reminders Intervention
This study will use a longitudinal, experimental design. Participants will be randomized to either the intervention or the control group.
- Conditions
- HAART Non-Adherence, HIV, HIV Infections
- Trial name
- NCT01049568
- Testing
- Cell Phone Intervention
- Where
- 5 sites in United States
- Volunteers
- 43 people
- Sponsor
- University of North Carolina, Chapel Hill
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