Clinical trials: Acquired Immunodeficiency Syndrome
HIV-1, AIDS
A Comparison Study of Kaletra Soft-Gel Capsules and Kaletra Tablets in an African American Cohort
The purpose of this study is to compare Kaletra tablets with Kaletra soft-gel capsules to see if there is any change in the side effects you may have and to see how people in the study feel about using the tablets.
- Trial name
- NCT00268827
- Testing
- Kaletra soft-gel capsules switched to Kaletra tablets, MOS-HIV Health and Medication Satisfaction Survey, Global Conditioning Improvement and Therapy Preference Questionnaire
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- AIDS Arms Inc.
Paediatric HIV Diagnosis Disclosure
Pediatric HIV Disclosure Intervention
With increased availability of antiretroviral therapy (ART) and improved care, increasing numbers of perinatally infected children are surviving into adolescence.
- Trial name
- NCT01773642
- Testing
- Cognitive behavioral intervention to support pediatric HIV disclosure
- Where
- 6 sites in Uganda
- Volunteers
- 600 people
- Sponsor
- University of Connecticut
HIV Primary Infection
Diagnostic Performance of a Novel Lipoarabinomannan.
The Fujifilm SILVAMP TB LAM (FujiLAM; Fujifilm, Tokyo, Japan) is a novel (not commercialized) urine based point-of-care assay to diagnose TB in HIV-positive patients.
- Trial name
- FUJILAM (NCT05036694)
- Testing
- FUJILAM KIT
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Médecins Sans Frontières, Kenya
HIV Infections
Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine
The purpose of this study is to evaluate the safety and immune response to an HIV clade C vaccine and to an MF59- or alum-adjuvanted clade C Env protein in healthy, HIV-uninfected adults.
- Trial name
- HVTN107 (NCT03284710)
- Testing
- ALVAC-HIV (vCP2438), Bivalent Subtype C gp120/MF59, Bivalent Subtype C gp120 admixed with Al(OH)3 Suspension
- Where
- 6 sites in Mozambique, South Africa and 1 more
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
An Open-Label, Crossover Study to Assess the Effect of Food on the Oral Bioavailability and Pharmacokinetic Profile of 3'-Deoxy-3'-Fluorothymidine (FLT) in Asymptomatic Human Immunodeficiency Virus (HIV)-Infected Subjects
To characterize the pharmacokinetics of orally administered FLT (in a liquid formulation) after single doses in both the fed and fasting states; to assess the effect of food on the oral bioavailability of FLT
- Trial name
- NCT00002260
- Testing
- Alovudine
- Where
- United States
- Sponsor
- Lederle Laboratories
HIV
Assisting HIV-infected Mothers in Disclosing Their Serostatus to Their Children
This study will develop and evaluate the effectiveness of an intervention designed to assist HIV-infected mothers of young children in determining whether and how to appropriately disclose their HIV serostatus to their children.
- Trial name
- TRACK (NCT00429546)
- Testing
- Teaching, Raising, and Communicating with Kids (TRACK), Treatment as usual
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of California, Los Angeles
HIV Infections
Molecular Diversity of HIV-1 Group O Strains and Treatment Management in Cameroon
Infections with HIV-1 group O are found in 1 to 3 % of persons living with HIV in Cameroon. The natural history and treatment response is not well understood.
- Trial name
- NCT00658346
- Testing
- Treatment initiation for HIV-1 group O infected patients, Treatment initiation for HIV-1 group M infected patients
- Where
- 2 sites in Cameroon
- Volunteers
- 141 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Acquired Immunodeficiency Syndrome, Human Immunodeficiency Virus Type
Adherence & Health Outcome Differences Amongst HIV Infected Patients Prescribed HAART
This study is designed to see how HIV infected patients perform when taking a single fixed dose HIV medication compared to a regimen with multiple tablets.
- Trial name
- HOST (NCT02322827)
- Where
- United States
- Volunteers
- 445 people
- Sponsor
- Olayemi Osiyemi MD
Cervical Cancer, Human Papillomavirus
Accuracy of Portable Colposcopy and HPV Genotypes Among HIV+ Women
This study will evaluate the effectiveness of portable colposcopy when compared to conventional colposcopy (25x magnification of the cervix, the gold standard) and Visualization Inspection with Acetic acid (VIA, with 1x…
- Conditions
- Cervical Cancer, Human Papillomavirus, Human Immunodeficiency Virus
- Trial name
- NCT02338141
- Testing
- Portable colposcopy (Cerviscope), Conventional colposcopy (Wallach Zoomscope)
- Where
- Haiti
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV Infections
Safety of and Immune Response to a Prime-Boost Vaccine Regimen in HIV-Uninfected Vaccine-Naive Adults
The purpose of this study is to evaluate the safety of and immune response to a two-vaccine regimen in healthy, HIV-uninfected adults who have never received an HIV preventive vaccine before.
- Trial name
- NCT00820846
- Testing
- pGA2/JS7 DNA vaccine, MVA/HIV62 vaccine
- Where
- 12 sites in United States, Peru
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Measurement of Plasma and Intracellular Concentrations of Raltegravir
The primary purpose of this study is to analyze and compare plasma and intracellular concentrations of Raltegravir (RAL) in blood plasma and in peripheral blood mononuclear cells, using high performance liquid chromatography…
- Trial name
- NCT01214486
- Testing
- Raltegravir
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Nebraska
Tuberculosis, Pulmonary
Atorvastatin to Reduce Inflammation After Tuberculosis Treatment Completion
This is a proof-of-concept phase IIB, double-blind, randomized, placebo-controlled trial to evaluate the safety and efficacy of 40 mg atorvastatin to reduce persistent lung inflammation after successful TB treatment completion in…
- Trial name
- StatinTB (NCT04147286)
- Testing
- Atorvastatin 40mg
- Where
- South Africa
- Volunteers
- 220 people
- Sponsor
- University of Cape Town
HIV/AIDS
Same-Day Treatment With Genvoya vs. EFV/TDF/3TC
Randomized, open-label study comparing Elvitegravir-Cobicistat-Tenofovir Alafenamide-Emtricitabine (Genvoya) vs. Efavirenz-Tenofovir Disoproxil Fumarate-Lamivudine (EFV-TDF-3TC) in patients starting ART on the day of HIV…
- Trial name
- NCT03405194
- Testing
- Elvitegravir, Cobicistat, TAF, FTC, Efavirenz, TDF, and 3TC
- Sponsor
- Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic
Healthy
Improving Consent and Survey Procedures for Young MSM in Web-based HIV Prevention
A two-part study to test the efficacy of alternative consent procedures and the efficacy of alternative methods to improve survey completion.
- Trial name
- NCT02139566
- Testing
- Video consent (high-tech), Video consent (low-tech), FAQ format consent
- Where
- United States
- Volunteers
- 2,405 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV, Major Depressive Disorder
CID 0911 - Adaptation of A Depression Treatment Intervention for HIV Patients in Cameroon
The purpose of this study is to adapt depression treatment intervention for HIV patients in Cameroon. The PI will validate a depression severity measure, adapt key elements of the intervention to the Cameroon context, train…
- Trial name
- ADEPT (NCT02156622)
- Volunteers
- 55 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections
Acupressure to Treat Nausea and Vomiting in HIV/AIDS Patients
The purpose of this study is to see whether acupressure (acupuncture using pressure applied by the hands instead of needles) can help nausea and vomiting in persons with HIV/AIDS.
- Trial name
- NCT00017823
- Testing
- Acupressure
- Where
- United States
- Sponsor
- National Institute of Nursing Research (NINR)
HIV Infections, HPV Infection
Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya
This randomized, placebo-controlled trial will evaluate self-administered 5-fluorouracil (5FU) to improve human papillomavirus (HPV) clearance after thermal ablation (TA) in Women With Human Immunodeficiency Virus (HIV) (WWH) in…
- Conditions
- HIV Infections, HPV Infection, Cervix Cancer, CIN2
- Trial name
- ASCEND (NCT07545746)
- Testing
- 5% 5-fluorouracil Topical Cream
- Where
- 2 sites in Kenya
- Volunteers
- 140 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
HIV Infections
Study of Itraconazole in Patients With Advanced HIV Infection
To demonstrate a dosage regimen for intravenous itraconazole that produces a plasma concentration range comparable to that obtained after currently used oral dosages of itraconazole oral solution; and to obtain preliminary safety…
- Trial name
- NCT00002370
- Testing
- Itraconazole
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Janssen, LP
HIV Infections
Evaluating the Immunogenicity of the AIDSVAX B/E Vaccine and the MVA/HIV62B Vaccine in Healthy, HIV-1-Uninfected Adults Who Previously Received MVA/HIV62B in DNA/MVA or MVA/MVA Regimens in HVTN 205
The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of the AIDSVAX B/E vaccine and the MVA/HIV62B vaccine in healthy, HIV-1-uninfected adults who previously received MVA/HIV62B in DNA/MVA or…
- Trial name
- NCT02852005
- Testing
- MVA/HIV62B vaccine, AIDSVAX B/E vaccine
- Where
- 9 sites in United States, Peru
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Opioid-Related Disorders
SIRI Checklist: An Integrated Hospital Model to Optimize HIV Prevention in Persons Who Inject Drugs
The purpose of this study is to develop and test a serious injection-related injections (SIRI) checklist aimed at increasing evidence-based treatment for rural people who use drugs (PWUD) including innovative, long-acting…
- Conditions
- HIV Infections, Opioid-Related Disorders, Pre-Exposure Prophylaxis (PrEP)
- Trial name
- SHAPE (NCT05480956)
- Testing
- SIRI Checklist, Enhanced Peer Recovery Coach, SIRI Checklist + Enhanced Peer Recovery Coach
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
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