Clinical trials: Acquired Immunodeficiency Syndrome
Tenofovir, Tenofovir Alafenamide Fumarate
Tenofovir Exposures in Advanced Kidney Disease Study
Phamacokinetic study to evaluate tenofovir, emtricitabine and tenofovir alafenamide exposures in people with HIV who have chronic kidney disease stage 4 (estimated glomerular filtration rate [eGFR] 15-29 mL/min/1.73m2) or stage 3…
- Conditions
- Tenofovir, Tenofovir Alafenamide Fumarate, Chronic Kidney Diease, Kidney Failure
- Trial name
- TEAK (NCT07812571)
- Testing
- Plasma sampling for tenofovir and emtricitabine, Descovy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Carcinoma, Non-Small-Cell Lung
Study to Evaluate Using Nelfinavir With Chemoradiation for Non-small Cell Lung Cancer
This study combines nelfinavir (NFV) with radiation therapy and chemotherapy as a treatment for non-small cell lung cancer (NSCLC) who are considered candidates for pre-operative treatment.
- Trial name
- NCT00791336
- Testing
- Nelfinavir
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Iowa
STI, Mycoplasma Genitalium Infection
Mycoplasma Genitalium Infection and Associated Antimicrobial Resistance Among HIV-infected Male in Hong Kong
Worldwide, Mycoplasma genitalium (MG) is increasingly reported as an emerging cause of sexually transmitted infections. Internationally, the prevalence of MG is higher in male with urethritis and community groups especially among…
- Trial name
- NCT05789134
- Testing
- self-sampling kits for STI testing in the laboratory
- Where
- Hong Kong
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
HIV Infections, Proteinuria
Pilot Study of Raltegravir Switch to Resolve Tenofovir Induced Proteinuria
The study is designed to evaluate the proportion of patients with tenofovir induced proteinuria that will resolve their proteinuria when the tenofovir containing nucleoside/nucleotide backbone is switched to a raltegravir…
- Trial name
- RALPIR (NCT01044771)
- Testing
- change from tenofovir to raltegravir
- Volunteers
- 20 people
- Sponsor
- Metropolis Medical
HIV
Effects of Probiotics on Microbial Translocation and Immune Activation Markers in HIV-positive Patients on Combined Antiretroviral Therapy
Combined antiretroviral therapy (cART)-treated patients have increased mortality and morbidity compared to age-matched seronegative individuals.
- Trial name
- PROBIO-HIV (NCT02164344)
- Testing
- probiotics
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
HIV Infections, Acquired Immunodeficiency Syndrome
Vicriviroc in HIV-Treatment Experienced Subjects (Study P04405AM5)
Vicriviroc (vye-kri-VYE-rock) is an investigational drug (not yet approved by Government Regulatory Authorities for commercial use) that belongs to a new class of drugs, called CCR5 receptor blockers.
- Trial name
- NCT00523211
- Testing
- Vicriviroc
- Volunteers
- 506 people
- Sponsor
- Merck Sharp & Dohme LLC
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Stroke
Effects of Training Caregivers on the Outcomes of Stroke Survivors and Caregivers in Zimbabwe
The burden of stroke has continued to increase in Zimbabwe in the last 3 decades. resulting in increased burden of care to family caregivers.
- Trial name
- NCT02569099
- Testing
- Caregiver training
- Where
- Zimbabwe
- Volunteers
- 376 people
- Sponsor
- University of Zimbabwe
HIV
Females of African American Legacy Empowering Self (FemAALES)
The FemAALES Project is a community collaborative two-arm intervention designed to prevent HIV (human immunodeficiency) and STD (sexually transmitted disease) infection and transmission among African American women and men by…
- Trial name
- FemAALES (NCT02189876)
- Testing
- Standard of Care, FemAALES
- Where
- 2 sites in United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science
HIV Infections, Chickenpox
A Comparison of 882C87 Versus Acyclovir in the Treatment of Herpes Zoster in Patients With Weakened Immune Systems
To determine the efficacy of oral 882C87 compared with oral acyclovir in the treatment of localized herpes zoster in immunocompromised patients. To assess the safety and tolerance of oral 882C87 in immunocompromised patients.
- Trial name
- NCT00002315
- Testing
- Netivudine, Acyclovir
- Where
- 25 sites in United States
- Volunteers
- 400 people
- Sponsor
- Glaxo Wellcome
HIV Seropositivity, Disclosure
ANRS12373 GUNDO SO - Evaluation of an Empowerment Program for WLHIV in Mali
The objective of this research is to measure the short- and mid-term effects of an empowerment program focused on serostatus disclosure management for women living with HIV (WLHIV) in Mali on the "burden of secrecy".
- Conditions
- HIV Seropositivity, Disclosure, Empowerment, HIV/AIDS
- Trial name
- NCT03795415
- Testing
- Gundo So
- Where
- 6 sites in Mali
- Volunteers
- 224 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections, Acquired Immunodeficiency Syndrome
Medications for Chronic HIV: Education and Collaboration
This study will examine whether a computerized, self-administered assessment of patient medication adherence and health behaviors, plus support for adherence, improves the ability of clinicians to identify adherence problems and…
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Medication Adherence
- Trial name
- MedCHEC (NCT01038076)
- Testing
- MedCHEC Tablet Computer & Adherence Care
- Where
- 3 sites in United States
- Volunteers
- 371 people
- Sponsor
- Boston University
Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus
Study of People With HIV Infection Who Have High Viral Loads Despite Combination Antiretroviral Therapy
Background: The human immunodeficiency virus (HIV) causes acquired immune deficiency syndrome (AIDS). Combination antiretroviral therapy (ART) drugs treat HIV infection.
- Conditions
- Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, AIDS Virus, Human Immunodeficiency Virus
- Trial name
- NCT01976715
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Randomized Placebo-controlled Pilot Trial of Prebiotics+Glutamine in HIV Infection
A rapid and almost complete loss of CD4+ T cells from the gut associated lymphoid tissue (GALT) occurs early in HIV infection, with a permanent damage in the intestinal barrier, changes in gut microbiota, increased bacterial…
- Trial name
- MicroVIH (NCT01838915)
- Testing
- Prebiotics+Glutamine
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Hiv, Atherosclerosis
Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
The goal of this clinical trial is to conduct a dietary intervention targeting HIV specific gut microbiota alterations for primary atherosclerotic cardiovascular disease (ASCVD) prevention and evaluate its effectiveness in…
- Conditions
- Hiv, Atherosclerosis, Diet, Healthy
- Trial name
- NCT06560840
- Testing
- dietary intervention
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Fudan University
HIV Seropositivity
Revealing Increased Axonal Loss in Treated HIV Patients
HIV patients may suffer sooner from aging than average population, including brain aging. Our hypothesis is that if brain dysfunctions are explained by a quicker loss of neurons in HIV patients, this loss could be detected…
- Trial name
- OCTIHIV (NCT02003989)
- Testing
- ophthalmologic examination and MRI
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
HIV
Peru Decentralized HIV Care
The purpose of this study is to understand the processes by which HIV care is decentralized, an evidence-informed strategy to improve retention in HIV care, in Peru.
- Trial name
- NCT05910268
- Testing
- NIATx + ECHO
- Where
- 2 sites in United States, Peru
- Volunteers
- 1,450 people
- Sponsor
- Yale University
Pneumonia, Pneumococcal, Hiv
Prevention of Missed Opportunities for HIV Diagnosis by Promoting HIV Testing of Patients With Pneumococcal Pneumonia at Nice University Hospital (PneumoVIH)
According to usual practices, HIV testing should be performed for each patient diagnosed for pneumococcal pneumonia. Unfortunately, in 2018, only 27% of patients were tested for HIV following pneumococcal pneumonia in Nice…
- Trial name
- PneumoVIH (NCT04909268)
- Testing
- HIV testing
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
HIV Infection, Liver Failure
Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipients
This phase I/II, multi-center study is designed to determine the pharmacokinetic profile of Raltegravir in patients with end stage liver disease and to assess drug-drug interaction when Raltegravir is combined with…
- Conditions
- HIV Infection, Liver Failure, Evidence of Liver Transplantation
- Trial name
- LIVERAL (NCT01022476)
- Testing
- Raltegravir potassium
- Where
- France
- Volunteers
- 14 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients
To evaluate and compare 3 anti-pneumocystis regimens plus zidovudine (AZT) in persons with HIV infection and T4 cell count less than 200 cells/mm3.
- Trial name
- NCT00000991
- Testing
- Pentamidine isethionate, Sulfamethoxazole-Trimethoprim, Dapsone
- Where
- 21 sites in United States, Tanzania
- Volunteers
- 600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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