Clinical trials: Acquired Immunodeficiency Syndrome
HIV Infections
Innovative Administration of Long-Acting Injectables for HIV Treatment Enhancement at Home
This study will support the expansion of long-acting injectable antiretroviral therapy (LAI-ART) in non-clinical settings by developing, implementing, and evaluating a comprehensive, theory-informed training intervention to…
- Trial name
- INVITE-Home (NCT06488846)
- Testing
- INVITE-Home, Clinic-Administered LAI-ART, Oral ART
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, San Francisco
Transgender Women, HIV/AIDS
Effects of Gender-Affirming Hormone Therapy Among Transgender Women
In this study, investigators plan to evaluate the cardiometabolic effects of initiating gender-affirming hormone therapy among transgender women with and without HIV.
- Conditions
- Transgender Women, HIV/AIDS, Cardiovascular Diseases, Metabolic Disease
- Trial name
- NCT04128488
- Testing
- Abdominal MR Imaging, Cardiac MRI/MRS, Oral Glucose Tolerance Testing
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV/AIDS
Demand Creation for Couples' HIV Counseling and Testing
This study aims at assessing the effect of a demand-creation intervention on couples' HIV counseling and testing (couples' HCT) uptake among married couples who have never tested together as a couple.
- Trial name
- NCT02492061
- Testing
- Demand creation for couples' HCT
- Volunteers
- 3,076 people, healthy volunteers welcome
- Sponsor
- Makerere University
HIV
A Phase IV, Open-label Single-arm Study Investigating the Pharmacokinetics and Pharmacodynamics of the Antiretroviral Combination of Rilpivirine and Ritonavirboosted Darunavir in Therapy-naive HIV-1 Infected Patients.
For patients who are starting to take antiretroviral medication (to treat HIV) for the first time, there are now a variety of different medicines which may be taken together as a combination in order to form an effective…
- Trial name
- NCT01736761
- Testing
- Darunavir, Ritonavir and Rilpivirine
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- St Stephens Aids Trust
HIV-1-infection
HIV Resistance, Molecular Epidemiology and New Treatment Strategies in the Eastern European Region and in Russia
Cohort based prospective monitoring of the spread of HIV drug resistance during a phase when new anti-HIV drugs are introduced.
- Trial name
- NCT06127290
- Where
- 4 sites in Germany, Italy and 2 more
- Volunteers
- 200 people
- Sponsor
- Euresist Network GEIE
HIV, Depression
Pharmacokinetic Drug-drug Interaction Study Between RaltEgravir and CITALopram in Healthy Subjects (RECITAL).
Depression is the most common mental health disorder among HIV-patients. Recognizing and treating depression is important in order to improve quality of life and health outcomes in those living with HIV.
- Trial name
- RECITAL (NCT01978782)
- Testing
- raltegravir, citalopram
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
HIV Infection Primary
Kinetics of HIV-RNA Decay in Seminal Plasma of Men Treated by Dolutegravir at the Time of Primary HIV Infection
Sponsor: IMEA - Fondation Internationale Léon Mba C.H.U. Bichat - Claude Bernard 46, Rue Henri Huchard - 75018 PARIS Tél. : 01.40. 25. 63.
- Trial name
- DOLUPRIM (NCT02976259)
- Testing
- Dolutegravir
- Volunteers
- 20 people
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
HIV (Human Immunodeficiency Virus)
The DART DELIVER-02 Study
This research study aims to find out how safe and well tolerated the experimental study drugs are when given to persons with HIV (PWH) taking antiretroviral therapy (ART).
- Trial name
- DELIVER-02 (NCT07217379)
- Testing
- MGD020, MGD014, Vorinostat
- Where
- 3 sites in United States, Kenya
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Methamphetamine Use Disorders, HIV
Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH
The purpose of this study is to learn more about how accelerated theta burst stimulation affects methamphetamine craving and brain activity.
- Trial name
- NCT06830980
- Testing
- intermittent theta burst stimulation (iTBS), continuous theta burst stimulation (cTBS)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Gopalkumar Rakesh
MASLD, HIV (Human Immunodeficiency Virus)
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV
Metabolic dysfunction-associated steatotic liver disease (MASLD), commonly known as fatty liver disease, is increasingly prevalent worldwide.
- Trial name
- MASLD (NCT07640880)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yinzhong Shen
Stress, Blood Pressure
Adapting a Stress Management Intervention to Reduce Cardiovascular Disease Risk
Women living with HIV have 2-4x higher risk for cardiovascular disease compared to women without HIV, with women living with HIV in the Southern US being particularly at risk.
- Conditions
- Stress, Blood Pressure, Cardiovascular Diseases (CVD)
- Trial name
- NCT06811896
- Testing
- Stress Management and Resiliency Training Program, Usual Care
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Sarcoma, Kaposi, HIV Infections
A Study of Doxorubicin in the Treatment of AIDS-Related Kaposi's Sarcoma
To study the natural course of AIDS related Kaposi's sarcoma and to determine the usefulness and safety of weekly administration of small doses of doxorubicin.
- Trial name
- NCT00000996
- Testing
- Doxorubicin hydrochloride
- Where
- 12 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pediatric HIV Infection
Active Search for Pediatric HIV/AIDS (ASPA)
The Active Search for Pediatric HIV/AIDS (ASPA) aims at assessing the acceptability, feasibility and effectiveness of the targeted provider-initiated-testing and counseling (tPITC) in comparison with the blanket…
- Trial name
- ASPA (NCT03024762)
- Testing
- targeted Provider-Initiated-Testing and Counseling (tPITC)
- Where
- 3 sites in Cameroon
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- Research for Development International
HIV/AIDS, Cognitive Impairment
A Randomized Pilot Trial Evaluating the Impact of a Yoga Intervention on Cognition in Older Adults Infected With HIV
Approximately 50% of people living with HIV (and as many as 80% over the age of 50) have difficulties with cognitive functions such as memory and thinking that can have a profound negative impact on activities of daily living and…
- Conditions
- HIV/AIDS, Cognitive Impairment, Aging, Mobility Limitation
- Trial name
- NCT03071562
- Testing
- Yoga-mindfulness
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Adria Quigley
HIV Infection, Infection, Human Immunodeficiency Virus
Healthy Volunteer Study To Assess The Bioavailability of GSK1265744 When Administered Orally Either When Fasted or Following a Meal.
To evaluate the single dose relative bioavailability of GSK1265744 10mg administered in either oral solution fasted, two 5mg tablets fasted, or two 5mg tablets following a moderate meal.
- Trial name
- NCT00812318
- Testing
- GSK1265744 10 mg oral solution, GSK1265744 5 mg tablet
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Infections, Cytomegalovirus Infections
Valganciclovir to Reduce T Cell Activation in HIV Infection
The purpose of this study is to determine whether treatment with valganciclovir decreases T cell activation levels among HIV-infected patients with asymptomatic cytomegalovirus (CMV) co-infection, potentially improving immune…
- Trial name
- NCT00264290
- Testing
- Valganciclovir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
HIV Infections
Tenofovir-lamivudine-dolutegravir Combination as Second-line ART: a Randomised Controlled Trial
The strategy to support virological suppression on second-line antiretroviral treatment (ART) includes the provision of ART that has a low pill burden, good tolerability, low toxicity, is easily monitored, has a high barrier to…
- Trial name
- ARTIST (NCT03991013)
- Testing
- Dolutegravir 50 mg
- Where
- South Africa
- Volunteers
- 192 people
- Sponsor
- University of Cape Town
HIV-1, HIV Infections
Safety and Immunogenicity Study of Candidate HIV-1 Vaccine Given to Healthy Infants Born to HIV-1/2-uninfected Mothers
Objectives: Safety and immunogenicity of MVA.HIVA vaccine in 20-week-old healthy Gambian infants born to HIV-1/2-uninfected mothers.
- Trial name
- PedVacc001 (NCT00982579)
- Testing
- MVA.HIVA
- Where
- The Gambia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical Research Council
HIV Infections
A Behavioral Intervention to Reduce Sexual Risk Among African-American Men Who Have Sex With Men
The purpose of this project is to test the efficacy of an HIV prevention behavioral intervention to reduce sexual risk among African-American men who have sex with men (MSM).
- Trial name
- NCT00691496
- Testing
- Behavioral intervention to reduce sexual risk among African-American men who have sex with men
- Where
- United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HIV Infections
Online HIV Prevention Vignette Evaluation
This is an evaluation of the effect that an online live action, dramatic vignette about four gay men, two HIV positive and two HIV negative, struggling with the responsibility for safer sex has on the sexual behavior and HIV…
- Trial name
- NCT00249327
- Testing
- education
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Public Health Solutions
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