Clinical trials: Actinic Keratoses, active
Actinic Keratosis (AK)
An Open-Label Pharmacokinetic Study for Patients With Actinic Keratosis on the Upper Extremities or the Face
The research study will evaluate how the body absorbs and reacts to reformulated Levulan Kerastick when applied to actinic keratosis lesions (AKs) on the skin of the forearms or face followed by photodynamic therapy (PDT), a…
- Trial name
- NCT07729579
- Testing
- Investigational drug, Photodynamic therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Keratosis, Actinic Keratoses
Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and Forehead
The aim of the study is to evaluate the efficacy and safety of a combined approach of cryotherapy and tirbanibulin for the treatment of actinic keratosis of the scalp and forehead, repeated every 4 months.
- Trial name
- TIRBACRYO (NCT07273656)
- Testing
- Cryotherapy + Tirbanibulin
- Volunteers
- 59 people
- Sponsor
- University Hospital, Lille
Actinic Keratoses
Efficacy and Safety of Cryotherapy Versus 5-Fluorouracil in the Treatment of Actinic Keratosis
The goal of this clinical trial is to compare the effectiveness and safety of two treatments-cryotherapy and 5-Fluorouracil (5-FU)-for actinic keratosis, a common skin condition caused by long-term sun exposure.
- Trial name
- NCT06461442
- Testing
- Cryotherapy, 5Fluorouracil
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of California, Davis
Actinic Keratosis, Imipramine
The Effect of Topical Imipramine on Photodynamic Therapy-Mediated Immunosuppression on Forearms or Face on US Veterans
The purpose of this study is to test the use of topical imipramine in combination with topical photodynamic therapy's (PDT) effect on the effectiveness and pain immunosuppression following treatment.
- Conditions
- Actinic Keratosis, Imipramine, Photodynamic Therapy
- Trial name
- NCT06778434
- Testing
- Imipramine, Control Vehicle
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Basal Cell Carcinoma
Basal Cell Carcinoma Chemoprevention Trial
This is an intent-to-treat, parallel design, multicenter randomized trial and the primary intervention is a double-blind comparison of imiquimod (IMQ) vs.
- Trial name
- B3C (NCT05212246)
- Testing
- 5% Imiquimod cream
- Where
- 8 sites in United States
- Volunteers
- 1,630 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Actinic Keratoses
Investigation of the Effect of Lipikar Baume AP+M
Application of Lipikar Baume AP+M at least twice daily for 4 weeks on one of the two arms according to a randomization scheme The purpose of this study is to observe the skin barrier function, transepidermal water loss and…
- Trial name
- NCT06385340
- Testing
- Lipikar Baume AP+M
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- CentroDerm GmbH
Actinic Keratosis (AK)
Evaluate RLS-1496 Topical Cream for Actinic Keratosis
This clinical trial will assess the safety and tolerability of topical application of RLS-1496 cream to lesions and adjacent skin on the left forearm of adults with actinic keratoses (AK) on the arms.
- Trial name
- NCT07340697
- Testing
- RLS-1496 1.0% cream
- Where
- 4 sites in United States
- Volunteers
- 24 people
- Sponsor
- Rubedo Life Sciences, Inc.
Imipramine, Photodynamic Therapy
The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
The purpose of this study is testing the use of topical Imipramine in combination with topical photodynamic therapy's (PDT) effect on pain following treatment.
- Conditions
- Imipramine, Photodynamic Therapy, Actinic Keratosis
- Trial name
- NCT05688904
- Testing
- Imipramine, Vehicle
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wright State University
Actinic Keratoses, Aging
The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population
The purpose of this study is to determine if the Fractionated Laser Resurfacing (FLR) procedure can protect one forearm/wrist from precancerous actinic keratosis (AKs) as well as prevent skin cancer in older subjects with active…
- Conditions
- Actinic Keratoses, Aging, Non-Melanoma Skin Cancer
- Trial name
- NCT06428721
- Testing
- Fractionated Laser Resurfacing
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wright State University
Actinic Keratoses, Aging
Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia
This study is following up on previous studies that have demonstrated that geriatric subjects respond different to ultraviolet B (UVB) light than young subjects.
- Conditions
- Actinic Keratoses, Aging, Non-Melanoma Skin Cancer
- Trial name
- NCT03906253
- Testing
- Fractionated Laser Resurfacing
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Wright State University
Actinic Keratoses, Patient Decision Aid
Patient Decision Aid for the Treatment of Actinic Keratosis
This study evaluates whether a Patient Decision Aid for the field-directed treatment of actinic keratosis has an effect on shared decision making and patient satisfaction.
- Trial name
- NCT06008171
- Testing
- Patient Decision Aid
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- Maastricht University Medical Center
Actinic Keratosis (AK)
Study of the Photoprotection and Prevention of Actinic Damage With Anthelios Fluide 100 KA+ UVMune 400 in Patients With Multiple Actinic Keratoses
Participants will be invited to take part in a research study as they have been diagnosed with multiple actinic keratosis lesions (AK).
- Trial name
- NCT07335003
- Testing
- Tested product group, Control group
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- Cosmetique Active International
Actinic Keratosis
Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities
This Phase 3, randomized, multi-center, evaluator-blind, vehicle-controlled study evaluates the efficacy and safety of reformulated Levulan Kerastick (aminolevulinic acid HCl 20%) combined with photodynamic therapy (PDT) for…
- Trial name
- NCT07144852
- Testing
- Reformulated Levulan Kerastick containing aminolevulinic acid hydrochloride (ALA HCl), 20%, Vehicle, Blue Light Photodynamic Therapy Illuminator device, BLU-U® model 4170E.
- Where
- 22 sites in United States
- Volunteers
- 260 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Photo-damage, Actinic Keratosis (AK)
Multimodal Laser Treatment of Photodamaged Skin
The Multimodal Laser Project is a prospective, randomized, split-face clinical study investigating a novel combination of laser and light-based treatments for facial photodamage with the long-term perspective of improving skin…
- Trial name
- NCT07789002
- Testing
- 1927-nm thulium laser, 1550-nm Er:Glass laser, Intense Pulsed Light
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Merete Haedersdal
Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder
SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography
This clinical trial aims to assess the efficacy of Optical Coherence Tomography (OCT) in the early diagnosis of oral cancer. It focuses on Oral Potentially Malignant Disorders (OPMDs) as precursors to Oral Squamous Cell Carcinoma…
- Conditions
- Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder, Oral Leukoplakia, Proliferative Verrucous Leukoplakia
- Trial name
- SYMILIS OCT (NCT06321003)
- Testing
- OCT (Optical Coherence Tomography)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Palermo
Actinic Keratoses
Implementation of Actinic Keratosis Guideline Among General Practitioners.
This study investigates 5-fluorouracil cream prescription trends by general practitioners for the treatment of field changes of actinic keratosis over the years 2016-2021.
- Trial name
- NCT05976048
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Maastricht University Medical Center
Actinic Keratosis (AK)
Investigation of the Efficacy and Tolerability of Topical Applied Tirbanibulin on Actinic Keratoses With Downward-directed Proliferation Patterns
The aim of this study is to observe the influence of tirbanibulin on proliferation patterns of actinic keratoses (efficacy on proliferation score according to Schmitz et al.).
- Trial name
- Tir2401 (NCT06648447)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Thomas Dirschka
Actinic Keratoses
Cryotherapy in Combination With Red Light PDT for Actinic Keratosis of Full Face
40 patients randomized 1:1 to receive cryotherapy followed by 10% ALA gel Red light PDT vs. to 10% ALA gel Red Light PDT followed by cryotherapy.
- Trial name
- NCT06745999
- Testing
- Ameluz 10% Topical Gel, Red Light PDT, Cryotherapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Psoriasis Treatment Center of Central New Jersey
Actinic Keratosis of Face and Scalp
Phase 3 - Evaluation of Veregen® 10% Ointment as New Herbal Topical Treatment for Actinic Keratosis
The goal of this clinical trial is to show superiority of Veregen® 10% ointment to Placebo measured by complete (100%) clearance of a pre-defined treatment area (TA) following a treatment period of 12 weeks and a 4-weeks…
- Trial name
- EXACT-1 (NCT07137819)
- Testing
- Topical treatment
- Where
- Germany
- Volunteers
- 280 people
- Sponsor
- Aresus Pharma GmbH
Nonmelanoma Skin Cancer, Actinic Keratosis
Therapeutic Induction of Dermal Remodeling in Veterans to Prevent Actinic Neoplasia Caused by Chronic Environmental Exposure to Ultraviolet Radiation
The investigators' previous studies demonstrate geriatric subject skin responds differently to ultraviolet B (UVB) light compared to young subject skin, which contribute to increased rates of nonmelanoma skin cancer (NMSC) and…
- Trial name
- NCT07648407
- Testing
- Microneedling, Trichloroacetic acid peel
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- VA Office of Research and Development