Clinical trials: Activation, Patient
Type 2 Diabetes
Exercise Study to Help Patients Who Have Type 2 Diabetes and Depression.
The purpose of this study is to test an exercise treatment that includes behavioral strategies to improve blood sugar control in women with type 2 diabetes who are depressed and overweight.This research study may lead to a…
- Trial name
- NCT01024790
- Testing
- Exercise group
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Massachusetts, Worcester
Communication, Trust
CALS Patient Activated Learning System (PALS)
The overall goal in this line of inquiry is to test whether the Patient Activated Learning System (PALS) is effective in reducing disparities in access to reliable, easily understood health information, and whether this increased…
- Conditions
- Communication, Trust, Health Knowledge, Attitudes, Practice
- Trial name
- NCT04212117
- Testing
- The Patient Activated Learning System (PALS), WebMD
- Where
- United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Cornell University
Congenital Bleeding Disorder, Haemophilia A With Inhibitors
Prediction of the Efficacy of Activated Recombinant Human Factor VII in Adult Congenital Haemophilia A or B Patients With Inhibitors by Use of Thromboelastography
This trial is conducted in Europe and the United States of America (USA). The aim of this trial is to evaluate the basal and spiked TEG® (Thromboelastography) or ROTEM® (Thromboelastometry) profiles of frequently bleeding…
- Conditions
- Congenital Bleeding Disorder, Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
- Trial name
- NCT01561924
- Testing
- eptacog alfa (activated)
- Where
- 7 sites in United States, Denmark and 2 more
- Volunteers
- 17 people
- Sponsor
- Novo Nordisk A/S
Metabolic Syndrome
Study Protocol of the EMPOWER-SUSTAIN Project
A pilot randomised controlled trial will be conducted in UiTM Primary Care Clinic, Selayang Campus, Selangor, Malaysia. A total of 232 patients with Metabolic Syndrome (MetS) will be recruited; 116 will be randomised to receive…
- Trial name
- NCT04120779
- Testing
- The EMPOWER-SUSTAIN e-Health Self-Management Intervention
- Volunteers
- 232 people
- Sponsor
- Universiti Teknologi Mara
Non-small Cell Lung Cancer
Safety and Efficacy of BKM120 in Patients With Metastatic Non-small Cell Lung Cancer
The purpose of this two-stage phase II study is to assess the efficacy of BKM120, as measured by determining the progression free survival (PFS), in patients with pretreated metastatic Non-small Cell Lung Cancer (NSCLC) that…
- Trial name
- BASALT-1 (NCT01297491)
- Testing
- BKM120
- Where
- 92 sites in United States, Argentina and 16 more
- Volunteers
- 63 people
- Sponsor
- Novartis Pharmaceuticals
Systemic Lupus Erythematosus, BAFF Polymorphism
BAFF and APRIL and RESPONSE TO BELIMUMAB in SLE
This project is intended to identify the routes on which BAFF and APRIL act in order to detect possible future candidates to Belimumab treatment among patients diagnosed of SLE.
- Trial name
- BAFF (NCT03919643)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Melanoma
Dendritic Cell Activating Scaffold in Melanoma
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of investigational melanoma vaccines. Phase I studies also try to define the appropriate dose of the investigational vaccine, in this case…
- Trial name
- NCT01753089
- Testing
- WDVAX
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dana-Farber Cancer Institute
Lung Adenocarcinoma, EGFR Activating Mutation
EGFR-TKI Combined With Concurrent or Sequential Chemotherapy for Patients of Gradual Progression
To compare the efficacy of simultaneous EGFR-TKI and chemotherapy with that of sequential treatment after patients gradually progressed from first-line EGFR-TKI treatment.
- Trial name
- NCT03544814
- Testing
- icotinib combined with pemetrexed plus cisplatin, first icotinib and then pemetrexed plus cisplatin
- Volunteers
- 99 people
- Sponsor
- Shanghai Chest Hospital
Precapillary Pulmonary Hypertension, Pulmonary Arterial Hypertension
Evolution of Hypoxic Burden and Sympathetic/Parasympathetic Balance in Patients With Pulmonary Hypertension
Background and Rationale: Sleep-disordered breathing and nocturnal hypoxemia are highly prevalent in patients with precapillary pulmonary hypertension (PH), and current guidelines recommend systematic sleep assessment in this…
- Conditions
- Precapillary Pulmonary Hypertension, Pulmonary Arterial Hypertension, Sleep-disordered Breathing, Nocturnal Hypoxemia
- Trial name
- HRV&PH (NCT07464184)
- Testing
- Standard Clinical and Functional Assessment, Overnight Polysomnography
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Rouen
Diabetes Mellitus, Type 2
Evaluation of a Patient Portal Intervention for Diabetes: A Pilot Randomized Controlled Trial
The purpose of this study is to conduct a two-arm, parallel-design, pragmatic randomized controlled trial of a patient portal intervention for diabetes, My Diabetes Care, to evaluate its effect on patient activation and secondary…
- Trial name
- NCT03947333
- Testing
- My Diabetes Care
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- Vanderbilt University Medical Center
Mastocytosis, Bones
Relationship Between Circulating Sclerostin and Bone Lesions in Patients With Mastocytosis
Mastocytosis is very rare and highly heterogeneous group of disorders, characterized by the accumulation of clonal mast cells which can infiltrate several organs and tissues.
- Trial name
- NCT06440148
- Testing
- SCLEROSTIN
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Multiple Sclerosis
Does Microglial Activation Promote Lesion Growth and Progression Among Multiple Sclerosis Patients
The purpose of this study is to assess whether increased microglial activation (measured using TSPO-PET) at lesion rim is associated with more rapid lesion growth during 10 year follow up.
- Trial name
- FUP-MS (NCT04625049)
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Hospital Rapid Response Team, Hospital Medical Emergency Team
Deep Learning Based Early Warning Score in Rapid Response Team Activation
The objective of this study is to evaluate the safety and clinical usefulness of the Deep learning based Early Warning Score (DEWS).
- Trial name
- NCT04951973
- Testing
- Deep Learning Based Early Warning Score (DEWS)
- Volunteers
- 50,000 people
- Sponsor
- Seoul National University Hospital
SSM, Mastocytosis, Indolent
(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis
This is a multi-part, randomized, double-blind, placebo-controlled Phase 2 clinical study comparing the safety and efficacy of bezuclastinib (CGT9486) plus best supportive care (BSC) with placebo plus BSC in patients with…
- Conditions
- SSM, Mastocytosis, Indolent, Mastocytosis, Systemic, Mastocytosis
- Trial name
- NCT05186753
- Testing
- Bezuclastinib Tablets (Formulation A), Bezuclastinib Tablets (Formulation B)
- Where
- 57 sites in United States, Australia and 13 more
- Volunteers
- 237 people
- Sponsor
- Cogent Biosciences, Inc.
Heart Failure
Quartet Lead and Resynchronization Therapy Options III (QUARTO_III)
The purpose of the study is to assess prospectively at 6 months the percentage of responder patients implanted with a Cardiac Resynchronization Therapy (CRT-D) device and a Quartet Left Ventricular (LV) quadripolar lead and with…
- Trial name
- QUARTO_III (NCT02476201)
- Testing
- MPP ON
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Abbott Medical Devices
CKD 5D, Hemodialysis
Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients
Vascular calcification (VC) is a predictor of cardiovascular morbidity and mortality. Hemodialysis (HD) patients suffer from severe vascular calcifications.
- Trial name
- NCT01407601
- Testing
- daily supplementation of MK-7 over 6 weeks
- Where
- 3 sites in Germany
- Volunteers
- 53 people
- Sponsor
- RWTH Aachen University
Stroke
Investigation of Activation of Latissimus Dorsi Muscle Segments During Functional Reach Activity in Chronic Stroke Patients
Latissimus Dorsi (LD); Medial sacrum, lumbar vertebrae and lower thoracic vertebrae 10-12 lateral to the spinous processus. It is a fan-like wide muscle that connects to the inferior angle of the scapula and ribs, adheres to the…
- Trial name
- NCT04181151
- Testing
- Electromyographic device
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Mild to Moderate Persistent Asthma
Efficacy and Safety of Activation Energy Serum (AES) Versus Placebo in Persistent Asthma.
This study aims to find out if AES ( Activation Energy Serum) , a blend of natural minerals , is effective and safe for the treatment of asthma if taken for 4 weeks .
- Trial name
- NCT01939951
- Testing
- Activation Energy Serum
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- California Allergy and Asthma Medical Group, Inc.
Gaucher Disease, Type 1
Treatment Protocol of Velaglucerase Alfa for Patients With Type 1 Gaucher Disease
Gaucher disease is a rare lysosomal storage disorder caused by the deficiency of the enzyme glucocerebrosidase (GCB). Due to the deficiency of functional GCB, glucocerebroside accumulates within macrophages leading to cellular…
- Trial name
- NCT00954460
- Testing
- velaglucerase alfa
- Where
- 32 sites in United States
- Sponsor
- Shire
Low Back Pain
Effects of Tactile Stimuli for Lumbar Multifidus Muscle Activation in Healthy Adults and Patients With Low Back Pain
The purpose of this study is to compare combined tactile stimulation and verbal instruction to verbal instruction only on lumbar multifidus muscle activation in asymptomatic healthy adults and in patients with LBP.
- Trial name
- NCT02836860
- Testing
- Tactile stimuli
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University