Clinical trials: Active Ageing
Disability or Chronic Disease Leading to Disablement
Barriers to Physical Activity in Patients With Cognitive, Neuromotor or Sensory Impairments During Aging
People with disabilities are less physically active than the general population. Their barriers to physical activity are multiple and include intrapersonal, organizational, societal and interpersonal reasons.
- Trial name
- NO-BARRIERS (NCT05294068)
- Testing
- standard of care for patients with cognitive impairments, standard of care for patients with neuromotor impairments, standard of care for patients with sensory impairments
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Institut de Sante Parasport Connecte Synergies
Aging, Mobility Disability
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.
- Trial name
- BRIO (NCT06940037)
- Testing
- Progressive Resistance Training, Health Education
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Sarcopenia
Sarcopenia, Active Aging and Oral Microbiota. Effects of HIIT in Older Adults
To analyze the effects of a high intensity exercises program by intervals on sarcopenia, active aging and oral microbiota in older adults.
- Trial name
- NCT05220670
- Testing
- HIIT, MICT
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- University of Jaén
Aging, Adults With Overweight and Obesity
Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in Adults With a Metabolically Challenging Profile
Early-onset metabolic disturbances (such as mild hyperglycemia, subclinical dyslipidemia, excess body fat, and reduced functional capacity) represent one of the major public health challenges among middle-aged and older adults.
- Conditions
- Aging, Adults With Overweight and Obesity, Supplementation, Exercise
- Trial name
- NCT07504068
- Testing
- Group 1: Exercise + thermogenic supplement (EX-TS)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- University of Valencia
Sarcopenia
Nutritional and Contractile Regulation of Muscle Growth
Muscle wasting, which involves the loss of muscle tissue, is common in many conditions, such as cancer, AIDS, trauma, kidney failure, bone fracture, and sepsis.
- Trial name
- NCT00891696
- Testing
- Rapamycin, Amino acid supplementation, Low-intensity resistance exercise
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Hypoxia, Cerebral Hypoxia
Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly
In line with the ever-growing aging of Western populations, the development of preventive strategies to slow down the effects of aging on cardiovascular health represents a major challenge in order to preserve functional…
- Conditions
- Hypoxia, Cerebral Hypoxia, Brain Diseases, Exercise
- Trial name
- HYPOXAGE (NCT05048680)
- Testing
- Hypoxia and/or Exercise
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Subjective Cognitive Decline, Age-Related Cognitive Decline
Lifestyle, Exercise and Diet: The LEAD Study
This study will explore the impact of an exercise and nutrition (EX+NUTR) , relative to exercise alone (EX) intervention, on brain structure and function as well as blood biomarkers in older adults with subjective cognitive…
- Trial name
- LEAD (NCT03056508)
- Testing
- Exercise plus nutrition, Exercise
- Where
- 4 sites in Canada
- Volunteers
- 14 people
- Sponsor
- Rotman Research Institute at Baycrest
Myocardial Infarction, Stroke
Women's Health Initiative Strong and Healthy Study
The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality, Hip Fractures
- Trial name
- WHISH (NCT02425345)
- Testing
- Physical Activity
- Volunteers
- 49,331 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Aging, Physical Functioning
Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository
The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in…
- Conditions
- Aging, Physical Functioning, Cognitive Functioning, Fitness
- Trial name
- PPS (NCT01720472)
- Testing
- Biomarker studies
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Spinal Cord Injuries, Aging
Exercise and Nutrition Education for Older Adults With Spinal Cord Injury: A Pilot Randomized Controlled Trial
Older adults living with a spinal cord injury (SCI) experience an increased burden of secondary health conditions than, coupled with age-related complications, may negatively affect physical and mental health, as well as…
- Trial name
- NCT07845851
- Testing
- Individualized Exercise Training, Nutrition Education, Behavioral Support
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Cognitive Aging
Elucidating How Physical Activity and Sleep Relate to Optimal Cognitive Ageing
Increased longevity is one of the greatest success stories in public health. However, ageing is accompanied by cognitive decline which affects people's daily functioning and, if it develops to dementia, their ability to live…
- Trial name
- PASOCA (NCT05455229)
- Where
- Belgium
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Aging, Music
Brain Imaging and Behavioural Changes Following Cued-movement Training of Finger Sequences in Healthy Older Adults
The goal of this study is to examine changes in the brain, behavior, and personal experience when music is used to guide learning of finger movement sequences (compared to visual stimuli alone) in healthy older adults.
- Conditions
- Aging, Music, Motor Activity, Magnetic Resonance Imaging
- Trial name
- NMSOA (NCT06174740)
- Testing
- Music-cued audiovisual motor training, Visually-cued motor training
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Patient Compliance
Cognitive Regulation Training and Exercise Trial
The purpose of this double-blinded, randomized controlled study is to compare CORTEX (Cognitive Regulation Training and Exercise), a multi-faceted, center- and home-delivered- general and exercise-specific-active and traditional…
- Trial name
- CORTEX-II (NCT03124667)
- Testing
- Games, Videos
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Aging, Frail Elderly Syndrome
HMB Supplementation in Addition to Multicomponent Exercise in Old Adults
Evidence supports the fact that multicomponent exercise and β-hydroxy-β-methylbutyrate (HMB) supplementation are, separately, effective in improving old adult's health and palliate functional metabolic diseases in the elderly.
- Conditions
- Aging, Frail Elderly Syndrome, Physical Activity
- Trial name
- HEAL (NCT03827499)
- Testing
- HMB dietary supplementation, Multicomponent physical exercise program
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Stress
Managing Stress and Social Ties for Health Aging
There has been a dramatic rise from 46% to 59% in the percentage of households with only 1-2 people from 1970 to 2000. A 40% increase in the number of people living alone is projected for 2010.
- Trial name
- NCT01204021
- Testing
- Tai Chi Chih, Stress Education Control
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Parkinson Disease, Movement Disorders
Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease
Veterans with mid to later stage Parkinson's disease (PD) may not be able to work out as hard as they need to, to prevent brain cell loss.
- Conditions
- Parkinson Disease, Movement Disorders, Neurodegeneration
- Trial name
- HI-LITE (NCT06088355)
- Testing
- HV-PDAE: High Volume Partnered Dance Aerobic Exercise, MV-PDAE: Moderate Volume Partnered Dance Aerobic Exercise, MV-WALK: Moderate Volume Walking
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- VA Office of Research and Development
Sedentary Behavior, Aging
Promoting Fall Prevention Workshops
Physical Activity (PA) is recognized as the most effective method to prevent falls in the elderly. Yet despite there being a consensus now that Physical Activity (PA) is effective in practice, there remain many obstacles to…
- Trial name
- NCT04134585
- Testing
- semi-structured interviews
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sarcopenia, High Blood Pressure
The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia
Current prevention and treatment of high blood pressure (BP) in sarcopenia, by non-pharmacological approaches remain limited and are far from optimal.
- Conditions
- Sarcopenia, High Blood Pressure, Hypertension
- Trial name
- INERTIA (NCT04255745)
- Testing
- progressive resistance training
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Healthy Aging, Exercise Therapy
Land vs. Water Exercises on Performance and Swimming Behavior in Older Adults
This study aims to investigate the effects of an 8-week combined land and aquatic exercise program (conducted 3 days per week) on physical performance, recreational swimming behaviors, and water-related risk perceptions in older…
- Conditions
- Healthy Aging, Exercise Therapy, Resistance Training, Hydrotherapy
- Trial name
- NCT07784205
- Testing
- 8-Week Beach and Aquatic Exercise Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Eskisehir Technical University