Clinical trials: Active Surveillance for Prostate Cancer
Prostate Cancer
Therapeutics in Active Prostate Cancer Surveillance
Testing if short-term use of apalutamide can reduce image defined tumour volumes in men with detectable lesion on multi-parametric Magnetic Resonance Imaging (mpMRI) and being managed by Active Surveillance.
- Trial name
- TAPS01 (NCT03365297)
- Testing
- Apalutamide
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- CCTU- Cancer Theme
Prostate Cancer
The Metformin Active Surveillance Trial (MAST) Study
This study aims to see if metformin can delay the time to progression in men with low risk prostate cancer when compared to a placebo.
- Trial name
- MAST (NCT01864096)
- Testing
- Metformin
- Where
- 12 sites in Canada
- Volunteers
- 408 people
- Sponsor
- University Health Network, Toronto
Localized Prostate Cancer
Evaluation of Efficacy of TOOKAD® (VTP) Versus Active Surveillance for Intermediate Risk Localized Prostate Cancer
Multi-center, prospective, randomized controlled clinical trial that will compare two treatment methods (PGA with TOOKAD® VTP and Active Surveillance) for treating localized prostate cancer.
- Trial name
- NCT04225299
- Testing
- TOOKAD®
- Where
- United States
- Sponsor
- Steba Biotech S.A.
Prostate Adenocarcinoma
Cholecalciferol Supplement in Treating Patients With Localized Prostate Cancer Undergoing Observation
This randomized clinical trial studies how well cholecalciferol supplement works in treating patients with localized prostate cancer undergoing observation.
- Trial name
- NCT00887432
- Testing
- Cholecalciferol, Laboratory Biomarker Analysis, Patient Observation
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Roswell Park Cancer Institute
Prostate Cancer
Exercise During Active Surveillance for Prostate Cancer
The broad goal of the Exercise During Active Surveillance for Prostate Cancer (ERASE) trial is to examine the effects of exercise in prostate cancer patients undergoing active surveillance.
- Trial name
- ERASE (NCT03203460)
- Testing
- High-intensity aerobic interval training (HIIT)
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Alberta
Prostate Cancer
Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr
This study will be assessing the ability of PSMA-PET CT to determine the absence of clinically significant prostate cancer in patients on active surveillance (AS) with low risk and favorable intermediate-risk prostate cancer.
- Trial name
- ESCAPE (NCT05948657)
- Testing
- PSMA-PET CT
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Prostate Cancer
Multiparametric Magnetic Resonance Imaging of the Prostate to Assess Disease Progression and Genomics in Patients Undergoing Active Surveillance for Prostate Cancer
Background: Active surveillance (AS) is a standard approach to treat low and intermediate risk prostate cancer. For AS, disease progression is monitored.
- Trial name
- NCT04692675
- Testing
- mpMRI
- Where
- United States
- Volunteers
- 508 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
Efficacy and Safety Study of TOOKAD® Soluble for Localised Prostate Cancer Compared to Active Surveillance.
The aims of this study are: to assess the impact of TOOKAD® Soluble-Vascular Targeted Photodynamic Therapy (VTP) on the rate of absence of definite cancer using patients on active surveillance as a comparison (co-primary…
- Trial name
- PCM301 (NCT01310894)
- Testing
- TOOKAD® Soluble
- Where
- 50 sites in Belgium, Finland and 8 more
- Volunteers
- 413 people
- Sponsor
- Steba Biotech S.A.
Prostate Cancer, Active Surveillance for Prostate Cancer
Micro-Ultrasound for Detecting Clinically Significant Prostate Cancer in Active Surveillance
Active surveillance is a common approach for men with low-risk or favorable intermediate-risk prostate cancer, aimed at avoiding or delaying treatment while closely monitoring the disease.
- Conditions
- Prostate Cancer, Active Surveillance for Prostate Cancer, Imaging Techniques
- Trial name
- MUS-AS (NCT07386171)
- Testing
- Micro-Ultrasound (mUS)
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Prostate Cancer
The Active Surveillance Study
The Active Surveillance study is a prospective study developed to look at the association of biomarkers with PrCa presentation and progression among men on Active Surveillance and stratify it by their genetic risk.
- Trial name
- AS (NCT05810467)
- Testing
- Active Surveillance
- Where
- 4 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Prostate Cancer
Virtual Prostate Biopsy Protocol for Patients on Active Surveillance and at Risk of Prostate Cancer
The purpose of this study is to examine the use of MRI surveillance for patients with no prostate cancer, potential prostate cancer, or diagnosed low-grade prostate cancer.
- Trial name
- NCT03823001
- Testing
- virtual biopsy (VB) monitoring protocol
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Response of Patients on Surveillance for Prostate Cancer to Dutasteride
Hypothesis: That, in men on surveillance for favorable risk prostate cancer treated with dutasteride, prostate specific antigen (PSA) kinetics is of value in identifying those men who harbor occult high grade prostate cancer.
- Trial name
- NCT01525914
- Testing
- Dutasteride
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer
Study to Evaluate 99mTc-MIP-1404 SPECT/CT Imaging in Men With Biopsy Proven Low-Grade Prostate Cancer
99mTc-MIP-1404 is a radioactive diagnostic imaging agent indicated for imaging men with newly diagnosed prostate cancer whose biopsy indicates a histopathologic Gleason Score of ≤ 3+4 severity who are candidates for active…
- Trial name
- proSPECT-AS (NCT02615067)
- Testing
- 99mTc-MIP-1404 Injection, Whole-Body Planar and pelvic SPECT/CT scan
- Where
- 45 sites in United States, Canada
- Volunteers
- 531 people
- Sponsor
- Molecular Insight Pharmaceuticals, Inc.
Prostate Cancer
Prostate Cancer Intervention Versus Observation Trial (PIVOT)
Radical prostatectomy provides potentially curative removal of the cancer. However, it subjects patients to the morbidity and mortality of the surgery and may be neither necessary nor effective.
- Trial name
- PIVOT (NCT00007644)
- Testing
- Radical prostatectomy
- Where
- 31 sites in United States
- Volunteers
- 731 people
- Sponsor
- VA Office of Research and Development
Adenocarcinoma of Prostate
Devel. and Eval. of an Active Surveillance Decision Aid for Men With Low or Intermediate Grade Prostate Cancer
The overall goal of this project is to test an interactive, multi-media decision aid in the form of an electronic clinical decision dashboard designed to improve the quality of clinical decision making for initial treatment of…
- Trial name
- NCT02342626
- Testing
- Dashboard
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Rochester
Prostate Cancer
Carbohydrate Restricted Diet Intervention for Men on Prostate Cancer Active Surveillance
This phase 2 waitlist-controlled, randomized trial is designed to compare the difference in proliferative index (Ki67) between carbohydrate restricted diet and usual care over a 6 month period in men with prostate cancer who have…
- Trial name
- NCT03679260
- Testing
- Carbohydrate restricted diet, Non-restricted diet, Phone counseling with dietitian
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Cedars-Sinai Medical Center
Prostate Cancer, Prostate Adenocarcinoma
Active Surveillance for Low Risk Prostate Cancer
An active surveillance protocol for patients diagnosed low-risk prostate cancer will be held. We plan to use PSA (prostate-specific antigen) testing, DRE (digital rectal examination), TRUS (transrectal ultrasound), MRI (magnetic…
- Trial name
- NCT04146077
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Prostate Cancer
Comprehensive Monitoring of Men With Prostate Cancer Cared for by "Active Surveillance
Prostate cancer is the most commonly diagnosed cancer in men. However, there is a wide range in prognosis determined by a host of factors.
- Trial name
- NCT05840484
- Testing
- Active Surveillance
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer
Using Walk With Ease Walking Program With Men 65 and Older Being Treated for Prostate Cancer
This study is testing a walking program called Walk with Ease by the Arthritis Foundation with men undergoing treatment for prostate cancer.
- Trial name
- NCT02139774
- Testing
- Walk with Ease
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Prostate Adenocarcinoma, PSA Failure
White Button Mushroom Sup for the Reduction of PSA in Pts With Biochemically Rec or Therapy Naive Fav Risk Prostate CA
This phase II trial studies how well white button mushroom supplement works in reducing prostate-specific antigen (PSA) levels in patients with prostate cancer that has come back (recurrent) or has favorable risk and has not…
- Conditions
- Prostate Adenocarcinoma, PSA Failure, PSA Progression, Recurrent Prostate Carcinoma
- Trial name
- NCT04519879
- Testing
- Clinical Observation, Patient Observation, Questionnaire Administration
- Where
- 7 sites in United States
- Volunteers
- 133 people
- Sponsor
- City of Hope Medical Center