Clinical trials: Active Surveillance for Prostate Cancer
Prostate Cancer
Decision Support Tools for Men With Prostate Cancer- Clinical & Lifestyle Model
A UCSF PI-initiated study with a primary goal to improve decision quality, anxiety, and uncertainty, thereby increasing appropriate uptake of active surveillance and reducing over-treatment of low-risk prostate cancer.
- Trial name
- NCT02451345
- Testing
- Personalized risk model+website+coaching intervention
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of California, San Francisco
Prostate Cancer
Vitamin D3 Supplementation for Low-Risk Prostate Cancer: A Randomized Trial
Vitamin D promotes the differentiation of prostate cancer cells and maintains the differentiated phenotype of prostate epithelial cells.
- Trial name
- VD3PCa (NCT01759771)
- Testing
- Vitamin D3
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- VA Office of Research and Development
Localized Prostate Cancer, Active Surveillance for Prostate Cancer
Active Surveillance Exercise Clinical Trial
This phase 2, open-label, dual-center, two-arm randomized controlled trial (RCT) investigates the effects of 16 weeks of structured aerobic training, relative to usual care (print material with physical activity guidance).
- Trial name
- ASX (NCT02435472)
- Testing
- Exercise, Cardiopulmonary Exercise Test (CPET)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of California, San Francisco
Prostate Cancer
MRI Based Active Selection for Treatment Trial
The main purpose of this study is to determine if Magnetic Resonance Imaging (MRI), along with MRI targeted biopsy of suspicious lesions, is of value in detecting patients who would be likely to require treatment earlier.
- Trial name
- MAST (NCT02242773)
- Testing
- Multi-Parametric MRI, MRI-Guided Biopsy
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Miami
Prostatic Neoplasms, Prostate Cancer
Calcitriol or Placebo in Men for Prostate Cancer Active Surveillance
After the diagnosis of prostate cancer, many men alter their lifestyle or diet or use various supplements in an attempt to retard the growth of their cancer.
- Trial name
- NCT00482157
- Testing
- Vitamin D (Calcitriol)
- Sponsor
- Stanford University
Prostate Cancer Stage I
Identify Genes/Pathways Responsible for Progression From Low Risk to Higher Risk Prostate Cancer
In Taiwan, about 70% of new incident prostate cancer patients have localized disease. Most patients were detected by PSA screening.
- Trial name
- NCT03789253
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Prostate Cancer
Prospective Observation Study of Insulin Sensitivity During and After Gonadotropin Releasing Hormone Agonist Therapy for Prostate Cancer
The purpose of this research study is to find out if a certain type of hormone therapy, gonadotropin-releasing hormone agonist (GnRH agonist), affects the way the body produces and responds to insulin.
- Trial name
- NCT00456144
- Testing
- Gonadotropin Releasing Hormone Agonist Therapy
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Prostate Cancer
Genomics in Michigan to AdJust Outcomes in Prostate canceR (G-MAJOR) for Men With Newly Diagnosed Favorable Risk Prostate Cancer
This study seeks to determine the clinical impact of Gene Expression Classifier (GEC) testing in prostate cancer care while also developing a pragmatic approach for improved GEC clinical use and future study.
- Trial name
- NCT04396808
- Testing
- Decipher, Prolaris, Oncotype Dx Genomic Prostate Score (GPS)
- Where
- 8 sites in United States
- Volunteers
- 805 people
- Sponsor
- University of Michigan Rogel Cancer Center
Prostate Cancer
Surveillance or Focal Therapy
Patients with newly diagnosed low-intermediate risk prostate cancer often are not advised of all the options in an easy to understand way.
- Trial name
- SOFT (NCT07207902)
- Testing
- Explainer video
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Kaiser Permanente
Localized Prostate Cancer
WATER IV PCa (AS Sub-study)
The WATER IV study is a multicenter, prospective, randomized clinical trial that aims to evaluate the safety and efficacy of Aquablation therapy in men with localized prostate cancer.
- Trial name
- NCT07650448
- Testing
- Aquablation Therapy, Active Surveillance
- Where
- 25 sites in United States, Hong Kong
- Volunteers
- 333 people
- Sponsor
- PROCEPT BioRobotics
Prostate Cancer
Seoul National University Prospectively Enrolled Registry for Prostate Cancer With Active Surveillance
In this study, the investigators aim to establish the prostate cancer active surveillance prospective cohort in our institution, and finally investigate the 5 year rates of reclassification during active surveillance as the…
- Trial name
- SUPER-PC-AS (NCT02971085)
- Testing
- Active surveillance
- Where
- South Korea
- Volunteers
- 410 people
- Sponsor
- Seoul National University Hospital
Prostate Cancer
Older Men's Decision Making About Active Surveillance for Prostate Cancer - Aim 3: Decision Aid Efficacy Testing
This protocol describes pilot testing of an educational shared decision-making intervention to help men with localized prostate cancer make decisions with their health care providers about if and when to de-escalate surveillance…
- Trial name
- NCT06785441
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- M.D. Anderson Cancer Center
Nonmalignant Neoplasm, Prostate Cancer
MRI and Magnetic Resonance Spectroscopy Imaging in Patients Receiving Dutasteride for Benign Prostatic Hypertrophy and Low-Risk Prostate Cancer
RATIONALE: Diagnostic procedures, such as MRI and magnetic resonance spectroscopy imaging, may help in learning how well dutasteride works in patients with benign prostatic hypertrophy and low-risk prostate cancer.
- Trial name
- NCT00706966
- Testing
- dutasteride
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Prostate Cancer
Focal Therapy for Prostate Cancer - A Pilot Study of Focal Low Dose Rate Brachytherapy
This project will develop and evaluate a treatment plan for prostate focal therapy based on low dose rate brachytherapy. The participants entering this study are those suitable for active surveillance.
- Trial name
- FTPC (NCT01830166)
- Testing
- Low Dose Radiation Focal Brachytherapy
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- British Columbia Cancer Agency
Cancer of the Prostate
European Randomised Study of TOOKAD® Soluble for Prostate Cancer vs Active Surveillance. Post Study Follow-up
This is an open observational extended follow-up study of patients originally randomized into TOOKAD® Soluble VTP therapy or active surveillance (control group). Additional 60-month follow-up study
- Trial name
- NCT04017325
- Testing
- no intervention (post study follow up)
- Where
- 36 sites in Finland, France and 6 more
- Volunteers
- 374 people
- Sponsor
- Steba Biotech S.A.
Prostate Cancer
Anxiety in Patients Under Active Surveillance for Localized Prostate Cancer and Their Partners.
Prostate cancer (PCa) is the most common cancer and the third leading cause of cancer-related death among men in France. Active surveillance is one of the management options for low-risk prostate cancer.
- Trial name
- ANCAPRO (NCT07351461)
- Testing
- Patient on active surveillance
- Where
- France
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Prostate Cancer
High-Intensity Training for Men With Prostate Cancer on Active Surveillance: A Feasibility Study
This is a randomized study aiming to assess the feasibility of a phase II randomized controlled trial of different high-intensity training interventions and usual care (UC) in men with prostate cancer (PCa) undergoing active…
- Trial name
- NCT04266262
- Testing
- High-intensity interval training (HIIT), High-Intensity resistance training (HIRT)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Toronto
Prostate Cancer
TherApeutics in Early ProState Cancer (TAPS02)
This is a phase 2, randomised, multicentre, double-blind, placebo-controlled trial investigating the use of short term androgen deprivation therapy in the form of apalutamide (Erleada) in men on active surveillance for prostate…
- Trial name
- NCT05191680
- Testing
- Apalutamide Oral Tablet [Erleada]
- Where
- 6 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Macroscopic Tumor Visualized at MRI, Tumor Size Allowing Partial Prostate Treatment Volume
Stereotactic Focal Radiotherapy as an Alternative Treatment to Active Surveillance for Low and Intermediate Risk Prostate Cancer
*Rationale : Active surveillance of prostate cancer helps to avoid the morbidity associated with curative radical prostatectomy /radiotherapy in patients with early stage disease.
- Conditions
- Macroscopic Tumor Visualized at MRI, Tumor Size Allowing Partial Prostate Treatment Volume, CAPRA SCORE ≤5
- Trial name
- TOPPGUN-RS (NCT07152067)
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- 2 sites in Belgium
- Volunteers
- 146 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Low Risk Prostate Cancer, Clinically Significant Prostate Cancer
Study of PSMA PET/CT Imaging to Help Select Men With Low-Risk Prostate Cancer for Active Surveillance
This is a multicenter, prospective diagnostic accuracy study evaluating the Istanbul PSMA PET/CT Criteria (IPPC) for selecting patients with biopsy-confirmed low-risk prostate cancer (ISUP Grade 1) for active surveillance (AS).
- Trial name
- I-SELECT (NCT07168616)
- Testing
- Ga-68 PSMA11 PET/CT
- Where
- 10 sites in Turkey (Türkiye)
- Volunteers
- 201 people
- Sponsor
- Istanbul University - Cerrahpasa