Clinical trials: Active Surveillance for Prostate Cancer
Prostate Cancer
A Tailored Polygenic Risk Score for Predicting Progression in Prostate Cancer Under Active Surveillance
Prostate cancer is the most common malignancy in men, and in patients with low-risk disease, active surveillance represents the preferred initial approach to avoid unnecessary treatments.
- Trial name
- PRS-AS (NCT07491406)
- Where
- Italy
- Volunteers
- 185 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Older Men's Decision Making About Active Surveillance for Prostate Cancer - Aim 3: Decision Aid Cognitive and Usability Testing
This protocol describes development and user testing of an educational shared decision making intervention to help men with prostate cancer who are on active surveillance make decisions with their health care providers about if…
- Trial name
- NCT05497024
- Testing
- Interviews, Surveys
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- M.D. Anderson Cancer Center
Localized Prostate Cancer
Phase II Study of Feasibility of Focal Therapy for Prostate Cancer of Good Prognosis With Permanent I125 Localized Implant.
This is a pilot prospective biomedical study of interventional type which includes 17 patients on 24 months (12 months of inclusion and 12 months of follow-up).
- Trial name
- CURIEFOCALE (NCT01902680)
- Testing
- Focal brachytherapy
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Institut Claudius Regaud
Prostate Cancer
Outcome Assessment of an Active Surveillance Program for Low Risk Prostate Cancer: An Observational Study
The purpose of this research study is to monitor the feasibility and outcome of the Active Surveillance Program for men with low risk prostate cancer.
- Trial name
- NCT01376661
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- St. Joseph Hospital of Orange
Prostate Cancer, Organoid
Observation of Clinical Consistency of Organoid-chips Drug Sensitivity in Chemotherapy for PCa With Visceral Metastasis
This project plans to establish an organoid chip model of prostate cancer patients with internal organ metastasis from surgical or biopsy tissue sources, and test the sensitivity of commonly used chemotherapy drugs based on…
- Trial name
- NCT06536725
- Testing
- Building Organoid-on-chips models
- Where
- 2 sites in China
- Volunteers
- 35 people
- Sponsor
- Tianjin Medical University Second Hospital
Hormone Refractory Prostate Cancer
Radiotherapy vs Observation for CRPC
The purpose of the study is to determine whether radiotherapy improves cancer control and overall survival among patients with Castration resistant prostate cancer.
- Trial name
- NCT01590498
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Zhengzhou University
Prostate Cancer
Prostate Cancer Active Surveillance Metformin Trial
To determine whether the use of metformin in patients with low-risk prostate cancer can delay progression to clinically significant prostate cancer.
- Trial name
- NCT01733836
- Testing
- Metformin
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Prostate Cancer, Oligometastases
Stereotactic Body Radiation for Prostate Oligometastases
Men with oligometastatic prostate cancer lesions will be randomized (1:2) to observation versus SBRT. The study will NOT be blinded. Within three weeks of the initial treatment planning, SBRT (1-5 fractions) will be administered.
- Trial name
- ORIOLE (NCT02680587)
- Testing
- SBRT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer
Active Surveillance for Cancer of the Prostate (ASCaP)
Active Surveillance (A.S.) of prostate cancer (CaP) is the systematic monitoring of men with low-risk, localized lesions, with curative treatment of those whose tumors show substantial progression. A.S.
- Trial name
- ASCaP (NCT00949819)
- Testing
- Active surveillance
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Prostate Cancer
Observation of Outcomes and Side Effects of Cesium-131 in Combination With External Beam Radiation for the Treatment of Intermediate to High Risk Prostate Cancer
The purpose of this study is to observe PSA response and incidence of side effects in patients diagnosed with intermediate to high risk prostate cancer and treated with Cesium-131 in combination of external beam therapy.
- Trial name
- NCT00621413
- Where
- 9 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- IsoRay Medical, Inc.
Prostate Cancer
The Value of MultiSpectral 3 Tesla MRI in Active Surveillance of Prostate Cancer
MultiSpectral 3 Tesla MRI (MS3TMRI) can increase the yield of Trans Rectal Ultrasound Biopsy (TRUSBx) to improve identification of patients on active surveillance requiring treatment.
- Trial name
- NCT01896713
- Testing
- MS3TMRI
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer
Prospective Evaluation of Mp-MRI, MR-guided Biopsy, and Molecular Markers for Active Surveillance of Prostate Cancer
Active Surveillance (AS) is a treatment option in patients with favorable risk prostate cancer. According to the current guidelines patients are monitored by prostate specific antigen (PSA) testing (every 3 months) and regular…
- Trial name
- PROMM-AS (NCT03979573)
- Testing
- Multiparametric MRI, Radiomics, MR-guided Biopsy
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Prostate Cancer
Active Surveillance for Low-risk Prostate Cancer - Evaluation of the Efficacy of Minimally Invasive Active Surveillance
The STHLM3-AS study will evaluate the specificity of a new proposed protocol for active surveillance using the Stockholm3 test in combination with MRI targeted biopsies for prostate cancer detection in men with diagnosed low-risk…
- Trial name
- STHLM3AS (NCT03956108)
- Testing
- MRI+targeted biopsies+Stockholm3-test, PSA + systematic biopsies
- Where
- Sweden
- Volunteers
- 280 people
- Sponsor
- Karolinska Institutet
Prostate Cancer
Non-systemic Treatment for Patients With Low-volume Metastatic Prostate Cancer
Prostate cancer patients diagnosed with a biochemical recurrence and limited metastases are conventionally treated with androgen deprivation therapy.
- Trial name
- NCT01558427
- Testing
- Surveillance, Salvage treatment
- Where
- Belgium
- Volunteers
- 62 people
- Sponsor
- University Hospital, Ghent
Prostatic Neoplasms, Prostate Cancer
Focal Therapy for Prostate Cancer
Prostate cancer is the most common solid organ cancer among men and is the second leading cause of cancer death. In 2013 about 238,590 men will be diagnosed with prostate cancer and 29,720 men will die of the cancer.
- Trial name
- NCT01802307
- Testing
- Brachytherapy
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Prostate Cancer
New Treatment Modalities for Localized Prostate Cancer
The purpose of this study is to evaluate the effectiveness of four of the nowadays most established primary treatments for patients with clinically localized prostate cancer (active surveillance, robot-assisted radical…
- Trial name
- TTOPROST/OBS (NCT05523856)
- Testing
- Active Surveillance, Robot-Assisted Radical Prostatectomy, Intensity-Modulated Radiotherapy
- Volunteers
- 480 people
- Sponsor
- Fundacion IMIM
Prostate Cancer
A Study to Examine the Effectiveness of Aspirin and/or Vitamin D3 to Prevent Prostate Cancer Progression
To demonstrate the acceptability and feasibility of recruitment to a randomised chemoprevention study of standard (300mg) or low dose (100mg) aspirin vs. placebo and/or Vitamin D3 vs.
- Trial name
- PROVENT (NCT03103152)
- Testing
- High dose Aspirin & Vitamin D, Low dose Aspirin , Vitamin D
- Where
- 7 sites in United Kingdom
- Volunteers
- 104 people
- Sponsor
- Queen Mary University of London
Prostate Cancer
A Study to Evaluate the Safety, Tolerability and Efficacy of a Liproca® Depot Injection in Patients With Prostate Cancer
A Single Blind, Two-Stage Dose Finding Study to Evaluate the Safety, Tolerability and Efficacy of a Single Liproca® Depot Injection into the Prostate in Patients with Localized Prostate Cancer,Assigned to Active Surveillance who…
- Trial name
- NCT03348527
- Testing
- 2-Hydroxyflutamide Depot
- Where
- 10 sites in Canada, Finland and 1 more
- Volunteers
- 61 people
- Sponsor
- Lidds AB
Prostatic Neoplasm
Active Surveillance or Radical Treatment for Newly Diagnosed Patients With a Localized, Low Risk, Prostate Cancer START
The purpose of the START project is to evaluate the acceptability, the safety and the cost-effectiveness of a population based program of active surveillance for patients newly diagnosed with a localized, low risk, prostate…
- Trial name
- START (NCT03348722)
- Testing
- Active surveillance, Radical prostatectomy, Radiotherapy
- Where
- Italy
- Volunteers
- 850 people
- Sponsor
- Rete Oncologica Piemonte, Valle d'Aosta
Prostate Cancer
Active Surveillance for Prostate Cancer With Indolent Features
In patients with prostate cancer with indolent features, disease progrssion may be very slow and in many cases will never become clinically evident during the patient's lifetime.
- Trial name
- NCT00421265
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Assaf-Harofeh Medical Center