Clinical trials: Activity, Motor
Acute Myeloid Leukemia
Acute Myeloid Leukaemia (AML) Patients Undergoing Induction Chemotherapy
Fatigue, reduced quality of life and declines in physical function are common in patients undergoing chemotherapy for acute myeloid leukaemia (AML).
- Trial name
- NCT01170598
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Toronto Rehabilitation Institute
Squamous Cell Carcinoma of the Head and Neck (SCCHN), Metastatic Castration Resistant Prostate Cancer (mCRPC)
Avelumab With Bempegaldesleukin With or Without Talazoparib or Enzalutamide in Advanced or Metastatic Solid Tumors
Evaluation of the combination of avelumab + bempegaldesleukin (NKTR-214 ) in locally advanced squamous cell carcinoma of the head and neck ( metastatic SCCHN) and avelumab + bempegaldesleukin (NKTR-214) + talazoparib or…
- Trial name
- NCT04052204
- Testing
- avelumab, Bempegaldesleukin, talazoparib
- Where
- 5 sites in United States, Belgium and 2 more
- Volunteers
- 3 people
- Sponsor
- Pfizer
HIV-1 Infection
3BNC117 Monoclonal Antibody in HIV-infected Subjects During Treatment Interruption
This study evaluates the effects of two infusions of 3BNC117 in preventing or delaying rebound of viral load during a brief treatment interruption of standard ART and its safety during a brief analytical interruption of…
- Trial name
- NCT02446847
- Testing
- 3BNC117, ART Interruption
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Rockefeller University
Weight Loss, Weight, Body
Sleep Goal-focused Online Access to Lifestyle Support
The overall goal of the study is to develop a novel weight loss intervention for postpartum people by providing strategies to improve sleep, diet, and physical activity behaviors.
- Trial name
- SGOALS (NCT05942326)
- Testing
- Sleep GOALS, Education
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Osteoporotic Fractures, Spinal Fractures
Build Better Bones With Exercise
The long-term goal of our research team is to conduct a large multicentre study to evaluate whether tailored home exercise can prevent fractures in high-risk individuals.
- Trial name
- B3E (NCT01761084)
- Testing
- Exercise and behaviour change strategies
- Where
- Canada
- Volunteers
- 141 people
- Sponsor
- University of Waterloo
Prediabetes, Overweight
FRESH Study (Fitness, Relaxation and Eating to Stay Healthy)
To examine whether a lifestyle program results in weight loss and thereby delays or prevents progression of pre-diabetes to diabetes, we propose a pilot randomized controlled trial of 6 weeks duration with 30 participants held at…
- Trial name
- FRESH (NCT01636258)
- Testing
- Stress Management, Diet, Exercise
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- The Cleveland Clinic
Refractory Diffuse Large B-cell Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma
Relapsed/Refractory Large B-cell Lymphoma With NT-I7 Post-CD19 CAR T-cell Therapy
This is a multicenter Phase 1b study evaluating the safety, tolerability, and preliminary anti-tumor activity of NT-I7 administration following standard of care CD19 chimeric antigen receptor T-cell (CAR T-cell) therapy for…
- Conditions
- Refractory Diffuse Large B-cell Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma, High-grade B-cell Lymphoma, DLBCL Arising From Follicular Lymphoma
- Trial name
- NCT05075603
- Testing
- Efineptakin alfa, Tisagenlecleucel, Axicabtagene ciloleucel
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- NeoImmuneTech
Alzheimer's Disease
Alzheimer's Prevention Through Exercise
The purpose of this study is to learn about the possible benefits of aerobic exercise in controlling or reducing the amount of amyloid present in the brain, reducing changes in brain structure that may lead to Alzheimer's Disease…
- Trial name
- APEx (NCT02000583)
- Testing
- Aerobic Exercise, Standard of Care
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Kansas Medical Center
Impulse Control Disorders
Restoring Cognitive Control (ReCon) in Acute Nicotine Withdrawal
The purpose of this study is to explore the safety, tolerability and activity of SXC-2023 or placebo when dosed for 5 days in adults with tobacco use disorder who voluntarily abstain from the use of cigarettes.
- Trial name
- NCT03887429
- Testing
- SXC-2023
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Promentis Pharmaceuticals, Inc.
Coronary Artery Disease Risk High
FITT Exercise Counseling With Interactive Accelerometry and Physical Activity in Adolescents at Increased Risk of Early Cardiovascular Disease: A Pilot Study
This pilot study seeks to compare the change in energy expenditure and fitness levels of patients seen in the Children's Hospital Preventive Cardiology program receiving standard of care provider exercise counseling to similar…
- Trial name
- NCT01394705
- Testing
- BodyMedia
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Nicotine Dependence
Effects of Varenicline on Brain Activity During Nicotine Abstinence
This project aims to define mechanisms through which varenicline might be an effective smoking cessation medication.
- Trial name
- NCT00602927
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cerebrovascular Disease; Sequelae
Machines Assisting Recovery From Stroke
Locomotor disability remains a major obstacle to community function in stroke survivors. This disability is best characterized by the reduced gait speed and enhanced risk of falls that is observed in the majority of stroke…
- Trial name
- MARS (NCT02787694)
- Testing
- Factor Targeted Walking Training, treadmill
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Alabama at Birmingham
Heart Failure
Acute Effects of Beet Juice Consumption on Exercise Capacity in Heart Failure
The purpose of this project will be to determine whether consumption of beet juice concentrate prior to exercise may acutely improve exercise tolerance in patients with heart failure.
- Trial name
- NCT01946542
- Testing
- beet juice concentrate
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Jason Allen, Ph.D.
Hypertension
Understanding the Exercise-Hypertension Paradox
Hypertension affects 37% of the Veteran population, making it the most common medical condition treated by the VA Health Care System. Physical activity is the first line of defense in the treatment and management of hypertension.
- Trial name
- NCT02034422
- Testing
- Oral Antioxidant, Exercise rehabilitation
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Carcinoma, Midline
A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK525762 in Subjects With NUT Midline Carcinoma (NMC) and Other Cancers
This study is divided into two parts; Part 1 of the study is a dose escalation phase to select the recommended dose for Part 2 based on the safety, pharmacokinetic, and pharmacodynamic profiles observed after oral administration…
- Trial name
- NCT01587703
- Testing
- GSK525762
- Where
- 17 sites in United States, Australia and 5 more
- Volunteers
- 196 people
- Sponsor
- GlaxoSmithKline
Solid Tumor, Adult, Triple Negative Breast Cancer
AVID100 in Advanced Epithelial Carcinomas
Approximately 90 male and female patients with documented solid tumor malignancies of epithelial origin that are locally advanced or metastatic, and either refractory to standard therapy or for whom no standard therapy is…
- Conditions
- Solid Tumor, Adult, Triple Negative Breast Cancer, Head and Neck Squamous Cell Carcinoma, Non Small Cell Lung Cancer
- Trial name
- NCT03094169
- Testing
- AVID100 IV
- Where
- 10 sites in United States
- Volunteers
- 49 people
- Sponsor
- Formation Biologics
Multiple Sclerosis
A Placebo Controlled Trial of Dalfampridine ER for Ambulatory Activity in People With Multiple Sclerosis
A randomized placebo controlled double-blind cross-over trial of Dalfampridine ER for effect on ambulatory activity in people with multiple sclerosis
- Trial name
- NCT01356940
- Testing
- dalfampridine ER
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Brown, Theodore R., M.D., MPH
Neurofibromatosis 1
Antioxidant Therapy With N-acetylcysteine for Learning and Motor Behavior in Children With Neurofibromatosis Type 1
Children with neurofibromatosis type 1 (NF1) commonly suffer from the effects of cognitive, behavioral, and motor impairments. At present there is no specific treatment for this NF1 complication.
- Trial name
- NF1NAC (NCT04481035)
- Testing
- N-acetylcysteine (NAC)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Disease
Measuring the Implementation of the LiFE Program in Primary Care for Older Adults Aged 75 Years or Older
The goal of this study is to evaluate how to implement an evidence-based lifestyle-integrated strength and balance exercise (LiFE) intervention in primary care to promote increased physical activity (PA) and improvements in…
- Trial name
- Mi-LIFE (NCT02266225)
- Testing
- Lifestyle-integrated Functional Exercise
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Melanoma
ATL001 in Patients With Metastatic or Recurrent Melanoma
This is a first-in-human, open-label, multi-centre, phase I/IIa study to characterize the safety and clinical activity of ATL001, autologous clonal neoantigen reactive T cells (cNeT) administered intravenously in adults with…
- Trial name
- NCT03997474
- Testing
- ATL001, Checkpoint Inhibitor
- Where
- 10 sites in Spain, United Kingdom
- Volunteers
- 13 people
- Sponsor
- Achilles Therapeutics UK Limited