Clinical trials: Acute Asthma Exacerbation
Lower Respiratory Tract Infection (LRTI)
Procalcitonin Antibiotic Consensus Trial (ProACT)
The ProACT study is a 5 year, multicenter study that will test the effect of implementation of a novel procalcitonin guideline on antibiotic use and adverse outcomes in Emergency Department (ED) patients with Lower Respiratory…
- Trial name
- ProACT (NCT02130986)
- Testing
- Procalcitonin level, Results of procalcitonin (PCT) level to treating clinician, Provide procalcitonin guideline to treating clinician
- Where
- 13 sites in United States
- Volunteers
- 1,664 people
- Sponsor
- University of Pittsburgh
Asthma, Asthma Exacerbations
Vitamin D In the Prevention of Viral-induced Asthma in Preschoolers
In this 7-month randomized controlled trial, children aged 1 to less than 6 years, with recurrent asthma attacks triggered mostly by colds, will receive a high dose of vitamin D or a placebo every 3.5 months during their usual…
- Conditions
- Asthma, Asthma Exacerbations, Preschool Child, Vitamin D
- Trial name
- DIVA (NCT03365687)
- Testing
- Vitamin D
- Where
- 9 sites in Canada
- Volunteers
- 323 people
- Sponsor
- Professor Francine Ducharme
Asthma
Peak Expiratory Flow Rate for Emergency Department Management of Acute Asthma Exacerbation
Patients presenting to the emergency department with acute asthma exacerbation will be assigned to peak-expiratory flow rate (PEFR) guided management and non-PEFR guided management.
- Trial name
- NCT03420651
- Testing
- Peak Expiratory Flow Rate (PEFR), Standard Clinical Judgement
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Hennepin Healthcare Research Institute
Asthma; Status, Asthma in Children
Pragmatic RCT of High-dose Oral Montelukast for Moderate and Severe Pediatric Acute Asthma Exacerbations
Objective: To determine the extent to which high-dose (30mg) oral montelukast, added to standard treatment in children with moderate and severe acute exacerbations improves outcomes.
- Conditions
- Asthma; Status, Asthma in Children, Asthma Acute, Asthma Attack
- Trial name
- NCT03277170
- Testing
- Montelukast Oral Granules
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Acute Severe Asthma
Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children
The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate
- Trial name
- NCT02112305
- Testing
- isotonic magnesium sulphate, 50% magnesium sulphate
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Queen Sirikit National Institute of Child Health
Asthma
Nebulized Magnesium Sulfate in Children With Moderate to Severe Asthma Exacerbation
The purpose of this study is to evaluate the effectiveness of nebulized magnesium sulfate as a vehicle for albuterol in children with moderate to severe asthma exacerbation.
- Trial name
- NCT01515995
- Testing
- Nebulized magnesium sulfate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Asthma in Children
Leo Study Unstable Asthma
This is a prospective, observational study to investigate the agreement of the Leo device signal derivation with gold standard asthmatic testing in recently exacerbated asthmatic children.
- Trial name
- NCT05308277
- Testing
- Leo device monitoring
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- ResMed
Asthma in Children, Asthma Attack
Timely Administration of IV Magnesium Sulfate in Patients With a Moderate Asthma Exacerbation
This study aims to identify whether early administration of magnesium sulfate in moderate asthma exacerbations can potentially avoid admission, decrease length of stay in the emergency department (ED), decrease length of stay…
- Trial name
- NCT06137040
- Testing
- Magnesium Sulfate within the first hour, No Magnesium sulfate within the first hour
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Asthma Acute, Asthma Childhood
ASMact: Study on Management of Bronchial Asthma
Standardization According to GINA 2025 Recommendations for the Treatment, Management, and Follow-up of Acute Asthma Attacks: Observational, Multicenter Cohort Study.
- Conditions
- Asthma Acute, Asthma Childhood, Asthma in Children, Asthma Crisis
- Trial name
- NCT07412769
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Meyer Children's Hospital IRCCS
Asthma
The Impact of Implementing a Nursing-driven Clinical Pathway for Inpatient Management of Children With Asthma
Asthma is the most common chronic disease of childhood and is responsible for large portion of pediatric admissions to Canadian hospitals.
- Trial name
- NAP (NCT02037841)
- Testing
- Nursing-driven clinical pathway for management of inpatient asthma
- Where
- Canada
- Volunteers
- 113 people
- Sponsor
- Children's Hospital of Eastern Ontario
COPD Exacerbation Acute, Asthma Acute
Study on Acupuncture Treatment of Chronic Airway Diseases(Asthma and Chronic Obstructive Pulmonary Disease)
For patients in the acute phase of chronic airway diseases, on the basis of guideline-directed treatment, the experimental group was given acupuncture treatment, while the control group was given sham acupuncture treatment.
- Trial name
- NCT06869525
- Testing
- Acupuncture
- Volunteers
- 576 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Bronchial Asthma
Effect of Addition of Oral Montelukast to Standard Treatment in Acute Moderate to Severe Asthma in Children
Available evidences show a role of oral montelukast in acute asthma. Safety of oral montelukast is well established in children, as evidenced by use of oral montelukast in long term management of asthma.
- Trial name
- Montelukast (NCT00565955)
- Testing
- montelukast
- Where
- India
- Volunteers
- 116 people
- Sponsor
- All India Institute of Medical Sciences
Asthma
Positive Expiratory Pressure for the Treatment of Acute Asthma in Children
Asthma is a leading cause of emergency department (ED) visits for children. A novel way of treating asthma is the use of positive expiratory pressure (PEP).
- Trial name
- NCT02494076
- Testing
- EzPAP, Standard Care
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Colorado, Denver
Steroids In Management Of Acute Asthma Exacerbations
Steroids In The Management Of Acute Asthma Exacerbations In Children, Which Form Is More Suitable?
The aim of this study is to compare the efficacy of a single dose of intramuscular dexamethasone versus 3 days of twice-daily oral prednisolone in the management of mild to moderate asthma exacerbations in children and test…
- Trial name
- NCT03204760
- Testing
- Dexamethasone 8Mg Solution for Injection, Prednisolone Oral, Per 5 Mg
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Asthma
Prevention of Asthma Relapse After Discharge From Emergency
The purpose of this study is to compare the Symbicort® Turbuhaler® to both Pulmicort® Turbuhaler® and Bricanyl® Turbuhaler® for the treatment of asthma after discharge from the emergency room
- Trial name
- PARADE (NCT00326053)
- Testing
- Budesonide/formoterol
- Where
- 20 sites in Canada
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Rhinovirus Infection in Asthma
Mechanisms of Rhinovirus Induced Asthma Exacerbations
We, the investigators, hypothesise that there are distinct gene profiles in rhinovirus-induced acute exacerbations of asthma. We further hypothesise that these changes in gene expression involve both known mediators of the asthma…
- Trial name
- NCT01159782
- Testing
- Rhinovirus infection
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Bronchial Asthma
A Study of Step-up in Bronchial Asthma as a New End Point in Asthma Control (SURFE)
The goal of this observational study is to learn about the frequency needed for stepping-up treatment in patients with mild and moderate bronchial asthma.
- Trial name
- SURFE (NCT05632081)
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Bronchial Asthma, Status Asthmaticus
NiPPV in the Treatment of Acute Asthma Exacerbations
Study Summary: Title: A Randomized Controlled Trial of Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations Principal Investigator: Thomas J.
- Trial name
- NCT03219736
- Testing
- Standard of Care therapies, NiPPV Therapy, Routine Respiratory Care
- Where
- United States
- Sponsor
- Arkansas Children's Hospital Research Institute
Asthma
Benralizumab Exacerbation Study
This is an exploratory study, the focus of which is to understand the nature of asthma exacerbations that occur despite open label benralizumab therapy in severe eosinophilic asthma.
- Trial name
- BenRex (NCT04102800)
- Testing
- Benralizumab
- Where
- 15 sites in United Kingdom
- Volunteers
- 157 people
- Sponsor
- NHS Greater Glasgow and Clyde
Acute Asthma
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms
The hypothesis to be tested is that acutely ill asthmatics who do not resolve their attacks following standard doses of albuterol and require admission to hospital have single nucleotide polymorphisms of their B2 adrenergic…
- Trial name
- NCT01016444
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- MetroHealth Medical Center