Clinical trials: Acute Cardiac Failure
Acute Congestive Heart Failure, Heart Failure With Reduced Ejection Fraction
Circulating RNAs in Acute Congestive Heart Failure
The purpose of this American Heart Association-funded and NIH-funded study is to examine circulating RNAs in the acute CHF setting, how they change with decongestive therapy, and their function in vitro and in vivo.
- Conditions
- Acute Congestive Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Normal Ejection Fraction
- Trial name
- CRUCiAL (NCT03345446)
- Testing
- Cardiac MRI
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Acute Heart Failure
Subcutaneous Furosemide in Acute Decompensated Heart Failure Pilot
The Pilot study is designed to evaluate the overall safety and feasibility of a strategy based on subcutaneous delivery of furosemide. It will be used to inform the subsequent evaluation phase of the study (separate protocol).
- Trial name
- SUBQ-Pilot (NCT02877095)
- Testing
- Furosemide
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Adrian Hernandez
Acute Heart Failure, Pulmonary Congestion
Oxygen Targets in Acute Heart Failure With Pulmonary Congestion
REDOX-AHF compared two oxygen saturation targets in adults admitted with acute heart failure and clinical or radiological signs of congestion.
- Conditions
- Acute Heart Failure, Pulmonary Congestion, Hypoxemia
- Trial name
- REDOX-AHF (NCT05613218)
- Testing
- Oxygen
- Where
- 2 sites in Denmark
- Volunteers
- 135 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Heart Failure
CardioInsight 3 - LBBB
Background Cardiac Resynchronization Therapy (CRT) is proven to improve survival and heart function of patient with certain electrical conduction abnormality and heart failure.
- Trial name
- CardioInsight3 (NCT05556018)
- Testing
- Electrical Activation Mapping Guided Cardiac resynchronization therapy
- Where
- Hong Kong
- Volunteers
- 27 people
- Sponsor
- Chinese University of Hong Kong
Acute Heart Failure
Goal-directed Afterload Reduction in Acute Congestive Cardiac Decompensation Study
The purpose of this study is to determine whether an early goal-directed decrement of preload and afterload with a target systolic blood pressure of 90-110 mmHg by aggressive vasodilatation in patients with acute HF in the…
- Trial name
- GALACTIC (NCT00512759)
- Testing
- Goal-directed preload and afterload decrement
- Where
- 12 sites in Brazil, Bulgaria and 3 more
- Volunteers
- 781 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Heart Failure, Volume Overload
Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure
Acute heart failure is a condition where the heart suddenly cannot pump blood well enough for the body's needs. Many people admitted to the hospital with acute heart failure have too much fluid in the body.
- Trial name
- INFUSE-AHF (NCT07577596)
- Testing
- Intravenous furosemide continuous infusion, Intravenous furosemide bolus injections
- Where
- Denmark
- Volunteers
- 436 people
- Sponsor
- University of Aarhus
Delirium in Intensive Care Unit, Acute Heart Failure (AHF)
Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment in Acute Heart Failure
Delirium is an acute, fluctuating disturbance in attention and cognition that commonly complicates the course of critically ill patients, particularly those admitted with acute heart failure (AHF).
- Trial name
- NCT07781462
- Testing
- Low dose ketamine infusion, Dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Heart Failure
The Effects of Glucocorticoids on Mortality and Renal Function in Patients With Acute Decompensated Heart Failure
Evidence showed that glucocorticoids could induce potent diuretic actions and improve renal functions in patients with decompensated congestive heart failure.
- Trial name
- NCT00953303
- Testing
- glucocorticoid, standard care
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Hebei Medical University
Acute Coronary Syndrome, Angina Pectoris
Comparison of BIOdegradable Polymer and DuRablE Polymer Drug-eluting Stents in an All COmeRs PopulaTion (BIO-RESORT)
The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- BIO-RESORT (NCT01674803)
- Testing
- Orsiro, Synergy, Resolute Integrity
- Where
- Netherlands
- Volunteers
- 3,514 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Acute MI, Heart Failure
Cardiovascular Kidney and Metabolic Health Assessment and Patient Empowerment
The primary objective of CHAPERONE solution is to evaluate the efficacy of engaging, assessing, and enabling long term treatment strategy with Health Artificial Intelligence (AI) Chatbot, Copilot, Large Language Model (LLM) and…
- Conditions
- Acute MI, Heart Failure, Diabetes Mellitus, Kidney Disease
- Trial name
- CHAPERONE-CKM (NCT07403669)
- Testing
- CHAPERONE AI, CKMiq AI, Quality of Life
- Where
- 5 sites in United States, Sweden
- Volunteers
- 300 people
- Sponsor
- Aventyn, Inc.
Chronic Kidney Disease, Acute Heart Failure
Utility of Brain Natriuretic Peptide (BNP) in Patients With Type IV Cardio-renal Syndrome Admitted to the Intensive Care Unit (ICU)
Admission BNP was a useful marker for diagnosing and predicting type IV cardio-renal syndrome type IV in patients with chronic kidney disease admitted to the ICU for acute heart failure in a retrospective study.
- Trial name
- NCT01211886
- Volunteers
- 83 people
- Sponsor
- Hallym University Medical Center
Congestive Heart Failure
TARGET: A Study to Evaluate the Treatment of Patients With Acute Decompensated Heart Failure (ADHF) Using an Automated Fluid Management System
This is a prospective, single arm, early feasibility study designed to evaluate the safety and device performance of The RenalGuard System in the management of patients admitted with signs and symptoms of congestive heart failure…
- Trial name
- NCT03897842
- Testing
- Reprieve Cardiovascular System
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- CardioRenal Systems, Inc.
Acute Heart Failure
a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure
The goal of this observational is to study the prevalence of distinct congestion phenotypes and study their association with response to therapy and outcomes in acute heart failure patients.
- Trial name
- PROFILE-AHF (NCT06587854)
- Where
- Netherlands
- Volunteers
- 270 people
- Sponsor
- University Medical Center Groningen
Acute Heart Failure
Ketone Ester for Treatment Of Acute Heart Failure
Ketones have been suggested to have significant physiological effects in patients with heart failure. Potential mechanisms for these effects include energy provision for the failing heart and direct protective effects on other…
- Trial name
- KETO-AHF (NCT07434466)
- Testing
- Ketone Ester (KetoneAid MonoEster)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Acute Myocardial Infarction
β Blocker Use and Mortality in Hospital Survivors of Acute Myocardial Infarction Without Heart Failure
The aim of the study is to investigate the association between the use of β blockers and mortality among hospital survivors of acute myocardial infarction without heart failure.
- Trial name
- NCT02786654
- Where
- United Kingdom
- Volunteers
- 179,810 people
- Sponsor
- University of Leeds
Acute Respiratory Distress Syndrome, Septic Shock
Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
The implementation of this project will improve the effectiveness of surgical treatment and reduce the level of complications and mortality among patients with heart failure and heart failure in the terminal stage.
- Conditions
- Acute Respiratory Distress Syndrome, Septic Shock, Sepsis
- Trial name
- OST (NCT05042622)
- Testing
- Cytokine adsorber filter, Extracorporeal hemoperfusion cartridge
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan
Acute Decompensated Heart Failure
Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure
Acute decompensated heart failure (HF) is one of the most common cardiologic issues in emergency departments. Loop diuretics have long been recognized as the key for the treatment of Acute Decompensated Heart Failure…
- Trial name
- HSS (NCT05298098)
- Testing
- Hypertonic Saline Solution
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Heart Decompensation
Short-term Efficacy of Furosemide, Isosorbide Dinitrate and Their Combination in ADHF
Background: Acute decompensated heart failure (ADHF) is a common and potentially fatal cause of acute respiratory distress that requires immediate treatment in emergency department.
- Trial name
- NCT02649998
- Testing
- Furosemide, Isosorbide Dinitrate
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Acute Myocardial Infarction, Heart Failure
Dapagliflozin Effects on Cardiometabolic Outcomes in Patients With an Acute Heart Attack.
This study will evaluate the effect of dapagliflozin versus placebo, given once daily in addition to Standard of Care (SoC) therapies for patients with myocardial infarction (MI), for hospitalisation for heart failure (HHF)…
- Trial name
- DAPA-MI (NCT04564742)
- Testing
- Dapagliflozin
- Where
- 103 sites in Sweden, United Kingdom
- Volunteers
- 4,017 people
- Sponsor
- AstraZeneca
Cardiac Surgical Patients (CABG,Mammary Coronary Bypass Surgery,Plastic and Replacement of Valves, Atrial Septal Defect,Ventricular Septal Defect)
Evaluation of the Effectiveness and Safety of Vibro-acoustic Pulmonary Therapy (VAPT) in Complex Therapy for Acute Respiratory Failure of Mixed Type I-II Stages in Comparison With Percussion Massage in Cardiac Surgical Patients in the Early Postoperative Period
The goal of this observational study is to evaluate the effectiveness and safety of vibro-acoustic pulmonary therapy (VAPT) in complex therapy for the acute respiratory failure of mixed type I-II stages in comparison with…
- Trial name
- NCT06320483
- Testing
- Vibroacoustic device BARK VibroLUNG
- Where
- 5 sites in Kazakhstan
- Volunteers
- 310 people
- Sponsor
- Bark Technology LLP
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