Clinical trials: Acute Cardiac Failure
Heart Failure
One-year Outcomes of Electromechanical Activation Time (EMAT)-Guided vs. Symptom-guided Heart Failure Therapy in Acute Heart Failure Syndrome (AHFS) Patients
Left ventricular systolic time intervals, including pre-ejection period (PEP), ejection time (ET), and their ratio (PEP/ET), is determined by the systolic and diastolic function and ventriculo-arterial coupling.
- Trial name
- NCT01298232
- Testing
- Cardiophonogram
- Where
- 2 sites in Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hypoxemic Acute Respiratory Failure
High Flow Nasal Oxygen Therapy for Hypoxemy After Cardiac Surgery
The main objective of this study is to evaluate the gas exchange (ventilation-perfusion ratio) with the system Optiflow® compared to facial mask among patients having an acute respiratory failure after cardiac surgery.
- Trial name
- Optiflow (NCT01617252)
- Testing
- Optiflow / Facial mask
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Nantes University Hospital
Acute Heart Failure
Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF
The purpose of the study was to evaluate the efficacy, safety and tolerability of intravenous infusion of serelaxin, when added to standard therapy, in acute heart failure (AHF) patients.
- Trial name
- RELAX-AHF-2 (NCT01870778)
- Testing
- RLX030
- Where
- 540 sites in United States, Argentina and 33 more
- Volunteers
- 6,600 people
- Sponsor
- Novartis Pharmaceuticals
Congestive Heart Failure
Placebo Controlled, Randomized, Double-blind, Multi-center Study to Investigate the Efficacy and Tolerability of BAY58-2667
The purpose of this study is to assess a dose titration scheme, of a new drug (BAY58-2667) given intravenously, to evaluate if this is safe and can help to improve the well-being, symptoms (e.g.
- Trial name
- NCT00559650
- Testing
- Cinaciguat (BAY58-2667)
- Where
- 72 sites in United States, Canada and 15 more
- Volunteers
- 150 people
- Sponsor
- Bayer
Prospective Studies, Heart Failure
Correlation Between Peripheral Venous Pressure and Central Venous Pressure in the Cardiac Intensive Care Unit
In patients admitted to a coronary care unit, what is the correlation coefficient and limits of agreement for paired measurements of peripheral venous pressure and central venous pressure at multiple time points during the…
- Trial name
- NCT03526497
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The Cleveland Clinic
Acute Hypercapnic Respiratory Failure
Systematic Follow-up of Patients Surviving an Episode of Acute Hypercapnic Respiratory Failure in the ICU
There is currently no good description of patients surviving an episode of acute hypercapnic respiratory failure in the ICU. For instance, the prevalence of OSA and sleep hypoventilation in a stable clinical condition is not…
- Trial name
- NCT02111876
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Ligue Pulmonaire Genevoise
Acute Decompensated Heart Failure
The STIM-ADHF Study
The STIM-ADHF Study is a multi-center, observational study to assess the performance and safety of the CPNS System in patients with ADHF.
- Trial name
- NCT05313438
- Testing
- CPNS Therapy
- Where
- 6 sites in Hungary, Poland and 1 more
- Volunteers
- 13 people
- Sponsor
- Cardionomic Inc.
Cardiogenic Shock
Effect of Early Empagliflozin Initiation in Cardiogenic Shock.
Cardiogenic shock represents a severe condition of heart pump dysfunction. Despite advances in medical management, the mortality rate for this condition remains high.
- Trial name
- EMPASHOCKRETRO (NCT07450417)
- Testing
- Patient in cardiogenic shock treated or not early with SGLT2 inhibitors.
- Where
- France
- Volunteers
- 418 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure
Nt-proBNP Versus Clinical Guided Discharge in Acute Heart Failure
Our objective is to compare a policy of hospital discharge guided by NT-proBNP levels versus discharge guided by conventional clinical criteria, in patients admitted with acute heart failure.
- Trial name
- NCT01299350
- Testing
- Nt-proBNP guided discharge
- Where
- Spain
- Volunteers
- 125 people
- Sponsor
- University of Valencia
Multiple Organ Failure, End Stage Cardiac Failure
Timing of Acute Palliative Care Consultation in Critically Ill Patients
A prospective randomized controlled trial studying the ordering of palliative care consultations in the emergency department (Ig) versus later palliative care consultations in the hospital--ICU or hospital ward(Cg).
- Conditions
- Multiple Organ Failure, End Stage Cardiac Failure, End Stage Chronic Obstructive Airways Disease, Chronic Kidney Disease Stage 5
- Trial name
- NCT02858778
- Testing
- Early order of palliative care consultation
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University
Congestive Heart Failure, Infections
Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?
There is evidence to suggest that patients make different end-of-life decisions if they understand the risks, benefits and alternatives of CPR and mechanical ventilation.
- Conditions
- Congestive Heart Failure, Infections, Sepsis, Acute Renal Failure
- Trial name
- NCT01878968
- Testing
- Script and CPR/Mechanical ventilation video.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jewish Hospital, Cincinnati, Ohio
Heart Failure
Slow Continuous Ultrafiltration Using Central vs Peripheral Line: Feasibility of Implementation, Safety and Efficacy in Acute Heart Failure Syndromes.
Slow continuous ultrafiltration using central vs peripheral line: feasibility of implementation, safety and efficacy in acute heart failure syndromes.
- Trial name
- NCT01630317
- Testing
- Peripheral line, Central line vein
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Parc de Salut Mar
Cardiac Arrest, Renal Failure
The Vital Signs to Identify, Target, and Assess Level (VITAL) Care Study III
To evaluate the effect of automated recording on frequency of recorded scores, number of automated notifications and serious events.
- Conditions
- Cardiac Arrest, Renal Failure, Respiration Failure, Myocardial Infarction
- Trial name
- NCT02973243
- Testing
- Automatic RR Measurement
- Where
- United Kingdom
- Volunteers
- 446 people
- Sponsor
- Philips Healthcare
Hypervolemic Hyponatremia
International, Multicenter, Open-Label and Randomized Withdrawal Study of Oral Lixivaptan in Heart Failure Patients With Chronic Hyponatremia
To demonstrate that after 12 weeks of open-label lixivaptan treatment, serum sodium is maintained in hyponatremic patients continuing to receive lixivaptan compared to placebo during the 4 week double blind treatment period.
- Trial name
- NCT00876876
- Testing
- Lixivaptan
- Volunteers
- 300 people
- Sponsor
- CardioKine Inc.
Heart Failure
Rehabilitation and Exercise Training After Hospitalization
Rehabilitation and Exercise Training after Hospitalization: Assessing Benefit in Acute Heart Failure (REHAB-HF) pilot is a multi-site, randomized clinical pilot study designed to establish the feasibility of conducting a larger…
- Trial name
- REHAB-HF (NCT01508650)
- Testing
- Usual care, Rehabilitation intervention
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Wake Forest University
Influenza, Pneumonia
Flublok v. Standard Dose Vaccine Effectiveness Among Kaiser Permanente Northern California Adults 18-64 Years
The overall objective of this study is to describe the effectiveness of Flublok Quadrivalent vaccine compared to standard dose inactivated influenza vaccine (SD-IIV) in adults 18 through 64 years of age.
- Conditions
- Influenza, Pneumonia, Lower Respiratory Tract Infection, Acute Myocardial Infarction
- Trial name
- NCT03694392
- Testing
- Flublok Quadrivalent, Standard Dose Inactivated Influenza Vaccine (SD-IIV)
- Where
- United States
- Volunteers
- 2,776,278 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Heart Failure
Effect of W-3 Polyunsaturated Fatty Acids on Serum Albumin Concentration in Patients With Acute Heart Failure, Hypoalbuminemia, and High Inflammatory Activity
Assess whether high doses of ?-3 fatty acids added to standard treatment of patients with acute hearta failure, hypoalbuminemia and high inflammatory activity, promotes an increase in serum albumin
- Trial name
- PROTEICA (NCT02708771)
- Testing
- Polyunsaturated fatty acids omega-3
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Hospital San Juan de la Cruz
Cardiovascular Diseases, Acute Coronary Syndrome
The IndONEsia ICCU Registry: a Multicenter Cohort of Intensive Cardiovascular Care Units Patients in Indonesia
Patients in the Intensive Cardiovascular Care Unit (ICCU) often present with cardiovascular disease (CVD) issues accompanied by various non-cardiovascular conditions.
- Conditions
- Cardiovascular Diseases, Acute Coronary Syndrome, Heart Failure, Heart Disease, Coronary
- Trial name
- NCT06265714
- Where
- 9 sites in Indonesia
- Volunteers
- 12,950 people
- Sponsor
- Universitas Indonesia
Myocardial Infarction, Acute
T2 Heart Mapping in AMI Population for the Prediction of Short Term Major Adverse Cardiovascular Events
A novel Cardiac MRI sequence, developed by Dr. Maria Altbach (Double Inversion radial fast Spin Echo T2 mapping), has been tested clinically.
- Trial name
- T2 AMI MRI (NCT01796743)
- Where
- United States
- Sponsor
- University of Arizona
Acute Renal Failure, Acute Kidney Injury
Pre-operative Short-term Administration of a Formula Diet Containing a Non-milk-derived Protein Source for Prevention of Acute Kidney Injury After Cardiac Surgery
Cardiac surgery is associated with a high risk of postoperative AKI with significant morbidity and mortality. To date, no preventive or therapeutic measures exist to prevent this.
- Trial name
- UNICORN (NCT03715868)
- Testing
- Non-milked derived protein source formula diet
- Where
- Germany
- Volunteers
- 117 people
- Sponsor
- University of Cologne
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.