Clinical trials: Acute Cardiac Failure
Myocardial Infarction (MI)
Efficacy and Safety Study of Proposed Biosimilar Product Reveliza vs Actilise in Patients With ST-segment Elevation Myocardial Infarction
Thi is is a multi-center, randomized, single-blind, parallel group clinical trial to evaluate the efficacy and safety of the intravenious thrombolysis with Revelise® (GENERIUM, Russia) in comparosin with the Actilyse® (Boehringer…
- Trial name
- NCT07146360
- Testing
- Revelise (GENERIUM, Russia), Actilyse® (Boehringer Ingelheim Pharma GmbH and Co.KG, Germany)
- Where
- 22 sites in Russia
- Volunteers
- 180 people
- Sponsor
- AO GENERIUM
Chronic Heart Failure With Reduced Ejection Fraction
Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction
The purpose of this study was to collect safety and tolerability data on LCZ696 in eligible PARADIGM-HF patients who received open-label investigational drug.
- Trial name
- NCT02226120
- Testing
- LCZ696
- Where
- 394 sites in United States, Argentina and 39 more
- Volunteers
- 1,980 people
- Sponsor
- Novartis Pharmaceuticals
Acute Myocardial Infarction, Congestive Heart Failure
Nicorandil Study to Reduce Cardiac Death After Percutaneous Coronary Intervention (PCI) in Hemodialysis Patients
Survival after invasive coronary revascularization is worse in patients with chronic kidney disease than in those without it. The investigators aimed to examine whether oral administration of nicorandil, a hybrid of nitrate and…
- Trial name
- NCT00848562
- Testing
- Nicorandil
- Where
- Japan
- Volunteers
- 129 people
- Sponsor
- Toujinkai Hospital
Dyspnea, Hypertension
Clevidipine vs Placebo or Standard of Care for Dyspnea and Blood Pressure Control in AHF
The purpose of this study is to evaluate dyspnea improvement and other parameters of efficacy and safety in acute heart failure (AHF) patients receiving an intravenous (IV) infusion of clevidipine in comparison to standard of…
- Conditions
- Dyspnea, Hypertension, Acute Heart Failure
- Trial name
- PRONTO II (NCT04592380)
- Testing
- Stage 1: Clevidipine (double-blinded), Stage 2: Clevidipine (open-label), Stage 2: Standard of Care (open-label)
- Where
- 9 sites in United States
- Sponsor
- The Medicines Company
Acute Decompensated Heart Failure, Volume Overload
Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR)
This clinical research study is being conducted in multiple hospitals in Belgium and approximately 519 patients with acute decompensated heart failure are expected to participate.
- Trial name
- Advor (NCT03505788)
- Testing
- Acetazolamide
- Where
- Belgium
- Volunteers
- 519 people
- Sponsor
- Ziekenhuis Oost-Limburg
Acute Heart Failure, Reduced Systolic Function
Eosinophil Indices in Patients With Acute Heart Failure
All consecutive patients admitted to the intensive care unit (ICU) with ADHF between January 2017 and December 2021 were enrolled in this retrospective study.
- Trial name
- NCT05410990
- Testing
- eosinophil and other hematological parameters
- Volunteers
- 395 people
- Sponsor
- Giresun University
Acute Heart Failure, Shock
Evolution of Molecular Biomarkers in Acute Heart Failure Induced by Shock
The relationship between shock, ischemia and reperfusion (I/R) injury, hemodynamic instability, systemic inflammatory response syndrome and multiorgan failure has been extensively investigated, but there is no consensus on the…
- Trial name
- Shockomics (NCT02141607)
- Where
- 3 sites in Belgium, Spain and 1 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shockomics Consortium
Right Heart Failure
Serial Multiparametric Evaluation of Right Ventricular Function After Left Ventricular Assist Device Implantation
The primary purpose of this study is to investigate the evolution of Right Ventricular (RV) function before and after left ventricular assist device (LVAD) implantation, using novel echocardiographic quantification of RV size and…
- Trial name
- EuroEchoVAD (NCT03552679)
- Testing
- Echocardiography
- Where
- 9 sites in Germany, Hungary and 5 more
- Volunteers
- 600 people
- Sponsor
- Erasmus Medical Center
Acute Coronary Syndrome, Heart Failure
Epicardial Infarct Repair Using CorMatrix®-ECM: Clinical Feasibility Study
Epicardial Infarct Repair with CorMatrix-Extracellular Matrix (ECM) is an open-label, non-randomized, feasibility pilot study. Following ischemic injury the ECM of the heart adversely remodels leading to cardiac fibrosis, left…
- Trial name
- EIR (NCT02887768)
- Testing
- Epicardial Infarct Repair with CorMatrix-ECM, Coronary Artery Bypass Grafting Surgery
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Calgary
Heart Failure
Point of Care NT-proBNP Testing for Suspected New Heart Failure Acute Care
Heart failure is a serious condition that can be difficult to diagnose quickly when patients present to hospital with symptoms such as breathlessness. Delays in diagnosis may delay treatment and adversely affect patient outcomes.
- Trial name
- NCT07793968
- Testing
- NT-proBNP testing
- Where
- United Kingdom
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of Stirling
Acute Decompensated Heart Failure, Congestive Heart Failure Compensated
Role of USCOM in Adult Patients With Heart Failure
Objective: The Ultrasonic Cardiac Output Monitor (USCOM) is a non-invasive, quantitative method for measuring and monitoring cardiovascular haemodynamic parameters in patients. The aims of this study are: 1.
- Trial name
- NCT02289508
- Testing
- Ultrasonic cardiac output monitor, Echocardiography
- Where
- China
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Sepsis, Cardiac Failure Acute
Clinical Assessment of Arterial Dynamic Elastance in ICU Patients, Dependent on Inotropic or Vasopressor Drugs.
The primary goal of the study is to determine Eadyn ( = PPV/SVV) as a functional measure of arterial load, in conjunction with other actual afterload indices, systemic vascular resistance and arterial elastance.
- Trial name
- NCT03621618
- Testing
- dobutamine, norepinephrine
- Where
- Belgium
- Sponsor
- Universitair Ziekenhuis Brussel
Heart Failure, Acute Decompensated Heart Failure
Reducing Readmission for Frail Elderly Patients With Decompensated Heart Failure
A randomized study designed to determine whether telephone based interventions can prevent return hospital visits for elderly and frail patients with acute symptoms of heart failure.
- Conditions
- Heart Failure, Acute Decompensated Heart Failure, Fragility, Emergencies
- Trial name
- HFF-ED (NCT03246035)
- Testing
- Intervention Group, Control Group (Standard Care)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Jewish General Hospital
Acute Heart Failure
A Study to Evaluate the Efficacy and Safety of Shenfu Zhusheye in Patients With Acute Heart Failure
The purpose of this study is to evaluate the efficacy and safety of Shenfu Zhusheye in patients with acute heart failure.
- Trial name
- NCT02135835
- Testing
- Shenfu Zhusheye, 5% glucose injection
- Where
- 25 sites in China
- Volunteers
- 365 people
- Sponsor
- China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.
Acute Heart Failure, Pulmonary Congestion
Oxygen Targets in Acute Heart Failure With Pulmonary Congestion
REDOX-AHF compared two oxygen saturation targets in adults admitted with acute heart failure and clinical or radiological signs of congestion.
- Conditions
- Acute Heart Failure, Pulmonary Congestion, Hypoxemia
- Trial name
- REDOX-AHF (NCT05613218)
- Testing
- Oxygen
- Where
- 2 sites in Denmark
- Volunteers
- 135 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Pneumonia, Heart Failure
Hospitalization at Home: The Acute Care Home Hospital Program for Adults
The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be…
- Conditions
- Pneumonia, Heart Failure, Cellulitis, Urinary Tract Infections
- Trial name
- NCT02864420
- Testing
- Home hospitalization, Inpatient Hospitalization
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Brigham and Women's Hospital
Acute Kidney Injury, Renal Insufficiency
Novel Biomarkers for Risk Prediction of Contrast-Induced Acute Kidney Injury Post Coronary Angiography
Contrast-induced acute kidney injury (CI-AKI) has been recognized as the third most common cause of hospital acquired AKI, after hypotension-associated hypo-perfusion and post-operative AKI.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Kidney Diseases
- Trial name
- NORDICA (NCT02263820)
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- Sapere Bio
Heart Failure, Acute Heart Failure
Protocol of Diuretics Use in Congestive Therapy in Heart Failure
The main objective of the study is to determine if a diuretic adaptation protocol in the decompensation of chronic heart failure is more effective but also safer than the current non-protocolized practice.
- Conditions
- Heart Failure, Acute Heart Failure, Chronic Heart Failure
- Trial name
- ProDUCT-HF (NCT03892148)
- Testing
- Furosemide, Hydrochlorothiazide
- Where
- 9 sites in France
- Volunteers
- 299 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiorenal Syndrome
Accuracy of Urinary NGAL in Predicting CardioRenal Syndrome in Acute Heart Failure at Emergency - CYNDERELA-HF Study
Rationale: Heart Failure (HF) elevated prevalence in Brasil and the world; 20-30% AHF patients develop CardioRenal Syndrome (CRS) type 1; Worsening Renal Failure (WRF) is a prognostic marker of mortality in Acute HF;NGAL is a…
- Trial name
- CYNDERELA-HF (NCT01364636)
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Pro-Cardiaco Hospital
Heart Failure, Acute Kidney Injury
Viral Illness in Pediatric Critical Care: Incidence Timing & Severity of Associated Heart Dysfunction & Acute Kidney Injury
The purpose of this study is to be able to better describe the incidence, timing and severity of myocardial dysfunction and acute kidney injury (AKI) following a documented respiratory viral illness (RSV, adenovirus…
- Trial name
- MyDAKI-01 (NCT01924663)
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Saskatchewan
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