Clinical trials: Acute Cardiac Failure
Heart Failure
NAtional TUnisian REgistry of Heart Failure
NATURE-HF is an observational, multicentric and longitudinal study of heart failure performed with 100 tunisian cardiologists.
- Trial name
- NATURE-HF (NCT03262675)
- Where
- Tunisia
- Volunteers
- 2,040 people
- Sponsor
- Dacima Consulting
Congestive Heart Failure
Sub-Q Versus IV Furosemide in Acute Heart Failure
This study evaluates the clinical efficacy of subcutaneously administered Furosemide Injection Solution versus intravenous administration of Furosemide Injection, United States Pharmacopeia (USP) in adult patients presenting to a…
- Trial name
- NCT02579057
- Testing
- Furosemide Injection Solution (SCP-101), Furosemide Injection Solution, USP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Acute Heart Failure
Rivaroxaban Once Daily Versus Dose-adjusted Vitamin K Antagonist on the Biomarkers in Acute Decompensated Heart Failure and Atrial Fibrillation (ROAD HF-AF)
Vitamin K antagonists (VKAs) are used to reduce the risk of stroke (cerebral vascular dysfunction) in AF patients. However, VKAs interact with drugs/food and the drug level is influenced by worsening of renal function, liver…
- Trial name
- NCT03490994
- Testing
- Rivaroxaban, Warfarin + LMWH
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Yonsei University
Acute Heart Failure
Assessing the Clinical Outcomes of Dapagliflozin Versus Acetazolamide in Patients With Acute Heart Failure
This study investigates the comparative clinical outcomes of dapagliflozin, an SGLT-2 inhibitor, versus acetazolamide, a carbonic anhydrase inhibitor, in patients hospitalized with acute heart failure (AHF).
- Trial name
- NCT06783166
- Testing
- Dapagliflozin 10mg, Acetazolamide 500mg
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Acute Heart Failure Syndrome
Respiratory Virus Infections in Acute Heart Failure
Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort.
- Trial name
- NCT06967441
- Where
- 3 sites in South Korea
- Volunteers
- 360 people
- Sponsor
- Minjae Yoon
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Chronic Heart Failure
TELEREHAB-BR: Cardiovascular Rehabilitation Models Trial
Introduction: Cardiovascular diseases remain the leading cause of mortality worldwide. Despite the proven effectiveness of cardiac rehabilitation (CR) programs, adherence remains unsatisfactory, especially in public healthcare…
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Chronic Heart Failure, Acute Coronary Syndromes (ACS)
- Trial name
- TELEREHAB-BR (NCT07734831)
- Testing
- Hybrid Cardiac Telerehabilitation, Traditional Center-Based Cardiac Rehabilitation (TCR), Usual Care Group
- Where
- Brazil
- Volunteers
- 219 people
- Sponsor
- University of the State of Santa Catarina
Acute Coronary Syndrome, Diabetes Mellitus
Acute Coronary Syndrome in Diabetic Patients
This study aims to compare the clinical profile and outcomes of acute coronary syndrome patients with diabetes and without diabetes.
- Conditions
- Acute Coronary Syndrome, Diabetes Mellitus, Heart Failure, Acute Pulmonary Edema
- Trial name
- NCT03607201
- Testing
- No intervention
- Where
- Indonesia
- Volunteers
- 86 people
- Sponsor
- Tarumanagara University
Heart Failure
Voice Analysis for Monitoring Patients With Heart Failure
This observational study involves ADHF patients at two sites in the United States and Germany. After informed consent and screening assessments, participants will perform daily voice recordings during their hospital stay, from…
- Trial name
- VAMP-HF (NCT06566911)
- Where
- 2 sites in United States, Germany
- Volunteers
- 70 people
- Sponsor
- Noah Labs
Congenital Cardiac Defect, Acute Renal Injury
Investigation of the Relationship Between Blood Transfusion Volume and Development of Renal Failure in Pediatric Patients Undergoing Cardiovascular Surgery
Blood transfusion strategies in cardiac surgery are a research topic that has been studied more for adults. There is not enough data on this subject for children in studies.
- Conditions
- Congenital Cardiac Defect, Acute Renal Injury, Blood Transfusion Complication
- Trial name
- NCT06889272
- Testing
- blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 205 people
- Sponsor
- Hacettepe University
Angina, Unstable, Cardiovascular Diseases
IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.
The purpose of this study is to test the impact of pharmacological myocardial metabolic support, in the form of intravenous (IV) glucose, insulin and potassium (GIK), for the treatment of patients with threatened or established…
- Conditions
- Angina, Unstable, Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- IMMEDIATE (NCT00091507)
- Testing
- GIK
- Where
- 13 sites in United States
- Volunteers
- 911 people
- Sponsor
- Tufts Medical Center
Heart Failure
High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure
The primary objective of this pilot trial is to determine whether inpatients presenting to the Emergency Department (ED) with symptoms suggestive of Acute Heart Failure (AHF), who receive supplemental oxygen adjusted at either a…
- Trial name
- HiLo (NCT02518828)
- Testing
- High SpO2, Low SpO2
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Acute Decompensated Heart Failure
Gas Exchange for Predicting Hospital Heart Failure Readmissions
To determine whether, and if so, which gas exchange parameters measured on the Shape-HF Cardiopulmonary Exercise Testing System predict 30 and 180 day re-hospitalization in subjects discharged from hospitalization for an episode…
- Trial name
- NCT01960218
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Shape Medical Systems, Inc.
Acute Cardiovascular Disease, Acute Coronary Syndrome
Naples Federico II Intensive Cardiac Care Unit Registry (Naples FED2-ICCU Registry)
This protocol proposes to prospectively evaluate current epidemiology, pharmacologic and invasive management and clinical outcomes of patients with acute cardiovascular diseases admitted at our ICCU.
- Conditions
- Acute Cardiovascular Disease, Acute Coronary Syndrome, Acute Heart Failure, Cardiogenic Shock
- Trial name
- NCT06162247
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Federico II University
Heart Failure, Cardiac Resynchronization Therapy
Prospective Multicentric Study Comparing the Acute Hemodynamic Effect of Three Modes of Stimulation in Cardiac Resynchronization Therapy Recipients
Cardiac Resynchronization Therapy (CRT) is an established treatment for patients with systolic heart failure and bundle branch block, improving functional capacity, quality of life and reducing morbi-mortality.
- Trial name
- 3 STIM (NCT03779802)
- Testing
- Device programming of ABBOTT CRT pacemaker or defibrillator
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- CMC Ambroise Paré
Covid19, Acute Cor Pulmonale
Cardiac Performance in Mechanically Ventilated COVID-19 Patients
Although COVID-19 affects primarily the respiratory system, several studies have shown evidence of cardiovascular alterations. Increased troponin levels were observed in a significant proportion of patients and this alteration…
- Conditions
- Covid19, Acute Cor Pulmonale, Cardiac Failure
- Trial name
- NCT04628195
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Obstructive Sleep Apnea, Pulmonary Edema Cardiac Cause
Obstructive Sleep Apnea Treatment on Cardiovascular Events in Patients With Acute Cardiogenic Pulmonary Edema: CPAP-CARE STUDY.
Despite the advances in the treatment of acute cardiogenic pulmonary edema (ACPE), the readmissions rates and cardiovascular events remain very high.
- Trial name
- CPAP-CARE (NCT03936751)
- Testing
- CPAP, Nasal Strips
- Where
- 4 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- University of Sao Paulo
Shock, Cardiogenic, Heart Failure
Effects of Pyruvate in Patients With Cardiogenic Shock and Intra-aortic Balloon Counterpulsation
Pyruvate is an intermediate of energy metabolism and was shown to possess pronounced positive inotropic effects in vitro and in vivo without altering myocardial oxygen consumption.
- Conditions
- Shock, Cardiogenic, Heart Failure, Acute Myocardial Infarction
- Trial name
- NCT00604331
- Testing
- Pyruvate
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Herzzentrum Goettingen
Hyponatremia
THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation
The purpose of this study is to determine the safety and efficacy of lixivaptan in the treatment of hyponatremia in patients with congestive heart failure.
- Trial name
- NCT00578695
- Testing
- lixivaptan
- Where
- 287 sites in United States, Argentina and 13 more
- Volunteers
- 652 people
- Sponsor
- CardioKine Inc.
Heart Failure, Cardiac Failure
Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic Treatment
The purpose of the research is to determine if patients have fewer Heart Failure (HF) events after receiving Aquapheresis (AQ) therapy compared to intravenous (IV) diuretics up to 90 days of discharge from the hospital.
- Conditions
- Heart Failure, Cardiac Failure, Acute Decompensated Heart Failure (ADHF)
- Trial name
- AVOID-HF (NCT01474200)
- Testing
- Isolated veno-venous ultrafiltration (AQ), IV Loop Diuretics (LD)
- Where
- 38 sites in United States
- Volunteers
- 224 people
- Sponsor
- Nuwellis, Inc.
Acute on Chronic Heart Failure
Model for Heart Failure ExAcerbation Reduction Trial
Heart failure is the leading cause of hospitalizations and readmissions in the United States and is a tremendous economic strain on our healthcare system.
- Trial name
- HEART (NCT01726985)
- Testing
- Parameter Based Clinical Disposition
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Cleveland Clinic Florida
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