Clinical trials: Acute Cardiac Failure
Heart Failure, Acute Heart Failure
Safety of Aerobic Exercise in Acute Heart Failure
This project deals with exercise in acute heart failure in three different groups (conventional medical treatment; exercise with non-invasive ventilation and exercise with placebo of non-invasive ventilation).
- Trial name
- NCT02782572
- Testing
- Exercise
- Volunteers
- 29 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Heart Transplantation, Acute Renal Failure
Metabolic Pattern of Cyclosporine A and Acute Renal Failure
Following heart transplantation many patients develop acute renal failure in the early posttransplant phase and some are in need of renal replacement therapy for shorter or longer time.
- Trial name
- NCT00264355
- Testing
- cyclosporine A
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University of Oslo School of Pharmacy
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Heart Failure, Acute Myocardial Infarction
Eplerenone in Heart Failure Treatment
Beta-blockers should be administered to all patients with heart failure stage II to IV according to NYHA.Beta-blockers reduce mortality and hospitalizations and improve the operational phase for all categories of patients with…
- Conditions
- Heart Failure, Acute Myocardial Infarction, Hypertension
- Trial name
- INOSET (NCT02344199)
- Where
- 3 sites in Greece
- Volunteers
- 450 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Heart Failure Acute, Remote Monitoring
Remote Monitoring After Heart Failure
Heart failure (HF) is a leading cause of hospitalisation and disability-adjusted life years lost, with mortality rates exceeding most cancers.
- Conditions
- Heart Failure Acute, Remote Monitoring, Nurse's Role
- Trial name
- NCT05447598
- Testing
- Nurse-led remote monitoring program, Usual care treatment
- Where
- 3 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Vestre Viken Hospital Trust
Heart Failure, Acute Coronary Syndrome
Bace1as Role in Heart Failure (BACE1AS-HF)
The objective of this project is 1) to explore the clinical relevance of BACE1-AS and BACE1 as therapeutic targets and 2) to evaluate their potentiality as biomarkers in ischemic heart failure (HF).
- Trial name
- BACE1AS-HF (NCT06213493)
- Testing
- measurement of RNAs
- Where
- Italy
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Acute Heart Failure
Empagliflozin for New On-set Heart Failure Study Regardless of Ejection Fraction
Heart failure (HF) is one of the most important reasons for hospital admission and is associated with high mortality and morbidity.
- Trial name
- EMPA (NCT05556044)
- Testing
- Empagliflozin 10 MG
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Heart Failure, Diastolic
Diuretics and Dopamine in Heart Failure With Preserved Ejection Fraction
Heart Failure with preserved Ejection Fraction (HFPEF) accounts for 40-50% of all heart failure patients with a frequency of hospital admissions for acute decompensation and short and long term mortality similar to patients with…
- Trial name
- ROPA-DOP (NCT01901809)
- Testing
- Furosemide, Dopamine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Congenital Cardiac Defect, Acute Renal Injury
Investigation of the Relationship Between Blood Transfusion Volume and Development of Renal Failure in Pediatric Patients Undergoing Cardiovascular Surgery
Blood transfusion strategies in cardiac surgery are a research topic that has been studied more for adults. There is not enough data on this subject for children in studies.
- Conditions
- Congenital Cardiac Defect, Acute Renal Injury, Blood Transfusion Complication
- Trial name
- NCT06889272
- Testing
- blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 205 people
- Sponsor
- Hacettepe University
Heart Failure; With Decompensation
Remote Dielectric Sensing (ReDS) Assisted Diuresis in Acute Decompensated Heart Failure
This study evaluates the use of a wearable vest capable of non-invasively measuring lung fluid content in hospitalized patients with heart failure
- Trial name
- RADAR-HF (NCT03586336)
- Testing
- ReDS-Guided, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Cardiac Electrophysiology, Anesthesia
Prophylactic Non-invasive Ventilation During Surgical Procedure in Rhythmology
Acute respiratory failure is frequent during rhythmology procedure under light sedation in high risks selected patients. Non invasive ventilation (NIV) is recommended for acute cardiogenic pulmonary oedema and sleep apnea.
- Conditions
- Cardiac Electrophysiology, Anesthesia, Acute Respiratory Failure
- Trial name
- VNI-RYTHMO (NCT02779998)
- Testing
- non invasive ventilation, Standard oxygen therapy with facial mask
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Grenoble
Heart Failure
Aquaresis Utility for Hyponatremic Acute Heart Failure Study
Hyponatremia is a common finding in acute heart failure (HF) patients and is associated with worse prognosis. In addition to its prognostic value, hyponatremia may have importance during the acute management of HF.
- Trial name
- AQUA-AHF (NCT02183792)
- Testing
- Tolvaptan, Furosemide
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Southern California
Heart Decompensation
Study of the Sudden Heart Failure Participant Population in the US
An observational study using data from a large US electronic health record database to find participants hospitalized with ADHF who do not have a concurring heart attack
- Trial name
- NCT03566264
- Testing
- Non-Interventional
- Where
- 2 sites in United States
- Sponsor
- Bristol-Myers Squibb
ARDS, Human, Lung Injury, Acute
Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients
The goal of this interventional crossover study, in intubated and mechanically ventilated Acute Respiratory Distress Syndrome (ARDS) patients, is to compare two positive end-expiratory pressure (PEEP) titration techniques…
- Conditions
- ARDS, Human, Lung Injury, Acute, Respiratory Distress Syndrome, Mechanical Ventilation Complication
- Trial name
- NCT03202641
- Testing
- PEEP ARDSnet, PEEP LRM
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Acute Heart Failure
Loop Diuretic Therapy in Acutely Decompensated Heart Failure
DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF.
- Trial name
- DIUR-AHF (NCT02638142)
- Testing
- Continuous Furosemide Infusion, Intermittent Furosemide Infusion
- Where
- 4 sites in Italy
- Volunteers
- 370 people
- Sponsor
- University of Siena
Intracardiac Thrombus, STEMI
Anticoagulation Therapy in Non-device-related Intra-cardiac Thrombus
Left ventricular thrombus is found in 10 to 25% of patients with impaired left ventricular function following ST-segment elevation myocardial infarction and up to 20% in dilated cardiomyopathy in observational studies.
- Conditions
- Intracardiac Thrombus, STEMI, Heart Failure
- Trial name
- ARGONAUT (NCT05825573)
- Testing
- Vitamin K antagonist, Direct oral anticoagulant
- Where
- 35 sites in France, Reunion
- Volunteers
- 340 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Heart Decompensation, Acute, Acute Kidney Injuries
POCUS-Guided Diuresis for Decompensated Heart Failure
Heart failure occurs when the heart cannot pump blood effectively, leading to fluid buildup in the body. This can cause problems such as difficulty breathing, swelling, and extreme tiredness.
- Trial name
- POCUSHF-GD (NCT06921603)
- Testing
- Furosemide (Standard Diuretic) Treatment, POCUS-Assessed Diuretic Management
- Where
- 5 sites in United States
- Volunteers
- 588 people
- Sponsor
- University of Pittsburgh
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent
Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing Treatment
With the aging of society, the use of cardiac pacing in patients with irreversible bradycardia is increasingly widespread. As early as the 1950s, right ventricular pacing (RVP) began to be used in patients with atrioventricular…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- NCT05575557
- Testing
- Right heart catheterization
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 6 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Cardiovascular Disease, Acute Rejection of Cardiac Transplant
Quantitative Detection of Circulating Donor-Specific DNA in Organ Transplant Recipients (DTRT-Multi-Center Study)
The primary goal of this Multicenter Study is to develop and to evaluate a method for measuring donor-specific cell free DNA in blood samples from transplant recipients as markers of rejection.
- Conditions
- Cardiovascular Disease, Acute Rejection of Cardiac Transplant, Cardiac Transplant Rejection, Heart Transplant Failure and Rejection
- Trial name
- DTRT (NCT02109575)
- Testing
- Blood Draw of up to 10 ml
- Where
- 8 sites in United States
- Volunteers
- 540 people
- Sponsor
- Medical College of Wisconsin
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