Clinical trials: Acute Cardiac Failure
Chronic Kidney Disease, Acute Heart Failure
Utility of Brain Natriuretic Peptide (BNP) in Patients With Type IV Cardio-renal Syndrome Admitted to the Intensive Care Unit (ICU)
Admission BNP was a useful marker for diagnosing and predicting type IV cardio-renal syndrome type IV in patients with chronic kidney disease admitted to the ICU for acute heart failure in a retrospective study.
- Trial name
- NCT01211886
- Volunteers
- 83 people
- Sponsor
- Hallym University Medical Center
Peritoneal Lesion
NGAL, an Early Predictive Marker of Acute Kidney Injury After Cardiac Surgery in Neonates and Infants
Urinary NGAL has been shown to be an early marker of acute kidney injury (AKI) following paediatric cardiac surgery (2 hours off pump).
- Trial name
- NGAL (NCT01219998)
- Where
- France
- Volunteers
- 205 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure
Acute Heart Failure Study in Patients Admitted to Emergency Department for Dyspnea
No studies have analyzed the predictive value of different anamnestic and clinical signs for the diagnosis of acute heart failure (AHF) in patients admitted to emergency department.
- Trial name
- PREDICA (NCT02835963)
- Testing
- Data collection
- Where
- 3 sites in France
- Volunteers
- 342 people
- Sponsor
- University Hospital, Toulouse
Myocarditis Acute
MYTHS - MYocarditis THerapy With Steroids
This is a phase III, multi-center international, single blind randomized controlled trial to test the efficacy of pulsed intravenous (IV) methylprednisolone versus standard therapy on top of maximal support in patients with Acute…
- Trial name
- MYTHS (NCT05150704)
- Testing
- Methylprednisolone, saline solution
- Where
- 49 sites in United States, Austria and 7 more
- Volunteers
- 288 people
- Sponsor
- Niguarda Hospital
Acute Decompensated Heart Failure
DR REGISTRY: Prospective Observational Study of ADHF Patients With Insufficient Response to Diuretics
The study objective is to observe and measure clinical outcomes, urine output, and safety events occurring during standard medical treatment of ADHF patients deemed to have insufficient diuretic response.
- Trial name
- NCT04877652
- Testing
- Standard of care
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- Revamp Medical Ltd.
Acute Renal Failure, Acute Kidney Injury
Early Diagnosis of Postoperative Acute Renal Failure-using Biomarker to Predict Outcome of Cardiac Surgery Associated Acute Kidney Injury
The purpose of this study is to determine soluble HJV could be an early diagnosis urinary biomarker of ischemia/reperfusion injury in post CPB-patients.
- Trial name
- NSARF (NCT01503710)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Heart Failure, Heart Failure - NYHA II - IV
Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared…
- Conditions
- Heart Failure, Heart Failure - NYHA II - IV, Heart Failure Acute, Acute Heart Failure (AHF)
- Trial name
- US-DASH (NCT07263035)
- Testing
- Furosemide intravenous solution
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Lakeland Regional Health Systems, Inc.
Acute Myocardial Infarction (AMI), Type 2 Diabetes Mellitus (T2DM)
SGLT2 Inhibitor Use After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Nationwide Cohort Study
This observational, retrospective cohort study aims to evaluate the impact of sodium-glucose cotransporter 2 (SGLT2) inhibitor use after acute myocardial infarction (AMI) in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- SGLT2i-AMI (NCT07198191)
- Testing
- SGLT2 inhibitors (e.g., dapagliflozin, empagliflozin), DPP4 inhibitors
- Where
- South Korea
- Volunteers
- 200,000 people
- Sponsor
- Yonsei University
Heart Failure
Balance and Executive Function in Middle-age and Older Patients With Heart Failure in Post-Acute Care Program
This trial is a single-center clinical trial in Taiwan with an expected enrollment of 60 people in Taiwan. The purpose of this trial is to compare the performance of middle-aged and elderly patients with subacute heart failure…
- Trial name
- NCT06463496
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Chia-Jung
Atrial Fibrillation, Heart Failure
Diltiazem vs. Metoprolol in the Acute Management of AF in Patients With HFrEF
Atrial fibrillation (AF) is the most common arrhythmia, accounting for one third of all hospital admissions and 1% of all emergency department visits (ED). Approximately 65% of those presenting to the ED with AF are admitted.
- Trial name
- NCT02938260
- Testing
- Metoprolol vs Diltiazem
- Volunteers
- 48 people
- Sponsor
- RaeAnn Hirschy
Stroke, Myocardial Injury
Mechanisms And Prognosis of Stroke-Heart Syndrome
The incidence of stroke-heart syndrome following acute stroke, which encompasses both acute ischemic stroke and acute intracerebral hemorrhage, is notably high and is strongly associated with increased mortality and poor outcomes…
- Conditions
- Stroke, Myocardial Injury, Heart Failure, Acute Coronary Syndromes
- Trial name
- MAP-SHS (NCT06954103)
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Chensheng Pan
Cardiogenic Shock, Cardiorenal Syndrome
Levosimendan Infusion in Critically Ill Patients With Cardiogenic Shock
To determine whether Levosimendan infusion in patients with cardiogenic shock and cardiorenal syndrome refractory to standard inotropic therapy, improves hemodynamics and renal function, whilst being safe.
- Conditions
- Cardiogenic Shock, Cardiorenal Syndrome, Acute Kidney Failure
- Trial name
- NCT04917497
- Testing
- Levosimendan
- Volunteers
- 43 people
- Sponsor
- University of Zurich
Acute Coronary Syndrome, Chronic Kidney Disease
Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients
A 4 week-duration cross-over study on Ticagrelor and Clopidogrel for the Acute Coronary Syndrome (ACS) and Chronic Kidney Disease (CKD) subjects, focusing on the platelet inhibition and safety observation.
- Conditions
- Acute Coronary Syndrome, Chronic Kidney Disease, End-Stage Renal Disease
- Trial name
- APROVE-CKD (NCT02459288)
- Testing
- Clopidogrel first, Ticagrelor first
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Ping-Yen Liu
Acute Decompensated Heart Failure, Congestive Heart Failure Compensated
Role of USCOM in Adult Patients With Heart Failure
Objective: The Ultrasonic Cardiac Output Monitor (USCOM) is a non-invasive, quantitative method for measuring and monitoring cardiovascular haemodynamic parameters in patients. The aims of this study are: 1.
- Trial name
- NCT02289508
- Testing
- Ultrasonic cardiac output monitor, Echocardiography
- Where
- China
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Acute Aortic Dissection, Surgery (Cardiac)
Immune-Inflammatory Markers in Aortic Dissection
Identifying early on which patients with acute aortic dissection require closer monitoring may help with care planning. If simple, inexpensive values obtained from routine blood tests can provide additional information for…
- Conditions
- Acute Aortic Dissection, Surgery (Cardiac), Systemic Immune-inflammation Index, Postoperative Death
- Trial name
- NCT07683260
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Bursa City Hospital
Heart Failure Acute, Ventilator Lung
SGLT2 Inhibitors in Patients With ADHF During Ventilator Weaning
This study will explore the potential benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in preventing cardiac ischemia and cardiopulmonary edema in patients with acute decompensated heart failure during weaning from…
- Trial name
- NCT06142474
- Testing
- SGLT2 inhibitor
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Cardiac Output, High, Heart Failure
The Effect of Semi Fowler 30' Right Lateral on Cardiac Output in Acute Heart Failure
Heart failure is a special clinical syndrome such as difficulty breathing, fatigue, and swollen legs characterized by increased JVP, crackle lung sounds, and peripheral edema caused by heart disorders both structural and/or…
- Conditions
- Cardiac Output, High, Heart Failure, Pulmonary Edema With Heart Failure, Dyspnea; Cardiac
- Trial name
- SETTLECO (NCT06039397)
- Testing
- Semifowler 30' Right Lateral Body Position
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Universitas Indonesia
Heart Failure
High Sensitivity cTnT Rules Out Cardiac Insufficiency Trial (TACIT)
The purpose of this study is to better understand myocardial injury in AHF. Secondary analyses demonstrate the prognostic significance of troponin release. The absence of such release has been associated with less risk.
- Trial name
- TACIT (NCT02592135)
- Testing
- hsTnT level
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Indiana University
Acute Decompensated Heart Failure
Assessment of Coronary Flow Reserve in Heart Failure Patients After Ultrafiltration Versus Diuretics
The purpose of this research study is to compare the effects (good and bad) of ultrafiltration treatment with standard intravenous (in your vein) diuretic therapy (furosemide, torsemide, bumetanide) on your heart function and…
- Trial name
- NCT01457053
- Testing
- Loop diuretics (furosemide, torsemide, bumetanide), Ultrafiltration
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Cincinnati
Acute Heart Failure (AHF), Heart Failure
Urinary Chloride and Sodium Changes and Residual Congestion in Acute Heart Failure
The goal of this observational study is to learn how changes in urinary sodium and chloride levels relate to fluid overload and short-term outcomes in patients hospitalized with acute heart failure (AHF).
- Conditions
- Acute Heart Failure (AHF), Heart Failure, Congestion
- Trial name
- CLORINA-IC (NCT07597512)
- Where
- 4 sites in Spain
- Volunteers
- 223 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
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