Clinical trials: Acute Cardiac Syndrome
Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure
Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
The purpose of this study is to determine whether inhaled iloprost is safe and effective in pediatric patients with pulmonary hypertension who are sick in the intensive care unit.
- Conditions
- Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure, Persistent Pulmonary Hypertension of Newborn, Congenital Heart Defects
- Trial name
- NCT00981591
- Testing
- Iloprost
- Sponsor
- Seattle Children's Hospital
Ischemic Stroke, Acute Coronary Syndrome
Comparative Study of Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome
A pilot, prospective, comparative study. To include both male and female patients who have presented an ischaemic stroke (full stroke or TIA) or an ACS, 5 to 30 days prior to inclusion.
- Conditions
- Ischemic Stroke, Acute Coronary Syndrome, Obstructive Sleep Apnea Syndrome
- Trial name
- AVC/SCA (NCT00926874)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Atherosclerosis, Cardiovascular Diseases
Carotid Intraplaque Neovascularization Combined With Stress Echo
The root cause of heart attacks and strokes is atherosclerosis, the hardening and thickening of blood vessels due to the presence of "plaque" which is a build-up of fat and cholesterol in the walls of vessels.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- CIRCE (NCT05416385)
- Testing
- Carotid Contrast Enhanced Ultrasound
- Where
- 6 sites in Canada
- Volunteers
- 1,500 people
- Sponsor
- Dr. Amer Johri
Acute Coronary Syndrome
Echocardiographic Molecular Imaging for POC Detection of Ischemia
Molecular imaging with myocardial contrast echocardiography (MCE) relies on the non-invasive detection of targeted microbubbles (MBs) or other acoustically active agents.
- Trial name
- NCT07762495
- Testing
- Myocardial Contrast Echo (MCE) molecular imaging with Sonazoid
- Volunteers
- 80 people
- Sponsor
- University of Virginia
Ischemic Heart Disease, Myocardial Ischemia
Evaluate Safety And Effectiveness Of The Tivoli® DES and The Firebird2® DES For Treatment Coronary Revascularization
This is a prospective, multi-center, open label, randomized study to evaluate the efficacy and safety of The TIVOLI Biodegradable polymer Rapamycin-Eluting Stent comparing with The FIREBIRD2™ Rapamycin-eluting Stent (DES) for…
- Conditions
- Ischemic Heart Disease, Myocardial Ischemia, Coronary Artery Lesions,Primary, Coronary Disease
- Trial name
- NCT01681381
- Testing
- Tivoli® DES, Firebird2® DES
- Where
- China
- Volunteers
- 2,790 people
- Sponsor
- Essen Technology (Beijing) Co., Ltd.
Diabetes Mellitus, Acute Coronary Syndrome
Cardioprotective Effect of SGLT2-I in Diabetic Patients With AMI (SGLT2-I AMI PROTECT Study)
Despite their potential benefits on the heart with pleiotropic mechanisms, the cardioprotective effects of new glucose-lowering SGLT-2 inhibitors in patients with myocardial infarction - both in the acute and chronic phase - have…
- Trial name
- SGLT2-I AMI (NCT05261867)
- Where
- 7 sites in Belgium, Bulgaria and 1 more
- Volunteers
- 800 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Coronary Stenosis, Acute Coronary Syndrome
Coronary Plaque Geometry and Acute Coronary Syndromes
The aim of GEOMETRY study is to investigate the correlation between coronary plaque geometric modifications and lesion vulnerability in patients with suspected coronary artery disease referred for cardiac computed tomography…
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atherosclerosis
- Trial name
- NCT03702764
- Testing
- CCTA
- Where
- Romania
- Volunteers
- 1,000 people
- Sponsor
- Cardio Med Medical Center
Acute Coronary Syndrome
A Comparison of the TIMI, GRACE and HEART Scores
Various elements of patient history are checked and entered in the admission Case Recor Form (CRF). Three risk scores are calculated out of these elements, combined with physical examination, laboratory values and ECG-findings.
- Trial name
- HEART (NCT01398631)
- Where
- 10 sites in Netherlands
- Volunteers
- 2,440 people
- Sponsor
- R&D Cardiologie
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Effects of Icosapent Ethyl on Coronary Plaque, Inflammation, and Ventricular Remodeling
Even with standard treatments like statins, patients with coronary artery disease often face a residual risk of further heart events.
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, Coronary Artery Disease, Atherosclerosis Cardiovascular Disease
- Trial name
- NCT07641257
- Volunteers
- 420 people
- Sponsor
- Ruijin Hospital
Acute Coronary Syndrome
A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome
The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major adverse cardiovascular event (MACE) (the composite of cardiovascular [CV] death…
- Trial name
- LIBREXIA-ACS (NCT05754957)
- Testing
- Milvexian
- Where
- 1,003 sites in United States, Argentina and 42 more
- Volunteers
- 14,194 people
- Sponsor
- Janssen Research & Development, LLC
Post-Cardiac Arrest Syndrome
The Effect of IABP Early Insertion on Mortality in Post Cardiac Arrest Patients With Acute Coronary Syndrome
The prevalence of cardiac arrests is still high worldwide. Despite the return of spontaneous circulation (ROSC), mortality and morbidity in post cardiac arrest patients is reported high.
- Trial name
- NCT03638609
- Testing
- Intra Aortic Balloon Pump
- Where
- Indonesia
- Volunteers
- 102 people
- Sponsor
- Universitas Indonesia
Cardiogenic Shock, Acute Coronary Syndrome
Score TO Predict SHOCK - STOP SHOCK
The goal of this international multicenter study is to develop a scoring system to identify the risk of developing cardiogenic shock (CS) in patients suffering from acute coronary syndrome (ACS) utilising artificial intelligence.
- Conditions
- Cardiogenic Shock, Acute Coronary Syndrome, Acute Myocardial Infarction
- Trial name
- NCT05570864
- Where
- Slovakia
- Volunteers
- 50,000 people
- Sponsor
- Premedix Academy
Acute Coronary Syndromes, ST Elevation Myocardial Infarction
Chewing Versus Traditional Oral Administration of Ticagrelor in STEMI Patients
To examine chewing versus traditional oral administration of ticagrelor in ST-elevation Myocardial Infarction (STEMI) patients on platelet reactivity.
- Trial name
- NCT02725099
- Testing
- Chewing Ticagrelor, Oral Ticagrelor
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Heart Transplantation
Sevice-learning in Physiotherapy and Heart Transplantation and Acute Coronary Syndrome
A service-learning programme in physiotherapy students will be performed. 30 physiotherapy students will be randomly assigned to an intervention group (n=16) or to a control group (n=16).
- Trial name
- NCT04261998
- Testing
- Service-learning program
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Chest Pain, Acute Coronary Syndrome
Digital Decision Support in the Management of Patients With Chest Pain
The goal of this observational study is to develop a decision support system in patients presenting with chest pain in the prehospital setting.
- Conditions
- Chest Pain, Acute Coronary Syndrome, Chest--Diseases
- Trial name
- BRIAN2 (NCT05767619)
- Testing
- Troponin hs-cTnI, Plasma glucose
- Where
- 3 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Vastra Gotaland Region
Acute Coronary Syndrome
Enoxaparin Bioequivalence Study in Acute Coronary Syndrome Patients
Because of their anti-Xa and ease of administration activity, the Low molecular weight heparin represent an attractive alternative to the unfractionated heparin.
- Trial name
- Enoxaparine (NCT04552067)
- Testing
- Lovenox, Enoxaparin
- Where
- Tunisia
- Volunteers
- 172 people
- Sponsor
- University of Monastir
Chronic Coronary Syndrome, Acute Coronary Syndromes
Optimal LDL-C Target in High-risk Patients After PCI
Extensive evidence from epidemiological, genetic, and randomized controlled trials (RCTs) of lipid-lowering therapies has firmly established a causal relationship between low-density lipoprotein cholesterol (LDL-C) and…
- Conditions
- Chronic Coronary Syndrome, Acute Coronary Syndromes, Percutaneous Coronary Intervention, High Risk Patient
- Trial name
- REC-SAFETARGET (NCT06821711)
- Testing
- Intensive LDL-C control, Conventional LDL-C control
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- Xijing Hospital
Stable Angina Pectoris, Acute Coronary Syndrome
Randomized "All-comer" Evaluation of a Permanent Polymer Resolute Integrity Stent Versus a Polymer Free Cre8 Stent
The study objective is to assess the safety and efficacy of the Permanent Polymer Zotarolimus-Eluting Stent Resolute Integrity™ to the Polymer Free Amphilimus-Eluting Stent Cre8™ compared in an all-comer patient population.
- Trial name
- NCT02328898
- Testing
- Cre8 Stent, Resolute Integrity stent
- Where
- 3 sites in Luxembourg, Netherlands
- Volunteers
- 1,532 people
- Sponsor
- UMC Utrecht
Acute Coronary Syndromes
Registry of Acute Coronary Syndromes in the Lazio Region of Italy
The NET-SCA Registry has been designed to document and evaluate the clinical epidemiology and current management of Acute Coronary Syndromes in the Lazio Region of Italy.
- Trial name
- NET-SCA (NCT01216462)
- Where
- 8 sites in Italy
- Volunteers
- 3,000 people
- Sponsor
- San Filippo Neri General Hospital
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
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