Clinical trials: Acute Cardiac Syndrome
Coronary Atherosclerosis, Acute Coronary Syndrome
Prediction of Progression of Coronary Artery Disease (CAD) Using Vascular Profiling of Shear Stress and Wall Morphology
Although atherosclerosis is a systemic disease, its manifestations are focal and eccentric, and each coronary obstruction progresses, regresses, or remains quiescent in an independent manner.
- Conditions
- Coronary Atherosclerosis, Acute Coronary Syndrome, Percutaneous Coronary Intervention, Endothelial Shear Stress
- Trial name
- PREDICTION (NCT01316159)
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- Brigham and Women's Hospital
Acute Coronary Syndrome
European Ambulance Acute Coronary Syndrome (ACS) Angiography Trial
To show that the early administration of bivalirudin improves 30 day outcomes when compared to the current standard of care in participants with ST segment elevation acute coronary syndrome (STE-ACS), intended for a primary…
- Trial name
- EUROMAX (NCT01087723)
- Testing
- Bivalirudin, Heparin
- Where
- 145 sites in Austria, Czechia and 7 more
- Volunteers
- 2,198 people
- Sponsor
- The Medicines Company
Acute Coronary Syndrome, Myocardial Infarction (MI)
Tailoring Post Discharge - Remote Education and Access for Cardiac Health
Heart attacks are one of the top causes of death in Canada, with over 2,100 cases treated each year in Manitoba. Even though hospital care has improved, the period after going home is still risky.
- Trial name
- TPD-REACH (NCT07171580)
- Testing
- Remote Home Monitoring - Education, Remote Home Monitoring - Education and Support
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- St. Boniface Hospital
ACS (Acute Coronary Syndrome)
Assessing Chest Pain Using Point-of-Care High-Sensitivity Troponin I in the Emergency Department
The goal of this proposal is to improve the quality and value of care for patients with acute chest pain by investigating the potential impact of point-of-care (POC) high sensitivity cardiac troponin (hs-cTn) testing in the…
- Trial name
- ACUTE (NCT06899776)
- Testing
- Abbott i-STAT point of care (POC) device
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- Wake Forest University Health Sciences
Diagnoses Disease
HEARTBEAT-TROP. Polyethylene Glycol Precipitation to Unmask Macrotroponin
Troponin elevation can, among others, be due to myocardial infarction, acute inflammation or structural heart disease. Formation of macrocomplexes against troponin is an underestimated cause for persistent troponin elevation.
- Trial name
- MACRO-TROP (NCT07726420)
- Testing
- Polyethylene glycol precipitation, Transthoracic echocardiography
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Myocardial Infarction, Percutaneous Coronary Intervention (PCI)
Investigation to Assess the Effects of Drug-COATED Balloons for Treatment of Plaques Erosions Causing Acute Coronary Syndromes
Drug eluting balloon angioplasty might be a better alternative than medical treatment or stenting in subjects with plaque erosion, which is the second most common cause of myocardial infarction.
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention (PCI), Medical Treatment, Coronary Computed Tomographic Angiography
- Trial name
- DCB-PE (NCT07783880)
- Testing
- PCI with size matched DCB, GP IIbIIIa inhibitor or heparin & dual antiplatelet therapy
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- 3W-Research Collaboration Group
Coronary Artery Disease
Potential Impact of Cigarette Smoking on Platelet Reactivity in Patients on Dual Antiplatelet Therapy With P2Y12 Inhibitors
All consecutive patients undergone PTCA in the period between July 2013 and December 2013 are eligible to be enrolled. Study population are divided in : Group 1: smokers on dual antiplatelet therapy with ASA (100 mg once a day)…
- Trial name
- COPTER (NCT02026713)
- Testing
- quit smoking for a 2 weeks period
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Roma La Sapienza
Chest Pain, Myocardial Infarction
ECG Methods for the Prompt Identification of Coronary Events
There is a clear need to develop improved tools to stratify risk in patients who seek emergency care for chest pain, one of the most common and potentially deadliest conditions encountered in acute care settings.
- Conditions
- Chest Pain, Myocardial Infarction, Myocardial Ischemia, Acute Coronary Syndrome
- Trial name
- EMPIRE (NCT04237688)
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- University of Pittsburgh
Acute Coronary Syndrome
The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial
This study will test whether darapladib can safely lower the chances of having a cardiovascular event (such as a heart attack or urgent coronary revascularization (e.g.
- Trial name
- SOLID-TIMI 52 (NCT01000727)
- Testing
- Darapladib 160 mg, Standard Therapy
- Where
- 914 sites in United States, Argentina and 34 more
- Volunteers
- 13,026 people
- Sponsor
- GlaxoSmithKline
Aortic Dissection
Nordic Consortium for Acute Type A Aortic Dissection-2
The Nordic Consortium for Acute Type A Aortic Dissection-2 (NORCAAD-2) is a multicenter research collaboration involving up to 19 units in the Nordic countries and one in The Netherlands.
- Trial name
- NORCAAD-2 (NCT06862583)
- Testing
- surgery, endovascular intervention
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Karolinska Institutet
Acute Coronary Syndrome, Medication Adherence
Pharmacist-led Intervention to Enhance Medication Adherence in Post-acute Coronary Syndrome Patients in Vietnam
Adherence to treatment in post-acute coronary syndrome patients has been found to be poor in several studies. Pharmacists play a significant role in enhancing medication adherence and reducing rates of mortality and re-admission…
- Trial name
- NCT02787941
- Testing
- Pharmacist-delivered multifaceted intervention
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- University of Groningen
Acute Coronary Syndrome
Prediction of Cardiovascular Events in Vulnerable Patients Following Acute Coronary Syndrome
The purpose of this study is to determine if testing patients for endothelial dysfunction will help identify which patients are more likely at risk to have another heart attack in the future.
- Trial name
- NCT01500902
- Testing
- EndoPAT testing (non invasive device), WatchPAT testing (non-invasive device)
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Mayo Clinic
Refractory Thrombus in Patients With Acute Coronary Syndrome
Feasibility Trial Evaluating Efficacy and Safety of Solitaire™ Thrombus Retrieval Device in the Management of Refractory Thrombus in Patients With Acute Coronary Syndrome
The study is designed as a multicentre open label prospective feasibility trial to capture preliminary efficacy and safety information on Solitaire device to plan an appropriate pivotal study.
- Trial name
- Solitaire (NCT04692402)
- Testing
- Solitaire™ thrombus retrieval device
- Where
- 5 sites in Singapore
- Volunteers
- 51 people
- Sponsor
- Paul Ong
Acute Coronary Syndrome
Clinical Study to Compare the Pharmacokinetic Characteristics and Safety Between CKD-357 and D578 in Healthy Volunteers
A randomized, open-label, single dose, crossover study to evaluate pharmacokinetic profiles and safety/tolerability of CKD-357 in healthy volunteers
- Trial name
- NCT03671941
- Testing
- D578, CKD-357
- Where
- South Korea
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Acute Coronary Syndrome, Depressive Disorder
Comorbid Mental Disease and Heart Disease in Men
Mood disorders, anxiety disorders, and trauma-related stress (MD\AD\TRS) are common among men, particularly those suffering from heart disease (HD).
- Conditions
- Acute Coronary Syndrome, Depressive Disorder, Anxiety Disorders, Stress Disorders, Post-Traumatic
- Trial name
- MindTheHeart (NCT03354351)
- Testing
- Stepped-care model
- Volunteers
- 3,000 people
- Sponsor
- Universite de Moncton
Acute Coronary Syndrome, Coronary Artery Disease
Full-dose Atorvastatin After Acute Coronary Syndrome (ACS) in Non-revascularisable Coronary Artery Disease
This study was designed to test the hypothesis that the addition of full-dose atorvastatin (80 mg/day) to conventional medical treatment could reduce ischaemic recurrences after non-ST-elevation acute myocardial infarction…
- Trial name
- APRIRE (NCT01187992)
- Testing
- Atorvastatin
- Where
- Italy
- Volunteers
- 290 people
- Sponsor
- San Filippo Neri General Hospital
Acute Coronary Syndrome
Acute Coronary Syndome With ST Elevation in Northern Lorraine
Lorraine is one of the most affected French region by cardiovascular diseases with a mortality rate for ischemic heart disease higher than the national average in 2010.
- Trial name
- StemiLor (NCT03355898)
- Volunteers
- 340 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Acute Coronary Syndrome (ACS)
Platelet Function in Patients With an Acute Coronary Syndrome
The aims of the study are to: explore whether platelet reactivity in patients treated wih novel platelet inhibitors is associated with clinical outcome investigate whether a therapeutic window exist for novel platelet inhibitors…
- Trial name
- ATLANTIS-ACS (NCT01992484)
- Where
- Austria
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Vienna
Acute Coronary Syndrome
Telemonitoring of Patients With Acute Coronary Syndrome
It is planned to enroll 950 patients in an open, prospective, randomized study to assess the impact of telemonitoring on the development of clinical events and improve the quality of life of patients with acute coronary syndrome.
- Trial name
- TeleCor (NCT04862026)
- Where
- Russia
- Volunteers
- 950 people
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Acute Coronary Syndrome
Serum Tenascin-C Concentration in Patients With Acute Coronary Syndrome
This study valuates the serum Tenascin-C concentration in patients with acute coronary syndrome.
- Trial name
- NCT02767960
- Where
- China
- Volunteers
- 183 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
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