Clinical trials: Acute Cardiac Syndrome
Stroke, Epilepsy
Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases
Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs.
- Conditions
- Stroke, Epilepsy, Transient Global Amnesia (TGA)
- Trial name
- G-HeBra (NCT07009990)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Aortic Aneurysm and Dissection, Cardiac Valve Disease
Antibacterial Tactics Based on Presepsin Level in Thoracic Aorta Surgery Patients
According to the literature, presepsin was recommended not only as an effective indicator in the diagnosis of sepsis in intensive care units, but also as a reliable prognostic marker of postoperative inflammatory processes in…
- Conditions
- Aortic Aneurysm and Dissection, Cardiac Valve Disease, Thoracic Aortic Aneurysm, Thoracic Aortic Dissection
- Trial name
- NCT06336213
- Testing
- Ampicillin-sulbactam
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Myocardial Infarction
Time-restricted Eating Study (TRES): Impacts on Anthropometric, Cardiometabolic and Cardiovascular Health
The goal of this clinical trial is to learn about the effects of time-restricted eating in patients with history of acute coronary syndrome.
- Trial name
- TRES (NCT06007950)
- Testing
- Time-restricted eating 10-hr
- Where
- Malaysia
- Volunteers
- 48 people
- Sponsor
- Universiti Teknologi Mara
Acute Coronary Syndromes
Nitrate - Clopidogrel - Acute Coronary Syndrome
This study aims to investigate whether intravenous nitrate given during non-ST-elevation myocardial infarction (non-STEMI) affects the platelet inhibition of clopidogrel.
- Trial name
- NCT06878638
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Bursa Postgraduate Hospital
COVID-19 Pandemic, Diabetes
Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19
The COVID-19 pandemic has emerged as the most significant public health crisis of the 21st century. As of the end of January 2023, global confirmed cases have exceeded 670 million, with a domestic cumulative total of 10.24…
- Conditions
- COVID-19 Pandemic, Diabetes, Hypertension, Cardiac Disease
- Trial name
- NCT06231225
- Testing
- Incentive Spirometer respiratory training
- Volunteers
- 100 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Acute Coronary Syndrome
Effectiveness And Safety Of Dalteparin In Patients With Acute Coronary Syndromes Without ST Elevations In Clinical Practice
To collect data on safety and effectiveness of dalteparin in the management of non-ST segment elevated acute coronary syndromes in nursing home patients who will be treated conservatively (without percutaneous corornary…
- Trial name
- NCT00922766
- Testing
- Dalteparin
- Where
- 24 sites in India
- Volunteers
- 618 people
- Sponsor
- Pfizer
Acute Coronary Syndromes
Low-Dose IL-2 For The Reduction Of Vascular Inflammation In ACS -Clinical Outcomes & Follow-up Study
The preceding IVORY trial (NCT04241601) has completed. As atherosclerosis and its complications are driven by inflammation the investigators hypothesise that treatment with low-dose IL2 may reduce adverse cardiovascular outcomes…
- Trial name
- IVORY-FINALE (NCT06427694)
- Testing
- Aldesleukin, Dextrose 5% in water
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Coronary Artery Disease, Acute Coronary Syndrome
Smartphone GUIded MeDication AdherencE and Rehabilitation in Patients With Coronary Artery Disease
This study evaluates a smartphone-based cardiac rehabilitation program in adults with coronary artery disease. Half of patients will participate in a smartphone-based cardiac rehabilitation program while the other half will…
- Trial name
- smartGUIDE (NCT03207646)
- Testing
- BrightHeart®
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Stanford University
Surgical Bleeding, Aneurysms
CoSeal for Hemostasis of Aortic Anastamoses
Surgery on the aorta can be associated with significant blood loss. Most commonly this is due to bleeding at the site of aortic anastomosis. Surgical bleeding is associated with significant morbidity.
- Conditions
- Surgical Bleeding, Aneurysms, Aortic Dissection
- Trial name
- NCT01653769
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Michael Reardon, MD
Heparin-Induced Thrombocytopenia
Efficacy and Safety Study of Argatroban to Treat Heparin-Induced Thrombocytopenia
The purpose of the study is to evaluate efficacy and safety of argatroban in the patients with heparin-induced thrombocytopenia (HIT)/ HIT and thrombosis syndrome (HITTS).
- Trial name
- NCT00198588
- Testing
- argatroban
- Where
- 20 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Ministry of Health, Labour and Welfare, Japan
Percutaneous Coronary Intervention (PCI), Drug Coated Balloon
Registry of Coronary Disease Outcomes Revascularizing With Drug-Coated Balloons
The primary aim of this registry is to systematically collect and analyze real-world data on all patients undergoing PCI with the Protégé paclitaxel-eluting DCB to evaluate procedural outcomes, long-term efficacy, and safety…
- Conditions
- Percutaneous Coronary Intervention (PCI), Drug Coated Balloon, Paclitaxel, CAD - Coronary Artery Disease
- Trial name
- RECORD-DCB (NCT07231835)
- Where
- Netherlands
- Volunteers
- 3,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Intensive Care Unit Syndrome
Determination of Perioperative Acute Kidney Injury Incidence
In the last few years, acute renal injury (AKI) definition has been significantly changed. In the light of the data obtained from multicenter international studies, acute renal injury was redefined according to RIFLE, AKIN and…
- Trial name
- NCT02521350
- Volunteers
- 5,000 people
- Sponsor
- Acibadem University
Coronary Arterial Disease (CAD), Acute Coronary Syndromes
Identification Of High-risk Coronary Plaques By Multimodal Intravascular Imaging
This study is a multicenter prospective observational clinical study, which will be conducted in 11 hospitals, and approximately 500 subjects will be enrolled.
- Trial name
- PlaqueVision (NCT06681155)
- Testing
- Assessment of plaque morphology, structure, and stability in non-culprit lesions
- Where
- 11 sites in China
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Acute Coronary Syndrome, Prevention
Cholesterol Self-testing in Patients Post Acute Coronary Syndrome
The pharmacological reduction of LDL-C lowers cardiovascular risk and is therefore a priority in cardiovascular secondary prevention.
- Conditions
- Acute Coronary Syndrome, Prevention, LDL Hyperlipoproteinemia, Therapeutic Adherence
- Trial name
- C-Check (NCT06526013)
- Testing
- Cholesterol self-measurement
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Leipzig
Chest Pain, Acute Coronary Syndrome
Effectiveness and Safety of a Clinical Assessment and 0h/1h Troponin Rule-Out Protocol
Chest pain is a common presenting complaint at the Emergency Department (ED). Many of these patients undergo lengthy assessments in the ED or are admitted which contributes to ED and hospital crowding as well as a substantial…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Myocardial Infarction, Unstable Angina
- Trial name
- ESC-TROP (NCT03421873)
- Testing
- 0h/1h hs-cTnT protocol
- Where
- 5 sites in Sweden
- Volunteers
- 16,000 people
- Sponsor
- Ulf Ekelund
Acute Coronary Syndrome, Coronary Arteriosclerosis
The Elderly ACS II Trial
The objective of this study is to compare reduced-dose prasugrel and standard dose clopidogrel in patients older than 74 years with ACS, including non-ST-elevation (NSTEACS) and ST-elevation (STEMI) patients, undergoing early…
- Conditions
- Acute Coronary Syndrome, Coronary Arteriosclerosis, Myocardial Ischemia, Cardiovascular Diseases
- Trial name
- NCT01777503
- Testing
- prasugrel, Clopidogrel
- Where
- 2 sites in Italy
- Volunteers
- 1,457 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Acute Respiratory Distress Syndrome (ARDS)
The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With Acute Respiratory Distress Syndrome (ARDS) Managed on a Fluid Protocol
The objective of this study is to evaluate the association between positive end-expiratory pressure (PEEP) setting and cardiac function, as measured by cardiac index, in patients with acute respiratory distress syndrome (ARDS)…
- Trial name
- NCT01714583
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- Yale University
Chest Pain, Coronary Artery Disease
ARgentinean Risk Assessment Registry in ACS; the ARRA-RACS Study
The first aim of this trial is to assess the long-term prognostic value of Omega-3 index, which is a measure of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) relative to other fatty acids in the erythrocyte membrane…
- Conditions
- Chest Pain, Coronary Artery Disease, Unstable Angina Pectoris, Myocardial Infarction
- Trial name
- ARRA-RACS (NCT01377402)
- Where
- 10 sites in Argentina, Norway
- Volunteers
- 982 people
- Sponsor
- Helse Stavanger HF
Acute Myocardial Infarction, Acute Coronary Syndrome
COmparisoN of High-sensitivity Cardiac TRoponin I and T ASsays Trial
Compare the analytical and clinical performance of hs-cTnI and hs-cTnT assays for the diagnosis of acute myocardial injury and myocardial infarction in patients presenting to the emergency department in whom serial cTnI…
- Trial name
- CONTRAST (NCT03214029)
- Testing
- Cardiac troponin testing
- Where
- United States
- Volunteers
- 2,286 people
- Sponsor
- Fred Apple
Stable Angina, Unstable Angina
A Trial of Everolimus-eluting Stents and Paclitaxel-eluting Stents for Coronary Revascularization in Daily Practice: The COMPARE Trial
Instead of treating in-stent restenosis, the best strategy for patients is preventing in-stent restenosis. Recent advances in the understanding of the cellular mechanism responsible for smooth muscle cell proliferation…
- Conditions
- Stable Angina, Unstable Angina, Acute Coronary Syndrome
- Trial name
- COMPARE 1 (NCT01016041)
- Testing
- everolimus stent, paclitaxel stent
- Where
- Netherlands
- Volunteers
- 1,800 people
- Sponsor
- Maasstad Hospital
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