Clinical trials: Acute Cardiopulmonary Disease
Cardiac Surgery
Catecholamine-O-Methyl-Transferase(COMT)-Polymorphism in Cardiac Surgery
Although clinical risk factors for postoperative development of vasodilatory shock and acute renal failure have been identified; there is a considerable proportion of patients undergoing cardiac surgery where this syndrome cannot…
- Trial name
- NCT00334009
- Where
- Australia
- Volunteers
- 250 people
- Sponsor
- Austin Health
Cardiopulmonary Bypass, Cardiac Surgery
Cardiopulmonary Bypass Induced Red Blood Cell Lysis
Studying the dynamics of red blood cell lysis, pfH, protective proteins and organ injury, limits will be set for safe levels of pfH following the use of CPB.
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery, Kidney Injury, Acute
- Trial name
- NCT05189262
- Testing
- Blood and urine collection
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Maryland, Baltimore
Acute Respiratory Distress Syndrome (ARDS)
The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With Acute Respiratory Distress Syndrome (ARDS) Managed on a Fluid Protocol
The objective of this study is to evaluate the association between positive end-expiratory pressure (PEEP) setting and cardiac function, as measured by cardiac index, in patients with acute respiratory distress syndrome (ARDS)…
- Trial name
- NCT01714583
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- Yale University
Cardiac Surgery
Goal Directed Hemodynamic Management of Acute Heart Failure After Cardiac Surgery in Children
Goal directed therapy (GDT) utilises various monitoring techniques to assess cardiovascular performance and allows for timely interventions based on predetermined algorithms.
- Trial name
- NCT02617602
- Testing
- Goal directed therapy, Control
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Acute Kidney Injury
Study to Prevent Acute Kidney Injury After Cardiac Surgery Involving Cardiopulmonary Bypass
The objective of the study is to assess the safety and efficacy of ANG-3777 in preventing AKI compared to placebo when administered to patients at risk for developing acute kidney injury (AKI) following cardiac surgical…
- Trial name
- NCT02771509
- Testing
- ANG-3777
- Where
- 40 sites in United States, Brazil and 2 more
- Volunteers
- 275 people
- Sponsor
- Angion Biomedica Corp
Valvular Heart Disease
The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery
Sleep-disordered breathing has a prevalence of 30~80% in patients with heart diseases. Various studies have revealed a correlation between the incidence and various diseases such as heart failure, hypertension, diabetes, and…
- Trial name
- NCT04080219
- Where
- South Korea
- Volunteers
- 414 people
- Sponsor
- Yonsei University
Cardiopulmonary Arrest, Epinephrine Causing Adverse Effects in Therapeutic Use
Impact of Intracoronary Versus Intravenous Epinephrine Administration During Cardiac Arrest .
In hospital cardiac arrest (IHCA) is a major challenge imposed on almost all health care systems worldwide. Despite significant progress in cardiopulmonary resuscitation in the past few years, outcomes remain relatively poor with…
- Trial name
- (iCPR) (NCT05253937)
- Testing
- Epinephrin
- Where
- Lithuania
- Volunteers
- 160 people
- Sponsor
- Lithuanian University of Health Sciences
Acute Cardiovascular, Pneumonia
Evaluation of Lung Doppler Signals in Patients Presenting to EMD
Historically, ultrasound has been unable to provide interpretable data from the lung parenchyma, mainly because of the high total ultrasound energy attenuation and scattering by the air in the lungs.
- Conditions
- Acute Cardiovascular, Pneumonia, Pulmonary Embolism, CHF Exacerbation
- Trial name
- NCT01961141
- Where
- Israel
- Sponsor
- Echosense Ltd.
Acute Respiratory Distress Syndrome
Plasma Biomarkers of Cardiopulmonary Bypass Induced Acute Respiratory Distress Syndrome (CPB-ARDS)
The investigators aimed to establish a prospective cohort of patients undergoing cardiopulmonary bypass (CPB) in cardiac surgery from April 2021 to September 2022, in Wuhan.
- Trial name
- PBOARDS (NCT04696172)
- Where
- 2 sites in China
- Volunteers
- 525 people
- Sponsor
- Huazhong University of Science and Technology
Acute Coronary Syndrome
Using Cardiopulmonary Exercise Test as an Incentive to Outpatient Cardiac Rehabilitation for Acute Coronary Syndrome Survivors.
Exercise-based cardiac rehabilitation is a class I recommendation for acute coronary syndrome (ACS) patients. However, participate rate of outpatient rehabilitation is quite low and remains a global issue.
- Trial name
- NCT05401240
- Testing
- information reveal
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taichung Veterans General Hospital
Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia
Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)
Acute mesenteric ischemia (AMI) is a severe condition that might occur after cardiovascular surgery. Several risk factors for AMI, such as multimorbidity, the use of vasopressors, and an increase in inflammatory markers have been…
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia, Acute Kidney Injury, Non-Occlusive Mesenteric Ischaemia
- Trial name
- aMIKI (NCT06365827)
- Testing
- observational study
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Giessen
Acute Respiratory Distress Syndrome
Extravascular Lung Water and Pulmonary Vascular Permeability After Minimally Invasive Cardiac Surgery
The use of cardiopulmonary bypass (CPB) combined with one lung ventilation (OLV) allows to perform minimally invasive cardiac surgery (MICS) through small incisions.
- Trial name
- NCT02155387
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Freiburg
Lung Injury, Cardiopulmonary Bypass
Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
Acute lung injury (ALI) following cardiopulmonary bypass (CPB) is a serious complication, often prolonging the length of stay in ICU and potentially dealing to mortality.
- Trial name
- NCT04296071
- Testing
- Research study
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Sophia Koutsogiannaki
Heart Failure
Effects of Early Cardiopulmonary Rehabilitation in Patients With Acute Decompensated Heart Failure
Acute decompensated heart failure (ADHF) is a severe condition characterized by rapid deterioration of cardiac function, leading to impaired oxygen delivery and multi-organ dysfunction.
- Trial name
- NCT07155421
- Testing
- Early Cardiopulmonary Rehabilitation, Routine in-hospital care
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Izmir Bakircay University
Acute Coronary Syndrome, Pulmonary Embolism
Assessment of Acute Disease to Reduce Imaging Costs
Overtesting for Acute Coronary Syndrome(ACS) and Pulmonary Embolism (PE) in low risk Emergency Department(ED) patients can increase exposure of nondiseased patients to radiation, intravenous contrast and anticoagulation.
- Trial name
- QUAADRICs (NCT01059500)
- Testing
- Webtool
- Where
- 4 sites in United States
- Volunteers
- 550 people
- Sponsor
- Wake Forest University Health Sciences
COVID-19
Long-term Impact on Cardiopulmonary Function and Quality of Life in Patients Recovered From COVID-19.
FUNCTION is an observational cohort study conducted by researchers from the Instituto de Medicina Tropical Alexander von Humboldt at Universidad Peruana Cayetano Heredia and Cayetano Heredia Hospital.
- Trial name
- FUNCTION (NCT05386485)
- Testing
- None intervation
- Where
- Peru
- Volunteers
- 162 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Postoperative Pulmonary Atelectasis, Pneumothorax
Cardiopulmonary Bypass on Mechanical Power and Postoperative Pulmonary Complications
During cardiopulmonary bypass (CPB), oxygenation of the patient on the pump can be left completely under pump control, or the lungs can be ventilated with low tidal volume to reduce atelectasis.
- Conditions
- Postoperative Pulmonary Atelectasis, Pneumothorax, Pneumonia, Ards
- Trial name
- NCT06292767
- Testing
- mechanical power calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- TC Erciyes University
Acute Kidney Injury, Surgery-Complications
Precision Medicine in Cardiovascular Surgery Associated Acute Kidney Injury
The goal of this prospective observational study is to define a risk profile for cardiovascular surgery associated acute kidney injury (AKI), using clinical patient characteristics, operation parameters as well as blood and urine…
- Conditions
- Acute Kidney Injury, Surgery-Complications, Frailty
- Trial name
- PEAK (NCT06471621)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiogenic Shock Acute, Bypass, Cardiopulmonary
Prognosis of Patients With Mixed Cardiogenic-Vasoplegic Shock
Mixed cardiogenic-vasoplegic shock (M-CS) represents a distinct and severe phenotype of cardiogenic shock characterized by concomitant myocardial dysfunction and inappropriate systemic vasodilation.
- Conditions
- Cardiogenic Shock Acute, Bypass, Cardiopulmonary, Septic Shock, Mechanical Circulatory Support
- Trial name
- PROMIX (NCT07354568)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Kidney Failure, Acute
Fenoldopam in Pediatric Cardiac Surgery
The purpose of this study is to determine whether fenoldopam infusion during cardiopulmonary bypass in young children with congenital heart disease is able to reduce indicators of acute kidney injury (biomarkers reduction…
- Trial name
- NCT00982527
- Testing
- Fenoldopam
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute