Clinical trials: Acute Care Medical
Acute Myocardial Infarction (AMI), Chest Pain
One-hoUr Troponin Using a High-sensitivity Point-Of-Care Assay in Emergency Primary Care
Acute chest pain is a prevalent medical emergency in primary emergency care settings. Triage of chest pain prior to hospital admission presents significant challenges due to the absence of sufficiently sensitive diagnostic tools.
- Conditions
- Acute Myocardial Infarction (AMI), Chest Pain, Acute Coronary Syndromes (ACS), Non-cardiac Chest Pain
- Trial name
- OUT-POC (NCT06853626)
- Testing
- QuidelOrthos TriageTrue hs-cTnI whole-blood assay
- Where
- 6 sites in Norway
- Volunteers
- 2,500 people
- Sponsor
- University of Oslo
Intracranial Hypertension, Acute Brain Injury
Non-Invasive Triage for Intracranial Hypertension in Prehospital Care
This study tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with a sudden brain injury, such as stroke or head trauma, before they reach the hospital.
- Conditions
- Intracranial Hypertension, Acute Brain Injury, Stroke, Traumatic Brain Injury
- Trial name
- B4C-APH (NCT07747636)
- Testing
- Brain4care non-invasive intracranial pressure monitor, Optic nerve sheath diameter ultrasound
- Volunteers
- 180 people
- Sponsor
- Juliana Caldas
Resource-Limited Setting, Delphi Study
Consensus on Low-resource Setting Definition: An inteRnational Delphi sTudY (CLARITY-LRS)
The term "low-resource setting" (LRS) is widely used in global health and critical care, yet no universally accepted definition exists.
- Conditions
- Resource-Limited Setting, Delphi Study, Consensus, Critical Care
- Trial name
- CLARITY-LRS (NCT07826819)
- Where
- Bosnia and Herzegovina
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Clinical Centre of Republic of Srpska
Ischemic Stroke, Vascular Diseases
Schlaganfallkonsortium Rhein-Neckar (Stroke Consortium Rhine-Neckar)
FAST is an investigator-initiated multicenter study embedded in a German multistate acute stroke network. The main objectives of the FAST study are to improve outcomes and quality of care for stroke patients, to quantify the…
- Conditions
- Ischemic Stroke, Vascular Diseases, Cardiovascular Diseases
- Trial name
- FAST (NCT03157934)
- Testing
- not applicable (observational study)
- Where
- Germany
- Volunteers
- 12,000 people
- Sponsor
- University Hospital Heidelberg
Intensive Care Medicine, Acute Care Medical
Functional Incremental Stepping in Place Test (F-IST) Validation
The purpose of this multi-site prospective study is to assess validity of a new step test called Functional-Incremental Stepping-in-place- Test (F-IST) compared to gold-standard cardiopulmonary exercise testing (CPET) and to…
- Trial name
- F-IST (NCT06853236)
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kirby Mayer
Critical Illness, Acute Kidney Injury
Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG)
The administration of intravenous fluids is ubiquitous in the care of the critically ill. Commonly available isotonic crystalloid solutions contain a broad spectrum electrolyte compositions including a range chloride…
- Trial name
- SMART-SURG (NCT02547779)
- Testing
- 0.9% Saline, Physiologically-balanced isotonic crystalloid
- Where
- United States
- Volunteers
- 10,421 people
- Sponsor
- Vanderbilt University
Respiratory Tract Infections
Diagnostic Accuracy Comparison Between Telemedicine and Face-to-face Consultations in Respiratory Infection Patients.
This is a randomized study that sought to analyze the diagnostic accuracy of the telemedicine consultation of patients suspected of respiratory tract infections during COVID-19 pandemic in comparison with the face-to-face…
- Trial name
- NCT04806477
- Testing
- Telemedicine Consultation, Face-to-face Consultation
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- Hospital Israelita Albert Einstein
Pressure Ulcers
Simplified Acute Physiology Score 2 and Pressure Ulcer Prediction in ICU.
Critically ill patients admitted in intensive care units are at high risk of developing pressure ulcer (also known as pressure injury).
- Trial name
- IGS-2-MIR (NCT07732517)
- Testing
- Pressure ulcer
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Bordeaux
COVID-19, ARDS (Acute Respiratory Distress Syndrome)
Long-Term Outcomes After ICU-Treated COVID-19 ARDS
This observational cohort study describes long-term survival and patient-reported health after intensive care unit (ICU) treatment for COVID-19-related acute respiratory distress syndrome (ARDS) in adults treated in a single…
- Trial name
- NCT07397156
- Where
- Poland
- Volunteers
- 283 people
- Sponsor
- University in Zielona Góra
Acute Care Medical
More-2-Eat; Implementation of INPAC
M2E is a developmental evaluation of the implementation of the Integrated Nutrition Pathway for Acute Care, in five medical units in five hospitals in Canada.
- Trial name
- m2E (NCT02800304)
- Where
- 5 sites in Canada
- Volunteers
- 5,995 people
- Sponsor
- University of Waterloo
Cerebral Venous Sinus Thrombosis
MENA Regional Endovascular Intervention for Venous Cerebral Venous Sinus Thrombosis
REVIVE-CVST is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial evaluating whether early endovascular thrombectomy (EVT) combined with standard anticoagulation improves outcomes compared to…
- Trial name
- REVIVE-CVST (NCT07548346)
- Testing
- Endovascular Thrombectomy, Anticoagulation Therapy
- Where
- 14 sites in Egypt, Jordan and 6 more
- Volunteers
- 440 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Medical Intensive Care Unit (MICU) Patients, Oncology Unit Patients
Promoting Respect and Ongoing Safety Through Patient-centeredness, Engagement, Communication and Technology
The purpose of this project is to refine, implement, and evaluate a multi-component intervention that achieves sustainable and meaningful impact on healthcare quality, safety, and costs while ensuring dignity and respect for…
- Trial name
- PROSPECT (NCT02258594)
- Testing
- Web-Based Patient Centered Toolkit (PCTK), The Patient-SatisfActive® Model
- Where
- United States
- Volunteers
- 4,368 people
- Sponsor
- Brigham and Women's Hospital
Suicidal Ideas
Improving Care Provided to Patients Treated in a Level 1 Trauma Center Post-suicide Attempt
The aim of the study is to refine, elaborate, and pilot a brief intervention for adult patients following a suicide attempt provided during hospitalization in an acute medical setting.
- Trial name
- NCT01355848
- Testing
- Brief Intervention for Suicidality
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Long COVID
Optimising General Practice Long COVID Care - an Educational Intervention.
This trial will evaluate the feasibility of a pilot educational intervention for GPs that aims to enhance care and care outcomes among patients with long COVID at six general practices in the Ireland East region.
- Trial name
- GP-COV-ED (NCT06765421)
- Testing
- Intervention Group
- Volunteers
- 72 people
- Sponsor
- University College Dublin
Acute Coronary Syndromes, ST Elevation Myocardial Infarction
Smartphone AI Assistance for Prehospital ECG Interpretation
Prehospital providers interpret 12-lead electrocardiograms (ECGs) under time pressure and without immediate expert support. Missed acute coronary occlusion - occlusion myocardial infarction (OMI) - delays reperfusion, while false…
- Conditions
- Acute Coronary Syndromes, ST Elevation Myocardial Infarction, Non-ST Elevated Myocardial Infarction, Myocardial Infarction (MI)
- Trial name
- ECG-IA (NCT07810686)
- Testing
- Smartphone large language model assistance (GPT-4o, version-locked)
- Where
- Switzerland
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- École Supérieure de Soins Ambulanciers - College of Higher Education in Prehospital Care
Endocarditis, Stroke
Evaluation of the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis
Infectious endocarditis (IE) is a serious condition with an annual incidence of 3 to 10 per 100,000 people. Brain infarctions complicate approximately 20-40% of endocarditis.
- Trial name
- POMPEI (NCT05378126)
- Testing
- Neurological assessment
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Hospices Civils de Lyon