Clinical trials: Acute Cerebral Infarction
Ischemic Stroke
Thrombectomy in Patients Ineligible for iv tPA
the purpose of this study is to to compare the safety and effectiveness of stent-retrievers as a device class group with best medical care alone in the treatment of acute ischemic stroke (AIS) in patients who are not eligible for…
- Trial name
- THRILL (NCT02135926)
- Testing
- Thrombectomy, Best medical care
- Where
- 19 sites in Austria, Germany
- Volunteers
- 4 people
- Sponsor
- University Hospital Heidelberg
Acute Ischemic Stroke
Infarct Growth After Intravenous Tocilizumab in Adults With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy - ILLUMINATE
The goal of this phase II, placebo-controlled intervention study is to investigate whether tocilizumab, an interleukin-6 (IL-6) receptor inhibitor, may have a neuroprotective effect by reducing infarct growth in adults with acute…
- Trial name
- Illuminate (NCT07870681)
- Testing
- Tociliuzumab
- Where
- 6 sites in Denmark, Norway
- Volunteers
- 156 people
- Sponsor
- Oslo University Hospital
Stroke, Cerebrovascular Disorders
Intra-arterial Thrombolysis for Acute Ischemic Stroke With Medium Vessel Occlusion
Acute ischemic stroke (AIS) due to medium vessel occlusion (MeVO) or severe stenosis poses a significant clinical challenge. Recent large randomized controlled trials, DISTAL and ESCAPE-MeVO, demonstrated no significant benefit…
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Nervous System Diseases
- Trial name
- RESCUE MeVO (NCT07185022)
- Testing
- Intra-arterial Thrombolysis, Best Medical Treatment
- Where
- 6 sites in China
- Volunteers
- 282 people
- Sponsor
- The Second Hospital of Anhui Medical University
Ischemic Stroke
Heat-clearing and Blood-activating Chinese Medicinal Components in Acute Cerebral Infarction
The present study is designed to confirm the therapeutic effects of heat-clearing and blood-activating Chinese medicinal components in treatment of Acute Cerebral Infarction (ACI) and to investigate the therapeutic mechanisms of…
- Trial name
- NCT02544087
- Testing
- Ixeris of sonchifolia Hance, Panax notoginseng saponins, Ixeris of sonchifolia Hance combined with Panax notoginseng saponins
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Yunling Zhang
Acute Ichemic Stroke, Anterior Cerebral Artery Stroke
Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial
The primary purpose of this study is to evaluate the efficacy and safety of Baricitinib combined with endovascular therapy in patients with acute anterior circulation large vessel occlusion, to address futile recanalization with…
- Conditions
- Acute Ichemic Stroke, Anterior Cerebral Artery Stroke, Baricitinib
- Trial name
- NCT07449910
- Testing
- 2mg Baricitinib, 4mg Baricitinib, Guideline-based therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Stroke, Acute, Infarction, Middle Cerebral Artery
Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment.
The aim of the study is to determine the safety and efficacy on an autologous CD34+ subset bone marrow stem cell infusion into the middle cerebral artery in patients who have suffered acute middle cerebral artery stroke.
- Trial name
- NCT00761982
- Testing
- Infusion on autologous CD34+ stem cells into middle cerebral artery
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Central de Asturias
Atrial Fibrillation, Myocardial Infarction, Acute
Prognostic Role of LA Strain in Acute Myocardial Infarction
This is a single-center retrospective observational study in which we consecutively selected patients diagnosed with acute myocardial infarction from September 2019 to March 2024 at the Affiliated Hospital of Xuzhou Medical…
- Conditions
- Atrial Fibrillation, Myocardial Infarction, Acute, Stroke Ischemic, Mortality
- Trial name
- CMR-MI (NCT06408636)
- Testing
- Cardiac MRI
- Where
- China
- Volunteers
- 780 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Stroke
Evaluating Use of Microwave Technology to Differentiate Hemorrhagic Stroke From Infarction in the Acute Phase
This is a prospective, open, multicentre trial that will enrol patients with clinical signs of stroke in the acute phase admitted for CT scan. Follow-up microwave measurements will be performed after the acute phase.
- Trial name
- NCT02490306
- Testing
- Strokefinder MD100 measurement
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Mikael Elam
Ischemic Stroke
Mexidol® Safety and Efficacy in Treatment of Hyperacute and Acute Ischemic Stroke
The primary objective of this study is to further define the mechanisms of action of Mexidol® (solution for intravenous and intramuscular injection, 50 mg/ml) and Mexidol® FORTE 250 (film-coated tablets, 250 mg) in the hyperacute…
- Trial name
- NCT07575984
- Testing
- Mexidol, Glycine
- Where
- 9 sites in Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pharmasoft
Renal Replacement Therapy, Renal Dialysis
A Clinical Trial of IntensiVE Dialysis
This study will assess clinical outcomes of extended weekly hours of haemodialysis (>= 24 hours per week) compared with standard hours of haemodialysis (<=18 hours/week) in people with ESKD.
- Conditions
- Renal Replacement Therapy, Renal Dialysis, End Stage Kidney Disease, End Stage Renal Disease
- Trial name
- ACTIVE (NCT00649298)
- Testing
- haemodialysis
- Where
- 40 sites in Australia, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- The George Institute
Cerebral Infarction
Safty and Feasibility Study of Therapeutic Cooling in Acute Ischemic Stroke (COOLAID Øresund)
This study is designed to investigate the safty and feasibility of therapeutic hypothermia in acute stroke patients. Soon after arrival in the stroke unit patients are randomized to either hypothermia in the intensive care unit…
- Trial name
- NCT01500421
- Testing
- TH - Endovascular alone (Alsius®, Zoll, USA), TH - Endovascular + nasopharyngeal induction (Alsius®, Zoll, USA) (Rhinochill®, Benechill, USA), Intravenous cold saline and surface cooling (Arctic Sun, Medivance, USA)
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Bispebjerg Hospital
Acute Stroke, Ischemic Stroke, Acute
Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke
A prospective, multicenter, randomized, controlled, open-label, blinded endpoint trial to evaluate the safety and efficacy of intravenous administration of tirofiban for preventing early neurological deterioration after…
- Conditions
- Acute Stroke, Ischemic Stroke, Acute, Cerebral Infarction
- Trial name
- TREND-2 (NCT06587347)
- Testing
- Tirofiban Hydrochloride, Standard medical treatment (SMT)
- Where
- China
- Volunteers
- 302 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Evaluate Endovascular Treatment of Large Ischemic Stroke With Substantial Penumbra.
Large cerebral infarctions are frequent and associated with a poor outcome. Previous cohort studies results suggest that patients with an acute ischemic stroke with large core and substantial penumbra on perfusion imaging benefit…
- Trial name
- FrameLP (NCT05539404)
- Testing
- Endovascular treatment in addition of best medical treatment.
- Where
- 9 sites in France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Toulouse
Cerebral Infarction, Brain Ischemia
Penumbral Based Novel Thrombolytic Therapy in Acute Ischemic Stroke
Rationale The only proven therapy for acute stroke is tPA within 4.5 hours of symptom onset. This is the standard of care for patients presenting to our hospital within that time frame.
- Conditions
- Cerebral Infarction, Brain Ischemia, Stroke
- Trial name
- TIAS (NCT02101606)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Stroke, Acute Ischemic, Blood-Brain Barrier
The Efficacy and Safety of Y-3 Intracalvariosseous Injection Versus Intravenous Injection in the Treatment of Acute Large Hemispheric Infarction
A pilot study confirmed the feasibility and safety of neuroprotectant Y-3 intracalvariosseous(ICO) injection in patients with malignant middle cerebral artery infarction (mMCAI), showing a trend in improving 90-day functional…
- Trial name
- SOLUTION-2 (NCT06374667)
- Testing
- Y-3 ICO injection, Y-3 intravenous injection, Conventional treatment
- Where
- 6 sites in China
- Volunteers
- 134 people
- Sponsor
- yilong Wang
Stroke, Acute Myocardial Infarction
Stroke Prediction Through Internet Search Queries
Cerebrovascular disease (stroke) is a leading cause of mortality and disability. Common risk assessment tools for stroke are based on the Framingham equation, which relies on traditional cardiovascular risk factors (e.g.…
- Trial name
- NCT04755959
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Acute Ischemic Stroke
"The Effect of Trimetazidine on the Clinical Outcome of Acute Ischemic Stroke Patients"
The investigators need to test the effect of Trimetazidine on the pro-inflammatory marker Interleukin - 18 , NIHSS score, and mRs score of acute ischemic stroke patients.
- Trial name
- NCT06656442
- Testing
- Trimetazidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Myocardial Infarction, Stroke
The Brain Heart Interaction in Acute Stroke
Many studies have shown that acute cerebral dysfunction can impair cardiac function and autonomic control of blood pressure, heart rate and vascular tone, however, the size of the stroke is rarely reported.
- Trial name
- NCT02734082
- Where
- Switzerland
- Volunteers
- 204 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Traumatic Brain Injury, Ischemic Stroke
Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor
The goals of the project are to evaluate a noninvasive monitor of brain metabolism and blood flow in critically ill humans. If validated, such a reliable noninvasive brain blood flow and metabolism monitor, by allowing…
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NNOM (NCT02983786)
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Pennsylvania