Clinical trials: Acute Cerebrovascular Accident
Stroke
Safety and Efficacy of the Penumbra™ System in Acute Middle Cerebral Artery (MCA) Stroke
Stroke prognosis is intimately related to reperfusion. Reperfusion in acute setting can be achieved with different strategies - varying from intravenous rtPA from mechanical thrombectomy.
- Trial name
- NCT01133223
- Testing
- Penumbra™ System, Recombinant tissue plasminogen activator
- Where
- Brazil
- Sponsor
- Hospital de Clinicas de Porto Alegre
Ischemic Stroke, Acute
Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion
Iron overload has been associated with greater brain injury in ischemia/reperfusion experimental stroke models and ischemic stroke patients, especially in those treated with thrombolytic treatment.
- Trial name
- TANDEM-1 (NCT00777140)
- Testing
- Deferoxamine
- Where
- 4 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Germans Trias i Pujol Hospital
Stroke
Role of Anti-platelet in Treatment of Acute Ischemic Stroke
Role of anti-platelet in treatment of acute ischemic stroke to determine the safety of immediate anti-platelet therapy .that is started as soon as possible within the first 24 hours of the onset of symptoms.
- Trial name
- NCT03266731
- Testing
- Aspirin
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Stroke, Acute Ischemic Stroke
The Feasibility and Safety of RK-4 Injection Bypassing Blood-brain Barrier in the Treatment of Acute Large Hemispheric Infarction Using Intracalvariosseous Injection Device
A pilot study confirmed the feasibility and safety of neuroprotectant RK-4 intracalvariosseous(ICO) injection in patients with malignant middle cerebral artery infarction (mMCAI), showing a trend in improving 90-day functional…
- Conditions
- Stroke, Acute Ischemic Stroke, Blood-Brain Barrier
- Trial name
- SOLUTION-ICD (NCT07514949)
- Testing
- RK-4 ICO injection, Conventional treatment
- Where
- China
- Volunteers
- 6 people
- Sponsor
- yilong Wang
Stroke, Acute, Swallowing Disorder
Functionality, Cognition And Swallowing Skills In Patients With AcuteSTROKE
Aim: Studies in which the results of the screening test evaluating swallowing skills in acute stroke patients are evaluated together with other components that may affect swallowing function are limited.
- Conditions
- Stroke, Acute, Swallowing Disorder, Cognitive Impairment, Stroke
- Trial name
- NCT06288243
- Testing
- Clinician-observed assessment tests
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Medipol University
Acute Ischemic Stroke
Hypothermia in Acute Stroke With Thrombolysis Imaging Evaluation of Revascularization
The primary objective of this Phase 2 HASTIER study, as an ancillary study to ICTuS 2, is to compare key imaging measurements for serial changes in recanalization and reperfusion between hypothermia and normothermia treatment…
- Trial name
- HASTIER (NCT01778855)
- Testing
- IV t-PA and normothermia, IV-tPA and hypothermia
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of California, Los Angeles
Stroke
Augmenting Cerebral Blood Flow in Acute Ischemic Stroke
The most common type of stroke is ischemic (lack of blood flow to the brain due to a clot blocking a blood vessel). Time is brain and an average of 1.9 million brain nerve cells per minute are destroyed in patients experiencing a…
- Trial name
- NCT06911385
- Testing
- Arm Remote Ischemic Conditioning plus Pneumatic Compression lower limb
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Acute Ischemic Stroke
Safety and Efficacy of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis for Acute Ischemic Stroke
The purpose of this study is to determine the efficacy and safety of remote ischemic conditioning combined with intravenous thrombolysis in treating acute ischemic stroke.
- Trial name
- NCT04980625
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 558 people
- Sponsor
- Yi Yang
Acute Ischemic Stroke
Large Artery Occlusion Treated in Extended Time With Mechanical Thrombectomy Trial
A multi-center, prospective, randomized, open-label, adaptive group sequential designed, blinded endpoint assessment (PROBE) clinical trial of endovascular treatment among selected AIS
- Trial name
- LATE-MT (NCT05326932)
- Testing
- Mechanical thrombectomy
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Lili SONG
Acute Ischemic Stroke
A Single Ascending Dose of HRS-4029 in Healthy Subjects
The study is being conducted to evaluate the safety, tolerability and pharmacokinetics of HRS-4029 following a single intravenous dose administration in healthy subjects.
- Trial name
- NCT06905314
- Testing
- HRS-4029
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Sleep-Disordered Breathing, Sleep Architecture
Screening of OSA in Hospitalized Stroke Patients Using BSP
Obstructive sleep apnea (OSA) is prevalent in patients with stroke and has a negative effect on outcomes by predisposing them to recurrent stroke, increasing mortality, and so forth.
- Conditions
- Sleep-Disordered Breathing, Sleep Architecture, Stroke, Acute
- Trial name
- NCT05466864
- Testing
- Belun Sleep platform
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Intra Cerebral Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Intracranial Pressure and Optic Nerve Sheath Diameter With CLOSED Bundle
The design of the present study will be a multicenter prospective observational protocol. Approximately 100 patients will be recruited over the 24-month period with Acute Brain Injury (trauma brain injury, intracerebral…
- Conditions
- Intra Cerebral Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Trauma, Brain, Hypertension Intracranial
- Trial name
- CLOSED (NCT06057155)
- Testing
- ultrasound optic nerve sheath diameter assessment
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Istituto delle Scienze Neurologiche di Bologna
Acute Ischemic Stroke
Second Enhanced Control of Hypertension and Thrombectomy Stroke Study (ENCHANTED2)
ENCHANTED2 is an international, multicenter, prospective, randomised, open, blinded end-point assessed (PROBE) trial, to assess different approaches to manage blood pressure (BP) in acute ischemic stroke (AIS) patients who have…
- Trial name
- ENCHANTED2 (NCT04140110)
- Testing
- Intensive BP lowering
- Where
- China
- Volunteers
- 816 people
- Sponsor
- The George Institute for Global Health, China
Ischemic Stroke, Thrombolysis
Hypothermia in Acute Ischemic Stroke - Surface Versus Endovascular Cooling (HAIS-SE)
HAIS-SE is evaluating for the first time ever in a randomized controlled trial efficacy, tolerability, practicability and safety of endovascular versus surface cooling in awake stroke patients.
- Conditions
- Ischemic Stroke, Thrombolysis, Hypothermia
- Trial name
- HAIS-SE (NCT01665885)
- Testing
- ZOLL Thermogard XP, BARD/Medivance Arctic Sun 5000
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Heidelberg
Stroke, Ischemia Stroke
Minocycline in Stroke Study at Maimonides
The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acute stroke (ischemic or hemorrhagic) aged 18 years and older.
- Conditions
- Stroke, Ischemia Stroke, Hemorrhagic Strokes, Mortality
- Trial name
- NCT07237048
- Testing
- Minocycline 200mg
- Where
- United States
- Volunteers
- 1,164 people
- Sponsor
- Joyce Chen
Acute Ischemic Stroke, Physical Activity
Physical Activity Immediately After Acute Cerebral Ischemia
Stroke is the leading cause of adult disability in Europe and United States and the second leading cause of death worldwide and affects more than 10,000 Danes each year.
- Conditions
- Acute Ischemic Stroke, Physical Activity, Accelerometer
- Trial name
- NCT01594190
- Testing
- physical activity 15 minutes/day, physical activity, 2 x 30 minutes/day
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Hillerod Hospital, Denmark
Brain Infarction
Flying Intervention Team for Endovascular Treatment of Acute Ischemic Stroke in Rural Areas
The aim of this study is to compare time delay and safety parameters of stroke patients initially admitted to a rural primary stroke center (PSC) who receive endovascular treatment (EVT) by a Flying Intervention Team with…
- Trial name
- FIT (NCT04270513)
- Testing
- Endovascular treatment by Flying Intervention Team
- Where
- Germany
- Volunteers
- 477 people
- Sponsor
- Munich Municipal Hospital
Stroke
Fall Prevention and Locomotion Recovery in Post-stroke Patients: A Multimodal Training
The study proposes a novel rehabilitative program for the recovery of locomotor abilities in post-acute stroke patients. The hypothesis is that a rehabilitative program which involves a biofeedback cycling training combining…
- Trial name
- NCT02439515
- Testing
- Cycling, Balance, Standard physical therapy
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Fondazione Salvatore Maugeri
Nystagmus, Acquired, Stroke, Acute
Nystagmus Assessment for Patients Consulting in the Emergency Department for Acute Vertigo
This pilot study is perfomed to validate and document faisability of the use of Frenzel lens and the use of a diagnostic algorithm for the assessment of a special sign (nystagmus) observe in the eyes of patients consulting in the…
- Trial name
- NCT05176015
- Testing
- Frenzel Lens, Diagnostic Algorithm
- Where
- 5 sites in Canada
- Volunteers
- 120 people
- Sponsor
- CHU de Quebec-Universite Laval
Stroke, Ischemic
Safety and Efficacy of Therapeutic Hypothermia in Acute Ischemic Stroke
Therapeutic hypothermia (TH) in stroke has demonstrated robust neuroprotection in animals especially after ischemia-reperfusion injury, but its safety and efficacy remain controversial.
- Trial name
- THIS (NCT05779176)
- Testing
- Therapeutic hypothermia
- Where
- China
- Volunteers
- 252 people
- Sponsor
- RenJi Hospital
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