Clinical trials: Acute Cerebrovascular Accident
Stroke, Ischemic
MUcociliary Clearance IN Stroke
Stroke patients frequently suffer from stroke associated pneumonia. Pathophysiologically speaking, dysphagia and central nervous system (CNS)-injury induced immunosuppression largely contribute to the risk for pneumonia.
- Trial name
- MUCINS (NCT03884166)
- Testing
- bronchoscopy
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Charite University, Berlin, Germany
Acute Ischemic Stroke
SUMMIT RISE Study of Acute Ischemic Stroke Patients
SUMMIT RISE Study of Acute Ischemic Stroke Patients
- Trial name
- NCT07436156
- Testing
- Route 92 Medical Reperfusion Systems
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Route 92 Medical, Inc.
Ischemic Stroke
Predictive Role of KLK10 and Other Neuroinflammatory Molecules on Clinical Outcomes of AIS
This study aims to investigate the dynamic changes and differential expression characteristics of neuroinflammatory molecules such as kallikrein-related peptidase 10 (KLK10), soluble triggering receptor expressed on myeloid cells…
- Trial name
- NCT06549972
- Testing
- Acute Ischemic Stroke
- Where
- China
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Acute Stroke
Essential Acute Stroke Care in Low Resource Settings: a Pilot studY
An investigator-initiated, evaluator-blinded, prospective, multi centre, before-and-after, effectiveness-implementation hybrid design study to assess the feasibility of essential acute stroke care in a low resource setting
- Trial name
- EASY (NCT04157231)
- Testing
- Acute stroke care Intervention arm
- Where
- 4 sites in Nigeria, Peru
- Volunteers
- 300 people
- Sponsor
- The George Institute
Acute Ischemic Stroke
Evaluation of the Safety and Efficacy of Hemacord HPC, Cord Blood in Subjects With Acute Ischemic Stroke
This is a phase one study investigating the safety and efficacy profile of allogeneic cord blood hematopoietic progenitor cells (HPC, Cord Blood), when administered by intravenous infusion and intrathecal injection, in subjects…
- Trial name
- NCT03735277
- Testing
- HPC, Cord Blood
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- BHI Therapeutic Sciences
Acute Ischemic Stroke
Impact of an Immune Modulator Dimethyl Fumarate on Acute Ischemic Stroke
The investigators conduct this study to investigate whether oral administration of Dimethyl Fumarate, a Food and Drug Administration-approved drug for multiple sclerosis, is safe and effective in in alleviating neurologic…
- Trial name
- NCT04890353
- Testing
- Dimethyl fumarate
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Aleeto in Acute ISchemic Stroke：A RandomISed Controlled Clinical Trial
This study is a prospective, double-blind, 1:1:1 randomized controlled study aimed at evaluating the efficacy and safety of Aleeto treatment compared to placebo in improving the NIHSS score at 14 days in patients with moderate to…
- Trial name
- ASSIST (NCT06759753)
- Testing
- Aleeto
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Beijing Tiantan Hospital
Ischemia, Stroke
Edoxaban for TIA and Acute Minor Stroke
Transient ischemic attack (TIA) or minor ischemic stroke has a high risk of early recurrent stroke. As the golden standard, aspirin effect modestly on acute ischemic stroke, and slightly increase the risk of intracerebral…
- Conditions
- Ischemia, Stroke, Cerebral Infarction
- Trial name
- NCT02221102
- Testing
- Aspirin, edoxaban
- Where
- China
- Volunteers
- 3,700 people
- Sponsor
- Xijing Hospital
Ischemic Stroke, Acute, Rehabilitation Outcome
Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study
The study evaluates the effect and safety of Cerebrolysin administered during early rehabilitation in patients with moderate neurological impairment after acute ischemic stroke, conducted at the Department of Vascular Neurology…
- Conditions
- Ischemic Stroke, Acute, Rehabilitation Outcome, Cerebrolysin
- Trial name
- NCT07043686
- Testing
- Cerebrolysin treatment, Standard treatment (including neurorehabilitation) of acute ischemic stroke
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Stroke
Training Dual-task Balance and Walking in People With Stroke
Stroke is one of the most common chronic disabling conditions in Hong Kong. People after stroke may suffer from certain degree of physical impairment and disability.
- Trial name
- NCT02753322
- Testing
- Dual task training, Single-task training, Limbs exercise
- Where
- China
- Volunteers
- 84 people
- Sponsor
- The Queen Elizabeth Hospital
Acute Ischemic Stroke
Pro-urokinase for Extended-Window Posterior Circulation Stroke
This study aims to evaluate whether, in patients with imaging-confirmed acute ischemic stroke of the posterior circulation presenting within 4.5-24 hours after symptom onset and not scheduled for endovascular thrombectomy…
- Trial name
- PROMISE (NCT07617870)
- Testing
- rhPro-UK, Aspirin
- Where
- China
- Volunteers
- 586 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Stroke
Activated Protein C in Acute Stroke Trial
The purpose of this research study is to determine the safety and learn more about the dose of Activated Protein C (APC) in reducing the damage from stroke.
- Trial name
- APCAST (NCT00533546)
- Testing
- Activated Protein C
- Where
- 9 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Hemianopia, Stroke
Combined tDCS and Vision Restoration Training in Post-acute Stroke: an Exploratory Efficacy and Safety Study
The purpose of this Study is to determine whether non-invasive transcranial direct current stimulation (tDCS) is effective in increasing rehabilitation effects after stroke in visual Cortex.
- Trial name
- NCT02703870
- Testing
- verum tDCS, VRT
- Where
- 2 sites in Austria, Germany
- Volunteers
- 19 people
- Sponsor
- University of Magdeburg
Acute Ischemic Stroke
A Phase 2a Study to Evaluate the Dose-response, Safety, Tolerability, Efficacy, and Population Pharmacokinetics of Intravenous NTS-521 Infusions in the Early Recovery Treatment From Acute Ischemic Stroke
This is a trial to evaluate the safety and effect of three intravenous (IV) doses of NTS-521 for the early recovery treatment of acute ischemic stroke (AIS). Participants will be followed for 90 days.
- Trial name
- ACT-IVATE (NCT07742098)
- Testing
- NTS-521
- Volunteers
- 140 people
- Sponsor
- NeuroTrauma Sciences, LLC
Stroke, Cerebrovascular Accident
Robot-assisted Rehabilitation of the Upper Limb in Acute and Subacute Post-stroke Patients
The goal of this study is to determine if robot aided rehabilitation therapy can be equivalent to or more effective than conventional rehabilitation therapy at promoting functional recovery of the paretic upper limb in acute and…
- Conditions
- Stroke, Cerebrovascular Accident, Upper Extremity Paresis
- Trial name
- NCT01102309
- Testing
- Robot therapy (NeReBot), Conventional therapy
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- Eremo Hospital, Arco
Acute Ischemic Stroke
OPtimizing REperfusion by Primary Intra-Arterial ThRomboLysis for Medium Vessel Occlusion
PEARL-MeVO is an investigator-initiated, multicenter, prospective, randomized controlled, open-label, blinded endpoint (PROBE) clinical trial aiming at evaluating the efficacy and safety of primary intra-arterial thrombolysis in…
- Trial name
- PEARL-MeVO (NCT07137832)
- Testing
- Primary intra-arterial thrombolysis, Standard medical treatment
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Stroke, Acute Traumatic Brain Injury
Clinimetric Application of FOUR Scale as in Treatment and Rehabilitation of Patients With Acute Cerebral Injury
The aim of this study is to increase the effectiveness of clinical monitoring of patients with acute cerebral insufficiency by improving the discriminative ability of the FOUR scale.
- Conditions
- Stroke, Acute Traumatic Brain Injury, Subarachnoid Hemorrhage
- Trial name
- FOURACI (NCT06043167)
- Testing
- The predictive value russian rendition the FOUR score.
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Surgut Clinical Trauma Hospital
Ischemic Stroke, Atrial Fibrillation Symptomatic
Cerebral Microbleeds During NOACs or Warfarin Therapy in NVAF Patients With Acute Ischemic Stroke (CMB-NOW)
Anticoagulants are generally recognized as a necessary therapy to prevent the recurrence of ischemic stroke in patients with non-valvular atrial fibrillation (NVAF), but in some patients they also cause bleedings, particularly…
- Trial name
- CMB-NOW (NCT02356432)
- Where
- 3 sites in Japan
- Volunteers
- 86 people
- Sponsor
- Tokai University
AIS
A Multicentre, Randomised, Double-blind, Placebo-parallel Controlled Phase Ⅲ Clinical Trial Evaluating the Efficacy and Safety of BXOS110 Injection in the Treatment of Acute Ischaemic Stroke Within 3 Hours of Onset.
The purpose of this study was to evaluate the efficacy of early administration of BXOS110 for injection in reducing overall disability in patients with acute ischaemic stroke
- Trial name
- NCT07520565
- Testing
- BXOS110
- Where
- 9 sites in China
- Volunteers
- 1,112 people
- Sponsor
- Biocells (Beijing) Biotech Co.,Ltd
Trunk Control in Stroke
Comparative Effects of PNF (Rhythmic Stabilization With Stabilizing Reversal) and NDT (Facilitatory Techniques) on Trunk Control in Sub-Acute Stroke
A stroke is a serious cerebrovascular accident defined as the sudden onset of a neurological deficit caused by vascular changes. Stroke are classified into primarily two types; ischemic and hemorrhagic stroke.
- Trial name
- NCT07598487
- Testing
- PNF (Rhythmic Stabilization with Stabilizing Reversal techniques), NDT (Facilitatory Techniques)
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- University of Faisalabad
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