Clinical trials: Acute Cerebrovascular Disease
Infarction, Middle Cerebral Artery, Infarction, Anterior Cerebral Artery
Effect of Mesenchymal Stem Cells(MSCs) Transplantation for Acute Cerebral Infarction Patients
This is a placebo controlled, randomized, double blinded study including Phase 1 and Phase 2. Phase I study is a safety assessment and Phase 2 study is incline to assess effectiveness of MSCs.
- Conditions
- Infarction, Middle Cerebral Artery, Infarction, Anterior Cerebral Artery, Cerebral Infarction, Stroke, Ischemic
- Trial name
- NCT04093336
- Testing
- human umbilical cord mesenchymal stem cells, standardized treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai East Hospital
Acute Ischemic Stroke
Hemodynamic Optimization of Cerebral Perfusion After Endovascular Therapy in Patients With Acute Ischemic Stroke
Mechanical thrombectomy is a very effective treatment in patients who have suffered an acute ischemic stroke associated with intracranial large vessel occlusion.
- Trial name
- HOPE (NCT04892511)
- Testing
- Adjusted medication
- Where
- Spain
- Volunteers
- 814 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Stroke, Acute
Electrical Stimulation of the Paretic Upper Limb in the Early Stroke Phase
This study evaluates the effect of electrical somatosensory stimulation (ESS) on the restoration of upper limb functioning in acute stroke patients.
- Trial name
- NCT02250365
- Testing
- Continuous, suprasensory ESS, Intermittent, suprasensory ESS
- Where
- 3 sites in Denmark
- Volunteers
- 102 people
- Sponsor
- University of Copenhagen
Acute Ischemic Stroke, Cerebral Infarction
Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT)
Stroke is the second leading cause of death worldwide, and ischemic stroke is the most frequent type. Intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 hours of symptom onset is the most effective…
- Trial name
- TREND-IVT (NCT06548971)
- Testing
- Aspirin, Best medical management
- Where
- 119 sites in China
- Volunteers
- 1,184 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Evaluate the Efficacy and Safety of TTYP01 Tablets in the Treatment of Acute Ischemic Stroke
The study is designed as a multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy and safety of TTYP01 tablets in the treatment of acute ischemic stroke.
- Trial name
- NCT06648304
- Testing
- TTYP01 tablets
- Where
- China
- Volunteers
- 614 people
- Sponsor
- Shanghai Auzone Biological Technology Co., Ltd.
Acute Ischemic Stroke
Effectiveness of Early Intervention With Virtual Reality-Based Interactive Rehabilitation on Upper Extremity Muscle Strength, Cognitive Status, Hospital Anxiety, and Exercise Self-Efficacy in Patients With Acute Ischemic Stroke
This interventional study evaluates the impact of early virtual rehabilitation, starting 24 hours post-diagnosis of acute ischemic stroke, on upper limb strength, cognitive status, and self-efficacy.
- Trial name
- NCT07674329
- Testing
- Virtual reality-based interactive rehabilitation, bedside rehabilitation
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Acute Stroke
Efficacy Study of an Interactive Robot for the Rehabilitation of the Upper Limb in Acute Stroke Patients
Stroke is the principal cause of permanent disability within the investigators population. This incapacity justifies an intensive and prolonged multidisciplinary rehabilitation, which can be optimized by robotics.
- Trial name
- NCT02079779
- Testing
- Robotic-assisted therapy, Classical therapy
- Where
- 3 sites in Belgium
- Volunteers
- 45 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Ischaemic Stroke
The RETRAIN Trial Phase 2
Ischaemic strokes, caused by a disruption in the brain's blood supply, are the second leading cause of death and disability in the United Kingdom.
- Trial name
- RETRAIN 2 (NCT07197996)
- Testing
- Intermittent Pneumatic Compression, geko® T3
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- Firstkind Ltd
Ischemic Stroke, Remote Ischaemic Preconditioning
Effect of Remote Ischemic Preconditioning on Early Neurological Deterioration in Acute Perforating Artery Infarction
This study aims to conduct a prospective, randomized, double-blind, multicenter, parallel-controlled, group-sequential trialto scientifically evaluate the safety and efficacy of remote ischemic preconditioning (RIC) in preventing…
- Trial name
- RIC-END (NCT07237542)
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 910 people
- Sponsor
- Jinling Hospital, China
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Intracerebral Infarcts, Ischemic Stroke
Discharge Educational Strategies for Reduction of Vascular Events
DESERVE is a discharge education study using health workers to enroll and randomly assign 800 subjects diagnosed with TIA, or mild stroke to either risk factor education or usual care.
- Conditions
- Intracerebral Infarcts, Ischemic Stroke, Hemorrhagic Strokes, TIA's
- Trial name
- DESERVE (NCT01836354)
- Testing
- DESERVE education
- Where
- 3 sites in United States
- Volunteers
- 552 people
- Sponsor
- NYU Langone Health
Hemianopia, Stroke
Combined tDCS and Vision Restoration Training in Post-acute Stroke: an Exploratory Efficacy and Safety Study
The purpose of this Study is to determine whether non-invasive transcranial direct current stimulation (tDCS) is effective in increasing rehabilitation effects after stroke in visual Cortex.
- Trial name
- NCT02703870
- Testing
- verum tDCS, VRT
- Where
- 2 sites in Austria, Germany
- Volunteers
- 19 people
- Sponsor
- University of Magdeburg
Acute Ischemic Stroke
Efficacy and Safety of PCSK9 Inhibitors in Patients With Large-Artery Atherosclerosis (LAA) Ischemic Stroke
This prospective multicenter cohort study aims to evaluate the effectiveness and safety of early PCSK9 inhibitor therapy in patients with large-artery atherosclerotic ischemic stroke.
- Trial name
- NCT07540741
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Acute Ischemic Stroke
Safety and Efficacy of Edaravone Dexborneol for Acute Ischemic Stroke
The purpose of this study is to determine the efficacy and safety of edaravone dexborneol in treating acute ischemic stroke.
- Trial name
- NCT06645522
- Testing
- Edaravone dexborneol
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Yi Yang
Acute Ischemic Stroke
Study to Assess the Efficacy and Safety of QHRD106 Injection in Acute Ischemic Stroke.
The purpose of this study is to determine the efficacy and safety of QHRD106 injection in treating acute ischemic stroke.
- Trial name
- NCT07396337
- Testing
- QHRD106 Injection (Low-dose group), QHRD106 Injection (Middle-dose group), QHRD106 Injection (High-dose group)
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Changzhou Qianhong Bio-pharma Co., Ltd.
Ischemic Stroke, Haemorrhagic Stroke
The Effects of Posture on Cerebral Blood Flow Velocity During the Acute Phase of Stroke
After stroke, blood vessels in the brain can become damaged, and the brain's ability to control blood flow can be impaired. The brain therefore may be less able to maintain a healthy level of blood flow during challenges such as…
- Conditions
- Ischemic Stroke, Haemorrhagic Stroke, Cerebrovascular Accident, Acute Stroke
- Trial name
- NCT04972812
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Sheffield Hallam University
Stroke, Acute Ischemic Stroke
Extended Time Window Intravenous Tenecteplase Thrombolysis Registry for Acute Ischemic Stroke
The EXTEND-TNK Registry is a prospective, multicenter, observational cohort study designed to evaluate the effectiveness and safety of intravenous tenecteplase administered beyond 4.5 hours after last known well in patients with…
- Trial name
- EXTEND-TNK (NCT07536165)
- Testing
- Tenecteplase
- Where
- 2 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Stroke, Hemiparesis
Contralaterally Controlled FES of Arm & Hand for Subacute Stroke Rehabilitation
Impaired arm and hand function is one of the most disabling and most common consequences of stroke. The Investigators have developed Contralaterally Controlled Functional Electrical Stimulation (CCFES), an innovative…
- Conditions
- Stroke, Hemiparesis, Hemiplegia
- Trial name
- NCT01688856
- Testing
- Electrical Stimulator
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- MetroHealth Medical Center
Acute Stroke
Interdisciplinary Home Rehabilitation of Patients With Stroke. A Randomised Controlled Intervention Trial.
Objective: To evaluate the effect of interdisciplinary home rehabilitation of patients with acute stroke. The trial seeks to evaluate: 1.
- Trial name
- NCT00626353
- Testing
- Home-based rehabilitation, Standard care
- Where
- Denmark
- Volunteers
- 71 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Acute Stroke
Long-term Prognosis in Stroke Patients
A single-center cohort of patients with acute ischemic stroke and transient ischemic attack who admitted to the Severance hospital of Yonsei university and their long-term outcomes.
- Trial name
- NCT03510312
- Where
- South Korea
- Volunteers
- 9,000 people
- Sponsor
- Severance Hospital
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