Clinical trials: Acute Conditions
Analgesia, Pain, Acute
Duration of Analgesia With Dexmedetomidine and Ropivacaine in Brachial Plexus Block
This is a prospective, randomized, double blind study of adding dexmedetomidine to ropivacaine for Brachial plexus block and assessing the analgesia with VAS pain scales(0-10), Satisfaction scale by VAS scale(0-10) and time to…
- Conditions
- Analgesia, Pain, Acute, Peripheral Nerve Block
- Trial name
- NCT03385967
- Testing
- Dexmedetomidine, ropivacaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Postoperative Pain, Acute
PF614 Analgesic Activity in Acute Postoperative Pain (PF614-301)
The goal of this clinical trial is to evaluate the analgesic activity of PF614 (an oral oxycodone prodrug extended-release analgesic) for control of postsurgical pain in subjects scheduled for abdominoplasty surgery.
- Trial name
- NCT06602271
- Testing
- PF614 capsule
- Where
- 3 sites in United States
- Volunteers
- 320 people
- Sponsor
- Ensysce Biosciences
Leukemia
R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of R115777 in treating patients who have refractory or…
- Trial name
- NCT00004009
- Testing
- tipifarnib
- Where
- 3 sites in United States
- Sponsor
- University of Maryland, Baltimore
Acute Kidney Failure, Critical Illness
Effect of Protein Dosage on Persistent Acute Renal Failure in Critically Ill Patients.
Background: Acute kidney injury (AKI) is common in critically ill patients and is associated with worse outcomes, including longer ICU stay, need for dialysis, and higher mortality.
- Conditions
- Acute Kidney Failure, Critical Illness, Protein Intake, Nutritional Support
- Trial name
- NCT07631221
- Where
- 6 sites in Argentina
- Volunteers
- 344 people
- Sponsor
- Hospital Italiano de Buenos Aires
Acute Myeloid Leukemia
Biomarkers for Personalized Early Assessment of Response During Salvage Chemotherapy in People With Relapsed or Refractory Acute Myeloid Leukemia (PEARL15)
Background: -Acute myeloid leukemia (AML) is a cancer of the white blood cells. It can be fatal. Standard treatment involves intensive chemotherapy. Not all treatment works.
- Trial name
- NCT02527447
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pediatric Respiratory Diseases
Structured Light Plethysmography in Obstructive Airways Disease
Obstructive airways disease is the most common group of acute illnesses leading to hospital treatment in children. This group consists of different age-related diagnoses, such as bronchiolitis in infants or wheezing and asthma in…
- Trial name
- NCT03499938
- Testing
- Structured Light Plethysmography
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Bipolar Disorder
To Evaluate the Efficiency and Safety of Quetiapine Fumarate in the Treatment of Acute Manic Patients With Bipolar Disorder.
This is an open label, randomised, parallel-group study to compare the efficacy and safety of quetiapine and valproate used as monotherapy in the treatment of mania in patients hospitalised for an acute manic episode.
- Trial name
- NCT00742638
- Testing
- Quetiapine fumarate, Sodium valproate
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Bipolar I Disorder
Staccato Loxapine in Agitated Patients With Bipolar Disorder
Phase 3 safety and efficacy study of Staccato Loxapine in the treatment of acute agitation in bipolar 1 disorder patients.
- Trial name
- NCT00721955
- Testing
- Inhaled loxapine 5 mg, Inhaled loxapine 10 mg
- Where
- 6 sites in United States
- Volunteers
- 314 people
- Sponsor
- Alexza Pharmaceuticals, Inc.
Pain, Acute, Muscle Soreness
Analgesic Induces Similar Upper and Lower Body Pain Pressure Threshold Increases
Background: Both health professionals and consumers use menthol-based topical analgesics extensively for the temporary relief of pain from musculoskeletal ailments or injury.
- Conditions
- Pain, Acute, Muscle Soreness, Tendon Injuries
- Trial name
- NCT04677985
- Testing
- Menthol based topical analgesic
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Shock, Cardiogenic, Myocardial Infarction
Efficacy Study of LV Assist Device to Treat Patients With Cardiogenic Shock (ISAR-SHOCK)
The purpose of this study is to evaluate the efficacy and safety of a left ventricular assist device in comparison to a standard treatment with an intraaortic balloon pump (IABP) in patients with cardiogenic shock due to left…
- Trial name
- NCT00417378
- Testing
- Left Ventricular Assist Device Impella LP 2.5, Intraaortic Balloon Pump
- Where
- 2 sites in Germany
- Volunteers
- 26 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Osteoarthritis
Does Optimal Control of Pre-operative Chronic and Acute Pain Predict Improved Function After Orthopedic Surgery?
Despite the development of new pain medications, the prevalence of persistent postoperative pain (for more than three to six months) remains alarmingly high.
- Trial name
- NCT00581685
- Testing
- Pregabalin, Celecoxib
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Pain, Acute
Music for Pain in the Waiting Room
This is a single-site, three-arm, parallel-group randomized clinical trial (RCT). The clinical effects of two, 4-minute, audio-recorded, music interventions (one with lyrics and the other without) for orthopedic patients will be…
- Trial name
- NCT06511843
- Testing
- Pain Coping Information, Lyrical Music, Instrumental Music
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Florida State University
Spinal Cord Infarction, Spinal Cord Stroke
Descriptive Study of Acute Spontaneous Spinal Cord Infarction
Acute spontaneous Spinal Cord Infarctions (SCI) are an uncommon cause of myelopathy (5%), but their prognostic is heterogeneous and frequently severe. Positive diagnosis is difficult, one quarter of initial MRIs are normal.
- Conditions
- Spinal Cord Infarction, Spinal Cord Stroke, Vascular Myelopathy
- Trial name
- EDMIAS (NCT04372758)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Myocardial Infarction (MI)
Dual Antiplatelet Therapy Strategies After Acute Myocardial Infarction Undergoing PCI: Prasugrel vs Ticagrelor & 12 Months vs 1-3 Months
This study is testing different blood-thinning treatment strategies for people who have had a heart attack and were successfully treated with a coronary stent procedure (PCI).
- Trial name
- STREAMLINE (NCT07507500)
- Testing
- Prasugrel, Ticagrelor
- Where
- 5 sites in Ireland, Latvia and 3 more
- Volunteers
- 8,100 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
ST Elevation Myocardial Infarction (STEMI), Coronary Artery Disease
Metformin to Reduce Heart Failure After Myocardial Infarction
The investigators will evaluate the effect of metformin therapy during 4 months in non-diabetic patients following ST-elevation myocardial infarction on left ventricular ejection fraction as measured with cardiac magnetic…
- Conditions
- ST Elevation Myocardial Infarction (STEMI), Coronary Artery Disease, Heart Failure, Diabetes
- Trial name
- GIPS-III (NCT01217307)
- Testing
- Metformin
- Where
- Netherlands
- Volunteers
- 380 people
- Sponsor
- University Medical Center Groningen
Pain, Postoperative
Safety and Efficacy of Repeated Doses of PMI-150 (Intranasal Ketamine) in Acute Post-operative Pain Following Orthopedic Surgery
The purpose of this research study is to evaluate the safety and analgesic efficacy of PMI-150 (intranasal ketamine) compared to placebo in patients with acute post-operative pain following orthopedic trauma, injury, or surgery.
- Trial name
- NCT00709436
- Testing
- PMI-150 (intranasal ketamine)
- Where
- 16 sites in United States
- Volunteers
- 250 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Myocardial Infarction, Myocardial Infarction, Acute
BIO monitorinG in Patients With Preserved Left ventricUlar Function AfteR Diagnosed Myocardial Infarction
The BIO|GUARD-MI study investigates whether continuous arrhythmia monitoring and the consequent treatment after detected arrhythmias in patients after myocardial infarction with preserved cardiac function, but other risk factors…
- Conditions
- Myocardial Infarction, Myocardial Infarction, Acute, Myocardial Infarction Old
- Trial name
- BIO-GUARD-MI (NCT02341534)
- Testing
- BioMonitor
- Where
- 59 sites in United States, Australia and 12 more
- Volunteers
- 802 people
- Sponsor
- Biotronik SE & Co. KG
Low Back Pain, Mechanical
Battlefield Acupuncture for Acute/Subacute Back Pain in the Emergency Department
The randomized controlled study aims was to investigate the pain control of Battle Field Acupuncture as Primary or Adjunctive Treatment in Back Pain (Acute Musculoskeletal pain) in the (acute pain setting) Emergency Department vs…
- Trial name
- NCT03996564
- Testing
- Battlefield Acupuncture, Acetaminophen, Diclofenac
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- San Antonio Military Medical Center
Cirrhosis and Chronic Liver Disease
Predictors of Decompensation, Acute-on-chronic Liver Failure and Mortality in Liver Cirrhosis
The purpose of this study is to identify factors that predict the development of decompensation, acute-on-chronic liver failure (ACLF) and death in patients with liver cirrhosis.
- Trial name
- SoLiDaRity (NCT07438288)
- Testing
- Observation
- Where
- 3 sites in Singapore
- Volunteers
- 2,200 people
- Sponsor
- Singapore General Hospital
Status Epilepticus, Seizures
Nasal Versus Venous Lorazepam for Control of Acute Seizures in Children
Status epilepticus (SE) is a common pediatric emergency which is potentially life-threatening and requires rapid termination. Early and effective treatment is essential to prevent the morbidity and mortality associated with…
- Trial name
- INLOR (NCT00735527)
- Testing
- Lorazepam
- Where
- India
- Volunteers
- 140 people
- Sponsor
- All India Institute of Medical Sciences
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