Clinical trials: Acute Conditions
Pain, Acute
PENTHROX™ in the Canadian Emergency Department (ED)
This Canadian, multi-centre, prospective, real world study is designed to evaluate the effectiveness of low dose methoxyflurane (MEOF) (PENTHROX™) for the treatment of moderate to severe pain associated with trauma in the…
- Trial name
- ADVANCE-ED (NCT03868436)
- Testing
- Methoxyflurane 3mL
- Where
- 6 sites in Canada
- Volunteers
- 99 people
- Sponsor
- Purdue Pharma, Canada
Mechanical Ventilation Complication, Neuromuscular Electrical Stimulation
NMES to Prevent Respiratory Muscle Atrophy in Mechanically Ventilated Patients
Patients requiring prolonged time on the ventilator are susceptible to a wide range of clinical complications and excess mortality. It is therefore imperative for them to wean at the earliest possible time.
- Conditions
- Mechanical Ventilation Complication, Neuromuscular Electrical Stimulation, Muscle Weakness
- Trial name
- NCT03453944
- Testing
- VentFree prototype (VF03-K) active stimulation
- Where
- 3 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Nijmegen
Pain, Acute, Child Behavior
The Effect of "Quantum-Touch" on Pain, Fear, and Anxiety of the Children
This research is a randomized controlled experimental study designed to determine the effect of the Quantum-Touch method applied during the vascular access procedure in children aged 7-12 years, on the level of pain, fear and…
- Conditions
- Pain, Acute, Child Behavior, Anxiety and Fear, Venipuncture Site Reaction
- Trial name
- NCT05828264
- Testing
- Quantum touch
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Trakya University
Cerebral Hemorrhage, Acute Lobar Haematoma
Descriptive Study on MRI Contrast of Acute Cerebral Hemorrhage in Different Microangiopathies
Cerebral haemorrhage represents a minority of acute vascular syndromes (less frequent than ischemic stroke, at around 20%), but with a therapeutic impasse, having no specific treatment.
- Trial name
- GADO-ICH (NCT06781034)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Acute Kidney Injury, Kidney Diseases
Identification of Patients at Risk of CKD After AKI
The investigators will investigate whether new kidney biomarkers can identify patients who are at risk of chronic kidney disease after an episode of moderate / severe acute kidney injury in ICU.
- Trial name
- NCT05740709
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Pain in Herpes Zoster
NPC-06 to Pain Associated With Acute Herpes Zoster
To confirm the pain relief effect and the safety of NPC-06 (fosphenytoin sodium hydrate) in patients with pain associated with acute herpes zoster in a placebo-controlled, double-blind, parallel-group, comparative manner.
- Trial name
- NCT05480553
- Testing
- NPC-06
- Where
- 20 sites in Japan
- Volunteers
- 51 people
- Sponsor
- Nobelpharma
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q)
Rasburicase and Allopurinol in Treating Patients With Hematologic Malignancies
This randomized phase II trial studies how well giving rasburicase together with allopurinol works in treating patients with hematologic malignancies. Rasburicase may reduce the level of uric acid in the blood.
- Conditions
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Trial name
- NCT01564277
- Testing
- rasburicase, allopurinol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Roswell Park Cancer Institute
Acute HIV Infection
Early cART and cART in Combination With Autologous HIV-1 Specific Cytotoxic T Lymphocyte (CTL) Infusion in The Treatment of Acute HIV-1 Infected Adults
The purpose of this study is to assess the ability of the early initiation of cART or cART in combination with autologous HIV-1 specific cytotoxic T lymphocyte (CTL) infusion to achieve a post-treatment control among…
- Trial name
- NCT02231281
- Testing
- cART(TDF/AZT+3TC+LPV/r), CTL infusion
- Where
- 7 sites in China
- Volunteers
- 65 people
- Sponsor
- Yongtao Sun, MD, PhD
Acute Myocardial Infarction (AMI), Acute Myocardial Infarction of Anterior Wall
Recombinant Human Thymosin Beta 4 for Injection(NL005) for Acute Myocardial Infarction
The goal of this phase IIc clinical trial is to learn if recombinant human thymosin beta 4 injection (NL005) works to treat heart damage in people who have had a serious type of heart attack called ST-segment elevation myocardial…
- Conditions
- Acute Myocardial Infarction (AMI), Acute Myocardial Infarction of Anterior Wall, Acute Myocardial Infarction With ST Elevation, Acute Myocardial Infarction of Left Ventricle
- Trial name
- NCT07586865
- Testing
- Recombinant Human Thymosin Beta 4 Injection (NL005)
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Beijing Northland Biotech. Co., Ltd.
Stroke, Acute, Stroke
Functional Electrical Stimulation (FES) for Upper Extremity Recovery in Stroke
Stroke is the leading cause of activity limitation among older adults in the United States. NeuroMuscular Electrical Stimulation (NMES) can assist stroke survivors in regaining motor ability and decreasing activity limitation…
- Conditions
- Stroke, Acute, Stroke, Hemiparesis
- Trial name
- NCT00142792
- Testing
- NMES device with EMG-triggered and Cyclic capabilities
- Where
- 3 sites in United States
- Volunteers
- 122 people
- Sponsor
- MetroHealth Medical Center
Monitoring, Clinical Deterioration
Continuous Monitoring of Patients in and After the Acute Admission Ward to Optimize Clinical Pathways
Hospitals aim to hospitalize patients when necessary and discharge patients when possible. However, the triage process and discharge management of patients in e.g. the Acute Admission Ward, is not a trivial task.
- Conditions
- Monitoring, Clinical Deterioration, Acute Disease
- Trial name
- NCT05181111
- Testing
- Wearable Sensor, Usual Care
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Rijnstate Hospital
Chronic Kidney Disease
Prevention of Acute Kidney Injury - Molecular Mechanisms of Dietary Pre-conditioning in Human
The key objective of this pilot study is to assess the molecular mechanisms of renal pre-conditioning by a one-week low-calorie diet in humans.
- Trial name
- CR_LSP (NCT02745444)
- Testing
- low-calorie formula diet, protein-restricted diet
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Cologne
B-Cell Lymphoma, B Acute Lymphoblastic Leukemia
Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia
This trial aims to demonstrate the feasibility of this approach to reliably generate product and to safely administer the product to patients who have B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia.
- Conditions
- B-Cell Lymphoma, B Acute Lymphoblastic Leukemia, Diffuse Large B Cell Lymphoma, Mantle Cell Lymphoma
- Trial name
- NCT05281809
- Testing
- Chimeric Antigen Receptor (CAR) T-Cell Product (Autologous)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- John Lister
Psychomotor Impairment
Cannabis Effects on Driving-related Skills of Young Drivers
Motor vehicle collisions are the leading cause of death for young people. The investigators have recently found that driving after using cannabis is more common among young Canadian drivers than driving after drinking.
- Trial name
- NCT01592409
- Testing
- delta-9-tetrahydrocannabinol
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Acute Kidney Injury, Delirium
AKI and Delirium Risk Prediction and Cost Burden Study
The goal of this study is to learn how to better predict two common health problems that can happen during a hospital stay: acute kidney injury (AKI) and delirium. AKI is a sudden decline in kidney function.
- Trial name
- HAAKID (NCT07866560)
- Testing
- It is observational trial with no intervention being evaluated
- Where
- United States
- Volunteers
- 25,000 people
- Sponsor
- University of Nebraska
Acute Myeloid Leukemia, Acute Lymphocytic Leukemia
INCB018424 in Patients With Advanced Hematologic Malignancies
The goal of this clinical research study is to learn if ruxolitinib can help to control advanced hematological malignancies. The safety of this drug will also be studied.
- Conditions
- Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, Myelodysplastic Syndrome, Chronic Myelogenous Leukemia
- Trial name
- NCT00674479
- Testing
- INCB018424
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- M.D. Anderson Cancer Center
Injury Traumatic, Pain, Acute
Safety and Efficacy of Sufentanil Administration by Paramedics in Acute Trauma
The safety and efficacy of competence of paramedics to administer sufentanil intravenously in adult acute trauma patients without presence or without phone-call consult with an emergency medical doctor will be assessed in this…
- Trial name
- NCT06514469
- Testing
- Sufentanil intravenous administration followed consultation of remote physician, Sufentanil intravenous administration based on paramedic competency
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Zdravotnicka Zachranna Sluzba Karlovarskeho Kraje, P.O.
Acute Pain
Comparative Bioavailability of Dexketoprofen Trometamol Oral Solution vs Tablet Formulations
The purpose of this study is to compare the bioavailability of 25 mg DKP.TRIS given as an Enantyum® oral solution (Test formulation) and Keral® tablet (Reference formulation).
- Trial name
- NCT02209454
- Testing
- Enantyum® oral solution, Keral® tablet
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Menarini Group
Brain Ischemia
Mild Hypothermia in Acute Ischemic Stroke
Hypothesis: Mild hypothermia using non-invasive temperature management system in a stroke unit is safe and feasible in spontaneously breathing, alteplase-thrombolyzed patients with acute ischemic stroke.
- Trial name
- NCT00987922
- Testing
- Hypothermia
- Volunteers
- 36 people
- Sponsor
- University of Helsinki
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