Clinical trials: Acute Conditions
Cesarean Delivery, Postoperative Pain
The Effect of Intrathecal Morphine and Erector Spina Plan Block on Serum Cytokine Levels and Chronic Pain in Caesarean Section Surgery
Working Title The Effect of Intrathecal Morphine and Erector Spina Plan Block on Serum Cytokine Levels and Chronic Pain in Caesarean Section Surgery Study Description This study aims to evaluate the effects of intrathecal…
- Conditions
- Cesarean Delivery, Postoperative Pain, Cytokine Levels, Chronic Pain, Postoperative
- Trial name
- NCT06684015
- Testing
- İNTRATECHAL MORPHİNE GROUP, Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Ankara University
Metastatic Cancer, Cancer, Breast
Assessment of Sarcopenia at Diagnosis for Patients With Previously Untreated Metastatic Cancer or Hematologic Malignancy
Sarcopenia is defined as reduction in muscle mass and function according to the criteria of the European Working Group on Sarcopenia in older people.
- Conditions
- Metastatic Cancer, Cancer, Breast, Cancer Colon, Cancer, Rectum
- Trial name
- SPACE2 (NCT05154474)
- Testing
- Standard
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Weprom
Thermoregulation, Sleep Disturbance
Acute Sleep Deprivation on Whole-body Heat Exchange During Exercise-heat Stress in Young and Older Men
Sleep deprivation has long been thought to modulate thermoregulatory function. Seminal work on sleep deprivation and thermoregulation has demonstrated that sleep-deprived individuals experience greater elevations in core…
- Conditions
- Thermoregulation, Sleep Disturbance, Heat Exchange, Aging
- Trial name
- NCT05838014
- Testing
- Sleep deprivation, Normal sleep
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Musculoskeletal Pain
Patient Education to Improve Pain Management in Older Adults With Acute Musculoskeletal Pain: A Pilot Randomized Trial
This is a three arm pilot randomized trial. Patients will be assigned to: 1. Usual care 2. Video education in the Emergency Department (ED) 3.
- Trial name
- BETTER_Pilot (NCT02438384)
- Testing
- Video, Phone follow-up
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of North Carolina, Chapel Hill
Kidney Failure, Acute, Critical Illness
Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated.
- Trial name
- NCT00316576
- Testing
- Blood sampling for PCR
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Caen
Pain, Postoperative
Reducing Opioid Use and Misuse After Wisdom Molar Extractions
Reducing opioid prescription related use and misuse is a major focus for countering the national epidemic of opioid overdose and death.
- Trial name
- NCT04414917
- Testing
- Twin block, iPill dispenser
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Critical Illness, Sepsis
ICU Admission Diagnoses and ICU Mortality
This retrospective cohort study will evaluate whether syndromic clinical diagnoses present at ICU admission are associated with ICU mortality, independent of physiologic severity scores.
- Conditions
- Critical Illness, Sepsis, Septic Shock, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT07369206
- Where
- Turkey (Türkiye)
- Volunteers
- 1,248 people
- Sponsor
- Ataturk University
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM-iSMART-A: Decitabine / Venetoclax and Navitoclax in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART A (NCT05740449)
- Testing
- Decitabine, Venetoclax, Navitoclax
- Where
- Netherlands
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Acute Heart Failure
Effect of Short-Term Prednisone Therapy on C-Reactive Protein Change in Emergency Department Patients With Acute Heart Failure and Elevated Inflammatory Markers ( CORTAHF )
Acute heart failure (AHF) is a common discharge diagnosis in the emergency department (ED), associated with 1-month mortality of 6%, and a 30% risk rate of 1-month rehospitalisation.
- Trial name
- CORTAHF (NCT05668676)
- Testing
- Prednisone arm, Usual care
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Acute, Progressing Stroke
Safety and Efficacy of Therapeutic INduced HYPERTENSION in Acute Non-cardioembolic Ischemic Stroke (SETIN-HYPERTENSION)
The purpose of this study is to evaluate the safety and efficacy of the induced hypertension using phenylephrine in patients with noncardioembolic ischemic stroke.
- Trial name
- NCT01600235
- Testing
- Phenylephrine
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Samsung Medical Center
Mental Fatigue, Athletic Performance
Mental Fatigue, Attentional Focus, and Countermovement Jump Performance
This study examines whether short-term mental fatigue and different jump instructions affect how high people can jump. Thirty-two physically active university students will complete two testing sessions in random order: one after…
- Trial name
- NCT07779304
- Testing
- Mental-Fatigue Protocol (Stroop Task), Control Protocol (Nature Video), No Prescribed Focus Instruction
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Cancer
Controlled Trial Comparing Nomogram-based Versus Standard Allocation of Acute Normovolemic Hemodilution (ANH) During Hepatic Resection
The purpose of this study is to learn the best method of assigning patients to receive "acute normovolemic hemodilution" during liver surgery.
- Trial name
- NCT00902343
- Testing
- nomogram-based selection for acute normovolemic hemodilution, standard selection for ANH based on a planned resection of 3 or more segments
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Coronavirus, COVID-19 Respiratory Infection
Protocol for Assistance to Patients With Long Covid-19 Undergoing Treatment With HD-tDCS
COVID-19 is an infectious disease which presents a heterogenous clinical presentation. Recent investigations suggest that people who were infected by COVID-19 often develop physical disabilities (i.e.
- Trial name
- NCT05289115
- Testing
- Experimental group/ Active HD-tDCS
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Paraíba
Hepatectomy, Analgesia
Continous Quadratus Lumborum Block for Hepatic Surgery With Right Subcostal Incision
This prospective, randomized study, control study aims to compare the analgesic effect, opioids consumption, quality of recovery, length of hospital stay and et al.
- Conditions
- Hepatectomy, Analgesia, Nerve Block
- Trial name
- NCT02914015
- Testing
- Continous QLB (quadratus lumborum block), Philip CX50 Ultrasound Scanner, Ropivacaine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Cui Xulei
Post-Acute COVID-19 Vaccination Syndrome, Postviral Fatigue
Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination Syndrome
Some people report persistent health problems after receiving the COVID-19 vaccine. These symptoms persist well beyond typical short-term vaccine side effects and are not attributable to any other known medical conditions.
- Trial name
- CLEAR (NCT07400848)
- Testing
- Blood sampling and analysis, The continuous Reactive Hyperemia Index (InRHI) measured by EndoPAT
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Bern
Gallbladder, Gall Stones (&Amp; [Calculus - Gall Bladder])
Benchmarks in Acute Laparoscopic Cholecystectomy
The aim of this observational cohort study is to define peri- and postoperative reference values for acute laparoscopic cholecystectomy, using the achievable benchmarks of care methodology (ABC™).
- Conditions
- Gallbladder, Gall Stones (&Amp; [Calculus - Gall Bladder]), Gall Stone, Gallbladder Inflammation
- Trial name
- NCT06693076
- Testing
- Laparoscopic cholecystectomy
- Volunteers
- 40,000 people
- Sponsor
- Region Östergötland
Neuropathy, Digestive Cancer System
Prevention of Oxaliplatin-induced Neuropathic Pain by a Specific Diet
Use lay language. Oxaliplatin is a reference anticancer drug in the treatment of colorectal cancer. However, its use is hampered by a specific neurotoxicity, which is characterized by acute thermal hypersensitivity, notably to…
- Trial name
- NEUROXAPOL (NCT01775449)
- Testing
- Polyamines depleted diet, associating Polydol® cans and predefined menus low in polyamines
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Rib Fracture Multiple, Pain, Chest
RIB PAIN (Rib Fractures Treated With Parental Analgesia With Infused LidocaiNe)
Traumatic rib fractures (RF) are a relatively common occurrence in patients of all ages, with a 10% incidence in all trauma patients and are associated with significant morbidity and mortality.
- Conditions
- Rib Fracture Multiple, Pain, Chest, Pain, Acute, Respiratory Failure
- Trial name
- RIB PAIN (NCT03770208)
- Testing
- Intervention: Lidocaine
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Western University, Canada
B-NHL, B-Non Hodgkin Lymphoma
CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory B Cell Malignancies
Background: Acute lymphoblastic leukemia (ALL) is the most common cancer in children. About 90% of children and young adults who are treated for ALL can now be cured.
- Conditions
- B-NHL, B-Non Hodgkin Lymphoma, Acute Lymphocytic Leukemia, Acute Lymphoblastic Leukemia
- Trial name
- NCT05442515
- Testing
- CD19/CD22-CAR-transduced T cells, cyclophosphamide, fludarabine
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Obstructive Pulmonary Disease
Analysis of the Dynamics of the Lung Microbiota During Acute Exacerbation of COPD Requiring Admission to Intensive Care Unit
This study aims to investigate the correlation between pulmonary microbiota dynamics (including bacteria, fungi and viruses) and COPD exacerbation for COPD patients admitted to ICU
- Trial name
- ADMiRE (NCT03641235)
- Testing
- Sputum collection
- Where
- France
- Volunteers
- 29 people
- Sponsor
- University Hospital, Bordeaux
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