Clinical trials: Acute Conditions
Dyspnea
Basics in Acute Shortness of Breath EvaLuation (BASEL V) Study
To improve the diagnostic and prognostic utility of various biomarkers, detailed patient's history, physical examinations and technical devices in patients presenting with acute dyspnea.
- Trial name
- BASEL V (NCT01831115)
- Where
- 2 sites in Switzerland
- Volunteers
- 5,452 people
- Sponsor
- University Hospital, Basel, Switzerland
Sepsis, ARDS
Multicenter Prospective Cohort of Sepsis and ARDS in China
This prospective, multicenter, observational cohort study enrolls 6,000 adults with sepsis and/or acute respiratory distress syndrome (ARDS) at multiple hospitals in China.
- Trial name
- NCT07863908
- Testing
- Surveys, 6-Minute Walk Test, Blood collection
- Where
- 24 sites in China
- Volunteers
- 6,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Ischemia Reperfusion Injury, Cardiac Surgery Associated - Acute Kidney Injury
A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE)
This is a Randomized, Single-blind, Multi-center, Placebo-controlled, Phase 2a clinical trial of BX-001N to prevent patients from Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) and subsequent Major Adverse Kidney Events…
- Trial name
- NCT07164833
- Testing
- BX-001N Experimental group 1, BX-001N Experimental group 2
- Where
- 8 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Bilix Co.,Ltd.
Severe Acute Malnutrition, Wasting
A Novel Low-Cost Tool for a More Efficient and Reliable Weight-for-Height/Length Assessment
Weight-for-height/length z-score is one of the indicators used to diagnose acute malnutrition. In the existing method, the assessment involves three steps and takes significant time with a wider room for errors.
- Trial name
- Yared's-tool (NCT03780348)
- Testing
- New Method, Existing Method
- Volunteers
- 510 people
- Sponsor
- JSI Research & Training Institute, Inc.
Acute Myocardial Infarction, Percutaneous Coronary Intervention
Enhancing Cardiac Rehabilitation Through Behavioral Nudges
Adherence to cardiac rehabilitation is poor, and worse for minorities, women, and those with lower levels of education. Patients less likely to be referred to and complete cardiac rehab are at highest risk of adverse outcomes and…
- Conditions
- Acute Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Disease, Valvular Disease
- Trial name
- NCT03834155
- Testing
- Hospital-based CR + Movn Application, Choice of Hospital or home-based CR + Movn Application, Hospital-based CR + Movn Application + Nudge
- Where
- United States
- Volunteers
- 447 people
- Sponsor
- Denver Health and Hospital Authority
Bronchiolitis
Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old
1. Bronchiolitis is a leading cause of morbidity and mortality in children. It is an acute, infectious illness of the lower respiratory tract resulting in obstruction of the bronchioles.
- Trial name
- NCT00355043
- Testing
- Zinc sulphate 20 mg
- Where
- Bangladesh
- Volunteers
- 330 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Graft Versus Host Disease, Leukemia
Peripheral Stem Cell Transplantation Plus Filgrastim in Treating Patients With Acute or Chronic Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses…
- Conditions
- Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT00002833
- Testing
- Filgrastim, Cladribine, Cyclosporine
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer
Natural History Study of Fungal Infections of the Blood in Patients With Cancer or in Patients Who Have Undergone a Stem Cell Transplant
RATIONALE: Gathering information about how often fungal infections of the blood occur in patients with cancer or in patients who have undergone stem cell transplant may help doctors learn more about the disease.
- Trial name
- NCT00445952
- Testing
- clinical observation, management of therapy complications
- Where
- 5 sites in Belgium, France and 3 more
- Volunteers
- 304 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia
A Phase Ib/IIb, Open-label, Multi-center, Study of Oral Panobinostat Administered With 5-Azacitidine (in Adult Patients With Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML).
The purpose of this randomized, two-arm, open-label expansion phase study was to collect preliminary efficacy data of panobinostat at the recommended phase II dose (RPIID) level in combination with azacytidine (5-Aza) versus an…
- Conditions
- Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, Acute Myeloid Leukemia
- Trial name
- NCT00946647
- Testing
- Panobinostat (LBH589), 5-Azacytidine
- Where
- 38 sites in United States, Austria and 12 more
- Volunteers
- 113 people
- Sponsor
- Novartis Pharmaceuticals
Rectal Cancer, Retention, Urinary
Incidence of Acute Urine Retention: Randomized Clinical Trial Comparing Early, Mid or Late Urinary Catheter Removal in Patients With Rectal Resection
DESIGN: Randomized, open-label and parallel clinical trial, assigned to early, mid, or late withdrawal of urinary catheter with a 1: 1: 1 allocation ratio.
- Conditions
- Rectal Cancer, Retention, Urinary, Urinary Tract Infections, Surgical Site Infection
- Trial name
- RAOREC (NCT04751149)
- Testing
- Removal of Urinary Catheter
- Where
- Spain
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Hospital Donostia
Ischemia
The Effect of Ticagrelor or Clopidogrel on Endothelial Function During Acute and Chronic Treatment
To investigate if treatment with ticagrelor can mitigate the transient loss of endothelium-dependent vasodilatation of the resistance vasculature following a short period of ischemia, compared with clopidogrel at standard…
- Trial name
- NCT02580149
- Testing
- Ticagrelor, Clopidogrel
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Michael Wolzt, Prof. MD
Acute Pain
Analgesic Efficacy of Duloxetine in Patients Undergoing Lumbar Discectomy
Duloxetine is a serotonin-norepinephrine reuptake inhibitor primarily used for treatment of major depression and anxiety. Duloxetine also has been used in the treatment of chronic pain conditions, such as osteoarthritis and…
- Trial name
- NCT03549026
- Testing
- Duloxetine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Acute Myocardial Infarction, STEMI
Multi-modality Imaging in Acute Myocardial Infarction
The goal of this study is to use three (3) different imaging techniques:Fractional Flow Reserve (FFR) allows precise measurement of blood flow in the arteries to the heart, and is more reliable than pictures alone to determine…
- Conditions
- Acute Myocardial Infarction, STEMI, Coronary Artery Disease, Atherosclerotic Plaque Disruption With Thrombosis of Artery
- Trial name
- MIAMI (NCT02926755)
- Testing
- Coronary Angiography
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Corewell Health East
Lipedema, Knee Osteoarthritis
The Effect of Lipedema on Knee Osteoarthritis
This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context.
- Conditions
- Lipedema, Knee Osteoarthritis, Knee Acute and Chronic Pain, Knee
- Trial name
- NCT07575555
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Izmir Democracy University
Procedural Pain, Pain, Acute
Effect of Guided Imagery Method on Procedural Pain in Children
The study was conducted as a randomized controlled experimental trial. The children who attended a pediatric surgical clinic for venipuncture divided into two groups via randomization in the computer environment.
- Trial name
- NCT04978532
- Testing
- Guided Imagery, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Biruni University
Binge-Eating Disorder, Obesity
Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Acute Treatment
Brief Summary: This study will compare the effectiveness of cognitive behavioral therapy (CBT), lisdexamfetamine (LDX), and the combination of CBT and LDX for the treatment of binge-eating disorder in patients with obesity.
- Trial name
- NCT03924193
- Testing
- Lisdexamfetamine Dimesylate, Cognitive-Behavioral Therapy, Combination LDX and Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Yale University
Acute Pain, Lidocaine
Pharmacokinetic Profile of Lidocaine Given as a Weight-based Infusion for Postoperative Surgical Pain Control
Study Summary Title Pharmacokinetic profile of lidocaine given as a weight-based infusion for postoperative surgical pain control Short Title Pharmacokinetic profile of lidocaine given as a weight-based infusion for postoperative…
- Conditions
- Acute Pain, Lidocaine, Administration and Dosage
- Trial name
- NCT05402293
- Testing
- Blood samples to measure lidocaine levels
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University of Alberta
Diet, Healthy, Protein; Disease
Acute Meat and Alternative Intake (PRotEin DIet SatisfacTION Trial 3)
Introduction: Protein rich foods that are alternatives to farm-grown meat have received considerable consumer attention. Whilst meat alternatives were once niche food products aimed at vegetarians, they are increasingly marketed…
- Trial name
- PREDITION (NCT04545398)
- Testing
- Food. Beef, Pasture-raised, Food. Beef, Grain-fed, Food. Meat alternative
- Where
- New Zealand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Myocardial Infarction
ShenFu Injection for Myocardial Protection in Patients With Acute ST Segment Elevation Myocardial Infarction
The purpose of this study is to evaluate whether perioperative use of Shenfu Injection could reduce myocardial injury (enzymatic infarct size and infarct volume according to cardiac magnetic resonance imaging) in patients with…
- Trial name
- SF-STEMI (NCT02709798)
- Testing
- Shenfu Injection, 5% Glucose Injection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Anzhen Hospital
Sleep Apnea, COPD Exacerbation
Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA Overlap Syndrome (CO-OS)
Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) are both frequent respiratory diseases with estimated prevalences between 8 and 15% of the adult population.
- Conditions
- Sleep Apnea, COPD Exacerbation, Overlap Syndrome
- Trial name
- SLEEPOVEA (NCT05958563)
- Testing
- continuous positive airway pressure treatment
- Where
- 15 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Angers
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