Clinical trials: Acute Coronary Syndrome/ Myocardial Infarction
Myocardial Infarction
REPAIR-AMI: Intracoronary Progenitor Cells in Acute Myocardial Infarction (AMI)
Impaired contractile function after a heart attack of the heart is a major cause of "heart failure" limiting quality of life and prognosis, which cannot be prevented even with optimal standard therapy, including immediate…
- Trial name
- NCT00279175
- Testing
- Intracoronary infusion of enriched bone marrow-derived progenitor cells
- Where
- 17 sites in Germany, Switzerland
- Volunteers
- 204 people
- Sponsor
- A. M. Zeiher
ST Elevation Myocardial Infarction
Shanghai ST-segment Elevation Myocardial Infarction Cohort
ST-segment elevation myocardial infarction(STEMI) remains a major cause of morbidity and mortality worldwide, despite of the early reperfusion therapy, including fibrinolysis, primary percutaneous coronary intervention (PCI),and…
- Trial name
- NCT05450757
- Where
- 7 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Ruijin Hospital
Acute Myocardial Infarction
Ischemic Time and Extent of Myocardial Infarction (MI) With Cardiac Magnetic Resonance Imaging (CMRI) in Patients With ST Elevation Myocardial Infarction (STEMI) and Primary Percutaneous Coronary Intervention (PCI) Study
This study will assess relationship between ischemic time and the extent of myocardial infarction with cardiac magnetic resonance image in patients with STEMI (ST elevation myocardial infarction) and primary percutaneous coronary…
- Trial name
- ITEMMRI (NCT01401881)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medstar Health Research Institute
Acute Myocardial Infarction
Therapeutic Use of Ultrasound in Acute Coronary Artery Disease
In acute coronary artery disease, pre-clinical studies have indicated that, during a continuous infusion of intravenous perfluorocarbon containing microbubbles, the ultrasonic power delivered from a diagnostic ultrasound…
- Trial name
- NCT02410330
- Testing
- Therapeutic ultrasound with 20 usec, Repeated diagnostic high mechanical index
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Disease
Comparison of MECHANISM of Early and Late Vascular Responses Following Treatment of ST-elevation Acute Myocardial Infarction With Two Different Everolimus-eluting Stents: Randomized Controlled Trial Between Biodegradable Polymer and Durable Polymer Stent (MECHANISM-AMI-RCT)
To place two different everolimus-eluting stents (EES), a bioabsorbable polymer EES (Synergy®) and a permanent-type polymer EES (Xience®), randomly to the ST-elevation acute myocardial infarction (AMI) and to observe and compare…
- Trial name
- NCT03726892
- Testing
- PCI
- Where
- Japan
- Volunteers
- 120 people
- Sponsor
- Iwate Medical University
Cardiogenic Shock
Study on Early Intra-aortic Balloon Pump Placement in Acute Decompensated Heart Failure Complicated by Cardiogenic Shock
The aim of the study is to demonstrate the superiority of early intra-aortic balloon pump implantation at admission over local clinical practice (pharmacological only) in acute decompensated heart failure patients with…
- Trial name
- Altshock-2 (NCT04369573)
- Testing
- Early intra-aortic balloon pump (IABP) implantation, Standard of care as vasoactive agent
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Acute Coronary Syndrome
Infarction Register
The Aachener Digitale Myokardinfarkt Register (ADMIRE) is a prospektive registry study which was designed in order to obtain data of patients with acute coronary syndrome and herewith control and optimize guideline conform…
- Trial name
- ADMIRE (NCT00763945)
- Testing
- data collection
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- RWTH Aachen University
Early Management, Acute Heart Failure
Early Management Strategies of Acute Heart Failure for Patients With NSTEMI
There are always poor outcomes in patients with acute myocardial infarction(AMI) combined with elevated BNP/NT-proBNP level. An elevated BNP/NT-proBNP level highly indicates acute heart failure(AHF).Levosimendan is recommended in…
- Conditions
- Early Management, Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- EMSAHF (NCT03189901)
- Testing
- Regular management+Levosimendan
- Where
- 14 sites in China
- Volunteers
- 470 people
- Sponsor
- Qilu Hospital of Shandong University
Myocardial Infarction
Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial.
The purpose of this study is to test whether early pre-reperfusion metoprolol administration in patients suffering and acute myocardial infarction might reduce the size of myocardial necrosis.
- Trial name
- METOCARD-CNIC (NCT01311700)
- Testing
- Injectable (i.v.) metoprolol tartrate (up to 15 mg).
- Where
- 12 sites in Spain
- Volunteers
- 221 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Acute Coronary Syndrome
Prognosis of Treated Acute Coronary Syndrome Patients: a Multicenter Study
The MPCS-ACS Study (Multicenter Prospective Cohort Study on Acute Coronary Syndrome) is a comprehensive, forward-looking research project designed to evaluate the prognostic outcomes of patients diagnosed with acute coronary…
- Trial name
- MPCS-ACS (NCT05164601)
- Testing
- No Intervention - Observational Only
- Where
- 2 sites in China
- Volunteers
- 22,500 people
- Sponsor
- Xiang Xie
Myocardial Infarction
Post-conditioning to Reduce Infarct Size
When angioplasty (PTCA) and stenting of the blood vessels of the heart is the treatment for a Heart Attack, there is damage to the heart muscle that is caused by the sudden opening of the blood vessels.
- Trial name
- NCT00755469
- Testing
- Post-conditioning
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Minneapolis Heart Institute Foundation
ST Elevation Myocardial Infarction, Acute Coronary Syndrome
Effects of Acute, Rapid Lowering of LDL Cholesterol With Alirocumab in Patients With STEMI Undergoing Primary PCI
A randomized, double-blind, placebo controlled parallel group clinical trial evaluating the effects of acute treatment with a PCSK9 inhibitor (alirocumab) versus placebo on low-density lipoprotein (LDL) in 100 high-risk patients…
- Conditions
- ST Elevation Myocardial Infarction, Acute Coronary Syndrome, Hypercholesterolemia, Hyperlipidemias
- Trial name
- EPIC STEMI (NCT03718286)
- Testing
- Alirocumab
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Population Health Research Institute
Myocardial Infarction, Acute Coronary Syndrome
Impact on Public HEalth of a Network in Acute Myocardial Infarction Care
This is a multicenter retrospective observational study with STEMI (ST Elevation Myocardial Infarction) patients who have been treated in the northern Galician Hospitals.
- Trial name
- iPHENAMIC (NCT02501070)
- Where
- Spain
- Volunteers
- 5,937 people
- Sponsor
- Complexo Hospitalario Universitario de A Coruña
Acute Myocardial Infarction (AMI)
Acute MI UDMI Staging Diagnosis by High-sensitivity Cardiac Troponin-I
TROP-MI-STAGE is a multicenter retrospective diagnostic study designed to evaluate the role of high-sensitivity cardiac troponin I (hs-cTnI) in the diagnosis and clinical stage classification of acute myocardial infarction as…
- Trial name
- TROP-STAGES-MI (NCT07163988)
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- Rohan Dharmakumar
Myocardial Infarction, Acute, Heart Failure, Left Sided
Study to Assess Efficacy and Safety of CDR132L in Patients With Reduced Left Ventricular Ejection Fraction After Myocardial Infarction
This is a Phase 2, multicenter, randomized, parallel, 3-arm, placebo-controlled study to assess efficacy and safety of CDR132L in patients with reduced Left Ventricular Ejection Fraction (LVEF) (≤ 45%) after myocardial infarction…
- Trial name
- HF-REVERT (NCT05350969)
- Testing
- CDR132L
- Where
- 49 sites in Czechia, Germany and 6 more
- Volunteers
- 294 people
- Sponsor
- Cardior Pharmaceuticals GmbH
Vascular Diseases, Cardiovascular Diseases
The Long-term and Short-term Efficacy and Safety of Transplantation Autologous Bone Marrow Cells (BMCs) in Patients With the First STEMI (ST Segment Elevation Myocardial Infarction)
The purpose of this study is to test the hypothesis that the intracoronary transplantation of autologous mononuclear and CD 133 + bone marrow cells will improve left ventricular contractile function and will reduce the combined…
- Conditions
- Vascular Diseases, Cardiovascular Diseases, Acute Myocardial Infarction
- Trial name
- ESTABOMA (NCT01748383)
- Testing
- Transplantation of BMMCs, Transplantation of CD 133+ cells, stenting of IRA
- Where
- Russia
- Volunteers
- 85 people
- Sponsor
- Russian Academy of Medical Sciences
Cardiac Arrhythmias, Acute Myocardial Infarction (AMI)
Predict Arrhythmia Risk Using Intelligent Software
Cardiac arrhythmias frequently occur in patients admitted to the Coronary Care Unit (CCU). The majority of these patients are treated for an acute myocardial infarction, which carries an increased risk of life-threatening…
- Conditions
- Cardiac Arrhythmias, Acute Myocardial Infarction (AMI), Ventricular Tachycardia (VT), Ventricular Fibrillation
- Trial name
- PARIS (NCT07792694)
- Where
- Netherlands
- Volunteers
- 3,000 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Medication Adherence, Myocardial Infarction
A Nursing Intervention Program to Improve Therapeutic Adherence in Elderly People With Acute Myocardial Infarction
The objective of this study was to assess the impact of a nursing intervention on therapeutic adherence in elderly patients after acute myocardial infarction compared to a control group
- Trial name
- NCT04662762
- Testing
- Nursing intervention programme
- Volunteers
- 160 people
- Sponsor
- Hospital Universitari de Bellvitge
Myocardial Infarction, Cerebral Infarction
Acute Myocardial Infarction and Acute Cerebral Infarction (AMIAC) Registry and Follow-up
A registry of consecutive patients who were admitted and diagnosed with acute myocardial infarction or acute cerebral infarction were conducted at the Guangdong General Hospital or the First Affiliated Hospital of Guangzhou…
- Conditions
- Myocardial Infarction, Cerebral Infarction, Chronic Kidney Diseases, Mortality
- Trial name
- AMIAC (NCT03166696)
- Where
- 3 sites in China
- Volunteers
- 30,000 people
- Sponsor
- Guangdong Provincial People's Hospital
STEMI, NSTEMI
Prediction of Adverse Events From Non-PCI Coronary Plaques Using Machine Learning
The aim of our project is to predict, with the help of artificial intelligence (AI) and machine learning techniques, the natural history of non-flow-limiting coronary stenoses and to develop and validate a machine learning risk…
- Conditions
- STEMI, NSTEMI, Chronic Coranary Sindrome, Unstable Angina (UA)
- Trial name
- Predict AI (NCT07866144)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
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