Clinical trials: Acute Coronary Syndrome
Acute Coronary Syndrome
A2 AR as a Novel Biomarkers for Physician Decision-making Improvement Evaluation's Patients With Suspected Acute Coronary Syndrome But Negative Troponin.
One proposed strategy is the stratification of troponin-negative patients with biomarker testing at presentation to facilitate the clinically-appropriate rapid discharge from the emergency department of patients who present with…
- Trial name
- NCT03218007
- Testing
- blood samples
- Where
- France
- Volunteers
- 83 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Coronary Syndrome
The Effect of Clopidogrel and Ticagrelor With and Without Acetylsalicylic Acid (ASA) on Hemostatic System Activation at the Site of Plug Formation in Vivo in Man
Background: Coronary heart disease is the most common cause of death in industrialized countries. Revascularisation by percutaneous coronary angioplasty or thrombolysis is the main principle for treatment of the acute coronary…
- Trial name
- NCT02120092
- Testing
- Clopidogrel, Ticagrelor, ASA
- Where
- Austria
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Coronary Disease, Hypercholesterolemia
Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS)
The purpose of this study is to compare the effects of pitavastatin and atorvastatin on coronary plaque volume in patients with acute coronary syndrome and to clarify the relationship between coronary plaque volume, serum lipids…
- Trial name
- NCT00242944
- Testing
- Pitavastatin, Atorvastatin
- Where
- 3 sites in Japan
- Volunteers
- 307 people
- Sponsor
- Kyoto University
Ischemic Stroke, Acute Coronary Syndrome
Comparative Study of Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome
A pilot, prospective, comparative study. To include both male and female patients who have presented an ischaemic stroke (full stroke or TIA) or an ACS, 5 to 30 days prior to inclusion.
- Conditions
- Ischemic Stroke, Acute Coronary Syndrome, Obstructive Sleep Apnea Syndrome
- Trial name
- AVC/SCA (NCT00926874)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Pulmonary Hypertension, Valvular Heart Disease
Evaluating Right Ventricular (RV) Size and Function Using the Upper Valley RV Algorithm and Novel Imaging Modalities
The primary purpose of this study is to evaluate the diagnostic performance of three methods for measuring right ventricular size and function including the Philips Novel RV quantification technologies (RV Heart Model volumetric…
- Conditions
- Pulmonary Hypertension, Valvular Heart Disease, Congenital Heart Disease, Congestive Heart Failure
- Trial name
- UVRV (NCT03935178)
- Testing
- Measuring Right Ventricular Size and Function
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Coronary Artery Disease
Very Early veRsus Deferred Invasive Evaluation Using Computerized Tomography in Patients With Acute Coronary Syndromes
The aim of this study is to evaluate if acute invasive coronary evaluation and treatment conducted within 12 hours of diagnosis improves clinical outcome compared to a deferred, subacute strategy in patients with unstable angina…
- Trial name
- VERDICT-EDI (NCT02061891)
- Testing
- Invasive coronary evaluation (Deferred), Invasive coronary evaluation (Acute)
- Where
- Denmark
- Volunteers
- 2,500 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Smoking Cessation
The Safety of Transdermal Nicotine Immediately Following an Acute Coronary Syndrome
Continuing to smoke after having a heart attack greatly increases the risk of death and cardiac illness. The nicotine patch is a commonly used pharmacotherapy for smoking cessation and has great potential to help heart attack…
- Trial name
- STADIA (NCT00990197)
- Testing
- Transdermal nicotine patch
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Heart Failure, Sleep Apnea, Obstructive
Adaptive Servo-Ventilation In Acute Heart Failure Patients Protecting the Heart and Kidneys
The primary hypothesis of this study is: the use of minute ventilation-adaptive servo-ventilation (MV-ASV) during hospitalization will mitigate deterioration in renal function and prevent kidney injury in patients admitted with…
- Trial name
- ASLEEP PK (NCT02796638)
- Testing
- Adaptive Servo-Ventilation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Veterans Medical Research Foundation
Acute Coronary Syndrome (ACS)
EndoTic - Endothelium and Ticagrelor
Randomized clinical trial to assess the influence of treatment with ticagrelor or clopidogrel in the number of CECs (Circulating Endothelial Cells) and EPCs (Endothelial Progenitor Cells) in patients with ACS (Acute Coronary…
- Trial name
- NCT02244710
- Testing
- Ticagrelor vs Clopidogrel
- Where
- 3 sites in Spain
- Volunteers
- 109 people
- Sponsor
- Fundación Investigación Sanitaria en León
Acute Coronary Syndrome, Diabetes Mellitus
Platelet Aggregation in Diabetic Patients With Acute Coronary Syndrome Treated With Different Doses of Aspirin
Diabetes is an important risk factor of coronary atherosclerosis, and it's well known that platelets of diabetic patients are hyper reactive and so resistant to common antithrombotic therapy.
- Trial name
- DIABE-ASACS (NCT05293808)
- Testing
- aspirin 100 mg bis in die, aspririn 200 mg once daily, aspirin 100 mg once daily
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Federico II University
Respiratory Virus Infection, Stroke
Respiratory Virus Infections in Acutely Hospitalized Adult Patients With Pulmonary and Extrapulmonary Complications
Respiratory virus infections are one of the major causes of hospitalizations, and outbreaks of respiratory virus infection have led to severe economic loss.
- Conditions
- Respiratory Virus Infection, Stroke, Lung Disease, Acute Coronary Syndrome
- Trial name
- NCT03816059
- Testing
- Respiratory virus testing
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Acute Coronary Syndrome
The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin
Heart attacks are usually caused by clots in a coronary artery, depriving the heart muscle of blood. Platelets are the main type of blood cell causing clots to form and physicians typically give a combination of two anti-platelet…
- Trial name
- WILLOW TREE (NCT03869268)
- Testing
- Aspirin, Ticagrelor
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Acute Coronary Syndrome
Comparison of Strut Coverage With OPTIMAX Versus SYNERGY Stents
The purpose of this study is to compare vascular healing of the stented segment after deployment of titanium-nitride-oxide coated cobalt-chromium OPTIMAX™ bio-active stent (BAS) and SYNERGY™ everolimus-eluting stent (EES) in…
- Trial name
- OPTIMAX-OCT (NCT02464397)
- Testing
- Stent
- Where
- 2 sites in Belgium, Finland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- The Hospital District of Satakunta
Congestive Heart Failure, Infections
Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?
There is evidence to suggest that patients make different end-of-life decisions if they understand the risks, benefits and alternatives of CPR and mechanical ventilation.
- Conditions
- Congestive Heart Failure, Infections, Sepsis, Acute Renal Failure
- Trial name
- NCT01878968
- Testing
- Script and CPR/Mechanical ventilation video.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jewish Hospital, Cincinnati, Ohio
Acute Coronary Syndrome
GALNT4 in Patients With Acute Coronary Syndrome
The expression of GALNT4 in blood with acute coronary syndrome
- Trial name
- NCT03335514
- Testing
- expression of GALNT4
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Acute Coronary Syndromes
Nitrate - Clopidogrel - Acute Coronary Syndrome
This study aims to investigate whether intravenous nitrate given during non-ST-elevation myocardial infarction (non-STEMI) affects the platelet inhibition of clopidogrel.
- Trial name
- NCT06878638
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Bursa Postgraduate Hospital
Chest Pain, Acute Coronary Syndrome
The Evaluation and Management of Patients With Acute Chest Pain in China
The purpose of this study is to describe the characteristics, evaluation, management and outcomes of acute chest pain, and to provide opportunities for future initiatives to improve the emergency care for patients experiencing…
- Trial name
- NCT02384863
- Where
- 7 sites in China
- Volunteers
- 18,000 people
- Sponsor
- Yuguo Chen
Acute Coronary Syndrome, Myocardial Infarction
Future Optimal Research and Care Evaluation
Rationale: Acute coronary syndrome (ACS) is the leading cause of death worldwide. To improve cardiovascular care, research is needed.
- Trial name
- FORCE-ACS (NCT03823547)
- Where
- 4 sites in Netherlands
- Volunteers
- 99,999 people
- Sponsor
- J.M. ten Berg
Acute Coronary Syndrome
Different Doses of Rosuvastatin Therapy on Regression of Critical Coronary Atherosclerosis in ACS Patients
The purpose of this study is to determine whether Rosuvastatin 10mg/d or 20mg/d for 36 weeks can regress critical coronary atherosclerosis as determined by IVUS imaging in Chinese Acute Coronary Syndrome (ACS) patients.
- Trial name
- NCT02420899
- Testing
- rosuvastatin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Friendship Hospital
Angina, Unstable
Pilot Study on Shear-induced Platelet Aggregation in Acute Coronary Syndromes
The purpose of this study is to determine whether shear-induced platelet aggregation is able to discriminate first acute coronary syndrome (ACS) from recurrent ACS
- Trial name
- REACS (NCT00299143)
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France