Clinical trials: Acute Coronary Syndrome (ACS)
Acute Coronary Syndrome
Effects of Beta-blockade on Platelet Aggregation in Acute Coronary Syndrome
The Investigators will test the hypothesis that nonselective beta-blockers would have a more pronounced effect on platelet aggregation than selective beta-blockers in patients with acute coronary syndrome treated with dual anti…
- Trial name
- PLATE-BLOCK (NCT02809820)
- Testing
- Carvedilol, Metoprolol
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD)
Fexuprazan for Prevention of Upper Gastrointestinal Bleeding in High Bleeding Risk Patients Receiving Dual Antiplatelet Therapy
This study evaluates whether fexuprazan is effective in preventing upper gastrointestinal bleeding and related upper gastrointestinal clinical events in high bleeding risk patients who require dual antiplatelet therapy after…
- Trial name
- SAINT-FEXUDAPT (NCT07479056)
- Testing
- Fexuprazan 40mg, Lansoprazole 30mg
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- SUK MIN SEO
Acute Coronary Syndrome
Short-term Dual Anti Platelet Therapy in Patients With ACS Treated With the COMBO Dual-therapy Stent
Background: The optimal duration of dual antiplatelet therapy in ACS patients treated with DES is still under debate. This is especially true for STEMI patients in the era of new anticoagulants and antiplatelet agents.
- Trial name
- REDUCE (NCT02118870)
- Testing
- Treatment 90 days DAPT, Treatment 360 days DAPT
- Volunteers
- 1,500 people
- Sponsor
- Diagram B.V.
Acute Coronary Syndrome
"MetCool ACS"- Metformin "Cooling" Effect on Metformin-naive Patients Treated With PCI Because of Acute Coronary Syndrome
The aim of the study is the evaluation of the effect of metformin among the patients without diabetes, on the incidence of reintervention, unplanned revascularization, after full percutaneous coronary revascularization as a…
- Trial name
- NCT05305898
- Testing
- Metformin
- Where
- 14 sites in Poland
- Volunteers
- 2,000 people
- Sponsor
- Military Institute od Medicine National Research Institute
Chest Pain
Diagnostic Utility of Copeptin in Addition to High-sensitivity Cardiac Troponin for the Early Diagnosis of NSTE-ACS
Rapid and reliable exclusion of acute myocardial infarction (AMI) during an emergency department (ED) triage is a major unmet clinical need.
- Trial name
- COPACS (NCT01962506)
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- G. d'Annunzio University
Cost Sharing, Acute Coronary Syndrome
Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study
Current patterns of P2Y12 receptor inhibitor use provide an excellent opportunity to test the impact of copayment reduction on clinician choice of medication, patient adherence, and clinical outcomes.
- Trial name
- ARTEMIS (NCT02406677)
- Testing
- Study voucher card
- Where
- 272 sites in United States, Puerto Rico
- Volunteers
- 11,001 people
- Sponsor
- AstraZeneca
Acute Coronary Syndrome, Coronary Artery Disease
IPD Meta-analysis of De-escalation Treatment Strategy After PCI in ACS
We will perform a systemic review of previously published data and an updated patient-level meta-analysis of studies, including the most recent publications.
- Trial name
- NCT04848766
- Testing
- De-escalation Treatment Strategy of dual antiplatelet therapy
- Where
- South Korea
- Volunteers
- 9,000 people
- Sponsor
- Seoul National University Hospital
Acute Coronary Syndrome, Chest Pain
Efficacy Evaluation of Observation Unit Cardiac Magnetic Resonance Imaging (MRI) in Patients With Intermediate Risk Acute Chest Pain
The purpose of this study is to investigate the best way to evaluate patients with chest pain in the emergency department. It compares types of cardiac tests performed while receiving treatment in an observation unit.
- Trial name
- NCT00869245
- Testing
- OU - Cardiac MRI, OU - Conventional Care Testing
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Wake Forest University Health Sciences
Acute Coronary Syndrome
PLIN1 Variants in Precocious ACS (SCAPLIN)
This study aims to identify a genetic predisposition factor of precocious acute coronary syndrome occurrence (ACS). ACS is a major public health problem and the first cause of mortality in the world.
- Trial name
- NCT04904432
- Testing
- PLIN1 gene sequencing
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Coronary Syndrome
Randomized Trial of Prehospital Tropin Levels in Acute Coronary Syndrome (ACS)
This study randomizes patients seen by Redmond Medic One into a control arm and a study arm when they present with acute coronary syndrome and have non-contributory ECG's (i.e.non-STEMI).
- Trial name
- NCT00764205
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Redmond Fire Department Medic One
Acute Coronary Syndromes (ACS)
Influenza Vaccination After Acute Coronary Syndrome
The goal of this clinical trial is to learn if influenza vaccination can prevent adverse cardiac events in Chinese acute coronary syndrome patients.
- Trial name
- InVaACS (NCT07259252)
- Testing
- Influenza vaccine
- Where
- China
- Volunteers
- 6,620 people
- Sponsor
- Tongji Hospital
ACS - Acute Coronary Syndrome
Positive Psychology for Acute Coronary Syndrome Patients
This is a randomized controlled pilot trial in approximately 50 acute coronary syndrome patients to determine if a 12 week, telephone-delivered, combined positive psychology-motivational interviewing intervention is feasible and…
- Trial name
- PEACE-IV (NCT03122184)
- Testing
- Positive Psychology + Motivational Interviewing, Motivational Interviewing Health Education
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Massachusetts General Hospital
Acute Coronary Syndromes (ACS), Cardiac Rehabilitation
Patient-centered Personalized Cardiac Rehabilitation in Post Acute Coronary Syndrome (BREAK-trial)
The primary objective of this study is to compare an integrated, multidisciplinar patient-centered CRP (Cardiac Rehabilitation Program) (intervention group) especially focused on covering the needs for the female and fragile…
- Conditions
- Acute Coronary Syndromes (ACS), Cardiac Rehabilitation, Frailty, Women
- Trial name
- BREAK (NCT07038265)
- Testing
- Personalised treatment, Usual Care
- Where
- Spain
- Volunteers
- 202 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Dyslipidemia Associated With Acute Coronary Syndrome
Levels of Triglycerides and HDL-C in ACS Patients
Background Changes in high-density lipoprotein cholesterol and triglyceride levels have been linked to residual cardiovascular risk, whereas non-high density lipoprotein levels have been shown to be more predictive of…
- Trial name
- NCT03429517
- Testing
- Lipogram
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Non ST Segment Elevation Acute Coronary Syndrome
MCG for Identification of Myocardial Ischemia in Suspected NSTE-ACS Patients
The goal of this multi-center observational study is to learn about the effectiveness of magnetocardiography in rapid and accurate identification of ischemia in patients with suspected NSTE-ACS.
- Trial name
- NCT06197724
- Testing
- Magnetocardiography
- Where
- China
- Volunteers
- 14,090 people
- Sponsor
- Qilu Hospital of Shandong University
Acute Coronary Syndrome, Myocardial Infarction (MI)
Clinical Echocardiography and S' Wave for Early Recognition of Acute Coronary Syndrome in the Emergency Department, A Prospective Study
The goal of this prospective observational study is to assess the diagnostic accuracy of the tissue Doppler imaging (TDI) S' wave in detecting acute coronary syndrome (ACS) in adult patients presenting to the emergency department…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction (MI), Non-ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- CLEAR_ECHO (NCT06860997)
- Testing
- Tissue Doppler Imaging (TDI) S' Wave Echocardiography
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Acute Coronary Syndromes, Flow Mediated Dilation
A Prospective, Single-center, Observational Study Aiming to Assess the Predictive Role of Flow Mediated Dilatation in Acute Coronary Syndromes, Combined With Echocardiographic and Biochemical Indices
A prospective, single-center, observational study aiming to assess the predictive role of flow mediated dilatation in acute coronary syndromes, combined with echocardiographic and biochemical indices.
- Conditions
- Acute Coronary Syndromes, Flow Mediated Dilation, Endothelial Function (FMD)
- Trial name
- FLARE-ACS (NCT06890013)
- Testing
- Observation group
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Percutaneous Coronary Intervention
Pharmacodynamic Effects of Cangrelor in ACS or CCS Patients Undergoing PCI (POMPEII Registry)
This prospective registry was designed to carefully investigate the pharmacodynamic (PD) effects of cangrelor in all patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- POMPEII (NCT04790032)
- Testing
- Cangrelor
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Federico II University
Myocardial Infarction
Patients With Non-ST-segment Elevation Acute Coronary Syndrome
There are two types of acute coronary syndrome (ACS): ACS with persistent ST segment elevation (ACS ST +) and ACS without ST segment elevation (non-ST + ACS).
- Trial name
- SCA (NCT05159973)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
ST Elevation Myocardial Infarction
Effect of DLBS1033 After Primary PCI in Patients With STE-ACS
This is a prospective, randomized, double-blind, double-dummy, and controlled clinical study over a total of 4-week therapy with DLBS1033 in the management of STE-ACS after a primary PCI.
- Trial name
- NCT02976701
- Testing
- DLBS1033, Standard therapy
- Where
- Indonesia
- Volunteers
- 23 people
- Sponsor
- Dexa Medica Group