Clinical trials: Acute Coronary Syndromes
Non ST Elevation Myocardial Infarction
Clinical Effects of Eptifibatide Administration in High Risk Patients Presenting With Non-ST Segment Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Urgent Coronary Artery Bypass Graft Surgery in Short- and Long-Term Follow-up
1. INTRODUCTION Through last couple of years the number of patients treated for acute coronary event without persistent ST segment elevation in ECG has been growing.
- Trial name
- NCT01863134
- Testing
- Eptifibatide
- Where
- 6 sites in United States, Poland
- Volunteers
- 140 people
- Sponsor
- Medical University of Silesia
Coronary Disease
Effects of Atorvastatin on Myonecrosis
This study is designed as a prospective, randomized, placebo-controlled, double-blind analysis of atorvastatin 80 mg versus placebo administered on average 4 hours prior to percutaneous coronary intervention [PCI] (at least 2…
- Trial name
- NCT00344019
- Testing
- Atorvastatin 80mg, Screening
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Coronary Syndrome, Coronary Artery Disease
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
The primary objective of this study is to assess the accuracy in terms of sensitivity, specificity, negative and positive predicted values of the DL-based algorithm with respect to correct identification of the plaque and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- FOCUS DL (NCT06186336)
- Testing
- Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- GE Healthcare
Sleep Apnea, Obstructive, Acute Myocardial Infarction
Obstructive Sleep Apnea and Acute Myocardial Infarction and the Role of Continuous Positive Airway Pressure (CPAP)Treatment
Specific Aim 1. To determine the prevalence of OSA in patients of first-time AMI in acute phase By screening patients of first-time, single-vessel disease, Killip I AMI, and successful revascularization 2.
- Trial name
- NCT00821210
- Testing
- CPAP of optimal pressure
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Cardiovascular Diseases, Acute Coronary Syndrome
Pharmacogenomics of Anti-platelet Intervention-2 (PAPI-2) Study
It is standard treatment to take anti-platelet medication after cardiac catheterization and stent placement to help prevent the formation of blood clots that may cause heart attack or stroke.
- Trial name
- PAPI-2 (NCT01452152)
- Testing
- clopidogrel, prasugrel
- Where
- 5 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Maryland, Baltimore
Acute Coronary Syndrome
The GReek AntiPlatElet (GRAPE) Registry: A Multicenter Observational Prospective Investigation of Antiplatelet Treatment in Patients With Acute Coronary Syndrome Subjected to Percutaneous Coronary Intervention
This is a multicenter, prospective, observational investigation, focusing of antiplatelet treatment in patients with moderate to high risk acute coronary syndrome (TIMI risk score ≥3)subjected to percutaneous coronary…
- Trial name
- GRAPE (NCT01774955)
- Where
- 9 sites in Greece
- Volunteers
- 2,047 people
- Sponsor
- University of Patras
Acute Coronary Syndrome
Invasive vs Conservative Strategies in Non-ST-elevation Acute Coronary Syndrome and Comorbidities
The guidelines of clinical practice, based on the randomized studies, recommend an invasive strategy in non-ST elevation acute coronary syndrome (NSTEACS).
- Trial name
- MOSCA (NCT01645943)
- Testing
- Coronary angiogram
- Where
- 6 sites in Spain
- Volunteers
- 109 people
- Sponsor
- University of Valencia
Heart Failure, Acute Coronary Syndrome
Bace1as Role in Heart Failure (BACE1AS-HF)
The objective of this project is 1) to explore the clinical relevance of BACE1-AS and BACE1 as therapeutic targets and 2) to evaluate their potentiality as biomarkers in ischemic heart failure (HF).
- Trial name
- BACE1AS-HF (NCT06213493)
- Testing
- measurement of RNAs
- Where
- Italy
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Acute Coronary Syndrome, Platelet Function
Sampling P2Y12 Receptor Inhibition With Prasugrel and Ticagrelor in Patients Submitted to Thrombolysis
Introduction: Platelet aggregation plays an important role in ischemic complications in patients undergoing to percutaneous coronary intervention (PCI).
- Trial name
- SAMPA (NCT02215993)
- Testing
- Prasugrel, Ticagrelor
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Acute Coronary Syndrome
DAPT Strategy in HBR Patients Undergoing Complex PCI Following ACS: Second-Phase Beta Testing of a Patients Decision Aid
Among patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) and stent implantation, 17.5% are both at high bleeding risk (HBR) and have undergone complex PCI, which also places them at…
- Trial name
- BETA-DAPT (NCT07391358)
- Testing
- Patient decision aid to support shared decision-making between patients and clinicians
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Montreal Heart Institute
Atrial Fibrillation, Acute Coronary Syndrome
The Safety and Efficacy Of Rivaroxaban and Ticagrelor for Patients With Atrial Fibrillation After Percutaneous Coronary Intervention
Currently, there is minimal data on the combination of rivaroxaban and ticagrelor in patients with atrial fibrillation (AF) managed with percutaneous coronary intervention (PCI).
- Trial name
- CAPITAL PCI AF (NCT03331484)
- Testing
- Ticagrelor, Rivaroxaban
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Type 2 Diabetes Mellitus, Acute Coronary Syndrome
Association Between Time in Range and In-hospital Outcomes in Type 2 Diabetic Patients With Acute Coronary Syndrome
The aim of this study is to use real-time continuous glucose monitoring (real-time CGM) system to get a 14-days blood glucose profile of the hospitalized type 2 diabetes mellitus (T2DM) patients with acute coronary syndrome…
- Trial name
- NCT05389254
- Testing
- continuous glucose monitoring system, capillary blood glucose monitoring
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ningbo No. 1 Hospital
Shock, Cardiogenic, Myocardial Infarction
Efficacy Study of LV Assist Device to Treat Patients With Cardiogenic Shock (ISAR-SHOCK)
The purpose of this study is to evaluate the efficacy and safety of a left ventricular assist device in comparison to a standard treatment with an intraaortic balloon pump (IABP) in patients with cardiogenic shock due to left…
- Trial name
- NCT00417378
- Testing
- Left Ventricular Assist Device Impella LP 2.5, Intraaortic Balloon Pump
- Where
- 2 sites in Germany
- Volunteers
- 26 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Acute Coronary Syndrome (ACS), High On-treatment Platelet Reactivity (HTPR)
The Effect of IV Cangrelor and Oral Ticagrelor Study
Major heart attacks are caused by a number of factors, the two major of which are furring up of a coronary artery with atheroma and then sudden clot formation on this area leading to a blockage and interruption of blood flow.
- Conditions
- Acute Coronary Syndrome (ACS), High On-treatment Platelet Reactivity (HTPR), Microvascular Obstruction (MVO), ST-segment Elevation Myocardial Infarction (STEMI)
- Trial name
- NCT02733341
- Testing
- Cangrelor, Ticagrelor
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
COVID-19 Associated Cardiac Involvement, Remodeling, Left Ventricle
Myocardial Protection in Patients With Post-acute Inflammatory Cardiac Involvement Due to COVID-19
Long COVID or Postacute sequelae of COVID-19 infection (PASC) are increasingly recognised complications, defined by lingering symptoms, not present prior to the infection, typically persisting for more than 4 weeks.
- Conditions
- COVID-19 Associated Cardiac Involvement, Remodeling, Left Ventricle, Remodeling, Vascular, Left Ventricular Dysfunction
- Trial name
- MYOFLAME-19 (NCT05619653)
- Testing
- Prednisolone, Losartan
- Where
- 5 sites in Austria, Germany
- Volunteers
- 279 people
- Sponsor
- Valentina Puentmann
Acute Coronary Syndromes
Low-Dose IL-2 For The Reduction Of Vascular Inflammation In ACS -Clinical Outcomes & Follow-up Study
The preceding IVORY trial (NCT04241601) has completed. As atherosclerosis and its complications are driven by inflammation the investigators hypothesise that treatment with low-dose IL2 may reduce adverse cardiovascular outcomes…
- Trial name
- IVORY-FINALE (NCT06427694)
- Testing
- Aldesleukin, Dextrose 5% in water
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Acute Coronary Syndrome
Stress-Delta Biomarkers for Acute Coronary Syndrome Risk Stratification
Acute Coronary Syndrome (ACS) is a serious heart condition that is a leading cause of death in America. Cardiac stress testing is currently the best test to non-invasively identify which patients might be having ACS and may need…
- Trial name
- NCT02717702
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Duke University
Cardiovascular Diseases, Acute Coronary Syndrome
Testing P2Y12 Platelet Inhibitors Generics Beyond Bioequivalence
This is a pilot study that was conducted to prove the efficacy and safety of ticagrelor generically named Ticaloguard® compared to its brand Brilique® in healthy volunteers.
- Trial name
- NCT05474053
- Testing
- Ticagrelor 90mg (Brilique), Ticagrelor 90mg (Ticaloguard)
- Where
- Egypt
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Coronary Syndrome
Reducing Acute Coronary Syndrome Patient Delay
1. To test the effectiveness of the theory-based interventions (text+visual and text-only BCT-based interventions) against usual care in changing patients' intentions to phone ambulance immediately with symptoms of ACS ≥ 15…
- Trial name
- RAPiD (NCT02820103)
- Testing
- Text+Visual BCT-based intervention, Text-only BCT intervention, Leaflet information (control)
- Where
- United Kingdom
- Volunteers
- 177 people
- Sponsor
- Edinburgh Napier University
Sepsis, Cardiac Arrest
Thigh Muscle Mass and Muscle Wasting in Patients in the Emergency Department
The goal of this observational study is to evaluate whether thigh muscle mass and muscle wasting are associated with mortality in patients who visit the emergency department.
- Conditions
- Sepsis, Cardiac Arrest, Acute Respiratory Failure, Patients Who Visit Emergency Department
- Trial name
- NCT05978154
- Testing
- Thigh muscle mass and muscle wasting (exposure)
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Korea University Ansan Hospital