Clinical trials: Acute Coronary Syndromes (ACS)
Coronary Artery Disease
Optical Frequency Domain Imaging (OFDI) and Vascular Healing After Stent Placement
The use of drug eluting stents (DES) used to treat coronary artery blockages is limited by poor healing of the stented area. This will require the combined use of blood thinners such as aspirin and clopidogrel (i.e.
- Trial name
- OFDI-DM (NCT01794949)
- Testing
- Resolute Integrity stent
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Emory University
Acute Coronary Syndrome (ACS), Myocardial Infarction
TeleheartCR vs. Clinic-Based Cardiac Rehabilitation After Acute Coronary Syndrome
Cardiac rehabilitation (CR) is an effective evidence-based intervention that improves outcomes in patients with acute coronary syndrome (ACS), but many eligible patients do not complete the program.
- Trial name
- NCT07541014
- Testing
- Telehealth-enhanced Hybrid CR, Traditional Cardiac Rehabilitation
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Columbia University
Coronary Arterial Disease (CAD), Acute Coronary Syndromes (ACS)
Non-Invasive Follow-Up of Patients With Coronary Artery Disease Treated With Drug-Coated Balloon PCI Using CT-Derived Fractional Flow Reserve
This study investigates changes in coronary artery anatomy and physiology after treatment with a paclitaxel drug-coated balloon (DCB) during percutaneous coronary intervention (PCI).
- Conditions
- Coronary Arterial Disease (CAD), Acute Coronary Syndromes (ACS), Stable Coronary Artery Disease Undergoing PCI
- Trial name
- RECORD-CT-FFR (NCT07811960)
- Volunteers
- 150 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Coronary Syndrome, Coronary Artery Disease
Full-dose Atorvastatin After Acute Coronary Syndrome (ACS) in Non-revascularisable Coronary Artery Disease
This study was designed to test the hypothesis that the addition of full-dose atorvastatin (80 mg/day) to conventional medical treatment could reduce ischaemic recurrences after non-ST-elevation acute myocardial infarction…
- Trial name
- APRIRE (NCT01187992)
- Testing
- Atorvastatin
- Where
- Italy
- Volunteers
- 290 people
- Sponsor
- San Filippo Neri General Hospital
Acute Coronary Syndrome
Antiplatelet Therapy in Acute Coronary Syndrome(ACS). Safety and Efficacy of Switching Antiplatelet
This study aims to describe antiplatelet therapy in ACS in Andalusia and make an assessment of efficacy and safety of hospital use Prasugrel / ticagrelor vs.
- Trial name
- NCT02500290
- Where
- 8 sites in Spain
- Volunteers
- 2,000 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
ASCVD, NSTEMI
Telehealth Group Counseling and Preventive Care for Women
The purpose of this study is to utilize an innovative healthcare delivery strategy via telehealth group counseling sessions to improve engagement, adherence, and ultimately outcomes in female patients with atherosclerotic…
- Conditions
- ASCVD, NSTEMI, STEMI, Coronary Artery Disease
- Trial name
- NCT06404515
- Testing
- Telehealth Group Counseling
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Weill Medical College of Cornell University
Acute Coronary Syndrome
Clopidogrel to Prasugrel in Acute Coronary Syndrome (ACS) Patients
This study will evaluate the use of a prasugrel 60 mg loading dose (LD) administered during percutaneous coronary intervention (PCI) with and without a prior LD of clopidogrel on platelet inhibition in patients presenting with…
- Trial name
- NCT01115738
- Testing
- Prasugrel, Clopidogrel
- Where
- 3 sites in India
- Volunteers
- 282 people
- Sponsor
- Eli Lilly and Company
ACS - Acute Coronary Syndrome
European Unified Registries for Heart Care Evaluation and Randomised Trials Italy
Major advances in cardiovascular medicine have been driven by innovations in basic research in biological and technical sciences.
- Trial name
- EuroHeart ITA (NCT07283809)
- Testing
- Adherence to European Society of Cardiology (ESC) quality indicators
- Where
- 57 sites in Italy
- Volunteers
- 5,000 people
- Sponsor
- Heart Care Foundation
Acute Coronary Syndrome (ACS)
Effect of Perioperative Clopidogrel Responsiveness on Ischemic Outcome in Patients With Acute Coronary Syndrome Undergoing Off-pump Coronary Artery Bypass Surgery
The whole blood Thrombelastograph (TEG®) Platelet Mapping™ assay measures clot strength, maximal amplitude (MA), reflecting maximal platelet function, and detects the reduction in platelet function, presented as percentage…
- Trial name
- NCT02184884
- Testing
- MACE after OPCAB, without MACE after OPCAB
- Where
- South Korea
- Volunteers
- 195 people
- Sponsor
- Yonsei University
ACS - Acute Coronary Syndrome
Magnetocardiography (MCG) Device Use in Patients With Elevated Troponin
This prospective device study will examine the feasibility of MCG data collection in a hospital setting using the SandboxAQ MCG device as a potential method to more accurately and quickly quantify cardiac disease of patients with…
- Trial name
- DUET (NCT06620744)
- Testing
- Sponsor MCG deivce
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- SB Technology, Inc.
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
IVUS-Guided Sirolimus-Coated Balloon Versus Sirolimus-Eluting Stent for De Novo Large Vessel Lesions in ACS
The goal of this interventional study is to evaluate the efficacy and safety of an intravascular ultrasound (IVUS)-guided sirolimus-coated balloon (SCB)-based strategy versus planned sirolimus-eluting stent (SES) implantation in…
- Trial name
- IVUS-SCB (NCT07796412)
- Testing
- IVUS-Guided Sirolimus-Coated Balloon, IVUS-Guided Sirolimus-Eluting Stent
- Where
- China
- Volunteers
- 150 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardio Vascular Disease, Acute Coronary Syndromes (ACS)
Qatar Cardiometabolic Retrospective Cohort-Analysis Using Artificial Intelligence
Cardiovascular disease is the leading cause of death worldwide, and individuals with diabetes or other cardiometabolic conditions are at increased risk of adverse cardiovascular outcomes.
- Conditions
- Cardio Vascular Disease, Acute Coronary Syndromes (ACS), Type 2 Diabetes, Pre Diabetes
- Trial name
- QCRC-AI (NCT07515807)
- Where
- Qatar
- Volunteers
- 10,000 people
- Sponsor
- Weill Cornell Medical College in Qatar
Coronary Artery Disease
The TEACH (Texting After ACS Discharge) Pilot Randomized Trial
Although there have been substantial advances in the treatment of heart disease, heart attacks remain one of the leading causes of death and suffering around the world.
- Trial name
- NCT05628337
- Testing
- Motivational texting, Control
- Where
- Canada
- Volunteers
- 241 people
- Sponsor
- Sunnybrook Health Sciences Centre
Acute Coronary Syndrome
DAPT Strategy in HBR Patients Undergoing Complex PCI Following ACS: Second-Phase Beta Testing of a Patients Decision Aid
Among patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) and stent implantation, 17.5% are both at high bleeding risk (HBR) and have undergone complex PCI, which also places them at…
- Trial name
- BETA-DAPT (NCT07391358)
- Testing
- Patient decision aid to support shared decision-making between patients and clinicians
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Montreal Heart Institute
Acute Coronary Syndrome, Hemorrhage
Platelet Reactivity After an Eastern Asian Loading Dose of Prasugrel in Taiwanese ACS Patients
Prasugrel has a faster onset of action and greater platelet inhibition with less inter-individual response variability than clopidogrel.
- Conditions
- Acute Coronary Syndrome, Hemorrhage, Treatment Side Effects
- Trial name
- PREP-TAMI (NCT04768582)
- Testing
- P2Y12-reaction-units (PRU) by VerifyNow-P2Y12 assay
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Feng Yuan Hospital, Ministry of Health and Welfare
ACS - Acute Coronary Syndrome, NSTEMI - Non-ST Segment Elevation MI
MCG Discovery Study in Emergency Departments
This prospective discovery study is designed to demonstrate the feasibility of using an unshielded, mobile MCG device in an Emergency Department (ED) setting.
- Trial name
- NCT06095557
- Testing
- Sponsor MCG device
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- SB Technology, Inc.
Non ST Segment Elevation Acute Coronary Syndrome
Pre Hospital Triage of Patients at Intermediate and High Risk for ACS
RESEARCH QUESTION: Is a treatment strategy that includes direct referral to a PCI center for intermediate to high-risk patients with non-ST elevation acute coronary syndrome (NSTE-ACS), both cost-effective and non-inferior for…
- Trial name
- ARTICA-2 (NCT07252245)
- Testing
- Integrating the HEAR score and hs POC troponin into pre hospital triage decision-making:
- Where
- 3 sites in Netherlands
- Volunteers
- 1,048 people
- Sponsor
- Cyril Camaro
Cardiovascular Diseases
Hunting for the Off-Target Properties of Ticagrelor on Endothelial Function in Humans (HI-TECH)
The purpose of this randomized, cross-over study, is to ascertain if ticagrelor, but not prasugrel or clopidogrel, is associated to an improved endothelial function as assessed with peripheral arterial tonometry and markers of…
- Trial name
- HI-TECH (NCT02587260)
- Testing
- Ticagrelor, Prasugrel, Clopidogrel
- Where
- 5 sites in Italy, Netherlands and 2 more
- Volunteers
- 54 people
- Sponsor
- Erasmus Medical Center
Cardiac Rehabilitation, Heart Failure
Cardiac REhabilitation COhort at the Medicine Campus DaVos to invEstigate Recovery
The RECOVER study, titled Cardiac Rehabilitation Cohort at the Medicine Campus Davos for Exploration of Recovery, is a prospective, non-interventional, monocentric cohort study conducted at the Hochgebirgsklinik Davos.
- Conditions
- Cardiac Rehabilitation, Heart Failure, Cardiac Arrest (CA), ACS (Acute Coronary Syndrome)
- Trial name
- RECOVER (NCT07096973)
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- Hochgebirgsklinik Davos
Acute Coronary Syndrome
Rivaroxaban ACS Specialist Cohort Event Monitoring Study
Rivaroxaban is a medicine which reduces the formation of blood clots. Acute coronary syndrome (ACS) comprises a range of disorders, including heart attack and unstable angina, caused by a sudden reduction in blood flow to part of…
- Trial name
- ROSE ACS (NCT02673437)
- Testing
- This is a non-interventional study
- Where
- 2 sites in United Kingdom
- Volunteers
- 701 people
- Sponsor
- Drug Safety Research Unit, Southampton, UK