Clinical trials: Acute Decompensated Heart Failure
Acute Decompensated Heart Failure
DORAYA-HF Early Feasibility Study
The study objective is to evaluate the feasibility of the Doraya Catheter and measure clinical performance and safety endpoints, in ADHF patients deemed to have insufficient diuretic response.
- Trial name
- NCT05206422
- Testing
- Doraya Catheter
- Where
- 14 sites in United States
- Volunteers
- 21 people
- Sponsor
- Revamp Medical Inc.
Acute Decompensated Heart Failure, Volume Overload
Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR)
This clinical research study is being conducted in multiple hospitals in Belgium and approximately 519 patients with acute decompensated heart failure are expected to participate.
- Trial name
- Advor (NCT03505788)
- Testing
- Acetazolamide
- Where
- Belgium
- Volunteers
- 519 people
- Sponsor
- Ziekenhuis Oost-Limburg
Heart Failure, Lung Congestion
Use of ReDS Technology in Patients With Acute Heart Failure
Background: Fluid overload, especially pulmonary congestion, is one of the main contributors into heart failure (HF) readmission risk and it is a clinical challenge for clinicians.
- Trial name
- NCT04305717
- Testing
- ReDS-guided strategy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Decompensated Chronic Heart Failure, Heart Failure NYHA Class III
Epidemiology and Prognostic of the Acute Heart Failure
EPICAL 2 (Epidemiology and prognostic of the Acute Heart Failure) is an epidemiological, observational, prospective and multicenter study.
- Conditions
- Decompensated Chronic Heart Failure, Heart Failure NYHA Class III, Acute Pulmonary Edema, Cardiogenic Shock
- Trial name
- EPICAL2 (NCT02880358)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Central Hospital, Nancy, France
Acute Decompensated Heart Failure
Readily Available Urinary Sodium Analysis in Patients With Acute Decompensated Heart Failure
The goal of this clinical trial is to compare physician-guided (SOC) versus nurse-led natriuresis-guided diuretic therapy in patients with acute decompensated heart failure (ADHF).
- Trial name
- EASY-HF (NCT06278792)
- Testing
- Diuretic protocol, Standard of Care
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Ziekenhuis Oost-Limburg
Heart Failure, Acute Decompensated Heart Failure
Use of POC Pocket Ultrasound in the Estimation of Left and Right Atrial Pressures
This study will assess the reliability of POC ultrasound in estimating right and left atrium pressures in patients with acute decompensated heart failure.
- Trial name
- POCUSP (NCT03897647)
- Testing
- General Electric (GE) VScan
- Sponsor
- Montefiore Medical Center
CHF, ADHF
Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)
The purpose of this study is to determine the relationship between the levels of Ribonucleic acid (RNA) circulating molecules, including ones in extracellular vesicles from different organs in the blood and in the saliva of…
- Conditions
- CHF, ADHF, Control
- Trial name
- SEAL-HF (NCT06169540)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Hemolysis Intravascular, Acute Decompensated Heart Failure
HEMolysis in a Percutaneous Axial Flow LVAD, Effects of Pentoxifylline in a Randomized Controlled Trial
Temporary mechanical circulatory support devices are increasingly used for short-term support in patients with decompensated cardiogenic shock. Recently, a new axial flow pump has become widely available with the Impella System.
- Trial name
- NCT04391231
- Testing
- Pentoxifylline Oral Product
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Heart Failure, Heart Failure - NYHA II - IV
Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared…
- Conditions
- Heart Failure, Heart Failure - NYHA II - IV, Heart Failure Acute, Acute Heart Failure (AHF)
- Trial name
- US-DASH (NCT07263035)
- Testing
- Furosemide intravenous solution
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Lakeland Regional Health Systems, Inc.
Heart Failure, Acute Decompensated Heart Failure
Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistance
Evaluation of the safety and efficacy of the ModulHeart System in patients hospitalized with acute decompensated heart failure (ADHF) and diuretic resistance
- Conditions
- Heart Failure, Acute Decompensated Heart Failure, Cardiorenal Syndrome, Heart Failure, Congestive
- Trial name
- NCT06174623
- Testing
- ModulHeart Support
- Where
- 5 sites in Australia, Georgia
- Volunteers
- 5 people
- Sponsor
- Puzzle Medical Devices Inc.
Chronic Heart Failure, Acute Decompensated Heart Failure
PREcision meDICine in Treatment in CardioVascular Disease
The main goal of PREDICT-CVS is to demonstrate that a personalized, AI-derived biomarker-guided medication treatment algorithm that provides advice to the treating professional is superior to prevent clinical events and improve…
- Trial name
- PREDICT-CVD (NCT07369141)
- Testing
- ASSIST-HF AI- algorithm, Standard of Care (Investigator Choice)
- Where
- 4 sites in Netherlands
- Sponsor
- Maastricht University Medical Center
Heart Failure Patients
TELEMACO-S: a Telemonitoring Project in Cardiology and Technology Transfer
The primary objective of this research project is to prevent heart failure decompensation through a wearable-based telemonitoring system (smartwatches), with a focus on the development and validation of a multiparametric…
- Trial name
- TELEMACO-S (NCT07375251)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Valentina Micheluzzi
Acute Heart Failure, Low Cardiac Output Syndrome
Exogenous Ketones for Acutely Decompensated HEart Failure
This study will evaluate whether supplementation of exogenous ketones in patients with severe left ventricular dysfunction and acutely decompensated heart failure requiring inotropic therapy would improve the patient's…
- Conditions
- Acute Heart Failure, Low Cardiac Output Syndrome, Hemodynamic Instability, Ketosis
- Trial name
- KADHEF (NCT04698005)
- Testing
- 25g Ketone monoester without added salts
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Heart Decompensation, Congestive Heart Failure
An Open-label, One-arm, Study to Evaluate the Hemodynamic Changes and Safety of Nesiritide for Acute Decompensated Heart Failure
The present study was an open-label, uncontrolled, and multi-centered phase III clinical trial for evaluation of the efficacy (clinical efficacy and hemodynamics) and safety of nesiritide.
- Trial name
- NCT00813202
- Testing
- Nesiritide
- Where
- 4 sites in China
- Volunteers
- 41 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Acute Decompensated Heart Failure (ADHF)
Effects of Continued Administration of Empagliflozin in Patients With Heart Failure on Active SGLT2 Inhibitor Treatment Admitted for Acute Decompensated Heart Failure
The goal of this clinical trial is to test the hypothesis that the continuation of empagliflozin during decongestive therapy in the setting of acute decompensated and hospitalized heart failure patients is not inferior compared…
- Trial name
- EMPA-CON (NCT07038356)
- Testing
- Empagliflozin 10 MG Oral Tablet [Jardiance]
- Where
- 12 sites in Germany
- Volunteers
- 536 people
- Sponsor
- Christian Schulze
Chronic Heart Failure, Lung; Congestive
Usefulness of Lung Ultrasound in Ambulatory Management of Patients With Chronic Heart Failure
Purpose. The aim of this study is to evaluate whether lung ultrasound, in addition to physical examination, leads to a reduction of the admission rate for acute decompensated heart failure of patients with chronic heart failure…
- Conditions
- Chronic Heart Failure, Lung; Congestive, Acute Decompensated Heart Failure
- Trial name
- NCT03262571
- Testing
- Lung ultrasound
- Where
- Italy
- Volunteers
- 244 people
- Sponsor
- IRCCS San Raffaele
Heart Failure, Acute Decompensated Heart Failure
Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
This is a prospective, multi-center, single-arm, early feasibility study that aims to evaluate the safety of the Impella BTR™ in adult patients requiring left-ventricular hemodynamic support, and to evaluate the effectiveness of…
- Trial name
- BTR EFS (NCT05291884)
- Testing
- Impella BTR
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Abiomed Inc.
Heart Failure, Acute Decompensated Heart Failure
Reducing Readmission for Frail Elderly Patients With Decompensated Heart Failure
A randomized study designed to determine whether telephone based interventions can prevent return hospital visits for elderly and frail patients with acute symptoms of heart failure.
- Conditions
- Heart Failure, Acute Decompensated Heart Failure, Fragility, Emergencies
- Trial name
- HFF-ED (NCT03246035)
- Testing
- Intervention Group, Control Group (Standard Care)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Jewish General Hospital
Heart Failure Acute, Heart Failure，Congestive
Effects of Empagliflozin on Clinical Outcomes in Patients With Acute Decompensated Heart Failure
Acute decompensated heart failure is the fastest growing disease in the world and the leading cause of hospital admissions worldwide.
- Conditions
- Heart Failure Acute, Heart Failure，Congestive, Heart Failure; With Decompensation
- Trial name
- EMPA-RESPONSE (NCT03200860)
- Testing
- Empagliflozin 10 MG
- Where
- 5 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen