Clinical trials: Acute Depression
Acute Ischaemic Stroke, Depression
Screening of New Markers of Gut Microbiota in Stroke and Depression: a Cross-sectional Study
Objectives of Study： Through the cross-sectional study of stroke and depression, key biomarkers are targeted by screening disease-associated intestinal bacteria, metabolites and immune factors through multi-omics techniques.
- Trial name
- NCT06379464
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Long COVID
Neurobiological Underpinnings of Neuropsychological Consequences in Long COVID
Objectives: To describe the standardized evaluation of the psychological and cognitive function of long COVID patients and their evolution, to compare immunological and HPA-axis related biomarkers between long COVID patients and…
- Trial name
- Cov-N-Psy (NCT06279936)
- Testing
- Neuropsychological battery, Surveys and symptom severity questionnaires, Blood withdrawal
- Where
- Belgium
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Bipolar Disorder
Bipolar Disorder Study for Men and Women
A Placebo Controlled Study Evaluating Efficacy and Safety of Medication in Patients with Bipolar Disorder
- Trial name
- NCT00056277
- Testing
- lamotrigine
- Where
- 20 sites in United States
- Volunteers
- 150 people
- Sponsor
- GlaxoSmithKline
AECOPD, BIOMASS FUEL
Effect of Pulmonary Rehabilitation in Females With Acute Exacerbation of COPD Induced by Biomass Fuel Smoke
COPD represents an important public health challenge that is both preventable and treatable. GOLD is committed to improving the health of people at risk of and with COPD, wherever they happen to have been born, and wishes to do…
- Conditions
- AECOPD, BIOMASS FUEL, Pulmonary Rehabilitation
- Trial name
- AECOPD BIOMASS (NCT07509736)
- Testing
- Intervention 1 → Arm 1 (pulmonary rehabilitation group).
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Acute Coronary Syndrome, Tobacco Use
Post Acute Cardiac Event Smoking (PACES) Study
Summary of the Project : Quitting smoking following acute coronary syndrome (ACS) can reduce mortality up to 50%. However, depression and smoking are highly co-morbid and depressed mood may interfere with cessation and…
- Trial name
- NCT03413423
- Testing
- BAT-CS, Smoking Cessation and Health & Wellness
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- Hennepin Healthcare Research Institute
Depressive Disorder
Acute Efficacy and 6 Months Follow up After Electroconvulsive Therapy
The overall aim of the current project is to assess the acute and long term outcome of ECT (both patient and clinician rated) in a non-selected patient cohort from ordinary clinical activity, and to seek out factors predicting…
- Trial name
- NCT05388461
- Testing
- electroconvulsive therapy
- Where
- 2 sites in Norway
- Volunteers
- 600 people
- Sponsor
- Haukeland University Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Interoceptive Awareness
Interoception and Symptom Perception in Acute COPD Exacerbation
Interoception refers to the process of perceiving and interpreting internal physiological signals and plays a central role in symptom perception.
- Trial name
- NCT07719231
- Testing
- No Intervention: Observational Cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Saglik Bilimleri Universitesi
Acute Ischemic Stroke, Upper Extremity Hemiplegia
Kinesio Taping for Upper Extremity Motor Function in Acute Stroke Patients
This randomized, controlled clinical trial was conducted to evaluate the effects of kinesio taping on upper extremity motor recovery in patients with acute ischemic stroke who presented with flaccid muscle tone.
- Conditions
- Acute Ischemic Stroke, Upper Extremity Hemiplegia, Kinesio Taping
- Trial name
- KT-AcuteStroke (NCT07300605)
- Testing
- Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Koç University
Depression, Suicide
Ketamine for Depression and Suicide Risk
The purpose of this research study was to find out if the medication known as ketamine could help the symptoms of depression. This drug is approved by the U.S.
- Trial name
- Ketamine (NCT02094898)
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Bipolar Disorder
Effects of Electroconvulsive Therapy (ECT) in Bipolar Depression
The primary purpose of this study is to use magnetic resonance spectroscopy (MRS) to measure the levels of several brain chemicals including, but not limited to, glutamate, glutamine, and N-acetylaspartate, before and after…
- Trial name
- NCT01557933
- Testing
- No interventions will be used
- Sponsor
- Mclean Hospital
Depressive Disorder, Bipolar Disorder
Effect of African Drumming in Mood Disorders
This pilot study evaluated whether participating in an African drumming activity for 45 minutes immediately improved mental well-being among 13 adults diagnosed with acute mood disorders who were attending a private mental health…
- Trial name
- NCT02675712
- Testing
- African drumming
- Volunteers
- 13 people
- Sponsor
- University of Stellenbosch
Acute Stroke, Anxiety Disorders
Anxiety and Depression Disorder in Patient Treated With rTPA for Mangment of Acute Ischemic Stroke
In fact theWorld Health Organization estimates that 2-3% in general populations of countries across the world tend to be affected by severe mental disorders (1) Thrombolytic therapy seems to be of great importance in achieving…
- Conditions
- Acute Stroke, Anxiety Disorders, Depression
- Trial name
- NCT04484558
- Testing
- Actilyse
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Acute Pain, Depression
Single-dose Ketamine for the Reduction of Pain and Depression in the Emergency Department
In this proposal, the investigators will determine if a single dose of intravenous (IV) ketamine (in combination with midazolam) reduces pain severity, depressive symptoms and need for opiate analgesics both in the ED and in the…
- Trial name
- NCT03436121
- Testing
- Ketamine, Midazolam
- Sponsor
- Maria Pacella
Intensive Care Unit Survivors, Informal Caregivers (Family and Friends)
Improving Psychological Distress Among Critical Illness Survivors and Their Caregivers
Patients who receive life support in intensive care units commonly suffer from persistent depression, anxiety, and post-traumatic stress disorder (PTSD) symptoms after discharge.
- Trial name
- NCT01983254
- Testing
- coping skills training, education program
- Where
- 4 sites in United States
- Volunteers
- 417 people
- Sponsor
- Duke University
Bipolar Depression, Suicidal Ideation
NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar Depression
NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. NeuroRx has developed a sequential therapy consisting of IV NRX-100 (ketamine HCL) for rapid stabilization of…
- Trial name
- SevereBD (NCT03396601)
- Testing
- Ketamine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- NeuroRx, Inc.
Depressive Symptoms, Aging
ABSORB (Amount of Blueberries So Older Adults Reap Benefits)
This randomized, cross-over, pilot study aims to compare preliminary impact of a standard dose of blueberry powder (24 g) vs a higher dose (48 g) on the bioavailability of flavonoids and inflammatory biomarkers in older adults…
- Trial name
- NCT05937165
- Testing
- Freeze-dried Blueberry Powder
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Depressive Disorder
Intramuscular Ketamine Versus Aripiprazole and Escitalopram in the Treatment of Resistant Depression
The treatment of resistant depression should be optimized aiming at complete remission of symptoms, a complex condition due to several factors.
- Trial name
- KETProject (NCT04234776)
- Testing
- Ketamine, Cognition, Suicide risk
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- University of Sao Paulo
Bipolar Disorder
Escitalopram in Bipolar Depression: a Placebo-controlled Study of Acute and Maintenance Treatment
Funding: An investigator-initiated trial funded by H. Lundbeck AS. Study design: Prospective, randomised, placebo-controlled parallel-group multicenter study.
- Trial name
- NCT00464191
- Testing
- escitalopram
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Nordfjord Psychiatric Centre
Schizophrenia, Schizotypal Disorder
The OPUS YOUNG Trial. Early Intervention Versus Treatment as Usual for Adolescents With First-episode Psychosis
The OPUS YOUNG (OY) study investigates the efficacy of early intervention service versus treatment as usual (TAU) for adolescents aged 12-17 years with a first-episode psychosis.
- Conditions
- Schizophrenia, Schizotypal Disorder, Delusional Disorder, Acute and Transient Psychotic Disorder, Unspecified
- Trial name
- OPUS-YOUNG (NCT04916626)
- Testing
- OPUS YOUNG, Treatment as Usual
- Where
- Denmark
- Volunteers
- 284 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Acute Coronary Syndrome, Depressive Symptoms
Comparison of Depression Identification After Acute Coronary Syndrome: Quality of Life and Cost Outcomes
The purpose of this study is to examine, in a randomized controlled trial, the benefits and costs of the American Heart Association's (AHA) advisory for depression screen and treatment of post-acute coronary syndrome patients.
- Trial name
- CODIACSQoL (NCT01993017)
- Testing
- Cognitive Behavioral Therapy (CBT), Antidepressant Medication, Standard Care
- Where
- 4 sites in United States
- Volunteers
- 1,501 people
- Sponsor
- Columbia University