Clinical trials: Acute Depression
Depression, Anxiety
Mediterranean-style Dietary Pattern (MDP), Mood and Anxiety
Observational studies and a limited numbers of RCTs have observed that habitual Mediterranean-style dietary pattern (MDP) consumption is associated with improved mental health and cognition.
- Trial name
- MediMood (NCT05927376)
- Testing
- Mediterranean diet, Western diet
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Breast Cancer, Chronic Pain
Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
Pre-existing pain and severe postoperative pain are predictors of persistent pain after surgery, but a complete understanding on the development of persistent pain is still lacking.
- Conditions
- Breast Cancer, Chronic Pain, Acute Pain, Depression, Anxiety
- Trial name
- B-CAPP (NCT03408717)
- Testing
- Questionnaires, Mechanical Temporal Summation assessment, Pain threshold assessment
- Where
- 2 sites in United States, Singapore
- Volunteers
- 220 people
- Sponsor
- KK Women's and Children's Hospital
Acute Kidney Injury, Decision Making ,Shared
Shared Decision-Making for Families in Critical Dialysis Initiation
Background:Acute kidney injury (AKI) is a frequent and serious complication in critically ill patients, often necessitating difficult decisions about starting hemodialysis.
- Conditions
- Acute Kidney Injury, Decision Making ,Shared, Emotional Dysfunction
- Trial name
- NCT07150182
- Testing
- The Integrated Shared Decision-making Program
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University WanFang Hospital
Stroke, Acute, Expressive Aphasia
Music After Stroke To Enhance Rehabilitation
Music that is familiar and preferred by patients has been shown to heighten neuroplasticity and can mitigate these disabilities.
- Conditions
- Stroke, Acute, Expressive Aphasia, Movement, Abnormal, Depressive Disorder
- Trial name
- MASTER (NCT04441515)
- Testing
- Ipod with music, ipod with books to listen, ipod only with usual care
- Volunteers
- 12 people
- Sponsor
- Pace University
Acute Coronary Syndrome
Direct Angioplasty for Non ST Elevation Acute Coronary Events: DANCE Pilot Study
This is a pilot feasibility study to evaluate if patients with ST depression Acute Coronary Syndrome who are taken directly to the catheter laboratory for angiogram and angioplasty +/- stents will fare better that patients who…
- Trial name
- DANCE (NCT01172990)
- Testing
- Immediate Invasive Management, Conventional Management
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Suicidal Ideation/Behavior, Depression
Randomized, Placebo-controlled Multicenter Trial of Lithium Plus Treatment as Usual (TAU) for Acute Suicidal Ideation and Behavior in Patients With Suicidal Major Depressive Episode
The primary hypothesis of this confirmatory study is that lithium therapy will acutely decrease suicidal ideation and/or suicidal behaviour in inpatients with a major depressive episode (MDE, unipolar and bipolar disorder…
- Trial name
- NCT02039479
- Testing
- Lithium Carbonate
- Where
- 5 sites in Germany
- Volunteers
- 254 people
- Sponsor
- Technische Universität Dresden
Post COVID-19 Syndrome, Stress Disorders
A Study of Activity Leader to Forest Therapy Campaign in Different Environments Targets on the Participants Which Had Been Infected by SARS-COV-2
The goal of this clinical trial is to investigate the impact of self-guided forest healing activities and guided forest healing activities on the reduction of psychological stress inindividuals diagnosed with the new coronavirus.
- Conditions
- Post COVID-19 Syndrome, Stress Disorders, Life Quality, Depression Anxiety Disorder
- Trial name
- NCT06601920
- Testing
- Forest healing activities
- Where
- Taiwan
- Volunteers
- 161 people
- Sponsor
- Taipei City Hospital
Traumatic Brain Injuries
Therapeutic Benefits of Pareidolia in Acute Traumatic Brain Injury Patients
This study will investigate whether viewing and identifying meaningful shapes or images hidden within nature pictures (pareidolia) can improve motivation and engagement in rehabilitation therapy for adults with mild to moderate…
- Trial name
- NCT07867119
- Testing
- Therapeutic Benefits of Pareidolia, Active Comparator #1
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Shirley Ryan AbilityLab
Acute Coronary Syndrome, Depressive Disorder
Comorbid Mental Disease and Heart Disease in Men
Mood disorders, anxiety disorders, and trauma-related stress (MD\AD\TRS) are common among men, particularly those suffering from heart disease (HD).
- Conditions
- Acute Coronary Syndrome, Depressive Disorder, Anxiety Disorders, Stress Disorders, Post-Traumatic
- Trial name
- MindTheHeart (NCT03354351)
- Testing
- Stepped-care model
- Volunteers
- 3,000 people
- Sponsor
- Universite de Moncton
Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure
Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
This study targets adult patients treated with high flow nasal cannula (HFNC) at emergency department (ED) of Severance hospital, Yonsei university.
- Conditions
- Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure, Hypercapnic Acute
- Trial name
- NCT06064409
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Stroke
Efficacy of Fluoxetine - a Trial in Stroke
The purpose of this study is to investigate whether routine administration of fluoxetine 20mg once daily in the 6 months initiated during the acute stroke improves the patient's functional outcome.
- Trial name
- EFFECTS (NCT02683213)
- Testing
- Fluoxetine
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Karolinska Institutet
Suicidality
A Study of Nopan Treatment of Acute Suicidality
Anecdotal evidence and several clinical studies found the mixed opioid agonist-antagonist Nopan to be an effective antidepressant with a rapid onset of action.
- Trial name
- NCT01046851
- Testing
- Nopan
- Where
- 3 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Prof. Yoram Yovell
Bipolar Disorder, Depression
Acute Psychotherapy for Bipolar II Depression
This proposed study is designed to compare the efficacy of interpersonal and social rhythm therapy (IPSRT) alone to IPSRT plus medication as an acute treatment for bipolar II depression.
- Trial name
- NCT01133821
- Testing
- IPSRT plus quetiapine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Holly Swartz
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Acute Bipolar Depression
Efficacy and Safety of Quetiapine Versus Quetiapine Plus Lithium in Bipolar Depression
The purpose of this study is to compare the efficacy of quetiapine fumarate monotherapy with quetiapine fumarate in combination with lithium in the treatment of a major depressive episode in patients with bipolar disorder.
- Trial name
- QUALITY (NCT00883493)
- Testing
- Quetiapine fumarate XR, Lithium carbonate
- Where
- 24 sites in Argentina, Brazil and 7 more
- Volunteers
- 421 people
- Sponsor
- AstraZeneca
Long Covid-19, Emotional Disorder
Effectiveness and Acceptability of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in People With Long COVID-19.
This Randomized Controlled Trial (RCT) aims to assess the effectiveness and acceptability of the Unified Protocol (UP) in an online group format for the treatment of emotional disorders in adults.
- Conditions
- Long Covid-19, Emotional Disorder, Anxiety, Depression Disorders
- Trial name
- UP-LONGCOVID-R (NCT06928480)
- Testing
- Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders, Treatment as Usual (TAU)
- Where
- 2 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Schizophrenia, Schizotypal Disorder
Feasibility of a Novel Process-based Treatment for Patients With Psychosis
The purpose of this single-arm feasibility study is to develop and pilot test a novel process-based and modular group therapy approach for patients with acute psychotic symptoms in an inpatient setting.
- Conditions
- Schizophrenia, Schizotypal Disorder, Delusional Disorder, Brief Psychotic Disorder
- Trial name
- PROBAS (NCT04874974)
- Testing
- Metacognitive and Defusion Training
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Anxiety, Depressive Symptoms
Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by open-label naturalistic follow-up.
- Trial name
- AtLAS-A (NCT04245436)
- Testing
- Duloxetine, Escitalopram
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Depression
rTMS Response Trajectories in Depression
Notwithstanding the cumulative evidence on the safety and efficacy of transcranial magnetic stimulation in depression care, the non-response rate to transcranial magnetic stimulation (TMS) amongst treatment-resistant depression…
- Trial name
- NCT03348761
- Testing
- rTMS group
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Acute Depression, Major Depressive Episode
Study of Functional Networks in Resting fMRI
The primary purpose is to compare with resting fMRI the functional networks of rest (RTS) in unipolar depression and in bipolar depression.
- Trial name
- DEPIMAGE (NCT03323073)
- Testing
- Resting state fMRI
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris