Clinical trials: Acute Depression
Molecular Mechanisms of Pharmacological Action, Depression
Citalopram and Self Emotional Processing
This study is investigating the effect of an acute dose of citalopram on emotional processing about the self. Using a parallel-group double-blind design, participants will be randomised to receive either an acute dose of…
- Conditions
- Molecular Mechanisms of Pharmacological Action, Depression, Depressive Disorder, Mental Disorder
- Trial name
- NCT04169230
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Suicide, Attempted, Suicide and Depression
Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents
This project aims to examine the signal of efficacy of ketamine, a rapidly acting medication shown to decrease suicidality in adults in as short as hours or days, as opposed to weeks.
- Conditions
- Suicide, Attempted, Suicide and Depression, Suicide Threat
- Trial name
- TASK (NCT04592809)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Myocardial Infarction, Intensive Care Unit Syndrome
Effect of Listening to Relatives' Voice Recordings on Chest Pain, Anxiety, and Depression in Coronary ICU Patients
The aim of the study was to evaluate the effect of listening to the voice recordings of relatives of patients with acute myocardial infarction (AMI) who were treated in the coronary intensive care unit on chest pain, anxiety and…
- Trial name
- NCT06260085
- Testing
- Relatives vioce record
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ordu University
Bipolar Disorder
Acute Treatment of Bipolar II Depression
This study will compare the medications lithium and lamotrigine (Lamictal®) in treating depression in individuals with bipolar II disorder.
- Trial name
- NCT00074776
- Testing
- Lithium, Lamotrigine
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Stanford University
Major Depression
Efficacy and Safety of Homeopathy for Moderate Depression (Acute Phase)
To assess the two components of individualized homeopathic treatment for acute depression, i.e., to investigate the specific effect of individualized Q-potencies versus placebo and to investigate the effect of different…
- Trial name
- DEP-HOM (NCT01178255)
- Testing
- homeopathic q-potencies, homeopathic case history taking type I, homeopathic case history type II
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Charite University, Berlin, Germany
Long-COVID, Post-acute COVID-19 Syndrome
Effectiveness of Non-invasive Neuromodulation in Patients With Long-COVID
Sleep quality and duration are critical to cognitive, emotional and physical well-being, and poor sleep quality has been associated with an increased risk of cognitive, psychological and cardiometabolic disorders.
- Trial name
- NCT06456502
- Testing
- Non-invasive neuromodulation
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Universidad Rey Juan Carlos
Long COVID, Major Depressive Disorder
Presynaptic Imaging in Major Depressive Episodes After COVID-19
The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric symptoms occurring within 3 months after mild to moderate COVID-19 infection (COVID-DNP).
- Conditions
- Long COVID, Major Depressive Disorder, Major Depressive Episode
- Trial name
- PCOV (NCT06086366)
- Testing
- [11C]DTBZ PET scan, [18F]SDM8 PET scan, MRI scan
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain
Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression
Volunteers will receive a weight-based opioid (remifentanil) infusion for 10 minutes. In the first run, serial pupillary measurements (pupillary unrest, pupil diameter) will be taken at baseline, and at 2.5-minute intervals…
- Conditions
- Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain, Overdose of Opiate, Respiratory Depression
- Trial name
- NCT04301895
- Testing
- Continuous conversational interaction, Remifentanil infusion
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ischemic Stroke, Acute, Post-stroke Anxiety
Benson Relaxation for Anxiety, Depression, and Insomnia After Stroke
Stroke is a leading cause of disability worldwide. Many patients experience anxiety, depression, and sleep disturbances in the early recovery phase, which can slow rehabilitation.
- Conditions
- Ischemic Stroke, Acute, Post-stroke Anxiety, Post-stroke Depression, Sleep
- Trial name
- BRT-Stroke (NCT07731282)
- Testing
- Benson Relaxation Technique, Structured Health Education
- Where
- 2 sites in China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Changchun University of Traditional Chinese Medicine
Major Depression
Escitalopram Plus PS128 vs. Escitalopram
The purpose of this study is to compare the efficacy and safety of escitalopram plus PS128 to escitalopram in the acute treatment of patients with major depressive disorder.
- Trial name
- NCT04093960
- Testing
- Lactobacillus plantarum PS128
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Kaohsiung Kai-Suan Psychiatric Hospital
Postoperative Pain, Acute, Postoperative Depression
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful than the other for improving…
- Conditions
- Postoperative Pain, Acute, Postoperative Depression, Anxiety, Sleep Disturbance
- Trial name
- NCT05625360
- Testing
- eHealth Mindful Movement and Breathing, Life Impacts Reflection, PROMIS Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Major Depressive Disorder
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-061)
A clinical study to determine the efficacy and safety of an Treatment of MK0869 in the treatment of depression.
- Trial name
- NCT00035295
- Testing
- MK0869, aprepitant
- Volunteers
- 584 people
- Sponsor
- Merck Sharp & Dohme LLC
Major Depressive Disorder
Sertraline vs. Venlafaxine XR
This is a randomized, double-blind, active control, 8-week, flexible dose study of sertraline vs. venlafaxine Extended Release in the acute treatment of Major Depression in male and female outpatient sites that will recruit 15-20…
- Trial name
- NCT00179283
- Testing
- sertraline, venlafaxine XR
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University
Depression, Post-COVID-19 Syndrome
Evaluation of DEPREXIL in Patients With Clinical Depression Through Psychological and Neuroendocrine Assessment
Clinical depression is a mood disorder that affects people of all ages with symptoms such as sadness, anger or frustration, appetite changes, difficulty concentrating and suicidal thoughts.
- Conditions
- Depression, Post-COVID-19 Syndrome, Depression Mild, Depression Moderate
- Trial name
- NCT06496087
- Testing
- DEPREXIL
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Catalysis SL
Acute Coronary Syndrome, Tobacco Use
Integrated Smoking Cessation and Mood Management for ACS Patients
Quitting smoking following acute coronary syndrome can reduce mortality up to 50%. However, depression and smoking are highly co-morbid and depressed mood may interfere with cessation and independently predicts mortality.
- Trial name
- PACES (NCT03029923)
- Testing
- Experimental: Behavioral Activation Treatment for Cardiac Smokers (BAT-CS), Smoking cessation plus Health and Wellness
- Where
- United States
- Sponsor
- The Miriam Hospital
Depression, Depression Severe
Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department
The purpose of this study is to examine the effect of a low-dose ketamine infusion on depression symptoms within the Emergency Department (ED) visit, and healthcare utilization after leaving the ED, when administered in the ED…
- Conditions
- Depression, Depression Severe, Depression Acute, Depression and Suicide
- Trial name
- NCT04266288
- Testing
- Ketamine, Sodium Chloride 0.9%
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- MercyOne Des Moines Medical Center
Psychiatric Hospitalization, Physical Inactivity
Impact of Exercise Groups on Patient Mental Health and Wellbeing in an Acute Psychiatric Inpatient Unit
More research is needed to elucidate the impacts of physical activity interventions on short- and long-term activity and neuropsychiatric symptoms (NPS) in psychiatric inpatients and to support its advantageousness when compared…
- Conditions
- Psychiatric Hospitalization, Physical Inactivity, Depression, Anxiety, Sleep
- Trial name
- NCT05859204
- Testing
- OT-led Exercise Group, Treatment as Usual - OT Groups
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Acute Coronary Syndromes, Depression
Integrating Depression Care in Acute Coronary Syndromes Care in China
The overall goal of this study is to develop, pilot test, implement, and evaluate a nurse-coordinated depression care model integrated into the care of Acute Coronary Syndromes (ACS) patients with rigorous assessment of…
- Trial name
- I-Care (NCT02195193)
- Testing
- Integrated care
- Where
- China
- Volunteers
- 4,043 people
- Sponsor
- The George Institute for Global Health, China
Treatment Resistant Depression
SAINT for Treatment of Preoperative Depression to Reduce Opioid Use Following Arthroplasty
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression.
- Trial name
- NCT04195308
- Testing
- Active TBS-DLPFC, Open label TBS-DLPFC
- Where
- United States
- Sponsor
- Stanford University
Heart Diseases, Depression
COPES Phase I Randomized Controlled Trial of Treatment For Distress in Heart Disease Patients
The specific aim of the "Coronary Patients Evaluation Study" (COPES) Project 2 is, within a Phase-I RCT, to examine patient satisfaction, treatment safety, and symptom reduction associated with treatment for symptoms of distress…
- Trial name
- NCT00158054
- Testing
- Enhanced depression care, Referred depression care
- Where
- 3 sites in United States
- Volunteers
- 157 people
- Sponsor
- Columbia University