Clinical trials: Acute Exacerbation Chronic Obstructive Pulmonary Disease
Obstructive Chronic Bronchitis With Acute Exacerbation
Respiratory Therapy in COPD Exacerbations
The purpose of this study is to determine effectiveness, feasibility and safety/tolerance of Respiratory Therapy in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease.
- Trial name
- TRESEPOCAS (NCT02125747)
- Testing
- No Respiratory Therapy, Respiratory Therapy
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Parc de Salut Mar
Chronic Obstructive Pulmonary Disease
Personalized Variable Versus Fixed Dose Glucocorticoid Therapy in AECOPD
The hypothesis is that in acute exacerbated Chronic Obstructive Pulmonary Disease (AECOPD), personalized variable dose glucocorticoid treatment will result in superior clinical outcome when compared to fixed dose therapy.
- Trial name
- NCT02147015
- Testing
- Glucocorticoids, Antibiotics, Inhaled corticosteroid (ICS)
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Chronic Obstructive Pulmonary Disease (COPD), Eosinophilic COPD
Prevalence and Clinical Outcome of Eosinophilic COPD
Chronic Obstructive Pulmonary Disease (COPD) is a lung condition characterized by chronic breathing symptoms and progressive airflow blockages.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Eosinophilic COPD, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Trial name
- NCT07734883
- Volunteers
- 70 people
- Sponsor
- Assiut University
COPD Exacerbation, COPD Exacerbation Acute
Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease
The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of…
- Trial name
- STOP-COPD (NCT05703919)
- Testing
- Titrated Oxygen, Standard Oxygen
- Where
- Denmark
- Volunteers
- 1,888 people
- Sponsor
- Central Denmark Region
Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases
Do the SPPB and 4-metre Gait Speed Predict Hospital Readmission in Patients Hospitalised for Acute Exacerbation if COPD?
This study aims to evaluate simple tests of physical function in hospitalised patients with chronic obstructive pulmonary disease (COPD) and to assess whether they can predict future hospital readmission.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases, Lung Diseases, Lung Diseases, Obstructive
- Trial name
- NCT01507415
- Where
- 2 sites in United Kingdom
- Volunteers
- 226 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
COPD, AECOPD
The CANadian EXAcerbation of COPD Trial
The natural history of Chronic Obstructive Pulmonary Disease (COPD) is marked by acute, episodic attacks known as exacerbations of COPD.
- Trial name
- CAN-EXACT (NCT07850648)
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pulmonary Disease, Chronic Obstructive
An Efficacy Study of GSK2269557 Added to Standard Care in Subjects With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The purpose of this study is to evaluate the efficacy of GSK2269557 administered in addition to standard of care in adult subjects diagnosed with an acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT02294734
- Testing
- GSK2269557
- Where
- 17 sites in Belgium, Denmark and 3 more
- Volunteers
- 126 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Analysis of Relationship Between Metabolic Biomarkers and Efficacy of Glucocorticoid in AECOPD
Evidences have shown that systemic glucocorticoid cannot not be benefit to all of the patients with AECOPD. The problem that how the clinicians can screen the patients who can benefit from systemic glucocorticoid needs to be…
- Trial name
- NCT04964037
- Testing
- No intervention
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
COPD Exacerbation, COPD
PCT-guided Treatment Regarding Antibiotic Use for Acute COPD Exacerbations
This study the investigators will examine whether procalcitonin-guided treatment regarding antibiotic therapy is non-inferior to usual care in patients who are admitted because of an acute COPD exacerbation when it comes to…
- Conditions
- COPD Exacerbation, COPD, Acute Copd Exacerbation
- Trial name
- PRECISION (NCT05854901)
- Testing
- Procalcitonin, Physician's decision
- Where
- 11 sites in Netherlands
- Volunteers
- 693 people
- Sponsor
- Erasmus Medical Center
Acute Exacerbation Chronic Obstructive Pulmonary Disease
Intravenous Alpha-1 Antitrypsin for Hospitalized Patients With COPD Exacerbations (AECOPD Study)
Intravenous augmentation therapy with purified preparations of AAT (Alpha1-antitrypsin) derived from human plasma is a well consolidated specific therapeutic option to treat the severe deficient state of AAT.
- Trial name
- NCT07125664
- Testing
- alpha1-proteinase inhibitor, produced from the plasma of human donors (Prolastin 1000 mg, powder and solvent for solution for infusion)
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases
Post-hospitalisation Nutritional Support and Gait Speed in COPD
To determine the feasibility of delivering different community nutritional interventions to chronic obstructive pulmonary disease (COPD) patients at moderate or severe risk of malnutrition following a hospitalisation for an acute…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases, Lung Diseases, Obstructive, Bronchitis, Chronic
- Trial name
- NCT02261350
- Testing
- Food fortification, Oral Nutritional Supplements
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Thyroid Eye Disease, Vasculitis
Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting
This is a pilot study to investigate serum prednisolone profiles in: Patients on high doses of prednisolone for any inflammatory disorder, both in the acute and chronic setting.
- Conditions
- Thyroid Eye Disease, Vasculitis, COPD Exacerbation Acute, Asthma
- Trial name
- EHD-Pred PK (NCT05012033)
- Testing
- No intervention - prednisolone is taken as part if routine clinical care.
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
Substudy of Protocol 2019-002498-80 - NCT04223050: Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation (O2flow-COPD)
As protocol NCT04223050. This substudy furthermore investigates the role of oxidative stress in the administration of oxygen in COPD patients.
- Trial name
- NCT05052125
- Testing
- Oxygen
- Where
- 2 sites in Denmark
- Volunteers
- 23 people
- Sponsor
- Mikkel Brabrand
Chronic Obstructive Pulmonary Disease
Safety & Efficacy of BCT197A2201 in COPD Patients Presenting With an Exacerbation
This study will assess preliminary parameters of safety and efficacy of a single dose of BCT197 in patients with a Chronic Obstructive Pulmonary Disease (COPD) exacerbation.
- Trial name
- NCT01332097
- Testing
- BCT197, Prednisone
- Where
- 6 sites in Bulgaria, Romania and 1 more
- Volunteers
- 183 people
- Sponsor
- Mereo BioPharma
Pulmonary Disease, Chronic Obstructive
Oscillating Positive Expiratory Pressure Devices and Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Sputum production increases in acute exacerbation of COPD, both in amount and consistency. It increases airways obstruction and hence delays improvement and prolongs hospital stay.
- Trial name
- SIMPLE (NCT03299231)
- Testing
- OPEP Aerobika
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Ain Shams University
Chronic Obstructive Pulmonary Disease (COPD), Decompensated COPD With (Acute) Exacerbation
Breathing-swallowing Interaction in Chronic Obstructive Pulmonary Disease Patients - Impact of Non Invasive Ventilation
In the investigators' knowledge there are no data about the impact of non invasive mechanical ventilation on the breathing-swallowing interaction.
- Trial name
- NCT01518075
- Testing
- Spontaneous Breathing, Non Invasive Mechanical Ventilation
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Chronic Obstructive Pulmonary Disease, High-flow Nasal Cannula
High-flow Nasal Cannula Nebulization of Beta 2 Adrenergic Agonist During Acute Exacerbation of Chronic Obstructive Pulmonary Disease
High-flow nasal cannula is an oxygenation technique increasingly used for patients admitted for acute respiratory failure. Literature essentially concerns "de novo" acute hypoxemic failure and the interest of high-flow during…
- Trial name
- OPTINEB (NCT03449056)
- Testing
- salbutamol
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Poitiers University Hospital
COPD, Sleep Apnea Hypopnea Syndrome
Prediction of Exacerbations and Management of COPD Patients With SAH Based on Millimeter Wave Radar Monitoring
Millimeter wave radar will be used to conduct non-contact monitoring continuously for patients' vital signs (eg. respiratory rate, heart rate, and chest/abdominal movement).
- Conditions
- COPD, Sleep Apnea Hypopnea Syndrome, Acute Exacerbation of COPD
- Trial name
- NCT05019911
- Testing
- Polysomnography, Millimeter wave radar equipment
- Where
- China
- Volunteers
- 922 people
- Sponsor
- Peking University Third Hospital
Chronic Obstructive Pulmonary Disease Severe
Risk Prediction Model for Exacerbating Phenotype in Patients With Chronic Obstructive Pulmonary Disease
This study is planned to be conducted based on the cohort of patients with severe chronic obstructive pulmonary disease in our hospital.
- Trial name
- NCT06198309
- Where
- China
- Volunteers
- 365 people
- Sponsor
- Li An
Chronic Obstructive Pulmonary Disease, Exacerbation of Chronic Obstructive Pulmonary Disease
Pre-Discharge Bundle for Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease to Reduce Readmissions
Hospital readmissions for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) pose burdens to the healthcare system and patients.
- Trial name
- NCT02135744
- Testing
- Bundle tool
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Henry Ford Health System