Clinical trials: Acute Exacerbation Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease
A Study Of ¹²⁹XE MRI To Assess Disease Progression In Patients With COPD Treated With Or Without Azithromycin And Standard-of-Care Medications
This study will test whether daily use of azithromycin will reduce the rate of exacerbations and improve lung ventilation and perfusion assessed by XE-MRI.
- Trial name
- NCT04353661
- Testing
- Azithromycin, HP xenon (¹²⁹XE)
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Genentech, Inc.
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Comparison of Aerosol Inhalation and Intravenous Glucocorticoid in the Treatment of Severe AECOPD
Comparison of aerosol inhalation and intravenous glucocorticoid in the treatment of severe AECOPD-------Multicenter, prospective, randomized, controlled clinical study
- Trial name
- NCT06189586
- Testing
- aerosol inhalation of glucocorticoids, intravenous injection of glucocorticoids
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Dong Yang
Acute Exacerbation of COPD
Effects of Chair-Based Exercise Training on Exercise Capacity in Patients With Acute Exacerbation of COPD
Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide, a respiratory disease characterized by chronic airflow limitation that is not completely reversible.
- Trial name
- NCT05563493
- Testing
- Treatment group, Chair-Based Exercise Training, Control group, Breathing exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Necmettin Erbakan University
COPD Exacerbation
Physical Activity in Chronic Obstructive Pulmonary Disease(COPD) Acute Exacerbation Patients
Patients who are suffering from Chronic Obstructive Pulmonary Disease (COPD) had a decreased level of physical activity which is consequentially related to another acute exacerbation event.
- Trial name
- NCT03437252
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Samsung Medical Center
Chronic Obstructive Pulmonary Disease
Study on the Effects and Mechanisms of Modified Ma Xing Shi Gan Decoction in Treating Acute Exacerbations of Chronic Obstructive Pulmonary Disease
This study adopted a multi-center, randomized, controlled trial design. Patients with acute exacerbation of chronic obstructive pulmonary disease who met the inclusion criteria were randomly assigned to the experimental group and…
- Trial name
- NCT07403032
- Testing
- modified Ma Xing Shi Gan Decoction, The specific drug comes from "Chinese Expert Consensus on the Diagnosis and Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (Revised Edition 2023)" and the GOLD guidelines
- Volunteers
- 200 people
- Sponsor
- Cuiling Feng
Acute Bronchitis, Acute Exacerbations of Chronic Bronchitis
A Multicenter, Randomized, Double-blind, Parallel Group Study to Determine the Optimal Dose of HL301 After 7 Days Oral Administration in Acute Bronchitis or Acute Exacerbations of Chronic Bronchitis Patients (HL301: Mixed Extract of Rehmannia Glutinosa, Schisandra and so on)
The purpose of this study is to determine the optimal dose of HL301 in patients with acute bronchitis or acute exacerbations of chronic bronchitis.
- Trial name
- HL301 (NCT02250027)
- Testing
- HL301 300mg capsule
- Where
- South Korea
- Volunteers
- 156 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Chronic Obstructive Pulmonary Disease
Tablet-assisted Training in Exacerbated COPD
Chronic obstructive pulmonary disease (COPD) is a public health problem with great morbidity. The main therapeutic strategy is inhalers.
- Trial name
- NCT03601403
- Testing
- inhaler technique
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Universidad de Granada
COPD, Acute Exacerbation of COPD
Evaluating Customized Antibiotic Duration (CDA) Strategy in Acute Exacerbations of COPD
The goal of this clinical trial is to learn whether a shorter course of antibiotics (7 days) works as well as the usual longer course (14 days) for adults admitted to hospital with a flare-up of chronic obstructive pulmonary…
- Trial name
- CDA (NCT07708337)
- Testing
- 7-day antibiotic course, 14-day antibiotic course
- Where
- Pakistan
- Volunteers
- 560 people
- Sponsor
- Capital Development Authority (CDA)
Bronchitis, Chronic Bronchitis
A Study of the Effectiveness and Safety of High Dose, Short-course Levofloxacin in the Treatment of Acute Bacterial Exacerbation (Worsening) of Chronic Bronchitis.
The purpose of this study is to evaluate the safety and effectiveness of four oral antibiotic treatment regimens for bacterial infections in patients with chronic bronchitis.
- Trial name
- NCT00042718
- Testing
- levofloxacin, azithromycin, amoxicillin/clavulanate
- Volunteers
- 659 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Pulmonary Disease, Chronic Obstructive
Calprotectin I Serum as a Diagnostic Marker
Lower respiratory tract infection is the most common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- NCT03474484
- Where
- Norway
- Volunteers
- 113 people
- Sponsor
- St. Olavs Hospital
Asthma, COPD
Acute Exacerbations Treated With BenRAlizumab (The ABRA Study)
Exacerbations of asthma and COPD are an important cause of hospital admission and the main cause of annual winter bed shortages.
- Trial name
- ABRA (NCT04098718)
- Testing
- Benralizumab, Prednisolone
- Where
- United Kingdom
- Volunteers
- 158 people
- Sponsor
- University of Oxford
COPD
Ultrasound of the Diaphragm Excursion Ratio as Physiological Biomarker in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
3.1 Introduction and rationale In 2020 an estimate of 562.700 people had Chronic Obstructive Pulmonary Disease (COPD) in the Netherlands, resulting in 21.335 hospital admissions.[1] An acute exacerbation COPD (AECOPD) in…
- Trial name
- Undated 2 (NCT07259174)
- Where
- 2 sites in Netherlands
- Volunteers
- 186 people
- Sponsor
- Isala
Acute Exacerbation of Chronic Obstructive Airways Disease
Optimization of Ventilator Setting for Acute Exacerbations of Chronic Obstructive Pulmonary Disease
The analysis of flow and pressure curves generated by ventilators can be useful in the individuation of patient-ventilator asynchrony, notably in COPD patients.
- Trial name
- NIMV01AECB (NCT01291303)
- Testing
- Optimized ventilation, Standard ventilation
- Where
- 6 sites in Italy, Switzerland
- Volunteers
- 70 people
- Sponsor
- University of Milan
COPD Acute Exacerbation
Rademikibart Add-on Treatment of an Acute COPD Exacerbation (Seabreeze STAT COPD)
This is a Phase 2, multicenter study in adult participants with an acute COPD exacerbation and type 2 inflammation
- Trial name
- NCT06940154
- Testing
- Rademikibart in prefilled syringe
- Where
- 52 sites in United States, Argentina and 4 more
- Volunteers
- 159 people
- Sponsor
- Connect Biopharm LLC
Chronic Obstructive Pulmonary Disease, Hyperglycemia
Insulin Therapy in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
The purpose of this study is to determine the effect of preventing hyperglycaemia in patients admitted to hospital with acute exacerbations of chronic pulmonary disease.
- Trial name
- NCT00467636
- Testing
- Blood glucose monitoring, Insulin Glulisine
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- The Royal Bournemouth Hospital
Chronic Obstructive Pulmonary Disease
Placebo Versus Antibiotics in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
The role of antibiotic therapy in patients with COPD remains controversial. While the outcome of several clinical trials is in favour of antibiotics, the quality of these studies in insufficient.
- Trial name
- NCT00170222
- Testing
- doxycycline
- Where
- Netherlands
- Volunteers
- 258 people
- Sponsor
- Medical Center Alkmaar
Pulmonary Disease, Chronic Obstructive
Etiology of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in Japan
The purpose of this prospective, epidemiological, cohort study is to evaluate the lung microbiome in stable-state chronic obstructive pulmonary disease (COPD) in Japanese participants
- Trial name
- NCT03957577
- Testing
- Prospective observational cohort study
- Where
- 13 sites in Japan
- Volunteers
- 70 people
- Sponsor
- GlaxoSmithKline
COPD Exacerbation Acute
The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 1
The proposed study will explore whether remote monitoring of a COPD patient can be undertaken using a wearable medical device.
- Trial name
- BREATH-TRACHER (NCT06419036)
- Testing
- Pneumowave DC
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Strathclyde
Chronic Obstructive Pulmonary Disease
Exhaled Breath Condensate (EBC) Assessment in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
This study aimed to assess airway inflammation in patients during the course of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) by serial analyses of their exhaled breath condensates (EBC).
- Trial name
- NCT00448500
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Chronic Bronchitis, Disease Exacerbation
VICTOR - Avelox® Intravenous (i.v.) in Acute Exacerbations of Chronic Bronchitis
This study is a local, prospective, open-label, company-sponsored, non interventional, multi-center study. Patients documented must suffer from an acute exacerbation of chronic bronchitis and take at least one dose of…
- Trial name
- VICTOR (NCT00876577)
- Testing
- Moxifloxacin (Avelox, BAY12-8039)
- Where
- China
- Volunteers
- 1,206 people
- Sponsor
- Bayer