Clinical trials: Acute Exacerbation Chronic Pulmonary Disease
Chronic Obstructive Pulmonary Disease
Theophylline and Steroids in Chronic Obstructive Pulmonary Disease (COPD) Study
The aim of this multi-centre, double blind, randomised, controlled trial (DBRCT) is to assess the effect of low dose theophylline, singly and in combination with low dose oral prednisone, on COPD (Chronic Obstructive Pulmonary…
- Trial name
- TASCS (NCT02261727)
- Testing
- Theophylline, Prednisone
- Where
- Australia
- Volunteers
- 1,670 people
- Sponsor
- The George Institute
Chronic Obstructive Lung Disease (COLD)
ANTEAB: a Study of Early Antibiotherapy in the ICU Management of Acute Exacerbations of COPD
Intensive Care Unit (ICU) admission for acute exacerbation of chronic obstructive lung disease (COLD) is a major cause of morbidity and mortality in such patients. Although bacterial of mortality in such patients.
- Trial name
- NCT00190437
- Testing
- Amoxicillin-clavulanic
- Where
- 2 sites in France
- Volunteers
- 520 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD, COPD Exacerbation Acute
ProAir Digihaler in COPD Disease Management: A Real World Study
A pilot study to explore the utilization of the TEVA ProAir Digihaler rescue medication use and inhalation parameters to identify disease deterioration to help in the management of COPD patients in clinical practice.
- Trial name
- NCT04821869
- Testing
- ProAir Digihaler, Digihaler
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Pulmonary Research Institute of Southeast Michigan
Pulmonary Disease, Chronic Obstructive
Investigate the Impact of Early Treatment Initiation With Tiotropium in Patients Recovering From Hospitalization for an Acute COPD Exacerbation 2
A randomized, placebo-controlled, double-blind, parallel group, multi-center study to assess the safety and efficacy of tiotropium bromide (18 µg) delivered via the HandiHaler® in Chronic Obstructive Pulmonary Disease (COPD)…
- Trial name
- NCT01662986
- Testing
- tiotropium bromide
- Where
- 50 sites in United States
- Volunteers
- 79 people
- Sponsor
- Boehringer Ingelheim
COPD Exacerbation, COPD
PCT-guided Treatment Regarding Antibiotic Use for Acute COPD Exacerbations
This study the investigators will examine whether procalcitonin-guided treatment regarding antibiotic therapy is non-inferior to usual care in patients who are admitted because of an acute COPD exacerbation when it comes to…
- Conditions
- COPD Exacerbation, COPD, Acute Copd Exacerbation
- Trial name
- PRECISION (NCT05854901)
- Testing
- Procalcitonin, Physician's decision
- Where
- 11 sites in Netherlands
- Volunteers
- 693 people
- Sponsor
- Erasmus Medical Center
COPD Exacerbation Acute, COPD Exacerbation
PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD
Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined acute worsening of respiratory symptoms requiring additional therapy.
- Trial name
- PAINT-COPD (NCT06160687)
- Testing
- PSV mode during NIV, ASV intellisync
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
COPD, COPD Exacerbation Acute
Relationship Between Plasma Metabolome and the Efficacy of Systemic Glucocorticoid in AECOPD
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) significantly increases the mortality of the patients with COPD. Guidelines have recommended systemic glucocorticoid as regular treatment.
- Trial name
- NCT04710849
- Testing
- Serum metabolic markers
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Chronic Obstructive Pulmonary Disease
Early Pulmonary Rehabilitation for Hospitalized Patients With Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a disease state characterized by airflow limitation that is not fully reversible.
- Trial name
- NCT00287625
- Testing
- Pulmonary rehabilitation
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Chronic Obstructive Pulmonary Disease
Evaluation of the Use of a Remote Monitoring and Follow-up Option for Patients With Chronic Obstructive Pulmonary Disease (BOREAL)
The purpose of this study is to evaluate the ability of the Bora Care remote monitoring solution to detect early acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- BOREAL (NCT05759247)
- Testing
- BORA Band (wristband)
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease
ECCO2R as an Adjunct to NIV in AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the UKs commonest chronic diseases and is responsible for a significant number of acute hospital admissions.
- Trial name
- NCT02086084
- Testing
- NIV, ECCO2R
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Respiratory Failure, Neuromuscular Disease
Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory Failure
The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients admitted to hospital with acute exacerbation of chronic respiratory failure.
- Conditions
- Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01174316
- Testing
- AutoVPAP™, VPAPIIIST-A™
- Where
- United Kingdom
- Sponsor
- ResMed
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD
Remote Monitoring of COPD Patients Experiencing an Acute Exacerbation Through Health Evaluations Using Wearable Mobile Technology
Chronic obstructive pulmonary disease (COPD) causes about 3 million deaths annually and significantly burdens healthcare systems, costing the EU 38.6 billion euros, largely due to frequent hospitalizations triggered by acute…
- Trial name
- COPD-BREATHE (NCT06890767)
- Testing
- Wearable mobile device, CAT Questionnaire, DHRQ Questionnaire
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- David Ruttens
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
T Lymphocyte Cells in Individuals Experiencing an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine whether the lungs of individuals with chronic obstructive pulmonary disease (COPD) contain resident memory T lymphocytes that can produce a combination of cytokines that induce the…
- Trial name
- NCT00281229
- Where
- 2 sites in United States
- Volunteers
- 481 people
- Sponsor
- University of Michigan
Pulmonary Disease, Chronic Obstructive
Predictive Ability of the Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) for Acute Exacerbations (PACE) in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) is a major health concern, with a substantial impact on a patient's life. However, the impact of COPD is currently under-recognised and, as a result, COPD is under-treated.
- Trial name
- PACE (NCT01254032)
- Where
- 19 sites in Australia, China and 2 more
- Volunteers
- 70 people
- Sponsor
- GlaxoSmithKline
Bronchitis, Chronic
AVANTI - Avelox® in Acute Exacerbations of chroNic bronchiTIs
The objective of this global non-interventional study is to evaluate the impact of Acute Exacerbation of Chronic Bronchitis(AECB) on the patient and the community as well as the safety and effect of a treatment with Moxifloxacin…
- Trial name
- NCT00846911
- Testing
- Moxifloxacin (Avelox, BAY12-8039)
- Where
- 8 sites in Albania, Bosnia and Herzegovina and 6 more
- Volunteers
- 2,672 people
- Sponsor
- Bayer
Acute Exacerbation Of Chronic Obstructive Pulmonary Disease
Effects of Chinese Medicine on Patients With Severe Acute Exacerbation of COPD
The purpose of this study was to evaluate the effects of Chinese Medicine on patients with severe AECOPD, and to provide a basis for the establishment of integrated CM and Western medicine diagnosis and treatment scheme for…
- Trial name
- NCT06455670
- Testing
- Sanhan Huayin recipe, Qingre Huatan recipe or Zaoshi Huatan recipe
- Volunteers
- 468 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Pulmonary Disease, Chronic Obstructive
Evaluate the Efficacy of Xuebijing Injection in Acute Exacerbations of COPD
Objective: A prospective multicenter randomized controlled trial to assess the efficacy and safety of Xuebijing injection for acute exacerbation of chronic obstructive pulmonary disease(AECOPD).
- Trial name
- NCT02937974
- Testing
- Xuebijing
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Chinese PLA General Hospital
Acute Exacerbation of COPD
Copd Exacerbation and Pulmonary Hypertension Trial
This trial will investigate whether patiens admitted with an acute exacerbation of chronic obstructive lung disease and pulmonary hypertension will benefit from a targeted pharmacological treatment.
- Trial name
- CODEX-P (NCT04538976)
- Testing
- Sildenafil
- Where
- 5 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Does Positive Expiratory Pressure Mask Therapy Improve Recovery From Acute Exacerbations of Chronic Obstructive Pulmonary Disease?
This study aims to identify whether the addition of positive expiratory pressure (PEP) mask therapy to standard medical care improves clinically important outcomes in individuals with acute exacerbations of chronic obstructive…
- Trial name
- NCT01101282
- Testing
- Positive expiratory pressure (PEP) mask therapy
- Where
- 2 sites in Australia
- Volunteers
- 92 people
- Sponsor
- La Trobe University
Frailty, Sarcopenia
The SHAPE Project (Hospital System for Physical Activity and Active Participation) After Hospitalized Decompensation of Respiratory Chronic Diseases
It is widely established that a lack of adapted physical activity (APA) and sedentary behaviors increase the prevalence of frailty, which exacerbates chronic diseases.
- Conditions
- Frailty, Sarcopenia, Hospital Discharge, Physical Activity
- Trial name
- SHAPE (NCT07663955)
- Testing
- Hospital System for Physical Activity and Active Participation
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Universitari de Bellvitge